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Volumn 163, Issue 2, 2003, Pages 591-607

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN; RAB PROTEIN; RAPAMYCIN; S6 KINASE; SERINE; TAU PROTEIN; THREONINE; UBIQUITIN; UNCLASSIFIED DRUG; ZINC SULFATE;

EID: 0041343303     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63687-5     Document Type: Article
Times cited : (273)

References (81)
  • 3
    • 0022595501 scopus 로고
    • Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
    • Braak H, Braak E, Grundke-Iqbal I, Iqbal K: Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 1986, 165:351-355
    • (1986) Neurosci Lett , vol.165 , pp. 351-355
    • Braak, H.1    Braak, E.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 6
    • 0026694783 scopus 로고
    • Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
    • Khatoon S, Grundke-Iqbal I, Iqbal K: Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 1992, 59:750-753
    • (1992) J Neurochem , vol.59 , pp. 750-753
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 7
    • 0028095224 scopus 로고
    • Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
    • Khatoon S, Grundke-Iqbal I, Iqbal K: Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 1994, 351:80-84
    • (1994) FEBS Lett , vol.351 , pp. 80-84
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 8
    • 0028227962 scopus 로고
    • Role of abnormally hyperphosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso A del C, Zaidi T, Grundke-Iqbal I, Iqbal K: Role of abnormally hyperphosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 1994, 91:5562-5566
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso, A.D.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 9
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso AC, Grundke-Iqbal I, Iqbal K: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 1996, 2:783-787
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Alonso, A.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 11
    • 0026504296 scopus 로고
    • A single gene encodes two isoforms of the p70 S6 kinase: Activation upon mitogenic stimulation
    • Reinhard C, Thomas G, Kozma SC: A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proc Natl Acad Sci USA 1992, 89:4052-4056
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4052-4056
    • Reinhard, C.1    Thomas, G.2    Kozma, S.C.3
  • 13
    • 0033604521 scopus 로고    scopus 로고
    • Ribosomal S6 kinase signaling and the control of translation
    • Dufner A, Thomas G: Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 1999, 253:100-109
    • (1999) Exp Cell Res , vol.253 , pp. 100-109
    • Dufner, A.1    Thomas, G.2
  • 14
    • 0030790548 scopus 로고    scopus 로고
    • Using structure to define the function of phosphoinositide 3-kinase family members
    • Domin J, Waterfield MD: Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett 1997, 410:91-95
    • (1997) FEBS Lett , vol.410 , pp. 91-95
    • Domin, J.1    Waterfield, M.D.2
  • 15
    • 0023673241 scopus 로고
    • Identification and characterization of a mitogenic-activated S6 Kinase
    • Jeno P, Ballou LM, Novak-Hofer I, Thomas G: Identification and characterization of a mitogenic-activated S6 Kinase. Proc Natl Acad Sci USA 1988, 85:406-410
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 406-410
    • Jeno, P.1    Ballou, L.M.2    Novak-Hofer, I.3    Thomas, G.4
  • 16
    • 0026757270 scopus 로고
    • An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase
    • Mukhopadhyay NK, Price DJ, Kyriakis JM, Pelech S, Sanghera J, Avruch J: An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J Biol Chem 1992, 267:3325-3335
    • (1992) J Biol Chem , vol.267 , pp. 3325-3335
    • Mukhopadhyay, N.K.1    Price, D.J.2    Kyriakis, J.M.3    Pelech, S.4    Sanghera, J.5    Avruch, J.6
  • 18
    • 0028533984 scopus 로고
    • Mitogenesis and protein synthesis: A role for ribosomal protein S6 phosphorylation?
    • Stewart MJ, Thomas G: Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation? BioEssays 1994, 16:1-7
    • (1994) BioEssays , vol.16 , pp. 1-7
    • Stewart, M.J.1    Thomas, G.2
  • 19
    • 0026688510 scopus 로고
    • Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver
    • Flotow H, Thomas G: Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J Biol Chem 1992, 267:3074-3078
    • (1992) J Biol Chem , vol.267 , pp. 3074-3078
    • Flotow, H.1    Thomas, G.2
  • 20
    • 0027336002 scopus 로고
    • p70s6k function is essential for G1 progression
    • Lane HA, Fernandez A, Lamb NJ, Thomas G: p70s6k function is essential for G1 progression. Nature 1993, 363:170-172
    • (1993) Nature , vol.363 , pp. 170-172
    • Lane, H.A.1    Fernandez, A.2    Lamb, N.J.3    Thomas, G.4
  • 21
    • 0033624269 scopus 로고    scopus 로고
    • Cellular function of p70S6K: A role in regulating cell motility
    • Berven LA, Crouch MF: Cellular function of p70S6K: a role in regulating cell motility. Immunol Cell Biol 2000, 78:447-451
    • (2000) Immunol Cell Biol , vol.78 , pp. 447-451
    • Berven, L.A.1    Crouch, M.F.2
  • 22
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991, 82:239-259
    • (1991) Acta Neuropathol (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 24
    • 0034714258 scopus 로고    scopus 로고
    • Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway
    • Kim S, Jung Y, Kim D, Koh H, Chung J: Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway. J Biol Chem 2000, 275:25979-25984
    • (2000) J Biol Chem , vol.275 , pp. 25979-25984
    • Kim, S.1    Jung, Y.2    Kim, D.3    Koh, H.4    Chung, J.5
  • 25
    • 0036176049 scopus 로고    scopus 로고
    • Signals of oxidant-induced cardiomyocyte hypertrophy: Key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase
    • Tu VC, Bahl JJ, Chen QM: Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. J Pharmacol Exp Ther 2002, 300:1101-1110
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 1101-1110
    • Tu, V.C.1    Bahl, J.J.2    Chen, Q.M.3
  • 27
    • 0030297178 scopus 로고    scopus 로고
    • Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress
    • Deibel MA, Ehmann WD, Markesbery WR: Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress. J Neurol Sci 1996, 143:137-142
    • (1996) J Neurol Sci , vol.143 , pp. 137-142
    • Deibel, M.A.1    Ehmann, W.D.2    Markesbery, W.R.3
  • 28
    • 0030804608 scopus 로고    scopus 로고
    • Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: A proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
    • Danscher G, Jensen KB, Frederickson CJ, Kemp K, Andreasen A, Juhl S, Stoltenberg M, Ravid R: Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material. J Neurosci Methods 1997, 76:53-59
    • (1997) J Neurosci Methods , vol.76 , pp. 53-59
    • Danscher, G.1    Jensen, K.B.2    Frederickson, C.J.3    Kemp, K.4    Andreasen, A.5    Juhl, S.6    Stoltenberg, M.7    Ravid, R.8
  • 29
    • 0031800225 scopus 로고    scopus 로고
    • Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain
    • Cornett CR, Markesbery WR, Ehmann WD: Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain. Neurotoxicology 1998, 19:339-345
    • (1998) Neurotoxicology , vol.19 , pp. 339-345
    • Cornett, C.R.1    Markesbery, W.R.2    Ehmann, W.D.3
  • 30
    • 0027361281 scopus 로고
    • Microtubule-associated protein tau: Abnormal phosphorylation of a non-paired helical pool in Alzheimer disease
    • Köpke E, Tung Y-C, Shaikh S, Alonso A del C, Iqbal K, Grundke-Iqbal I: Microtubule-associated protein tau: abnormal phosphorylation of a non-paired helical pool in Alzheimer disease. J Biol Chem 1993, 268:24374-24384
    • (1993) J Biol Chem , vol.268 , pp. 24374-24384
    • Köpke, E.1    Tung, Y.-C.2    Shaikh, S.3    Alonso, A.D.C.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 31
    • 0033169066 scopus 로고    scopus 로고
    • Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus
    • Tatebayashi Y, Iqbal K, Grundke-Iqbal I: Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. J Neurosci 1999, 9:5245-5254
    • (1999) J Neurosci , vol.9 , pp. 5245-5254
    • Tatebayashi, Y.1    Iqbal, K.2    Grundke-Iqbal, I.3
  • 32
    • 0025968532 scopus 로고
    • Alzheimer's disease affects limbic nuclei of the thalamus
    • Braak H, Braak E: Alzheimer's disease affects limbic nuclei of the thalamus. Acta Neuropathol (Berl) 1991, 81:261-268
    • (1991) Acta Neuropathol (Berl) , vol.81 , pp. 261-268
    • Braak, H.1    Braak, E.2
  • 33
    • 84907130484 scopus 로고
    • Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment
    • Braak H, Braak E, Ohm T, Bohl J: Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment. Stain Technol 1988, 63:197-200
    • (1988) Stain Technol , vol.63 , pp. 197-200
    • Braak, H.1    Braak, E.2    Ohm, T.3    Bohl, J.4
  • 34
    • 0015168149 scopus 로고
    • Silver staining of Alzheimer's neurofibrillary changes by means of physical development
    • Gallyas F: Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 1971, 19:1-8
    • (1971) Acta Morphol Acad Sci Hung , vol.19 , pp. 1-8
    • Gallyas, F.1
  • 35
    • 0028362458 scopus 로고
    • A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
    • Braak E, Braak H, Mandelkow EM: A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol (Berl) 1994, 87:554-567
    • (1994) Acta Neuropathol (Berl) , vol.87 , pp. 554-567
    • Braak, E.1    Braak, H.2    Mandelkow, E.M.3
  • 36
    • 0000276080 scopus 로고
    • Alzheimer's plaques and tangles: A controlled and enhanced silver-staining method
    • Campbell SK, Switzer RC, Martin TL: Alzheimer's plaques and tangles: a controlled and enhanced silver-staining method. Soc Neurosci Abstr 1987, 13:H678
    • (1987) Soc Neurosci Abstr , vol.13
    • Campbell, S.K.1    Switzer, R.C.2    Martin, T.L.3
  • 37
    • 0027490614 scopus 로고
    • Staging of Alzheimer-related cortical destruction
    • Braak H, Braak E, Bohl J: Staging of Alzheimer-related cortical destruction. Eur Neurol 1993, 33:403-408
    • (1993) Eur Neurol , vol.33 , pp. 403-408
    • Braak, H.1    Braak, E.2    Bohl, J.3
  • 38
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 39
    • 0026298636 scopus 로고
    • Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease
    • Iqbal K, Grundke-Iqbal I: Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease. Mol Neurobiol 1992, 5:399-410
    • (1992) Mol Neurobiol , vol.5 , pp. 399-410
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 40
    • 0025856776 scopus 로고
    • A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope
    • Ishiguro, K, Omori A, Sato K, Tomizawa K, Imahori K, Uchida T: A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope. Neurosci Lett 1991, 128:195-198
    • (1991) Neurosci Lett , vol.128 , pp. 195-198
    • Ishiguro, K.1    Omori, A.2    Sato, K.3    Tomizawa, K.4    Imahori, K.5    Uchida, T.6
  • 41
    • 0026487365 scopus 로고
    • Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
    • Hanger DP, Hughes K, Woodgett JR, Brion JP, Anderton BH: Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett 1992, 147:58-62
    • (1992) Neurosci Lett , vol.147 , pp. 58-62
    • Hanger, D.P.1    Hughes, K.2    Woodgett, J.R.3    Brion, J.P.4    Anderton, B.H.5
  • 42
    • 0026694067 scopus 로고
    • Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease
    • Ledesma MD, Correas I, Avila J, Diaz-Nido J: Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease. FEBS Lett 1992, 308:218-224
    • (1992) FEBS Lett , vol.308 , pp. 218-224
    • Ledesma, M.D.1    Correas, I.2    Avila, J.3    Diaz-Nido, J.4
  • 43
    • 0032530145 scopus 로고    scopus 로고
    • Protein phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules
    • Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K: Protein phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys 1998, 357:299-309
    • (1998) Arch Biochem Biophys , vol.357 , pp. 299-309
    • Sengupta, A.1    Kabat, J.2    Novak, M.3    Wu, Q.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 44
    • 0036938381 scopus 로고    scopus 로고
    • Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
    • Pei J-J, Braak H, Gong C-X, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF: Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration. Acta Neuropathologica 2002, 104:369-376
    • (2002) Acta Neuropathologica , vol.104 , pp. 369-376
    • Pei, J.-J.1    Braak, H.2    Gong, C.-X.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 45
    • 0026500429 scopus 로고
    • In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease
    • Mah VH, Eskin TA, Kazee AM, Lapham L, Higgins GA: In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease. Brain Res Mol Brain Res 1992, 12:85-94
    • (1992) Brain Res Mol Brain Res , vol.12 , pp. 85-94
    • Mah, V.H.1    Eskin, T.A.2    Kazee, A.M.3    Lapham, L.4    Higgins, G.A.5
  • 46
    • 0033549267 scopus 로고    scopus 로고
    • Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA
    • Yasojima K, McGeer EG, McGeer PL: Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA. Brain Res 1999, 831:301-305
    • (1999) Brain Res , vol.831 , pp. 301-305
    • Yasojima, K.1    McGeer, E.G.2    McGeer, P.L.3
  • 49
    • 0031812256 scopus 로고    scopus 로고
    • Chloroquine myopathy suggests that tau is degraded in lysosomes: Implication for the formation of paired helical filaments in Alzheimer's disease
    • Oyama F, Murakami N, Ihara Y: Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease. Neurosci Res 1998, 31:1-8
    • (1998) Neurosci Res , vol.31 , pp. 1-8
    • Oyama, F.1    Murakami, N.2    Ihara, Y.3
  • 50
    • 0030836345 scopus 로고    scopus 로고
    • Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathological evidence for a mechanism of increased β-amyloidogenesis
    • Cataldo AM, Barnett JL, Pieroni C, Nixon RA: Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathological evidence for a mechanism of increased β-amyloidogenesis. J Neurosci 1997, 17:6142-6151
    • (1997) J Neurosci , vol.17 , pp. 6142-6151
    • Cataldo, A.M.1    Barnett, J.L.2    Pieroni, C.3    Nixon, R.A.4
  • 51
    • 0025937121 scopus 로고
    • Brain ubiquitin is markedly elevated in Alzheimer disease
    • Wang GP, Khatoon S, Iqbal K, Grundke-Iqbal I: Brain ubiquitin is markedly elevated in Alzheimer disease. Brain Res 1991, 566:146-151
    • (1991) Brain Res , vol.566 , pp. 146-151
    • Wang, G.P.1    Khatoon, S.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 54
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active glycogen synthase kinase 3β(GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
    • Pei J-J, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF: Distribution of active glycogen synthase kinase 3β(GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol 1999, 58:1010-1019
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 1010-1019
    • Pei, J.-J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 55
    • 0031727983 scopus 로고    scopus 로고
    • Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK
    • Sironi JJ, Yen SH, Gondal JA, Wu Q, Grundke-Iqbal I, Iqbal K: Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK. FEBS Lett 1998, 436:471-475
    • (1998) FEBS Lett , vol.436 , pp. 471-475
    • Sironi, J.J.1    Yen, S.H.2    Gondal, J.A.3    Wu, Q.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 56
    • 0035830740 scopus 로고    scopus 로고
    • Inhibition of PP-2A upregulates CAMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356
    • Bennecib M, Gong C-X, Grundke-Iqbal I, Iqbal K: Inhibition of PP-2A upregulates CAMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS Lett 2001, 490:15-22
    • (2001) FEBS Lett , vol.490 , pp. 15-22
    • Bennecib, M.1    Gong, C.-X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 58
    • 0032578024 scopus 로고    scopus 로고
    • Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
    • Pei J-J, Grundke-Iqbal I, Eqbal K, Bogdanovic N, Winblad B, Cowburn RF: Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration. Brain Res 1998, 797:267-277
    • (1998) Brain Res , vol.797 , pp. 267-277
    • Pei, J.-J.1    Grundke-Iqbal, I.2    Eqbal, K.3    Bogdanovic, N.4    Winblad, B.5    Cowburn, R.F.6
  • 60
    • 0035881867 scopus 로고    scopus 로고
    • Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease
    • Vincent I, Bu B, Hudson K, Husseman J, Nochlin D, Jin L: Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease. Neuroscience 2001, 105:639-650
    • (2001) Neuroscience , vol.105 , pp. 639-650
    • Vincent, I.1    Bu, B.2    Hudson, K.3    Husseman, J.4    Nochlin, D.5    Jin, L.6
  • 61
    • 0035914046 scopus 로고    scopus 로고
    • Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells
    • Wang J, Tung YC, Wang Y, Li XT, Iqbal K, Grundke-Iqbal I: Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells. FEBS Lett 2001, 507:81-87
    • (2001) FEBS Lett , vol.507 , pp. 81-87
    • Wang, J.1    Tung, Y.C.2    Wang, Y.3    Li, X.T.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 62
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I, Jicha G, Rosado M, Dicksom DW: Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J. Neurosci 1997, 17:3588-3598
    • (1997) J Neurosci , vol.17 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dicksom, D.W.4
  • 63
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser J, Geldmacher DS, Herrup K: Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998, 18:2801-2807
    • (1998) J Neurosci , vol.18 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 64
    • 0025875819 scopus 로고
    • Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
    • Gomez N, Cohen P: Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. Nature 1991, 353:170-173
    • (1991) Nature , vol.353 , pp. 170-173
    • Gomez, N.1    Cohen, P.2
  • 65
    • 0030879686 scopus 로고    scopus 로고
    • Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ
    • Ferreira A, Lu Q, Orecchio L, Kosik KS: Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ. Mol Cell Neurosci 1997, 9:220-234
    • (1997) Mol Cell Neurosci , vol.9 , pp. 220-234
    • Ferreira, A.1    Lu, Q.2    Orecchio, L.3    Kosik, K.S.4
  • 67
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Aβ 42 fibrils
    • Gotz J, Chen F, van Dorpe J, Nitsch RM: Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Aβ 42 fibrils. Science 2001, 293:1491-1495
    • (2001) Science , vol.293 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 68
    • 84937167735 scopus 로고
    • Epidemiology of Alzheimer's disease: Issues of etiology and validity
    • Fratiglioni L: Epidemiology of Alzheimer's disease: issues of etiology and validity. Acta Neurol Scand 1993, 45(Suppl 1):1-70
    • (1993) Acta Neurol Scand , vol.45 , Issue.SUPPL. 1 , pp. 1-70
    • Fratiglioni, L.1
  • 69
    • 0035208849 scopus 로고    scopus 로고
    • Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis
    • Atzori C, Ghetti B, Piva R, Srinivasan AN, Zolo P, Delisle MB, Mirra SS, Migheli A: Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J Neuropathol Exp Neurol 2001, 60:1190-1197
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 1190-1197
    • Atzori, C.1    Ghetti, B.2    Piva, R.3    Srinivasan, A.N.4    Zolo, P.5    Delisle, M.B.6    Mirra, S.S.7    Migheli, A.8
  • 70
    • 0035087703 scopus 로고    scopus 로고
    • Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
    • Pei J-J, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF: Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. J Alzheimer Dis 2001, 3:41-48
    • (2001) J Alzheimer Dis , vol.3 , pp. 41-48
    • Pei, J.-J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6    Cowburn, R.F.7
  • 71
    • 12244279939 scopus 로고    scopus 로고
    • Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    • Pei J-J, Braak H, An W-L, Winblad B, Cowburn RF, Iqbal K, Grundke-Iqbal I, Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Mol Brain Res 2002, 109:45-55
    • (2002) Mol Brain Res , vol.109 , pp. 45-55
    • Pei, J.-J.1    Braak, H.2    An, W.-L.3    Winblad, B.4    Cowburn, R.F.5    Iqbal, K.6    Grundke-Iqbal, I.7
  • 72
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain
    • Gong CX, Shaikh S, Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K: Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J Neurochem 1995, 65:732-738
    • (1995) J Neurochem , vol.65 , pp. 732-738
    • Gong, C.X.1    Shaikh, S.2    Wang, J.Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 73
    • 0034088846 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease
    • Gong C-X, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K: Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem 2000, 275:5535-5544
    • (2000) J Biol Chem , vol.275 , pp. 5535-5544
    • Gong, C.-X.1    Lidsky, T.2    Wegiel, J.3    Zuck, L.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 74
    • 0034680902 scopus 로고    scopus 로고
    • Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain
    • Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K: Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett 2000, 485:87-93
    • (2000) FEBS Lett , vol.485 , pp. 87-93
    • Bennecib, M.1    Gong, C.X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 75
    • 0028902487 scopus 로고
    • Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
    • Wang J-Z, Gong C-X, Zaidi T, Grundke-Iqbal I, Iqbal K: Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem 1995, 270:4854-4860
    • (1995) J Biol Chem , vol.270 , pp. 4854-4860
    • Wang, J.-Z.1    Gong, C.-X.2    Zaidi, T.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 76
    • 0028924295 scopus 로고
    • A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle
    • Sontag E, Nunbhakdi-Craig V, Bloom GS, Mumby MC: A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle. J Cell Biol 1995, 128:1131-1144
    • (1995) J Cell Biol , vol.128 , pp. 1131-1144
    • Sontag, E.1    Nunbhakdi-Craig, V.2    Bloom, G.S.3    Mumby, M.C.4
  • 77
    • 0033534615 scopus 로고    scopus 로고
    • Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
    • Westphal RS, Coffee RL Jr, Marotta A, Pelech SL, Wadzinski BE: Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A. J Biol Chem 1999, 274:687-692
    • (1999) J Biol Chem , vol.274 , pp. 687-692
    • Westphal, R.S.1    Coffee R.L., Jr.2    Marotta, A.3    Pelech, S.L.4    Wadzinski, B.E.5
  • 78
    • 0034671578 scopus 로고    scopus 로고
    • TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G (1) arrest
    • Petritsch C, Beug H, Balmain A, Oft M: TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G (1) arrest. Genes Dev 2000, 14:3093-3101
    • (2000) Genes Dev , vol.14 , pp. 3093-3101
    • Petritsch, C.1    Beug, H.2    Balmain, A.3    Oft, M.4
  • 79
    • 0027534625 scopus 로고
    • Application of synthetic phospho- and unphospho-peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease
    • Liu WK, Moore WT, Williams RT, Hall FL, Yen SH: Application of synthetic phospho- and unphospho-peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease. J Neurosci Res 1993, 34:371-376
    • (1993) J Neurosci Res , vol.34 , pp. 371-376
    • Liu, W.K.1    Moore, W.T.2    Williams, R.T.3    Hall, F.L.4    Yen, S.H.5
  • 80
    • 0028593606 scopus 로고
    • Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404
    • Otvos L Jr., Feiner L, Lang E, Szendrei GI, Goedert M, Lee VM: Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J Neurosci Res 1994, 39:669-673
    • (1994) J Neurosci Res , vol.39 , pp. 669-673
    • Otvos L., Jr.1    Feiner, L.2    Lang, E.3    Szendrei, G.I.4    Goedert, M.5    Lee, V.M.6
  • 81
    • 0027939401 scopus 로고
    • Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites
    • Su JH, Cummings BJ, Cotman CW: Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. Neuroreport 1994, 5:2358-2362
    • (1994) Neuroreport , vol.5 , pp. 2358-2362
    • Su, J.H.1    Cummings, B.J.2    Cotman, C.W.3


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