-
1
-
-
34047242070
-
Sphingolipids and cell death
-
DOI 10.1007/s10495-007-0721-0, Special Issue on Mitochondria in Apoptosis
-
Morales A, Lee H, Goñi F et al. Sphingolipids and cell death. Apoptosis 2007; 12:923-39. (Pubitemid 46653290)
-
(2007)
Apoptosis
, vol.12
, Issue.5
, pp. 923-939
-
-
Morales, A.1
Lee, H.2
Goni, F.M.3
Kolesnick, R.4
Fernandez-Checa, J.C.5
-
2
-
-
20444363393
-
The ins and outs of sphingolipid synthesis
-
DOI 10.1016/j.tcb.2005.04.006, PII S0962892405001078
-
Futerman A, Riezman H. The ins and outs of sphingolipid synthesis. Trends Cell Biol 2005; 15:312-8. (Pubitemid 40805327)
-
(2005)
Trends in Cell Biology
, vol.15
, Issue.6
, pp. 312-318
-
-
Futerman, A.H.1
Riezman, H.2
-
3
-
-
34247520569
-
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate
-
DOI 10.1016/j.plipres.2007.03.001, PII S0163782707000033
-
Kihara A, Mitsutake S, Mizutani Y et al. Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res 2007; 46:126-44. (Pubitemid 46661866)
-
(2007)
Progress in Lipid Research
, vol.46
, Issue.2
, pp. 126-144
-
-
Kihara, A.1
Mitsutake, S.2
Mizutani, Y.3
Igarashi, Y.4
-
4
-
-
38449090335
-
Modulation of cell functions by glycosphingolipid metabolic remodeling in the plasma membrane
-
Prinetti A, Chigorno V, Mauri L et al. Modulation of cell functions by glycosphingolipid metabolic remodeling in the plasma membrane. J Neurochem 2007; 103(Suppl 1):113-25.
-
(2007)
J Neurochem
, vol.103
, Issue.SUPPL. 1
, pp. 113-25
-
-
Prinetti, A.1
Chigorno, V.2
Mauri, L.3
-
5
-
-
34547149529
-
Translational aspects of sphingolipid metabolism
-
DOI 10.1016/j.molmed.2007.06.002, PII S1471491407001074
-
Zeidan Y, Hannun Y. Translational aspects of sphingolipid metabolism. Trends Mol Med 2007; 13:327-36. (Pubitemid 47126985)
-
(2007)
Trends in Molecular Medicine
, vol.13
, Issue.8
, pp. 327-336
-
-
Zeidan, Y.H.1
Hannun, Y.A.2
-
7
-
-
35448989224
-
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
-
Murph M, GB M. Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Rev Mol Med 2007; 9:1-18.
-
(2007)
Expert Rev Mol Med
, vol.9
, pp. 1-18
-
-
Murph, M.G.B.M.1
-
8
-
-
0033884050
-
Compartmentalization of Ceramide Signaling: Physical Foundations and Biological Effects
-
DOI 10.1002/1097-4652(200009)184:3<285::AID-JCP2>3.0.CO;2-3
-
Kolesnick RN, Goni FM, Alonso A. Compartmentalization of ceramide signaling: Physical foundations and biological effects. J Cell Physiol 2000; 184(3):285-300. (Pubitemid 30625491)
-
(2000)
Journal of Cellular Physiology
, vol.184
, Issue.3
, pp. 285-300
-
-
Kolesnick, R.N.1
Goni, F.M.2
Alonso, A.3
-
9
-
-
12244284610
-
Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia
-
Itoh M, Kitano T, Watanabe M et al. Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. Clin Cancer Res 2003; 9(1):415-23. (Pubitemid 36109759)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.1
, pp. 415-423
-
-
Itoh, M.1
Kitano, T.2
Watanabe, M.3
Kondo, T.4
Yabu, T.5
Taguchi, Y.6
Iwai, K.7
Tashima, M.8
Uchiyama, T.9
Okazaki, T.10
-
10
-
-
0024795059
-
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
-
Okazaki T, Bell R, Hannun Y. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. J Biol Chem 1989; 264(32):19076-80.
-
(1989)
J Biol Chem
, vol.264
, Issue.32
, pp. 19076-80
-
-
Okazaki, T.1
Bell, R.2
Hannun, Y.3
-
12
-
-
33845637820
-
Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts
-
Valaperta R, Chigorno V, Basso L et al. Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts. FASEB J 2006; 20:1227-9.
-
(2006)
FASEB J
, vol.20
, pp. 1227-9
-
-
Valaperta, R.1
Chigorno, V.2
Basso, L.3
-
14
-
-
0035004561
-
Sphingosine kinase: A mediator of vital cellular functions
-
DOI 10.1016/S0090-6980(01)00108-3, PII S0090698001001083
-
Olivera A, Spiegel S. Sphingosine kinase: A mediator of vital cellular functions. Prostaglandins Other Lipid Mediat 2001; 64(1-4):123-34. (Pubitemid 32452286)
-
(2001)
Prostaglandins and Other Lipid Mediators
, vol.64
, Issue.1-4
, pp. 123-134
-
-
Olivera, A.1
Spiegel, S.2
-
15
-
-
0037162065
-
Sphingosine-1-phosphate and lipid phosphohydrolases
-
DOI 10.1016/S1388-1981(02)00132-4, PII S1388198102001324
-
Le Stunff H, Peterson C, Liu H et al. Sphingosine-1-phosphate and lipid phosphohydrolases. Biochim Biophys Acta 2002; 1582(1-3):8-17. (Pubitemid 34634106)
-
(2002)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, vol.1582
, Issue.1-3
, pp. 8-17
-
-
Le Stunff, H.1
Peterson, C.2
Liu, H.3
Milstien, S.4
Spiegel, S.5
-
16
-
-
0031892088
-
Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response
-
DOI 10.1073/pnas.95.1.150
-
Mandala SM, Thornton R, Tu Z et al. Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response. Proc Natl Acad Sci USA 1998; 95(1):150-5. (Pubitemid 28103922)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.1
, pp. 150-155
-
-
Mandala, S.M.1
Thornton, R.2
Tu, Z.3
Kurtz, M.B.4
Nickels, J.5
Broach, J.6
Menzeleev, R.7
Spiegel, S.8
-
17
-
-
34247617182
-
Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren
-
DOI 10.1016/j.molmed.2007.03.005, PII S1471491407000603
-
Bandhuvula P, Saba J. Sphingosine-1-phosphate lyase in immunity and cancer: Silencing the siren. Trends Mol Med 2007; 13(5):210-7. (Pubitemid 46687129)
-
(2007)
Trends in Molecular Medicine
, vol.13
, Issue.5
, pp. 210-217
-
-
Bandhuvula, P.1
Saba, J.D.2
-
18
-
-
10744227465
-
Increase of Nuclear Ceramide through Caspase-3-Dependent Regulation of the "Sphingomyelin Cycle" in Fas-Induced Apoptosis
-
DOI 10.1158/0008-5472.CAN-03-1383
-
Watanabe M, Kitano T, Kondo T et al. Increase of nuclear ceramide through caspase-3-dependent regulation of the "sphingomyelin cycle" in Fas-induced apoptosis. Cancer Res 2004; 64(3):1000-7. (Pubitemid 38176903)
-
(2004)
Cancer Research
, vol.64
, Issue.3
, pp. 1000-1007
-
-
Watanabe, M.1
Kitano, T.2
Kondo, T.3
Yabu, T.4
Taguchi, Y.5
Tashima, M.6
Umehara, H.7
Domae, N.8
Uchiyama, T.9
Okazaki, T.10
-
19
-
-
33749009744
-
The extended family of neutral sphingomyelinases
-
DOI 10.1021/bi061307z
-
Clarke C, Snook C, Tani M et al. The extended family of neutral sphingomyelinases. Biochemistry 2006; 45:11247-56. (Pubitemid 44453973)
-
(2006)
Biochemistry
, vol.45
, Issue.38
, pp. 11247-11256
-
-
Clarke, C.J.1
Snook, C.F.2
Tani, M.3
Matmati, N.4
Marchesini, N.5
Hannun, Y.A.6
-
20
-
-
0028930533
-
Role for ceramide in cell cycle arrest
-
Jayadev S, Liu B, Bielawska A et al. Role for ceramide in cell cycle arrest. J Biol Chem 1995; 270(5):2047-52.
-
(1995)
J Biol Chem
, vol.270
, Issue.5
, pp. 2047-52
-
-
Jayadev, S.1
Liu, B.2
Bielawska, A.3
-
21
-
-
15144359445
-
Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation
-
DOI 10.1074/jbc.273.12.6921
-
Yoshimura S, Banno Y, Nakashima S et al. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J Biol Chem 1998; 273(12):6921-7. (Pubitemid 28160357)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.12
, pp. 6921-6927
-
-
Yoshimura, S.-I.1
Banno, Y.2
Nakashima, S.3
Takenaka, K.4
Sakai, H.5
Nishimura, Y.6
Sakai, N.7
Shimizu, S.8
Eguchi, Y.9
Tsujimoto, Y.10
Nozawa, Y.11
-
22
-
-
0033783522
-
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
-
Liu Y, Wada R, Yamashita T et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000; 106(8):951-61.
-
(2000)
J Clin Invest
, vol.106
, Issue.8
, pp. 951-61
-
-
Liu, Y.1
Wada, R.2
Yamashita, T.3
-
23
-
-
0033537839
-
Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
-
Takeda Y, Tashima M, Takahashi A et al. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J Biol Chem 1999; 274(15):10654-60.
-
(1999)
J Biol Chem
, vol.274
, Issue.15
, pp. 10654-60
-
-
Takeda, Y.1
Tashima, M.2
Takahashi, A.3
-
24
-
-
0030712182
-
The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
-
Mansat V, Laurent G, Levade T et al. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation and apoptosis triggered by daunorubicin. Cancer Res 1997; 57(23):5300-4. (Pubitemid 27516367)
-
(1997)
Cancer Research
, vol.57
, Issue.23
, pp. 5300-5304
-
-
Mansat, V.1
Laurent, G.2
Levade, T.3
Bettaieb, A.4
Jaffrezou, J.-P.5
-
25
-
-
0033832534
-
Ordering of ceramide formation, caspase activation and Bax/ Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells
-
Sawada M, Nakashima S, Banno Y et al. Ordering of ceramide formation, caspase activation and Bax/ Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Cell Death Differ 2000; 7(9):761-72.
-
(2000)
Cell Death Differ
, vol.7
, Issue.9
, pp. 761-72
-
-
Sawada, M.1
Nakashima, S.2
Banno, Y.3
-
26
-
-
4344606268
-
P53-independent ceramide formation in human glioma cells during γ-radiation-induced apoptosis
-
DOI 10.1038/sj.cdd.4401428
-
Hara S, Nakashima S, Kiyono T et al. p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Cell Death Differ 2004; 11:853-61. (Pubitemid 39139744)
-
(2004)
Cell Death and Differentiation
, vol.11
, Issue.8
, pp. 853-861
-
-
Hara, S.1
Nakashima, S.2
Kiyono, T.3
Sawada, M.4
Yoshimura, S.5
Iwama, T.6
Banno, Y.7
Shinoda, J.8
Sakai, N.9
-
27
-
-
0028070326
-
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor α
-
Jayadev S, Linardic C, Hannun Y. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor a. J Biol Chem 1994; 269(8):5757-63. (Pubitemid 24242948)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.8
, pp. 5757-5763
-
-
Jayadev, S.1
Linardic, C.M.2
Hannun, Y.A.3
-
28
-
-
0028076002
-
The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction
-
Schütze S, Machleidt T, Krönke M. The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. J Leukoc Biol 1994; 56:533-41. (Pubitemid 24348808)
-
(1994)
Journal of Leukocyte Biology
, vol.56
, Issue.5
, pp. 533-541
-
-
Schutze, S.1
Machleidt, T.2
Kronke, M.3
-
29
-
-
34548522699
-
2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
-
DOI 10.1021/bi700017z
-
Lei X, Zhang S, Bohrer A et al. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Biochemistry 2007; 46:10170-85. (Pubitemid 47381276)
-
(2007)
Biochemistry
, vol.46
, Issue.35
, pp. 10170-10185
-
-
Lei, X.1
Zhang, S.2
Bohrer, A.3
Bao, S.4
Song, H.5
Ramanadham, S.6
-
30
-
-
0031851003
-
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
-
Bruno A, Laurent G, Averbeck D et al. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death Differ 1998; 5:172-82. (Pubitemid 28356554)
-
(1998)
Cell Death and Differentiation
, vol.5
, Issue.2
, pp. 172-182
-
-
Bruno, A.P.1
Laurent, G.2
Averbeck, D.3
Demur, C.4
Bonnet, J.5
Bettaieb, A.6
Levade, T.7
Jaffrezou, J.-P.8
-
31
-
-
0037103184
-
Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγ1: Implication in stem cell factor radioprotective effect
-
Maddens S, Charruyer A, Plo I et al. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: Implication in stem cell factor radioprotective effect. Blood 2002; 100:1294-301. (Pubitemid 34864284)
-
(2002)
Blood
, vol.100
, Issue.4
, pp. 1294-1301
-
-
Maddens, S.1
Charruyer, A.2
Plo, I.3
Dubreuil, P.4
Berger, S.5
Salles, B.6
Laurent, G.7
Jaffrezou, J.-P.8
-
32
-
-
0030960327
-
Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
-
DOI 10.1074/jbc.272.26.16281
-
Liu B, Hannun Y. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem 1997; 272:16281-7. (Pubitemid 27276449)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.26
, pp. 16281-16287
-
-
Liu, B.1
Hannun, Y.A.2
-
33
-
-
2342570273
-
Acid and neutral sphingomyelinases: Roles and mechanisms of regulation
-
DOI 10.1139/o03-091
-
Marchesini N, Hannun Y. Acid and neutral sphingomyelinases: Roles and mechanisms of regulation. Biochem Cell Biol 2004; 82:27-44. (Pubitemid 38580872)
-
(2004)
Biochemistry and Cell Biology
, vol.82
, Issue.1
, pp. 27-44
-
-
Marchesini, N.1
Hannun, Y.A.2
-
34
-
-
0014083339
-
Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease
-
Schneider PB, Kennedy EP. Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease. J Lipid Res 1967; 8(3):202-9.
-
(1967)
J Lipid Res
, vol.8
, Issue.3
, pp. 202-9
-
-
Schneider, P.B.1
Kennedy, E.P.2
-
35
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
DOI 10.1016/S0092-8674(00)80091-4
-
Santana P, Pena L, Haimovitz-Friedman A et al. Acid sphingomyelinase- deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 1996; 86:189-99. (Pubitemid 26286102)
-
(1996)
Cell
, vol.86
, Issue.2
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
36
-
-
0032128301
-
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
-
Zundel W, Giaccia A. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev 1998; 12(13):1941-6. (Pubitemid 28323868)
-
(1998)
Genes and Development
, vol.12
, Issue.13
, pp. 1941-1946
-
-
Zundel, W.1
Giaccia, A.2
-
37
-
-
0026458406
-
TNF activates NF-kB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown
-
Schutze S, Potthoff K, Machleidt T et al. TNF activates NF-kB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 1992; 71:765-76.
-
(1992)
Cell
, vol.71
, pp. 765-76
-
-
Schutze, S.1
Potthoff, K.2
Machleidt, T.3
-
38
-
-
20144367155
-
Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane
-
DOI 10.1074/jbc.M410869200
-
Kashkar H, Wiegmann K, Yazdanpanah B et al. Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J Biol Chem 2005; 280(21):20804-13. (Pubitemid 40776785)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20804-20813
-
-
Kashkar, H.1
Wiegmann, K.2
Yazdanpanah, B.3
Haubert, D.4
Kronke, M.5
-
39
-
-
0034488193
-
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
-
DOI 10.1385/JMN:15:2:85
-
Yu ZF, Nikolova-Karakashian M, Zhou D et al. Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production and neuronal apoptosis. J Mol Neurosci 2000; 15(2):85-97. (Pubitemid 32108678)
-
(2000)
Journal of Molecular Neuroscience
, vol.15
, Issue.2
, pp. 85-97
-
-
Yu, Z.F.1
Nikolova-Karakashian, M.2
Zhou, D.3
Cheng, G.4
Schuchman, E.H.5
Mattson, M.P.6
-
40
-
-
0032540959
-
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene
-
DOI 10.1074/jbc.273.29.18250
-
Schissel S, Keesler G, Schuchman E et al. The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J Biol Chem 1998; 273:18250-9. (Pubitemid 28334747)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.29
, pp. 18250-18259
-
-
Schissel, S.L.1
Keesler, G.A.2
Schuchman, E.H.3
Williams, K.J.4
Tabas, I.5
-
41
-
-
27744607641
-
Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment. Implications for endothelial apoptosis
-
Sathishkumar S, Boyanovsky B, Karakashian AA et al. Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: Implications for endothelial apoptosis. Cancer Biol Ther 2005; 4(9):979-86. (Pubitemid 41598594)
-
(2005)
Cancer Biology and Therapy
, vol.4
, Issue.9
, pp. 979-986
-
-
Sathishkumar, S.1
Boyanovsky, B.2
Karakashian, A.A.3
Rozenova, K.4
Giltiay, N.V.5
Kudrimoti, M.6
Mohiuddin, M.7
Ahmed, M.M.8
Nikolova-Karakashian, M.9
-
42
-
-
0036896823
-
Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors
-
Wright K, Messing E, Reeder J. Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. J Urol 2002; 168:2645-9. (Pubitemid 35402709)
-
(2002)
Journal of Urology
, vol.168
, Issue.6
, pp. 2645-2649
-
-
Wright, K.O.1
Messing, E.M.2
Reeder, J.E.3
-
43
-
-
0014663246
-
The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract
-
Nilsson A. The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract. Biochim Biophys Acta 1969; 176(2):339-47.
-
(1969)
Biochim Biophys Acta
, vol.176
, Issue.2
, pp. 339-47
-
-
Nilsson, A.1
-
44
-
-
33646146401
-
Alkaline sphingomyelinase: An old enzyme with novel implications
-
Duan RD. Alkaline sphingomyelinase: An old enzyme with novel implications. Biochim Biophys Acta 2006; 1761(3):281-91.
-
(2006)
Biochim Biophys Acta
, vol.1761
, Issue.3
, pp. 281-91
-
-
Duan, R.D.1
-
45
-
-
16244365239
-
Anticancer compounds and sphingolipid metabolism in the colon
-
Duan RD. Anticancer compounds and sphingolipid metabolism in the colon. In Vivo 2005; 19(1):293-300.
-
(2005)
Vivo
, vol.19
, Issue.1
, pp. 293-300
-
-
Duan, R.D.1
-
46
-
-
0029148660
-
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
-
Bose R, Verheij M, Haimovitz-Friedman A et al. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals. Cell 1995; 82(3):405-14.
-
(1995)
Cell
, vol.82
, Issue.3
, pp. 405-14
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
-
47
-
-
34547156711
-
Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HI-60 cells
-
DOI 10.1080/15287390701434364, PII 780842583
-
Son JH, Yoo HH, Kim DH. Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. J Toxicol Environ Health A 2007; 70(15-16):1310-8. (Pubitemid 47124012)
-
(2007)
Journal of Toxicology and Environmental Health - Part A: Current Issues
, vol.70
, Issue.15-16
, pp. 1310-1318
-
-
Son, J.H.1
Yoo, H.H.2
Kim, D.-H.3
-
48
-
-
18844434417
-
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
-
DOI 10.1038/nm1238
-
Petrache I, Natarajan V, Zhen L et al. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med 2005; 11:491-8. (Pubitemid 40685971)
-
(2005)
Nature Medicine
, vol.11
, Issue.5
, pp. 491-498
-
-
Petrache, I.1
Natarajan, V.2
Zhen, L.3
Medler, T.R.4
Richter, A.T.5
Cho, C.6
Hubbard, W.C.7
Berdyshev, E.V.8
Tuder, R.M.9
-
50
-
-
0029001622
-
DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis
-
Itoh G, Tamura J, M S et al. DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol 1995; 146:1325-31.
-
(1995)
Am J Pathol
, vol.146
, pp. 1325-31
-
-
Itoh, G.1
Tamura J M, S.2
-
51
-
-
34249674391
-
24-ceramide generation contributes to spontaneous neutrophil apoptosis
-
DOI 10.1189/jlb.0806529
-
Seumois G, Fillet M, Gillet L et al. De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. J Leukoc Biol 2007; 81:1477-86. (Pubitemid 46827970)
-
(2007)
Journal of Leukocyte Biology
, vol.81
, Issue.6
, pp. 1477-1486
-
-
Seumois, G.1
Fillet, M.2
Gillet, L.3
Faccinetto, C.4
Desmet, C.5
Francois, C.6
Dewals, B.7
Oury, C.8
Vanderplasschen, A.9
Lekeux, P.10
Bureau, F.11
-
52
-
-
33644641640
-
Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury
-
DOI 10.1038/sj.ki.5000057, PII 5000057
-
Itoh Y, Yano T, Sendo T et al. Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. Kidney Int 2006; 69:288-97. (Pubitemid 43323079)
-
(2006)
Kidney International
, vol.69
, Issue.2
, pp. 288-297
-
-
Itoh, Y.1
Yano, T.2
Sendo, T.3
Sueyasu, M.4
Hirano, K.5
Kanaide, H.6
Oishi, R.7
-
53
-
-
33747880401
-
Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
-
DOI 10.1093/carcin/bgi371, Special Issue on Chronic Pain
-
Moussavi M, Assi K, Gomez-Munoz A et al. Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. Carcinogenesis 2006; 27(8):1636-44. (Pubitemid 44288053)
-
(2006)
Carcinogenesis
, vol.27
, Issue.8
, pp. 1636-1644
-
-
Moussavi, M.1
Assi, K.2
Gomez-Munoz, A.3
Salh, B.4
-
54
-
-
22844450866
-
Resveratrol as an anticancer nutrient: Molecular basis, open questions and promises
-
DOI 10.1016/j.jnutbio.2005.01.017, PII S0955286305000355
-
Signorelli P, Ghidoni R. Resveratrol as an anticancer nutrient: Molecular basis, open questions and promises. J Nutr Biochem 2005; 16:449-66. (Pubitemid 41039220)
-
(2005)
Journal of Nutritional Biochemistry
, vol.16
, Issue.8
, pp. 449-466
-
-
Signorelli, P.1
Ghidoni, R.2
-
55
-
-
0642364447
-
Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling
-
DOI 10.1096/fj.03-0292fje
-
Scarlatti F, Sala G, Somenzi G et al. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 2003; 17(15):2339-41. (Pubitemid 39561486)
-
(2003)
FASEB Journal
, vol.17
, Issue.15
, pp. 2339-2341
-
-
Scarlatti, F.1
Sala, G.2
Somenzi, G.3
Signorelli, P.4
Sacchi, N.5
Ghidoni, R.6
-
57
-
-
0037151038
-
A functional role for the B56 α-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function
-
DOI 10.1074/jbc.M201830200
-
Ruvolo PP, Clark W, Mumby M et al. A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. J Biol Chem 2002; 277(25):22847-52. (Pubitemid 34967266)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.25
, pp. 22847-22852
-
-
Ruvolo, P.P.1
Clark, W.2
Mumby, M.3
Gao, F.4
Stratford May, W.5
-
58
-
-
0037354119
-
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3β, and induction of the mitochondrial-dependent intrinsic caspase pathway
-
DOI 10.1016/S1044-7431(02)00028-3
-
Stoica BA, Movsesyan VA, Lea PMt et al. Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta and induction of the mitochondrial-dependent intrinsic caspase pathway. Mol Cell Neurosci 2003; 22(3):365-82. (Pubitemid 36407599)
-
(2003)
Molecular and Cellular Neuroscience
, vol.22
, Issue.3
, pp. 365-382
-
-
Stoica, B.A.1
Movsesyan, V.A.2
Lea IV, P.M.3
Faden, A.I.4
-
59
-
-
0037030465
-
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
-
DOI 10.1038/sj.onc.1205497
-
von Haefen C, Wieder T, Gillissen B et al. Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells. Oncogene 2002; 21(25):4009-19. (Pubitemid 34679242)
-
(2002)
Oncogene
, vol.21
, Issue.25
, pp. 4009-4019
-
-
Von Haefen, C.1
Wieder, T.2
Gillissen, B.3
Starck, L.4
Graupner, V.5
Dorken, B.6
Daniel, P.T.7
-
60
-
-
0141757451
-
Radiation and ceramide-induced apoptosis
-
DOI 10.1038/sj.onc.1206702
-
Kolesnick R, Fuks Z. Radiation and ceramide-induced apoptosis. Oncogene 2003; 22(37):5897-906. (Pubitemid 37176710)
-
(2003)
Oncogene
, vol.22
, Issue.37 REV. ISS. 3
, pp. 5897-5906
-
-
Kolesnick, R.1
Fuks, Z.2
-
61
-
-
0037418843
-
2+: A control point for apoptosis
-
DOI 10.1126/science.1081208
-
2+: A control point for apoptosis. Science 2003; 300(5616):135-9. (Pubitemid 36423046)
-
(2003)
Science
, vol.300
, Issue.5616
, pp. 135-139
-
-
Scorrano, L.1
Oakes, S.A.2
Opferman, J.T.3
Cheng, E.H.4
Sorcinelli, M.D.5
Pozzan, T.6
Korsmeyer, S.J.7
-
62
-
-
0035860393
-
Bax-dependent apoptosis induced by ceramide in HL-60 cells
-
DOI 10.1016/S0014-5793(01)02836-8, PII S0014579301028368
-
Kim HJ, Mun JY, Chun YJ et al. Bax-dependent apoptosis induced by ceramide in HL-60 cells. FEBS Lett 2001; 505(2):264-8. (Pubitemid 32896678)
-
(2001)
FEBS Letters
, vol.505
, Issue.2
, pp. 264-268
-
-
Kim, H.J.1
Mun, J.Y.2
Chun, Y.J.3
Choi, K.H.4
Kim, M.Y.5
-
63
-
-
0027282044
-
Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
-
Boise L, González-García M, Postema C et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74:579-608.
-
(1993)
Cell
, vol.74
, pp. 579-608
-
-
Boise, L.1
González-García, M.2
Postema, C.3
-
64
-
-
0037066727
-
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1
-
DOI 10.1074/jbc.M112010200
-
Chalfant C, Rathman K, Pinkerman R et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 2002; 277:12587-95. (Pubitemid 34952617)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.15
, pp. 12587-12595
-
-
Chalfant, C.E.1
Rathman, K.2
Pinkerman, R.L.3
Wood, R.E.4
Obeid, L.M.5
Ogretmen, B.6
Hannun, Y.A.7
-
65
-
-
0033214095
-
Cathepsin D targeted by acid sphingomyelinase-derived ceramide
-
DOI 10.1093/emboj/18.19.5252
-
Heinrich M, Wickel M, Schneider-Brachert W et al. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J 1999; 18(19):5252-63. (Pubitemid 29465576)
-
(1999)
EMBO Journal
, vol.18
, Issue.19
, pp. 5252-5263
-
-
Heinrich, M.1
Wickel, M.2
Schneider-Brachert, W.3
Sandberg, C.4
Gahr, J.5
Schwandner, R.6
Weber, T.7
Brunner, J.8
Kronke, M.9
Schutze, S.10
-
66
-
-
2442661614
-
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
-
DOI 10.1038/sj.cdd.4401382
-
Heinrich M, Neumeyer J, Jakob M et al. Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ 2004; 11(5):550-63. (Pubitemid 38660140)
-
(2004)
Cell Death and Differentiation
, vol.11
, Issue.5
, pp. 550-563
-
-
Heinrich, M.1
Neumeyer, J.2
Jakob, M.3
Hallas, C.4
Tchikov, V.5
Winoto-Morbach, S.6
Wickel, M.7
Scheider-Brachert, W.8
Trauzold, A.9
Hethke, A.10
Schutze, S.11
-
67
-
-
0035827632
-
CD95 signaling via ceramide-rich membrane rafts
-
Grassme H, Jekle A, Riehle A et al. CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 2001; 276(23):20589-96.
-
(2001)
J Biol Chem
, vol.276
, Issue.23
, pp. 20589-96
-
-
Grassme, H.1
Jekle, A.2
Riehle, A.3
-
68
-
-
0037381124
-
Ceramide in Rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines
-
DOI 10.1002/jnr.10549
-
Kilkus J, Goswami R, Testai FD et al. Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines. J Neurosci Res 2003; 72(1):65-75. (Pubitemid 36373812)
-
(2003)
Journal of Neuroscience Research
, vol.72
, Issue.1
, pp. 65-75
-
-
Kilkus, J.1
Goswami, R.2
Testai, F.D.3
Dawson, G.4
-
69
-
-
0029862561
-
Sphingolipid metabolism and cell growth regulation
-
Spiegel S, AH Merrill J. Sphingolipid metabolism and cell growth regulation. FASEB J 1996; 10:1388-97. (Pubitemid 26347873)
-
(1996)
FASEB Journal
, vol.10
, Issue.12
, pp. 1388-1397
-
-
Spiegel, S.1
Merrill Jr., A.H.2
-
70
-
-
0034670042
-
Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells
-
Yatomi Y, Ohmori T, Rile G et al. Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells. Blood 2000; 96(10):3431-8.
-
(2000)
Blood
, vol.96
, Issue.10
, pp. 3431-8
-
-
Yatomi, Y.1
Ohmori, T.2
Rile, G.3
-
71
-
-
13944280988
-
G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
-
DOI 10.1002/jcb.20094
-
Radeff-Huang J, Seasholtz TM, Matteo RG et al. G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 2004; 92(5):949-66. (Pubitemid 44264244)
-
(2004)
Journal of Cellular Biochemistry
, vol.92
, Issue.5
, pp. 949-966
-
-
Radeff-Huang, J.1
Seasholtz, T.M.2
Matteo, R.G.3
Brown, J.H.4
-
72
-
-
0035793866
-
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
-
DOI 10.1126/science.1057559
-
Hobson JP, Rosenfeldt HM, Barak LS et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 2001; 291(5509):1800-3. (Pubitemid 32198987)
-
(2001)
Science
, vol.291
, Issue.5509
, pp. 1800-1803
-
-
Hobson, J.P.1
Rosenfeldt, H.M.2
Barak, L.S.3
Olivera, A.4
Poulton, S.5
Caron, M.G.6
Milstien, S.7
Spiegel, S.8
-
73
-
-
3042743990
-
FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
-
DOI 10.1111/j.1600-6143.2004.00476.x
-
Brinkmann V, Cyster J, Hla T. FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004; 4:1019-25. (Pubitemid 38868590)
-
(2004)
American Journal of Transplantation
, vol.4
, Issue.7
, pp. 1019-1025
-
-
Brinkmann, V.1
Cyster, J.G.2
Hla, T.3
-
75
-
-
0035976579
-
Lysophospholipids-receptor revelations
-
Hla T, Lee MJ, Ancellin N et al. Lysophospholipids-receptor revelations. Science 2001; 294(5548):1875-8.
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1875-8
-
-
Hla, T.1
Lee, M.J.2
Ancellin, N.3
-
76
-
-
0037201970
-
Sphingosine-1-phosphate: Dual messenger functions
-
DOI 10.1016/S0014-5793(02)03480-4, PII S0014579302034804
-
Payne SG, Milstien S, Spiegel S. Sphingosine-1-phosphate: Dual messenger functions. FEBS Lett 2002; 531(1):54-7. (Pubitemid 35232784)
-
(2002)
FEBS Letters
, vol.531
, Issue.1
, pp. 54-57
-
-
Payne, S.G.1
Milstien, S.2
Spiegel, S.3
-
77
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
DOI 10.1016/S0960-9822(00)00834-4
-
Xia P, Gamble JR, Wang L et al. An oncogenic role of sphingosine kinase. Curr Biol 2000; 10(23):1527-30. (Pubitemid 32003646)
-
(2000)
Current Biology
, vol.10
, Issue.23
, pp. 1527-1530
-
-
Xia, P.1
Gamble, J.R.2
Wang, L.3
Pitson, S.M.4
Moretti, P.A.B.5
Wattenberg, B.W.6
D'Andrea, R.J.7
Vadas, M.A.8
-
78
-
-
33644830810
-
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
-
DOI 10.1016/j.ccr.2006.02.023, PII S1535610806000584
-
Visentin B, Vekich J, Sibbald B et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion and angiogenesis in multiple tumor lineages. Cancer Cell 2006; 9:225-38. (Pubitemid 43357948)
-
(2006)
Cancer Cell
, vol.9
, Issue.3
, pp. 225-238
-
-
Visentin, B.1
Vekich, J.A.2
Sibbald, B.J.3
Cavalli, A.L.4
Moreno, K.M.5
Matteo, R.G.6
Garland, W.A.7
Lu, Y.8
Yu, S.9
Hall, H.S.10
Kundra, V.11
Mills, G.B.12
Sabbadini, R.A.13
-
79
-
-
0035525748
-
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
-
Cuvillier O, Levade T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood 2001; 98:2828-36.
-
(2001)
Blood
, vol.98
, pp. 2828-36
-
-
Cuvillier, O.1
Levade, T.2
-
80
-
-
0033558079
-
Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax
-
Goetzl E, Kong Y, Mei B. Lysophosphatidic acid and sphingosine 1-phosphate protection of T-cells from apoptosis in association with suppression of Bax. J Immunol 1999; 162(4):2049-56. (Pubitemid 29288824)
-
(1999)
Journal of Immunology
, vol.162
, Issue.4
, pp. 2049-2056
-
-
Goetzl, E.J.1
Kong, Y.2
Mei, B.3
-
81
-
-
0032579414
-
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes
-
DOI 10.1074/jbc.273.5.2910
-
Cuvillier O, Rosenthal DS, Smulson ME et al. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide- mediated apoptosis in Jurkat T-lymphocytes. J Biol Chem 1998; 273(5):2910-6. (Pubitemid 28133941)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.5
, pp. 2910-2916
-
-
Cuvillier, O.1
Rosenthal, D.S.2
Smulson, M.E.3
Spiegel, S.4
-
82
-
-
30544434809
-
Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner
-
DOI 10.1016/j.bbrc.2005.12.138, PII S0006291X05028986
-
Betito S, Cuvillier O. Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. Biochem Biophys Res Commun 2006; 340(4):1273-7. (Pubitemid 43083415)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.340
, Issue.4
, pp. 1273-1277
-
-
Betito, S.1
Cuvillier, O.2
-
83
-
-
20444506408
-
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
-
DOI 10.1074/jbc.M413744200
-
Taha TA, Kitatani K, Bielawski J et al. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem 2005; 280(17):17196-202. (Pubitemid 41389186)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.17
, pp. 17196-17202
-
-
Taha, T.A.1
Kitatani, K.2
Bielawski, J.3
Cho, W.4
Hannun, Y.A.5
Obeid, L.M.6
-
84
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
-
DOI 10.1074/jbc.M304455200
-
Liu H, Toman RE, Goparaju S et al. Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis. J Biol Chem 2003; 278:40330-6. (Pubitemid 37248601)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.41
, pp. 40330-40336
-
-
Liu, H.1
Toman, R.E.2
Goparaju, S.K.3
Maceyka, M.4
Nava, V.E.5
Sankala, H.6
Payner, S.G.7
Bektas, M.8
Ishii, I.9
Chun, J.10
Milstien, S.11
Spiegel, S.12
-
85
-
-
36349003001
-
Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2
-
DOI 10.1074/jbc.M703329200
-
Le Stunff H, Giussani P, Maceyka M et al. Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J Biol Chem 2007; 282:34372-80. (Pubitemid 350159464)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.47
, pp. 34372-34380
-
-
Le Stunff, H.1
Giussani, P.2
Maceyka, M.3
Lepine, S.4
Milstien, S.5
Spiegel, S.6
-
86
-
-
79959610282
-
Functions of the multifaceted family of sphingosine kinases and some close relatives
-
Spiegel S, Milstien S. Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem 2006.
-
(2006)
J Biol Chem
-
-
Spiegel, S.1
Milstien, S.2
-
87
-
-
15044363028
-
Recent advances in the protein kinase B signaling pathway
-
DOI 10.1016/j.ceb.2005.02.010, Cell Regulation
-
Woodgett JR. Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 2005; 17(2):150-7. (Pubitemid 40380938)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.2
, pp. 150-157
-
-
Woodgett, J.R.1
-
88
-
-
27844515097
-
The Akt of translational control
-
DOI 10.1038/sj.onc.1209098, PII 1209098
-
Ruggero D, Sonenberg N. The Akt of translational control. Oncogene 2005; 24(50):7426-34. (Pubitemid 41637982)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7426-7434
-
-
Ruggero, D.1
Sonenberg, N.2
-
89
-
-
0031840405
-
PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas
-
Tohma Y, Gratas C, Biernat W et al. PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. J Neuropathol Exp Neurol 1998; 57(7):684-9. (Pubitemid 28335057)
-
(1998)
Journal of Neuropathology and Experimental Neurology
, vol.57
, Issue.7
, pp. 684-689
-
-
Tohma, Y.1
Gratas, C.2
Biernat, W.3
Peraud, A.4
Fukuda, M.5
Yonekawa, Y.6
Kleihues, P.7
Ohgaki, H.8
-
90
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
DOI 10.1038/nature05933, PII NATURE05933
-
Carpten JD, Faber AL, Horn C et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007; 448(7152):439-44. (Pubitemid 47123510)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.-W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.-H.T.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
91
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2(7):489-501. (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
92
-
-
34250344614
-
Ceramide recruits and activates protein kinase C ζ (PKCζ) within structured membrane microdomains
-
DOI 10.1074/jbc.M700082200
-
Fox TE, Houck KL, O'Neill SM et al. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. J Biol Chem 2007; 282(17):12450-7. (Pubitemid 47100622)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.17
, pp. 12450-12457
-
-
Fox, T.E.1
Houck, K.L.2
O'Neill, S.M.3
Nagarajan, M.4
Stover, T.C.5
Pomianowski, P.T.6
Unal, O.7
Yun, J.K.8
Naides, S.J.9
Kester, M.10
-
93
-
-
0142091454
-
Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism
-
DOI 10.1128/MCB.23.21.7794-7808.2003
-
Powell DJ, Hajduch E, Kular G et al. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol Cell Biol 2003; 23(21):7794-808. (Pubitemid 37271476)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.21
, pp. 7794-7808
-
-
Powell, D.J.1
Hajduch, E.2
Kular, G.3
Hundal, H.S.4
-
94
-
-
0342980927
-
Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide- activated protein phosphatase in PC12 cells
-
DOI 10.1006/mcne.1999.0813
-
Salinas M, Lopez-Valdaliso R, Martin D et al. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Mol Cell Neurosci 2000; 15(2):156-69. (Pubitemid 30109119)
-
(2000)
Molecular and Cellular Neurosciences
, vol.15
, Issue.2
, pp. 156-169
-
-
Salinas, M.1
Lopez-Valdaliso, R.2
Martin, D.3
Alvarez, A.4
Cuadrado, A.5
-
95
-
-
4344614649
-
Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
DOI 10.1074/jbc.M406499200
-
Stratford S, Hoehn K, Liu F et al. Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 2004; 279:36608-15. (Pubitemid 39129005)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.35
, pp. 36608-36615
-
-
Stratford, S.1
Hoehn, K.L.2
Liu, F.3
Summers, S.A.4
-
96
-
-
0029073053
-
The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide
-
Law B, Rossie S. The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. J Biol Chem 1995; 270(21):12808-13.
-
(1995)
J Biol Chem
, vol.270
, Issue.21
, pp. 12808-13
-
-
Law, B.1
Rossie, S.2
-
98
-
-
34248402756
-
Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: Role of protein kinase Cζ and phosphatase
-
DOI 10.1128/IAI.01589-06
-
Dey R, Majumder N, Bhattacharjee S et al. Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: Role of protein kinase Czeta and phosphatase. Infect Immun 2007; 75:2136-42. (Pubitemid 46744299)
-
(2007)
Infection and Immunity
, vol.75
, Issue.5
, pp. 2136-2142
-
-
Dey, R.1
Majumder, N.2
Bhattacharjee, S.3
Majumdar, S.B.4
Banerjee, R.5
Ganguly, S.6
Das, P.7
Majumdar, S.8
-
99
-
-
0033588253
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
Schmitz-Peiffer C, Craig D, Biden T. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 1999; 274:24202-10.
-
(1999)
J Biol Chem
, vol.274
, pp. 24202-10
-
-
Schmitz-Peiffer, C.1
Craig, D.2
Biden, T.3
-
100
-
-
34250635347
-
Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells
-
DOI 10.1074/jbc.M610513200
-
Guan L, Song K, Pysz M et al. Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells. J Biol Chem 2007; 282:14213-25. (Pubitemid 47100475)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.19
, pp. 14213-14225
-
-
Guan, L.1
Song, K.2
Pysz, M.A.3
Curry, K.J.4
Hizli, A.A.5
Danielpour, D.6
Black, A.R.7
Black, J.D.8
-
101
-
-
24744459879
-
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines
-
DOI 10.1002/jnr.20550
-
Goswami R, Singh D, Phillips G et al. Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. J Neurosci Res 2005; 81:541-50. (Pubitemid 41297391)
-
(2005)
Journal of Neuroscience Research
, vol.81
, Issue.4
, pp. 541-550
-
-
Goswami, R.1
Singh, D.2
Phillips, G.3
Kilkus, J.4
Dawson, G.5
-
102
-
-
21244479753
-
Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway
-
DOI 10.1016/j.febslet.2005.05.067, PII S0014579305006939
-
Gómez-Muñoz A, Kong J, Parhar K et al. Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. FEBS Lett 2005; 579:3744-50. (Pubitemid 40897719)
-
(2005)
FEBS Letters
, vol.579
, Issue.17
, pp. 3744-3750
-
-
Gomez-Munoz, A.1
Kong, J.Y.2
Parhar, K.3
Shih, W.W.4
Gangoiti, P.5
Gonzalez, M.6
Eivemark, S.7
Salh, B.8
Duronio, V.9
Steinbrecher, U.P.10
-
103
-
-
34250809874
-
3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
-
DOI 10.1152/ajpheart.01331.2006
-
Means C, Xiao C, Li Z et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2007; 292:H2944-H2951. (Pubitemid 47084545)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.292
, Issue.6
-
-
Means, C.K.1
Xiao, C.-Y.2
Li, Z.3
Zhang, T.4
Omens, J.H.5
Ishii, I.6
Chun, J.7
Brown, J.H.8
-
104
-
-
0035853775
-
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells
-
Igarashi J, Bernier SG, Michel T. Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J Biol Chem 2001; 276(15):12420-6.
-
(2001)
J Biol Chem
, vol.276
, Issue.15
, pp. 12420-6
-
-
Igarashi, J.1
Bernier, S.G.2
Michel, T.3
-
105
-
-
34547124878
-
Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells: Evidence for an AMPK Rac1 Akt endothelial nitric-oxide synthase pathway
-
DOI 10.1074/jbc.M702182200
-
Levine Y, Li G, Michel T. Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK - Rac1 - Akt - endothelial nitric-oxide synthase pathway. J Biol Chem 2007; 282:20351-64. (Pubitemid 47100039)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.28
, pp. 20351-20364
-
-
Levine, Y.C.1
Li, G.K.2
Michel, T.3
-
106
-
-
33645211015
-
Modulation of total Akt kinase by increased expression of a single isoform: Requirement of the sphingosine-1-phosphate receptor Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells
-
Fieber C, Eldgridge J, Taha T et al. Modulation of total Akt kinase by increased expression of a single isoform: Requirement of the sphingosine-1-phosphate receptor Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. Exp Cell Res 2006; 312:1164-73.
-
(2006)
Exp Cell Res
, vol.312
, pp. 1164-73
-
-
Fieber, C.1
Eldgridge, J.2
Taha, T.3
-
107
-
-
0037044854
-
Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)
-
DOI 10.1074/jbc.M204764200
-
Tanimoto T, Jin ZG, Berk BC. Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem 2002; 277(45):42997-3001. (Pubitemid 35285679)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.45
, pp. 42997-43001
-
-
Tanimoto, T.1
Jin, Z.-G.2
Berk, B.C.3
-
108
-
-
17044371645
-
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
-
Limaye V, Li X, Hahn C et al. Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood 2005; 105:3169-77.
-
(2005)
Blood
, vol.105
, pp. 3169-77
-
-
Limaye, V.1
Li, X.2
Hahn, C.3
-
109
-
-
0035929583
-
Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3
-
Banno Y, Takuwa Y, Akao Y et al. Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. J Biol Chem 2001; 276:35622-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 35622-8
-
-
Banno, Y.1
Takuwa, Y.2
Akao, Y.3
-
110
-
-
0035965242
-
Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways
-
Igarashi J, Michel T. Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. J Biol Chem 2001; 276:36281-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 36281-8
-
-
Igarashi, J.1
Michel, T.2
-
111
-
-
1442265704
-
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
-
Baudhuin LM, Jiang Y, Zaslavsky A et al. S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). Faseb J 2004; 18(2):341-3.
-
(2004)
Faseb J
, vol.18
, Issue.2
, pp. 341-3
-
-
Baudhuin, L.M.1
Jiang, Y.2
Zaslavsky, A.3
-
112
-
-
0036765743
-
Akt activation induced by lysophosphatidic acid and sphingosine-1- phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific
-
DOI 10.1124/mol.62.3.660
-
Baudhuin L, Cristina K, Lu J et al. Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. Mol Pharmacol 2002; 62:660-71. (Pubitemid 36329385)
-
(2002)
Molecular Pharmacology
, vol.62
, Issue.3
, pp. 660-671
-
-
Baudhuin, L.M.1
Cristina, K.L.2
Lu, J.3
Xu, Y.4
-
113
-
-
34249280944
-
Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
-
DOI 10.1161/ATVBAHA.107.143735
-
Sanchez T, Skoura A, Wu M et al. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol 2007; 27:1312-8. (Pubitemid 46809419)
-
(2007)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.27
, Issue.6
, pp. 1312-1318
-
-
Sanchez, T.1
Skoura, A.2
Wu, M.T.3
Casserly, B.4
Harrington, E.O.5
Hla, T.6
-
114
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang C, Feng P, Ku B et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8:688-99.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 688-99
-
-
Liang, C.1
Feng, P.2
Ku, B.3
-
115
-
-
36249025723
-
Autophagy: Process and function
-
DOI 10.1101/gad.1599207
-
Mizushima N. Autophagy: Process and function. Genes Dev 2007; 21(22):2861-73. (Pubitemid 350133435)
-
(2007)
Genes and Development
, vol.21
, Issue.22
, pp. 2861-2873
-
-
Mizushima, N.1
-
116
-
-
32044465506
-
TOR signaling in growth and metabolism
-
DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124(3):471-84. (Pubitemid 43199434)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
117
-
-
17144427728
-
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
-
Takeuchi H, Kondo Y, Fujiwara K et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005; 65(8):3336-46. (Pubitemid 40524618)
-
(2005)
Cancer Research
, vol.65
, Issue.8
, pp. 3336-3346
-
-
Takeuchi, H.1
Kondo, Y.2
Fujiwara, K.3
Kanzawa, T.4
Aoki, H.5
Mills, G.B.6
Kondo, S.7
-
118
-
-
2442485884
-
Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1
-
DOI 10.1074/jbc.M313561200
-
Scarlatti F, Bauvy C, Ventruti A et al. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 2004; 279:18384-91. (Pubitemid 38623254)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.18
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
Sala, G.4
Cluzeaud, F.5
Vandewalle, A.6
Ghidoni, R.7
Codogno, P.8
-
119
-
-
41549086994
-
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
-
Patschan S, Chen J, Polotskaia A et al. Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. Am J Physiol Heart Circ Physiol 2008; 294:H1119-H29.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Patschan, S.1
Chen, J.2
Polotskaia, A.3
-
120
-
-
3042562282
-
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
-
DOI 10.1158/0008-5472.CAN-03-3084
-
Daido S, Kanzawa T, Yamamoto A et al. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004; 64(12):4286-93. (Pubitemid 38802435)
-
(2004)
Cancer Research
, vol.64
, Issue.12
, pp. 4286-4293
-
-
Daido, S.1
Kanzawa, T.2
Yamamoto, A.3
Takeuchi, H.4
Kondo, Y.5
Kondo, S.6
-
121
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
DOI 10.1074/jbc.M506182200
-
Lavieu G, Scarlatti F, Sala G et al. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 2006; 281:8518-27. (Pubitemid 43847954)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.13
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
122
-
-
19944434059
-
Inhibition of macroautophagy triggers apoptosis
-
DOI 10.1128/MCB.25.3.1025-1040.2005
-
Boya P, Gonzalez-Polo RA, Casares N et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25(3):1025-40. (Pubitemid 40165810)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.3
, pp. 1025-1040
-
-
Boya, P.1
Gonzalez-Polo, R.-A.2
Casares, N.3
Perfettini, J.-L.4
Dessen, P.5
Larochette, N.6
Metivier, D.7
Meley, D.8
Souquere, S.9
Yoshimori, T.10
Pierron, G.11
Codogno, P.12
Kroemer, G.13
-
123
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
DOI 10.1038/380075a0
-
Verheij M, Bose R, Lin X et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996; 380:75-9. (Pubitemid 26076240)
-
(1996)
Nature
, vol.380
, Issue.6569
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
Haimovitz-Friedman, A.11
Fuks, Z.12
Kolesnick, R.N.13
-
124
-
-
0032514918
-
BAD enables ceramide to signal apoptosis via Ras and Raf-1
-
DOI 10.1074/jbc.273.46.30419
-
Basu S, Bayoumy S, Zhang Y et al. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J Biol Chem 1998; 273(46):30419-26. (Pubitemid 28545515)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.46
, pp. 30419-30426
-
-
Basu, S.1
Bayoumy, S.2
Zhang, Y.3
Lozano, J.4
Kolesnick, R.5
-
125
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine- 1-phosphate
-
DOI 10.1038/381800a0
-
Cuvillier O, Pirianov G, Kleuser B et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996; 381(6585):800-3. (Pubitemid 26243122)
-
(1996)
Nature
, vol.381
, Issue.6585
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Cosot, O.A.5
Gutkind, J.S.6
Spiegel, S.7
-
126
-
-
0035089286
-
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
-
DOI 10.1046/j.1471-4159.2001.00164.x
-
Edsall LC, Cuvillier O, Twitty S et al. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem 2001; 76(5):1573-84. (Pubitemid 32198261)
-
(2001)
Journal of Neurochemistry
, vol.76
, Issue.5
, pp. 1573-1584
-
-
Edsall, L.C.1
Cuvillier, O.2
Twitty, S.3
Spiegel, S.4
Milstien, S.5
-
127
-
-
1842530218
-
i-Ras-MAPK-dependent Induction of Krüppel-like Factor 5
-
DOI 10.1074/jbc.M305025200
-
Usui S, Sugimoto N, Takuwa N et al. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J Biol Chem 2004; 279(13):12300-11. (Pubitemid 38445796)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.13
, pp. 12300-12311
-
-
Usui, S.1
Sugimoto, N.2
Takuwa, N.3
Sakagami, S.4
Takata, S.5
Kaneko, S.6
Takuwa, Y.7
-
128
-
-
79959615309
-
Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells
-
Hsieh HL, Sun CC, Wu CB et al. Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells. J Cell Biochem 2007.
-
(2007)
J Cell Biochem
-
-
Hsieh, H.L.1
Sun, C.C.2
Wu, C.B.3
-
129
-
-
0021932240
-
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
-
DOI 10.1038/313144a0
-
Libermann TA, Nusbaum HR, Razon N et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985; 313(5998):144-7. (Pubitemid 15192341)
-
(1985)
Nature
, vol.313
, Issue.5998
, pp. 144-147
-
-
Libermann, T.A.1
Nusbaum, H.R.2
Razon, N.3
-
130
-
-
0024787440
-
The expression of EGF receptors, EGF-like factors and c-myc in ovarian and cervical carcinomas and their potential clinical significance
-
Kohler M, Janz I, Wintzer HO et al. The expression of EGF receptors, EGF-like factors and c-myc in ovarian and cervical carcinomas and their potential clinical significance. Anticancer Res 1989; 9(6):1537-47.
-
(1989)
Anticancer Res
, vol.9
, Issue.6
, pp. 1537-47
-
-
Kohler, M.1
Janz, I.2
Wintzer, H.O.3
-
131
-
-
0028265306
-
Epidermal growth factor receptor content in human renal cell carcinomas
-
Yoshida K, Tosaka A, Takeuchi S et al. Epidermal growth factor receptor content in human renal cell carcinomas. Cancer 1994; 73(7):1913-8. (Pubitemid 24101971)
-
(1994)
Cancer
, vol.73
, Issue.7
, pp. 1913-1918
-
-
Yoshida, K.-I.1
Tosaka, A.2
Takeuchi, S.-I.3
Kobayashi, N.4
-
132
-
-
0028934811
-
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
-
Dbaibo G, Pushkareva M, Jayadev S et al. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci USA 1995; 92:1347-51.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1347-51
-
-
Dbaibo, G.1
Pushkareva, M.2
Jayadev, S.3
-
133
-
-
34548776512
-
Cip1/Waf1 induction and is prevented by MDM2 overexpression
-
DOI 10.1038/sj.cdd.4402198, PII 4402198
-
Phillips DC, Hunt JT, Moneypenny CG et al. Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression. Cell Death Differ 2007; 14(10):1780-91. (Pubitemid 47423645)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.10
, pp. 1780-1791
-
-
Phillips, D.C.1
Hunt, J.T.2
Moneypenny, C.G.3
Maclean, K.H.4
McKenzie, P.P.5
Harris, L.C.6
Houghton, J.A.7
-
134
-
-
34047191945
-
Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells
-
Wang J, Lv XW, Shi JP et al. Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. World J Gastroenterol 2007; 13(7):1129-34. (Pubitemid 46511019)
-
(2007)
World Journal of Gastroenterology
, vol.13
, Issue.7
, pp. 1129-1134
-
-
Wang, J.1
Lv, X.-W.2
Shi, J.-P.3
Hu, X.-S.4
-
135
-
-
33749534161
-
Telomeres and telomerase: The path from maize, Tetrahymena and yeast to human cancer and aging
-
DOI 10.1038/nm1006-1133, PII NM10061133
-
Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: The path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med 2006; 12(10):1133-8. (Pubitemid 44527346)
-
(2006)
Nature Medicine
, vol.12
, Issue.10
, pp. 1133-1138
-
-
Blackburn, E.H.1
Greider, C.W.2
Szostak, J.W.3
-
136
-
-
0030060521
-
Telomeres, telomerase and cancer
-
Greider CW, Blackburn EH. Telomeres, telomerase and cancer. Sci Am 1996; 274(2):92-7.
-
(1996)
Sci Am
, vol.274
, Issue.2
, pp. 92-7
-
-
Greider, C.W.1
Blackburn, E.H.2
-
137
-
-
0024916431
-
Recognition and elongation of telomeres by telomerase
-
Blackburn EH, Greider CW, Henderson E et al. Recognition and elongation of telomeres by telomerase. Genome 1989; 31(2):553-60. (Pubitemid 20118437)
-
(1989)
Genome
, vol.31
, Issue.2
, pp. 553-560
-
-
Blackburn, E.H.1
Greider, C.W.2
Henderson, E.3
Lee, M.S.4
Shampay, J.5
Shippen-Lentz, D.6
-
138
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich SL, Pruzan R, Ma L et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997; 17(4):498-502. (Pubitemid 27518407)
-
(1997)
Nature Genetics
, vol.17
, Issue.4
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
Ouellette, M.4
Tesmer, V.M.5
Holt, S.E.6
Bodnar, A.G.7
Lichtsteiner, S.8
Kim, N.W.9
Trager, J.B.10
Taylor, R.D.11
Carlos, R.12
Andrews, W.H.13
Wright, W.E.14
Shay, J.W.15
Harley, C.B.16
Morin, G.B.17
-
139
-
-
0035980052
-
Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line
-
Ogretmen B, Kraveka JM, Schady D et al. Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem 2001; 276(35):32506-14.
-
(2001)
J Biol Chem
, vol.276
, Issue.35
, pp. 32506-14
-
-
Ogretmen, B.1
Kraveka, J.M.2
Schady, D.3
-
140
-
-
35248872133
-
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1
-
DOI 10.1096/fj.07-8621com
-
Wooten-Blanks LG, Song P, Senkal CE et al. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. FASEB J 2007; 21(12):3386-97. (Pubitemid 47565557)
-
(2007)
FASEB Journal
, vol.21
, Issue.12
, pp. 3386-3397
-
-
Wooten-Blanks, L.G.1
Song, P.2
Senkal, C.E.3
Ogretmen, B.4
-
141
-
-
34247486847
-
High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells: High expression of CD55 as a novel character for side-population
-
DOI 10.1016/j.yexcr.2007.03.006, PII S0014482707001103
-
Xu JX, Morii E, Liu Y et al. High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells: High expression of CD55 as a novel character for side-population. Exp Cell Res 2007; 313(9):1877-85. (Pubitemid 46653875)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.9
, pp. 1877-1885
-
-
Xu, J.-X.1
Morii, E.2
Liu, Y.3
Nakamichi, N.4
Ikeda, J.-i.5
Kimura, H.6
Aozasa, K.7
-
142
-
-
0642338117
-
Sphingosine-1-phosphate signaling in endothelial activation
-
Ozaki H, Hla T, Lee MJ. Sphingosine-1-phosphate signaling in endothelial activation. J Atheroscler Thromb 2003; 10(3):125-31.
-
(2003)
J Atheroscler Thromb
, vol.10
, Issue.3
, pp. 125-31
-
-
Ozaki, H.1
Hla, T.2
Lee, M.J.3
-
143
-
-
33947163285
-
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells
-
DOI 10.1016/j.bbrc.2007.02.112, PII S0006291X07004214
-
Park KS, Kim MK, Lee HY et al. S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. Biochem Biophys Res Commun 2007; 356(1):239-44. (Pubitemid 46413154)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.356
, Issue.1
, pp. 239-244
-
-
Park, K.S.1
Kim, M.-K.2
Lee, H.Y.3
Kim, S.D.4
Lee, S.Y.5
Kim, J.M.6
Ryu, S.H.7
Bae, Y.-S.8
-
144
-
-
67649924581
-
Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells
-
Guo XZ, Zhang WW, Wang LS et al. [Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells]. Zhonghua Nei Ke Za Zhi 2006; 45(9):752-4.
-
(2006)
Zhonghua Nei Ke Za Zhi
, vol.45
, Issue.9
, pp. 752-4
-
-
Guo, X.Z.1
Zhang, W.W.2
Wang, L.S.3
-
145
-
-
0035114217
-
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer
-
Selzner M, Bielawska A, Morse MA et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 2001; 61(3):1233-40. (Pubitemid 32174448)
-
(2001)
Cancer Research
, vol.61
, Issue.3
, pp. 1233-1240
-
-
Selzner, M.1
Bielawska, A.2
Morse, M.A.3
Rudiger, H.A.4
Sindram, D.5
Hannun, Y.A.6
Clavien, P.-A.7
-
146
-
-
34250732783
-
Role of acid ceramidase in resistance to fasL: Therapeutic approaches based on acid ceramidase inhibitors and fasL gene therapy
-
DOI 10.1038/sj.mt.6300167, PII 6300167
-
Elojeimy S, Liu X, McKillop JC et al. Role of acid ceramidase in resistance to FasL: Therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 2007; 15(7):1259-63. (Pubitemid 46965321)
-
(2007)
Molecular Therapy
, vol.15
, Issue.7
, pp. 1259-1263
-
-
Elojeimy, S.1
Liu, X.2
Mckillop, J.C.3
El-Zawahry, A.M.4
Holman, D.H.5
Cheng, J.Y.6
Meacham, W.D.7
Mahdy, A.E.M.8
Saad, A.F.9
Turner, L.S.10
Cheng, J.11
A Day, T.12
Dong, J.-Y.13
Bielawska, A.14
Hannun, Y.A.15
Norris, J.S.16
-
147
-
-
36349008127
-
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells
-
DOI 10.1007/s00280-007-0465-0
-
Holman DH, Turner LS, El-Zawahry A et al. Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol 2008; 61(2):231-42. (Pubitemid 350160321)
-
(2008)
Cancer Chemotherapy and Pharmacology
, vol.61
, Issue.2
, pp. 231-242
-
-
Holman, D.H.1
Turner, L.S.2
El-Zawahry, A.3
Elojeimy, S.4
Liu, X.5
Bielawski, J.6
Szulc, Z.M.7
Norris, K.8
Zeidan, Y.H.9
Hannun, Y.A.10
Bielawska, A.11
Norris, J.S.12
-
148
-
-
34249828179
-
Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs
-
DOI 10.1016/j.ccr.2007.04.011, PII S1535610807001183
-
Swanton C, Marani M, Pardo O et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007; 11(6):498-512. (Pubitemid 46856907)
-
(2007)
Cancer Cell
, vol.11
, Issue.6
, pp. 498-512
-
-
Swanton, C.1
Marani, M.2
Pardo, O.3
Warne, P.H.4
Kelly, G.5
Sahai, E.6
Elustondo, F.7
Chang, J.8
Temple, J.9
Ahmed, A.A.10
Brenton, J.D.11
Downward, J.12
Nicke, B.13
-
149
-
-
33644526361
-
Sphingosine kinase 1 is up-regulated in colon carcinogenesis
-
DOI 10.1096/fj.05-4331fje
-
Kawamori T, Osta W, Johnson KR et al. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J 2006; 20(2):386-8. (Pubitemid 46671180)
-
(2006)
FASEB Journal
, vol.20
, Issue.2
, pp. 386-388
-
-
Kawamori, T.1
Osta, W.2
Johnson, K.R.3
Pettus, B.J.4
Bielawski, J.5
Tanaka, T.6
Wargovich, M.J.7
Reddy, B.S.8
Hannun, Y.A.9
Obeid, L.M.10
Zhou, D.11
-
150
-
-
24344501665
-
Immunohistochemical distribution of sphinqosine kinase 1 in normal and tumor lung tissue
-
DOI 10.1369/jhc.4A6606.2005
-
Johnson KR, Johnson KY, Crellin HG et al. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem 2005; 53(9):1159-66. (Pubitemid 41262984)
-
(2005)
Journal of Histochemistry and Cytochemistry
, vol.53
, Issue.9
, pp. 1159-1166
-
-
Johnson, K.R.1
Johnson, K.Y.2
Crellin, H.G.3
Ogretmen, B.4
Boylan, A.M.5
Harley, R.A.6
Obeid, L.M.7
-
151
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
French K, Schrecengost R, Lee B et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res 2003; 63:5962-9. (Pubitemid 37187498)
-
(2003)
Cancer Research
, vol.63
, Issue.18
, pp. 5962-5969
-
-
French, K.J.1
Schrecengost, R.S.2
Lee, B.D.3
Zhuang, Y.4
Smith, S.N.5
Eberly, J.L.6
Yun, J.K.7
Smith, C.D.8
-
152
-
-
33745964562
-
Antitumor activity of sphingosine kinase inhibitors
-
DOI 10.1124/jpet.106.101345
-
French K, Upson J, Keller S et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther 2006; 318:596-603. (Pubitemid 44061234)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.318
, Issue.2
, pp. 596-603
-
-
French, K.J.1
Upson, J.J.2
Keller, S.N.3
Zhuang, Y.4
Yun, J.K.5
Smith, C.D.6
-
153
-
-
23944509761
-
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression
-
DOI 10.1182/blood-2004-12-4832
-
Le Scolan E, Pchejetski D, Banno Y et al. Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood 2005; 106(5):1808-16. (Pubitemid 41208598)
-
(2005)
Blood
, vol.106
, Issue.5
, pp. 1808-1816
-
-
Le Scolan, E.1
Pchejetski, D.2
Banno, Y.3
Denis, N.4
Mayeux, P.5
Vainchenker, W.6
Levade, T.7
Moreau-Gachelin, F.8
-
154
-
-
33749185077
-
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
-
DOI 10.1128/MCB.02341-05
-
Kohno M, Momoi M, Oo M et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol 2006; 26:7211-23. (Pubitemid 44477697)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.19
, pp. 7211-7223
-
-
Kohno, M.1
Momoi, M.2
Oo, M.L.3
Paik, J.-H.4
Lee, Y.-M.5
Venkataraman, K.6
Ai, Y.7
Ristimaki, A.P.8
Fyrst, H.9
Sano, H.10
Rosenberg, D.11
Saba, J.D.12
Proia, R.L.13
Hla, T.14
-
155
-
-
33751225686
-
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
-
DOI 10.1073/pnas.0600050103
-
Oskouian B, Sooriyakumaran P, Borowsky A et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc Natl Acad Sci USA 2006; 103:17384-9. (Pubitemid 44788978)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.46
, pp. 17384-17389
-
-
Oskouian, B.1
Soonyakumaran, P.2
Borowsky, A.D.3
Crans, A.4
Dillard-Telm, L.5
Tam, Y.Y.6
Bandhuvula, P.7
Saba, J.D.8
-
156
-
-
2442571212
-
Min/+ Mice
-
Symolon H, Schmelz E, Dillehay D et al. Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice. J Nutr 2004; 134:1157-61. (Pubitemid 38619956)
-
(2004)
Journal of Nutrition
, vol.134
, Issue.5
, pp. 1157-1161
-
-
Symolon, H.1
Schmelz, E.M.2
Dillehay, D.L.3
Merrill Jr., A.H.4
-
157
-
-
0029953485
-
Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: Implications for dietary sphingolipids and colon carcinogenesis
-
Schmelz EM, Dillehay DL, Webb SK et al. Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: Implications for dietary sphingolipids and colon carcinogenesis. Cancer Res 1996; 56(21):4936-41. (Pubitemid 26374432)
-
(1996)
Cancer Research
, vol.56
, Issue.21
, pp. 4936-4941
-
-
Schmelz, E.M.1
Dillehay, D.L.2
Webb, S.K.3
Reiter, A.4
Adams, J.5
Merrill Jr., A.H.6
-
158
-
-
0035884179
-
Modulation of intracellular β-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids
-
Schmelz EM, Roberts PC, Kustin EM et al. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res 2001; 61(18):6723-9. (Pubitemid 32896494)
-
(2001)
Cancer Research
, vol.61
, Issue.18
, pp. 6723-6729
-
-
Schmelz, E.M.1
Roberts, P.C.2
Kustin, E.M.3
Lemonnier, L.A.4
Sullards, M.C.5
Dillehay, D.L.6
Merrill Jr., A.H.7
-
159
-
-
33644974376
-
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
-
Bonhoure E, Pchejetski D, Aouali N et al. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 2006; 20(1):95-102.
-
(2006)
Leukemia
, vol.20
, Issue.1
, pp. 95-102
-
-
Bonhoure, E.1
Pchejetski, D.2
Aouali, N.3
-
160
-
-
12444323123
-
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression
-
DOI 10.1038/sj.onc.1208019
-
Bektas M, Jolly PS, Muller C et al. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression. Oncogene 2005; 24(1):178-87. (Pubitemid 40143877)
-
(2005)
Oncogene
, vol.24
, Issue.1
, pp. 178-187
-
-
Bektas, M.1
Jolly, P.S.2
Muller, C.3
Eberle, J.4
Spiegel, S.5
Geilen, C.C.6
-
161
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P et al. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 2000; 289(5486):1938-42.
-
(2000)
Science
, vol.289
, Issue.5486
, pp. 1938-42
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
-
162
-
-
34249737950
-
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
-
DOI 10.1074/jbc.M610157200
-
Baran Y, Salas A, Senkal CE et al. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J Biol Chem 2007; 282(15):10922-34. (Pubitemid 47100788)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.15
, pp. 10922-10934
-
-
Baran, Y.1
Salas, A.2
Senkal, C.E.3
Gunduz, U.4
Bielawski, J.5
Obeid, L.M.6
Ogretmen, B.7
-
164
-
-
0242609355
-
Miglustat
-
McCormack P, Goa K. Miglustat. Drugs 2003; 63:2427-36.
-
(2003)
Drugs
, vol.63
, pp. 2427-36
-
-
McCormack, P.1
Goa, K.2
-
165
-
-
0038079762
-
Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase
-
Weiss M, Hettmer S, Smith P et al. Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Cancer Res 2003; 63(13):3654-8. (Pubitemid 36793049)
-
(2003)
Cancer Research
, vol.63
, Issue.13
, pp. 3654-3658
-
-
Weiss, M.1
Hettmer, S.2
Smith, P.3
Ladisch, S.4
-
166
-
-
0142059048
-
N-Butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset
-
DOI 10.1016/S0304-3835(03)00459-2
-
Guerrera M, Ladisch S. N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset. Cancer Lett 2003; 201(1):31-40. (Pubitemid 37297995)
-
(2003)
Cancer Letters
, vol.201
, Issue.1
, pp. 31-40
-
-
Guerrera, M.1
Ladisch, S.2
-
167
-
-
34347221936
-
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocyte leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity
-
DOI 10.3324/haematol.10968
-
Dbaibo GS, Kfoury Y, Darwiche N et al. Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. Haematologica 2007; 92(6):753-62. (Pubitemid 350155300)
-
(2007)
Haematologica
, vol.92
, Issue.6
, pp. 753-762
-
-
Dbaibo, G.S.1
Kfoury, Y.2
Darwiche, N.3
Panjarian, S.4
Kozhaya, L.5
Nasr, R.6
Abdallah, M.7
Hermine, O.8
El-Sabban, M.9
De The, H.10
Bazarbachi, A.11
-
168
-
-
22144486976
-
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators
-
DOI 10.1016/j.cellsig.2004.12.005, PII S089865680400289X
-
Billich A, Bornancin F, Mechtcheriakova D et al. Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Cell Signal 2005; 17:1203-17. (Pubitemid 40982611)
-
(2005)
Cellular Signalling
, vol.17
, Issue.10
, pp. 1203-1217
-
-
Billich, A.1
Bornancin, F.2
Mechtcheriakova, D.3
Natt, F.4
Huesken, D.5
Baumruker, T.6
-
169
-
-
33646426132
-
Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects
-
Gamble J, Xia P, Hahn C et al. Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. Int J Cancer 2006; 118:2412-20.
-
(2006)
Int J Cancer
, vol.118
, pp. 2412-20
-
-
Gamble, J.1
Xia, P.2
Hahn, C.3
-
170
-
-
35648995431
-
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
-
DOI 10.1002/pros.20645
-
Leroux M, Auzenne E, Evans R et al. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate 2007; 67:1699-717. (Pubitemid 350036956)
-
(2007)
Prostate
, vol.67
, Issue.15
, pp. 1699-1717
-
-
Leroux, M.E.1
Auzenne, E.2
Evans, R.3
Hail Jr., N.4
Spohn, W.5
Ghosh, S.C.6
Farquhar, D.7
McDonnell, T.8
Klostergaard, J.9
-
171
-
-
35648995431
-
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
-
DOI 10.1002/pros.20645
-
Leroux ME, Auzenne E, Evans R et al. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate 2007; 67(15):1699-717. (Pubitemid 350036956)
-
(2007)
Prostate
, vol.67
, Issue.15
, pp. 1699-1717
-
-
Leroux, M.E.1
Auzenne, E.2
Evans, R.3
Hail Jr., N.4
Spohn, W.5
Ghosh, S.C.6
Farquhar, D.7
McDonnell, T.8
Klostergaard, J.9
-
172
-
-
23844515685
-
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
-
DOI 10.1158/0008-5472.CAN-05-0850
-
Yasui H, Hideshima T, Raje N et al. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res 2005; 65(16):7478-84. (Pubitemid 41161283)
-
(2005)
Cancer Research
, vol.65
, Issue.16
, pp. 7478-7484
-
-
Yasui, H.1
Hideshima, T.2
Raje, N.3
Roccaro, A.M.4
Shiraishi, N.5
Kumar, S.6
Hamasaki, M.7
Ishitsuka, K.8
Tai, Y.-T.9
Podar, K.10
Catley, L.11
Mitsiades, C.S.12
Richardson, P.G.13
Albert, R.14
Brinkmann, V.15
Chauhan, D.16
Anderson, K.C.17
-
173
-
-
0028838590
-
N-(4-hydroxyphenyl)retinamide: Interactions with retinoid-binding proteins/ receptors
-
Sani BP, Shealy YF, Hill DL. N-(4-hydroxyphenyl)retinamide: Interactions with retinoid-binding proteins/ receptors. Carcinogenesis 1995; 16(10):2531-4.
-
(1995)
Carcinogenesis
, vol.16
, Issue.10
, pp. 2531-4
-
-
Sani, B.P.1
Shealy, Y.F.2
Hill, D.L.3
-
174
-
-
0028840629
-
N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma
-
Sheikh MS, Shao ZM, Li XS et al. N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma. Carcinogenesis 1995; 16(10):2477-86.
-
(1995)
Carcinogenesis
, vol.16
, Issue.10
, pp. 2477-86
-
-
Sheikh, M.S.1
Shao, Z.M.2
Li, X.S.3
-
175
-
-
0035392960
-
N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase
-
Wang H, Maurer BJ, Reynolds CP et al. N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. Cancer Res 2001; 61(13):5102-5. (Pubitemid 32681541)
-
(2001)
Cancer Research
, vol.61
, Issue.13
, pp. 5102-5105
-
-
Wang, H.1
Maurer, B.J.2
Patrick, C.P.3
Cabot, M.C.4
-
176
-
-
0034614095
-
Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
-
Maurer BJ, Melton L, Billups C et al. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst 2000; 92(23):1897-909. (Pubitemid 32036920)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.23
, pp. 1897-1909
-
-
Maurer, B.J.1
Melton, L.2
Billups, C.3
Cabot, M.C.4
Reynolds, C.P.5
-
177
-
-
0037147225
-
Ceramide signaling in fenretinide-induced endothelial cell apoptosis
-
DOI 10.1074/jbc.M209962200
-
Erdreich-Epstein A, Tran LB, Bowman NN et al. Ceramide signaling in fenretinide-induced endothelial cell apoptosis. J Biol Chem 2002; 277(51):49531-7. (Pubitemid 36014391)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.51
, pp. 49531-49537
-
-
Erdreich-Epstein, A.1
Tran, L.B.2
Bowman, N.N.3
Wang, H.4
Cabot, M.C.5
Durden, D.L.6
Vlckova, J.7
Reynolds, C.P.8
Stins, M.F.9
Groshen, S.10
Millard, M.11
-
178
-
-
34447115107
-
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells
-
DOI 10.1074/jbc.M700647200
-
Kraveka J, Li L, Szulc Z et al. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 2007; 282:16718-28. (Pubitemid 47093220)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.23
, pp. 16718-16728
-
-
Kraveka, J.M.1
Li, L.2
Szulc, Z.M.3
Bielawski, J.4
Ogretmen, B.5
Hannun, Y.A.6
Obeid, L.M.7
Bielawska, A.8
-
179
-
-
11144239577
-
γ-Tocopherol or combinations of vitamin E forms induce cell in human cells by interrupting sphingolipid synthesis
-
DOI 10.1073/pnas.0408340102
-
Jiang Q, Wong J, Fyrst H et al. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci USA 2004; 101(51):17825-30. (Pubitemid 40051971)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.51
, pp. 17825-17830
-
-
Jiang, Q.1
Wong, J.2
Fyrst, H.3
Saba, J.D.4
Ames, B.N.5
-
180
-
-
34347401415
-
Safingol toxicology after oral administration to TRAMP mice: Demonstration of safingol uptake and metabolism by N-acylation and N-methylation
-
DOI 10.1080/01480540701375018, PII 779836409
-
Morales PR, Dillehay DL, Moody SJ et al. Safingol toxicology after oral administration to TRAMP mice: Demonstration of safingol uptake and metabolism by N-acylation and N-methylation. Drug Chem Toxicol 2007; 30(3):197-216. (Pubitemid 47026913)
-
(2007)
Drug and Chemical Toxicology
, vol.30
, Issue.3
, pp. 197-216
-
-
Morales, P.R.1
Dillehay, D.L.2
Moody, S.J.3
Pallas, D.C.4
Pruett, S.5
Allgood, J.C.6
Symolon, H.7
Merrill Jr., A.H.8
-
181
-
-
34547880067
-
Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy
-
DOI 10.1089/ars.2007.1673
-
Grammatikos G, Teichgraber V, Carpinteiro A et al. Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy. Antioxid Redox Signal 2007; 9(9):1449-56. (Pubitemid 47255025)
-
(2007)
Antioxidants and Redox Signaling
, vol.9
, Issue.9
, pp. 1449-1456
-
-
Grammatikos, G.1
Teichgraber, V.2
Carpinteiro, A.3
Trarbach, T.4
Weller, M.5
Hengge, U.R.6
Gulbins, E.7
-
182
-
-
33646589316
-
Sphingolipid signaling and redox regulation
-
DOI 10.1016/j.freeradbiomed.2006.01.035, PII S089158490600089X
-
Won JS, Singh I. Sphingolipid signaling and redox regulation. Free Radic Biol Med 2006; 40(11):1875-88. (Pubitemid 43728861)
-
(2006)
Free Radical Biology and Medicine
, vol.40
, Issue.11
, pp. 1875-1888
-
-
Won, J.-S.1
Singh, I.2
-
183
-
-
35848953411
-
Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats
-
DOI 10.1007/s00432-007-0255-4
-
Andersson D, Cheng Y, Duan RD. Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. J Cancer Res Clin Oncol 2008; 134(1):101-7. (Pubitemid 350060690)
-
(2008)
Journal of Cancer Research and Clinical Oncology
, vol.134
, Issue.1
, pp. 101-107
-
-
Andersson, D.1
Cheng, Y.2
Duan, R.-D.3
-
184
-
-
30044434594
-
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
-
DOI 10.1124/mol.105.017145
-
Rosato RR, Maggio SC, Almenara JA et al. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury and the acid sphingomyelinase-dependent generation of ceramide. Mol Pharmacol 2006; 69(1):216-25. (Pubitemid 43048908)
-
(2006)
Molecular Pharmacology
, vol.69
, Issue.1
, pp. 216-225
-
-
Rosato, R.R.1
Maggio, S.C.2
Almenara, J.A.3
Payne, S.G.4
Atadja, P.5
Spiegel, S.6
Dent, P.7
Grant, S.8
-
185
-
-
27444435779
-
A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death
-
DOI 10.1194/jlr.M500136-JLR200
-
Darroch PI, Dagan A, Granot T et al. A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide and leads to cell death. J Lipid Res 2005; 46(11):2315-24. (Pubitemid 41532520)
-
(2005)
Journal of Lipid Research
, vol.46
, Issue.11
, pp. 2315-2324
-
-
Darroch, P.I.1
Dagan, A.2
Granot, T.3
He, X.4
Gatt, S.5
Schuchman, E.H.6
-
186
-
-
0344442387
-
Sphingosine-1-Phosphate in Inhibition of Male Germ Cell Apoptosis in the Human Testis
-
DOI 10.1210/jc.2003-030776
-
Suomalainen L, Hakala JK, Pentikainen V et al. Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. J Clin Endocrinol Metab 2003; 88(11):5572-9. (Pubitemid 37452771)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.11
, pp. 5572-5579
-
-
Suomalainen, L.1
Hakala, J.K.2
Pentikainen, V.3
Otala, M.4
Erkkila, K.5
Pentikainen, M.O.6
Dunkel, L.7
-
187
-
-
33846047834
-
Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis
-
DOI 10.1161/01.RES.0000253900.66640.34, PII 0000301220070105000008
-
Pchejetski D, Kunduzova O, Dayon A et al. Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. Circ Res 2007; 100(1):41-9. (Pubitemid 46066772)
-
(2007)
Circulation Research
, vol.100
, Issue.1
, pp. 41-49
-
-
Pchejetski, D.1
Kunduzova, O.2
Dayon, A.3
Calise, D.4
Seguelas, M.-H.5
Leducq, N.6
Seif, I.7
Parini, A.8
Cuvillier, O.9
|