Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats

Journal of Cancer Research and Clinical Oncology

Volumn 134, Issue 1, 2008, Pages 101-107

  Andersson, David ^a   Cheng, Yajun ^a   Duan, Rui Dong ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Aberrant crypt foci; Azoxymethane; Colon cancer; Rat; Sphingomyelinase; Ursolic acid

Indexed keywords

ALKALINE SPHINGOMYELINASE; AZOXYMETHANE; CASPASE; HYDROLASE; KETAMINE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; URSOLIC ACID; XYLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; COLON; COLON CANCER; CONTROLLED STUDY; CRYPT CELL; DRUG EFFECT; DYSPLASIA; ENZYME ACTIVITY; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AZOXYMETHANE; CARCINOGENS; COLON; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTESTINAL MUCOSA; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; TREATMENT OUTCOME; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 35848953411     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0255-4     Document Type: Article

References (34)

1. Andersson D, Liu JJ, Nilsson A, Duan RD (2003) Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. Anticancer Res 4:3317-3322
2. Andersson D, Nilsson Å, Duan R-D (2006) Ursolic acid and other pentacyclic triterpenoids stimulate intestinal alkaline sphingomyelinase in vitro. Eur J Lipid Sci Technol 2:103-108
3. Bird RP (1987) Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 2:147-151
4. Bird RP, Good CK (2000) The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol Lett 112-113:395-402
5. Chan TA, Morin PJ, Vogelstein B, Kinzler KW (1998) Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc Natl Acad Sci USA 2:681-686
6. Chatterjee S (1999) Neutral sphingomyelinase: past, present and future. Chem Phys Lipids 1-2:79-96
7. Duan RD, Nilsson A (2000) Sphingolipid hydrolyzing enzymes in the gastrointestinal tract. Methods Enzymol 311:276-286
8. Duan RD, Nyberg L, Nilsson A (1995) Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics. Biochim Biophys Acta 1:49-55
9. Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J et al (2003) Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem 40:38528-38536
10. Goni FM, Alonso A (2002) Sphingomyelinases: enzymology and membrane activity. FEBS Lett 1:38-46
11. Gulbins E, Li PL (2006) Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol 1:R11-R26
12. Hertervig E, Nilsson A, Nyberg L, Duan RD (1997) Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer 3:448-453
13. Hertervig E, Nilsson A, Bjork J, Hultkrantz R, Duan RD (1999) Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation? Br J Cancer 2:232-236
14. Hertervig E, Nilsson A, Cheng Y, Duan RD (2003) Purified intestinal alkaline sphingomyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells. J Cancer Res Clin Oncol 10:577-582
15. Jayadev S, Linardic CM, Hannun YA (1994) Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem 8:5757-5763
16. Kochanek KD, Murphy SL, Anderson RN, Scott C (2004) Deaths: final data for 2002. Natl Vital Stat Rep 5:1-115
17. Lemonnier LA, Dillehay DL, Vespremi MJ, Abrams J, Brody E, Schmelz EM (2003) Sphingomyelin in the suppression of colon tumors: prevention versus intervention. Arch Biochem Biophys 2:129-138
18. Lillienau J, Crombie DL, Munoz J, Longmire-Cook SJ, Hagey LR, Hofmann AF (1993) Negative feedback regulation of the ileal bile acid transport system in rodents. Gastroenterology 1:38-46
19. Liu J (1995) Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 2:57-68
20. Liu F, Cheng Y, Wu J, Tauschel HD, Duan RD (2006) Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells. Cancer Lett 1:141-146
21. Marchesini N, Hannun YA (2004) Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol 1:27-44
22. Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA (2004) Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem 24:25101-25111
23. Najid A, Simon A, Cook J, Chable-Rabinovitch H, Delage C, Chulia AJ et al (1992) Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. FEBS Lett 3:213-217
24. Novotny L, Vachalkova A, Biggs D (2001) Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview. Neoplasma 4:241-246
25. Pretlow TP, O'Riordan MA, Somich GA, Amini SB, Pretlow TG (1992) Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis 9:1509-1512
26. Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L (1998) Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 10:1212-1215
27. Selzner M, Bielawska A, Morse MA, Rudiger HA, Sindram D, Hannun YA et al (2001) Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 3:1233-1240
28. Sjoqvist U, Hertervig E, Nilsson A, Duan RD, Ost A, Tribukait B et al (2002) Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity. Inflamm Bowel Dis 4:258-263
29. Spiegel S, Merrill AH Jr (1996) Sphingolipid metabolism and cell growth regulation. Faseb J 12:1388-1397
30. Stoffel W (1975) Chemical synthesis of choline-labeled lecithins and sphingomyelins. Methods Enzymol 35:533-541
31. Subbaramaiah K, Michaluart P, Sporn MB, Dannenberg AJ (2000) Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Cancer Res 9:2399-2404
32. Takahashi M, Wakabayashi K (2004) Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci 6:475-480
33. Wu J, Cheng Y, Jonsson BA, Nilsson A, Duan RD (2005) Acid sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells. J Lipid Res 9:1944-1952
34. Wu M, Harvey KA, Ruzmetov N, Welch ZR, Sech L, Jackson K et al (2005) Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway. Int J Cancer 3:340-348