Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism

Journal of the National Cancer Institute

Volumn 92, Issue 23, 2000, Pages 1897-1909

  Maurer, Barry J ^a   Melton, Lisa ^b   Billups, Carolyn ^b   Cabot, Myles C ^c   Reynolds, C Patrick ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c JOHN WAYNE CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 2 HEXADECANOYLAMINO 3 MORPHOLINO 1 PROPANOL; ACYL COENZYME A; CASPASE; CERAMIDE; CYCLOSERINE; FENRETINIDE; FUMONISIN B1; GLUCOSYLCERAMIDE; GLYCEROL DERIVATIVE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN; PALMITIC ACID; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SAFINGOL; SAGROMOSTIM; SERINE; SERINE PALMITOYLTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; SPHINGOSINE ACYLTRANSFERASE; SPHINGOSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; TAMOXIFEN; TRITIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL COMPOSITION; CELL DEATH; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; ENZYME INHIBITION; FIBROBLAST; FLUORESCENCE MICROSCOPY; GLYCOSYLATION; HUMAN; HUMAN CELL; HYPOXIA; ISOTOPE LABELING; LIPID COMPOSITION; LIPID METABOLISM; LIPOGENESIS; LUNG CANCER; MELANOMA; NEUROBLASTOMA CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROMYELOCYTE; PROSTATE CANCER; SOLID TUMOR; STATISTICAL ANALYSIS; THIN LAYER CHROMATOGRAPHY;

EID: 0034614095     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/92.23.1897     Document Type: Article

References (79)

1. Neuroblastoma cell apoptosis induced by the synthetic retinoid N-(4-hydroxyphenyl)retinamide
2. N-(4-hydroxyphenyl)retinamide: A potent inducer of apoptosis in human neuroblastoma cells
3. The effect of tamoxifen and fenretinimide on human colorectal cancer cell lines in vitro
4. N-(4-Hydroxyphenyl) retinamide induces cell cycle specific growth inhibition in PC3 cells
5. Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines
6. N-(4-Hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid
7. Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity
8. Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells
9. Role of antioxidants and intracellular free radicals in retinamide-induced cell death
10. C-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide
11. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)retinamide in neuroblastoma cell lines
12. Signal transduction of stress via ceramide
13. Ceramide in the eukaryotic stress response
14. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation
15. Ceramide induces Bc12 dephosphorylation via a mechanism involving mitochondrial PP2A
16. Glucosylceramide synthase: Assay and properties
17. Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity
18. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
19. Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics
20. Signaling through protein kinase C
21. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
22. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NK-kappaB/JNK kinase and cell survival
23. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta
24. P70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex
25. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases
26. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
27. A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin
28. Inhibitors of glucosylceramide synthase
29. Improved inhibitors of glucosylceramide synthase
30. Tamoxifen retards glycosphingolipid metabolism in human cancer cells
31. Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy
32. Buthionine sulfoximine and myeloablative concentrations of melphalan overcome resistance in a melphalan-resistant neuroblastoma cell line
33. Biological classification of cell lines derived from human extracranial neural tumors
34. Characterization of human neuroblastoma cell lines established before and after therapy
35. Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells
36. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
37. Bone marrow gas tensions, bone marrow blood flow, and erythropoiesis in man
38. 2 tension measurements
39. A novel 96-well plate cytotoxicity assay based on fluorescence digital imaging microscopy
40. Ceramide synthase
41. Serine palmitoyltransferase
42. Drug combinations: From laboratory to practice
43. Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo
44. Enzymes of ceramide biosynthesis
45. Stereospecificities in the metabolic reactions of the four isomeric sphinganines (dihydrosphingosines) in rat liver
46. Studies on the desaturation of sphinganine. Ceramide and sphingomyelin metabolism in the rat and in BHK 21 cells in tissue culture
47. Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth
48. Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
49. Cytotoxicity of l-cycloserine against human neuroblastoma and medul-loblastoma cells is associated with suppression of ganglioside expression
50. Fumonisin toxicity and sphingolipid biosynthesis
51. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases
52. Inhibition of amino acid transferases by l-cycloserine
53. Selective inhibition of alanine aminotransferase and asparate aminotransferase in rat hepatocytes
54. Crystal structures of dialkylglycine decarboxylase inhibitor complexes
55. Pyruvate decarboxylating action of l-cycloserine. The significance of this in understanding its metabolic inhibitory action
56. Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant
57. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
58. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
59. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
60. Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells
61. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death
62. Execution of apoptosis: Converging or diverging pathways?
63. Aponecrosis: Morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis
64. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
65. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
66. Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst
67. Function for NF-kB in neuronal survival: Regulation by atypical protein kinase C
68. P70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex
69. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
70. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes
71. Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
72. Evidence for involvement of mitogen-activated protein kinase, rather then stress-activated protein kinase, in potentiation of 1-beta-d-arabinofuranoscylcytosine-induced apoptosis by interruption of protein kinase C signaling
73. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid
74. Pharmacologic issues for fenretinide chemotherapy (4-HPR, NSC-374551) [abstract]
75. A phase I pharmacokinetic study of fenretinide (HPR) in children with high-risk tumors
76. A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin
77. Phase I trial of high-dose tamoxifen as a modulator of drug resistance in combination with daunorubicin in patients with relapsed or refractory acute leukemia
78. Cross-resistance of topoisomerase I and II inhibitors in neuroblastoma cell lines