CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70

Journal of Neurochemistry

Volumn 90, Issue 1, 2004, Pages 231-244

  Urushitani, Makoto ^a,d   Kurisu, Junko ^a   Tateno, Minako ^a   Hatakeyama, Shigetsugu ^b   Nakayama, Kei Ichi ^b   Kato, Shinsuke ^c   Takahashi, Ryosuke ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d LAVAL UNIVERSITY   (Canada)

Author keywords

Amytrophic lateral sclerosis; CHIP; Hsp70; Proteasome degradation; Superoxide dismutase 1; Ubiquitin

Indexed keywords

CARBOXYL TERMINUS OF THE HSC70 INTERACTING PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; DITHIOTHREITOL; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN; POLYUBIQUITIN; PROTEASOME; PROTEIN; PROTEIN SUBUNIT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SPINAL CORD MOTONEURON; UBIQUITINATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INCLUSION BODIES; MACROMOLECULAR SUBSTANCES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; SUPEROXIDE DISMUTASE; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; MUS MUSCULUS;

EID: 3042817421     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02486.x     Document Type: Article

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