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Volumn 98, Issue 9, 2001, Pages 2828-2836

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CYTOCHROME C; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0035525748     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.9.2828     Document Type: Article
Times cited : (122)

References (63)
  • 1
    • 0029948396 scopus 로고    scopus 로고
    • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    • Cuvillier O, Pirianov G, Kleuser B, et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature. 1996;381:800-803.
    • (1996) Nature , vol.381 , pp. 800-803
    • Cuvillier, O.1    Pirianov, G.2    Kleuser, B.3
  • 2
    • 0030780015 scopus 로고    scopus 로고
    • Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation
    • Edsall LC, Pirianov G, Spiegel S. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J Neurosci. 1997;17:6952-6960.
    • (1997) J Neurosci , vol.17 , pp. 6952-6960
    • Edsall, L.C.1    Pirianov, G.2    Spiegel, S.3
  • 3
    • 0030694255 scopus 로고    scopus 로고
    • Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
    • Perez GI, Knudson CM, Leykin L, Korsmeyer SJ, Tilly JL. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat Med. 1997;3:1228-1232.
    • (1997) Nat Med , vol.3 , pp. 1228-1232
    • Perez, G.I.1    Knudson, C.M.2    Leykin, L.3    Korsmeyer, S.J.4    Tilly, J.L.5
  • 4
    • 0032579414 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate inhibits activation of caspases that cleave poly (ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes
    • Cuvillier O, Rosenthal DS, Smulson ME, Spiegel S. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly (ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. J Biol Chem. 1998;273:2910-2916.
    • (1998) J Biol Chem , vol.273 , pp. 2910-2916
    • Cuvillier, O.1    Rosenthal, D.S.2    Smulson, M.E.3    Spiegel, S.4
  • 5
    • 0032056362 scopus 로고    scopus 로고
    • 1α,25-Dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase
    • Kleuser B, Cuvillier O, Spiegel S. 1α,25-Dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. Cancer Res. 1998;58:1817-1824.
    • (1998) Cancer Res , vol.58 , pp. 1817-1824
    • Kleuser, B.1    Cuvillier, O.2    Spiegel, S.3
  • 6
    • 17344394207 scopus 로고    scopus 로고
    • Dual actions of sphingosine-1-phosphate: Extracellular through the Gi-coupled receptor Edg-1 and Intracellular to regulate proliferation and survival
    • Van Brocklyn JR, Lee M, Menzeleev R, et al. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and Intracellular to regulate proliferation and survival. J Cell Biol. 1998;142:229-240.
    • (1998) J Cell Biol , vol.142 , pp. 229-240
    • Van Brocklyn, J.R.1    Lee, M.2    Menzeleev, R.3
  • 7
    • 0033558079 scopus 로고    scopus 로고
    • Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax
    • Goetzl EJ, Kong Y, Mei B. Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. J Immunol. 1999;162:2049-2056.
    • (1999) J Immunol , vol.162 , pp. 2049-2056
    • Goetzl, E.J.1    Kong, Y.2    Mei, B.3
  • 8
    • 0033607517 scopus 로고    scopus 로고
    • Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells
    • Xia P, Wang L, Gamble JR, Vadas MA. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J Biol Chem. 1999;274:34499-34505.
    • (1999) J Biol Chem , vol.274 , pp. 34499-34505
    • Xia, P.1    Wang, L.2    Gamble, J.R.3    Vadas, M.A.4
  • 9
    • 0033786639 scopus 로고    scopus 로고
    • Oocyte apoptosis is suppressed by disruption of the acid sphingomyetinase gene or by sphingosine-1-phosphate therapy
    • Morita Y, Perez GI, Paris F, et al. Oocyte apoptosis is suppressed by disruption of the acid sphingomyetinase gene or by sphingosine-1-phosphate therapy. Nat Med. 2000;6:1109-1114.
    • (2000) Nat Med , vol.6 , pp. 1109-1114
    • Morita, Y.1    Perez, G.I.2    Paris, F.3
  • 10
    • 0035089286 scopus 로고    scopus 로고
    • Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
    • Edsall LC, Cuvillier O, Twitty S, Spiegel S, Milstien S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem. 2001;76:1573-1584.
    • (2001) J Neurochem , vol.76 , pp. 1573-1584
    • Edsall, L.C.1    Cuvillier, O.2    Twitty, S.3    Spiegel, S.4    Milstien, S.5
  • 11
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature. 2000;407:770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 12
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90: 405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 13
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 15
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102:33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 16
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen AM, Ekert PG, Pakusch M, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000;102:43-53.
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3
  • 17
    • 0034680876 scopus 로고    scopus 로고
    • Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway
    • Srinivasula SM, Datta P, Fan XJ, et al. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem. 2000;275:36152-36157.
    • (2000) J Biol Chem , vol.275 , pp. 36152-36157
    • Srinivasula, S.M.1    Datta, P.2    Fan, X.J.3
  • 18
    • 0034710649 scopus 로고    scopus 로고
    • Structural and biochemical basis of apoptotic activation by Smac/DIABLO
    • Chai J, Du C, Wu JW, et al. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000;406:855-862.
    • (2000) Nature , vol.406 , pp. 855-862
    • Chai, J.1    Du, C.2    Wu, J.W.3
  • 19
    • 0034700495 scopus 로고    scopus 로고
    • Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
    • Liu Z, Sun C, Olejniczak ET, et al. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 2000;408:1004-1008.
    • (2000) Nature , vol.408 , pp. 1004-1008
    • Liu, Z.1    Sun, C.2    Olejniczak, E.T.3
  • 20
    • 0034700491 scopus 로고    scopus 로고
    • Structural basis of IAP recognition by Smac/DIABLO
    • Wu G, Chai J, Suber TL, et al. Structural basis of IAP recognition by Smac/DIABLO. Nature. 2000;408:1008-1012.
    • (2000) Nature , vol.408 , pp. 1008-1012
    • Wu, G.1    Chai, J.2    Suber, T.L.3
  • 21
    • 0028300922 scopus 로고
    • Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): Demonstration of cell type-specific response
    • Mazurek N, Megidish T, Hakomori S-I, Igarashi Y. Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response. Biochem Biophys Res Commun. 1994;198:1-9.
    • (1994) Biochem Biophys Res Commun , vol.198 , pp. 1-9
    • Mazurek, N.1    Megidish, T.2    Hakomori, S.-I.3    Igarashi, Y.4
  • 22
    • 0030592536 scopus 로고    scopus 로고
    • Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity
    • Buehrer BM, Bardes ES, Bell RM. Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity. Biochim Biophys Acta. 1996;1303:233-242.
    • (1996) Biochim Biophys Acta , vol.1303 , pp. 233-242
    • Buehrer, B.M.1    Bardes, E.S.2    Bell, R.M.3
  • 23
    • 0032530864 scopus 로고    scopus 로고
    • N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide
    • Edsall L, Van Brocklyn JR, Cuvillier O, Kleuser B, Spiegel S. N, N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry, 1998;37:12892-12898.
    • (1998) Biochemistry , vol.37 , pp. 12892-12898
    • Edsall, L.1    Van Brocklyn, J.R.2    Cuvillier, O.3    Kleuser, B.4    Spiegel, S.N.5
  • 25
    • 0034717184 scopus 로고    scopus 로고
    • Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
    • Cuvillier O, Edsail L, Spiegel S. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J Biol Chem. 2000;275:15691-15700.
    • (2000) J Biol Chem , vol.275 , pp. 15691-15700
    • Cuvillier, O.1    Edsail, L.2    Spiegel, S.3
  • 26
    • 0035090339 scopus 로고    scopus 로고
    • Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells
    • Cuvillier O, Nava V, Murthy SK, et al. Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ. 2001;8:162-171.
    • (2001) Cell Death Differ , vol.8 , pp. 162-171
    • Cuvillier, O.1    Nava, V.2    Murthy, S.K.3
  • 27
    • 0033529534 scopus 로고    scopus 로고
    • Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
    • Scaffidi C, Schmitz I, Zha J, et al. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem. 1999;274:22532-22538.
    • (1999) J Biol Chem , vol.274 , pp. 22532-22538
    • Scaffidi, C.1    Schmitz, I.2    Zha, J.3
  • 28
    • 0034711239 scopus 로고    scopus 로고
    • Protein kinase C theta and epsilon promote T-cell survival by a Rsk-dependent phosphorylation and inactivation of BAD
    • Bertolotto C, Maulon L, Filippa N, Baler G, Auberger P. Protein kinase C theta and epsilon promote T-cell survival by a Rsk-dependent phosphorylation and inactivation of BAD. J Biol Chem. 2000;275:37246-37250.
    • (2000) J Biol Chem , vol.275 , pp. 37246-37250
    • Bertolotto, C.1    Maulon, L.2    Filippa, N.3    Baler, G.4    Auberger, P.5
  • 30
    • 0032508501 scopus 로고    scopus 로고
    • Evidence that protein kinase C epsilon mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-alpha-induced apoptosis in U937 histiocytic lymphoma cells
    • Mayne GC, Murray AW. Evidence that protein kinase C epsilon mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-alpha-induced apoptosis in U937 histiocytic lymphoma cells. J Biol Chem. 1998;273:24115-24121.
    • (1998) J Biol Chem , vol.273 , pp. 24115-24121
    • Mayne, G.C.1    Murray, A.W.2
  • 31
    • 0028095477 scopus 로고
    • Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
    • Cifone MG, De Maria R, Roncaioli P, et al. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med. 1994;180:1547-1552.
    • (1994) J Exp Med , vol.180 , pp. 1547-1552
    • Cifone, M.G.1    De Maria, R.2    Roncaioli, P.3
  • 32
    • 0028964917 scopus 로고
    • Fas-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway
    • Gulbins E, Bissonnette R, Mahboubi A, et al. Fas-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity. 1995;2:341-351.
    • (1995) Immunity , vol.2 , pp. 341-351
    • Gulbins, E.1    Bissonnette, R.2    Mahboubi, A.3
  • 33
    • 0031873198 scopus 로고    scopus 로고
    • Fas/CD95/Apo-1 activates the acidic sphingomyelinase via caspases
    • Brenner B, Ferlinz K, Grassmé H, et al. Fas/CD95/Apo-1 activates the acidic sphingomyelinase via caspases. Cell Death Differ. 1998;5:29-37.
    • (1998) Cell Death Differ , vol.5 , pp. 29-37
    • Brenner, B.1    Ferlinz, K.2    Grassmé, H.3
  • 34
    • 0033598821 scopus 로고    scopus 로고
    • Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids
    • Lepple-Wienhues A, Belka C, Laun T, et al. Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc Natl Acad Sci U S A. 1999;96:13795-13800.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13795-13800
    • Lepple-Wienhues, A.1    Belka, C.2    Laun, T.3
  • 35
    • 0347537940 scopus 로고    scopus 로고
    • Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
    • Verheij M, Bose R, Lin X, et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 1996;380:75-79.
    • (1996) Nature , vol.380 , pp. 75-79
    • Verheij, M.1    Bose, R.2    Lin, X.3
  • 36
    • 0029098277 scopus 로고
    • Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture
    • Smith ER, Merrill AH Jr. Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. J Biol Chem. 1995;270:18749-18758.
    • (1995) J Biol Chem , vol.270 , pp. 18749-18758
    • Smith, E.R.1    Merrill A.H., Jr.2
  • 37
    • 0031051559 scopus 로고    scopus 로고
    • Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases
    • Smith ER, Jones PL, Boss JM, Merrill AH Jr. Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases. J Biol Chem. 1997;272:5640-5646.
    • (1997) J Biol Chem , vol.272 , pp. 5640-5646
    • Smith, E.R.1    Jones, P.L.2    Boss, J.M.3    Merrill A.H., Jr.4
  • 39
    • 0027973628 scopus 로고
    • A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils
    • Ohta H, Yatomi Y, Sweeney EA, Hakomori S, Igarashi Y. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils. FEBS Lett. 1994;355:267-270.
    • (1994) FEBS Lett , vol.355 , pp. 267-270
    • Ohta, H.1    Yatomi, Y.2    Sweeney, E.A.3    Hakomori, S.4    Igarashi, Y.5
  • 40
    • 0028900748 scopus 로고
    • Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
    • Ohta H, Sweeney EA, Masamune A, et al. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res. 1995;55:691-697.
    • (1995) Cancer Res , vol.55 , pp. 691-697
    • Ohta, H.1    Sweeney, E.A.2    Masamune, A.3
  • 41
    • 0030004270 scopus 로고    scopus 로고
    • Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
    • Sweeney EA, Sakahura C, Shirahama T, et al. Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int J Cancer. 1996;66:358-366.
    • (1996) Int J Cancer , vol.66 , pp. 358-366
    • Sweeney, E.A.1    Sakahura, C.2    Shirahama, T.3
  • 42
    • 0031035476 scopus 로고    scopus 로고
    • In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells
    • Shirahama T, Sweeney EA, Sakakura C, et al. In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. Clin Cancer Res. 1997;3:257-264.
    • (1997) Clin Cancer Res , vol.3 , pp. 257-264
    • Shirahama, T.1    Sweeney, E.A.2    Sakakura, C.3
  • 43
    • 0032549509 scopus 로고    scopus 로고
    • Inhibition of sphingolipid-induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
    • Sweeney EA, Inokuchi J, Igarashi Y. Inhibition of sphingolipid-induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. FEBS Lett. 1998;425:61-65.
    • (1998) FEBS Lett , vol.425 , pp. 61-65
    • Sweeney, E.A.1    Inokuchi, J.2    Igarashi, Y.3
  • 44
    • 0032546933 scopus 로고    scopus 로고
    • Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells
    • Nakamura H, Oda T, Hamada K, et al. Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. J Biol Chem. 1998;273:15345-15351.
    • (1998) J Biol Chem , vol.273 , pp. 15345-15351
    • Nakamura, H.1    Oda, T.2    Hamada, K.3
  • 45
    • 0032571139 scopus 로고    scopus 로고
    • Involvement of Mac-1-medlated adherence and sphingosine 1-phosphate in survival of phorbol ester-treated U937 cells
    • Hamada K, Nakamura H, Oda T, et al. Involvement of Mac-1-medlated adherence and sphingosine 1-phosphate in survival of phorbol ester-treated U937 cells. Biochem Biophys Res Comm. 1998;244:745-750.
    • (1998) Biochem Biophys Res Comm , vol.244 , pp. 745-750
    • Hamada, K.1    Nakamura, H.2    Oda, T.3
  • 46
    • 0034662612 scopus 로고    scopus 로고
    • Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells
    • Nava V, Cuvillier O, Edsall L, et al. Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. Cancer Res. 2000;60:4468-4474.
    • (2000) Cancer Res , vol.60 , pp. 4468-4474
    • Nava, V.1    Cuvillier, O.2    Edsall, L.3
  • 47
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 48
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 1997;275:1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3
  • 49
    • 0029950290 scopus 로고    scopus 로고
    • Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
    • Susin SA, Zamzami N, Castedo M, et al. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med. 1996;184:1331-1341.
    • (1996) J Exp Med , vol.184 , pp. 1331-1341
    • Susin, S.A.1    Zamzami, N.2    Castedo, M.3
  • 50
    • 0032404536 scopus 로고    scopus 로고
    • The central executioners of apoptosis: Caspases or mitochondria?
    • Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol. 1998;8:267-271.
    • (1998) Trends Cell Biol , vol.8 , pp. 267-271
    • Green, D.1    Kroemer, G.2
  • 51
    • 0034284637 scopus 로고    scopus 로고
    • Mitochondria as the central control point of apoptosis
    • Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 2000;10:369-377.
    • (2000) Trends Cell Biol , vol.10 , pp. 369-377
    • Desagher, S.1    Martinou, J.C.2
  • 52
    • 0035369143 scopus 로고    scopus 로고
    • The mitochondrial apoptosome: A killer unleashed by the cytochrome seas
    • Adrain C, Martin SJ. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem Sci. 2001;26:390-397.
    • (2001) Trends Biochem Sci , vol.26 , pp. 390-397
    • Adrain, C.1    Martin, S.J.2
  • 53
    • 0030785790 scopus 로고    scopus 로고
    • The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
    • Susin SA, Zamzami N, Castedo M, et al. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med. 1997;186:25-37.
    • (1997) J Exp Med , vol.186 , pp. 25-37
    • Susin, S.A.1    Zamzami, N.2    Castedo, M.3
  • 54
    • 0028851406 scopus 로고
    • Inhibition of ceramide-induced apoptosis by Bcl-2
    • Martin SJ, Takayama S, McGahon AJ, et al. Inhibition of ceramide-induced apoptosis by Bcl-2. Cell Death Differ. 1995;2:253-257.
    • (1995) Cell Death Differ , vol.2 , pp. 253-257
    • Martin, S.J.1    Takayama, S.2    McGahon, A.J.3
  • 55
    • 9344222195 scopus 로고    scopus 로고
    • Bcl-2 interrupts the ceramide-mediated pathway of cell death
    • Zhang J, Alter N, Reed JC, et al. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996;93:5325-5328.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5325-5328
    • Zhang, J.1    Alter, N.2    Reed, J.C.3
  • 56
    • 0029949938 scopus 로고    scopus 로고
    • prlCE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
    • Smyth MJ, Perry DK, Zhang J, et al. prlCE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996;316:25-28.
    • (1996) Biochem J , vol.316 , pp. 25-28
    • Smyth, M.J.1    Perry, D.K.2    Zhang, J.3
  • 57
    • 0031041448 scopus 로고    scopus 로고
    • Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway
    • Dbaibo GS, Perry DK, Gamard CJ, et al. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med. 1997;185:481-490.
    • (1997) J Exp Med , vol.185 , pp. 481-490
    • Dbaibo, G.S.1    Perry, D.K.2    Gamard, C.J.3
  • 58
    • 0030692005 scopus 로고    scopus 로고
    • Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2
    • Zhang P, Liu B, Kang SW, et al. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J Biol Chem. 1997;272:30615-30618.
    • (1997) J Biol Chem , vol.272 , pp. 30615-30618
    • Zhang, P.1    Liu, B.2    Kang, S.W.3
  • 59
    • 0033974782 scopus 로고    scopus 로고
    • Ceramide in the eukaryotic stress response
    • Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000;10:73-80.
    • (2000) Trends Cell Biol , vol.10 , pp. 73-80
    • Hannun, Y.A.1    Luberto, C.2
  • 60
    • 0032514918 scopus 로고    scopus 로고
    • BAD enables ceramide to signal apoptosis via Ras and Raf-1
    • Basu S, Bayoumy S, Zhang Y, Lozano J, Kolesnick R. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J Biol Chem. 1998;273:30419-30426.
    • (1998) J Biol Chem , vol.273 , pp. 30419-30426
    • Basu, S.1    Bayoumy, S.2    Zhang, Y.3    Lozano, J.4    Kolesnick, R.5
  • 61
    • 0032569026 scopus 로고    scopus 로고
    • Inhibition of Akt kinase by cell-permeable ceramide and its implication for ceramide-induced apoptosis
    • Zhou H, Summers SA, Birnbaum MJ, Pittman RN. Inhibition of Akt kinase by cell-permeable ceramide and its implication for ceramide-induced apoptosis. J Biol Chem. 1998;273:16568-16575.
    • (1998) J Biol Chem , vol.273 , pp. 16568-16575
    • Zhou, H.1    Summers, S.A.2    Birnbaum, M.J.3    Pittman, R.N.4
  • 62
    • 0032128301 scopus 로고    scopus 로고
    • Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
    • Zundel W, Giaccia A. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev. 1998;12:1941-1946.
    • (1998) Genes Dev , vol.12 , pp. 1941-1946
    • Zundel, W.1    Giaccia, A.2
  • 63
    • 0034607914 scopus 로고    scopus 로고
    • Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473
    • Schubert KM, Scheid MP, Duronio V. Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. J Biol Chem. 2000;275:13330-13335.
    • (2000) J Biol Chem , vol.275 , pp. 13330-13335
    • Schubert, K.M.1    Scheid, M.P.2    Duronio, V.3


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