The ins and outs of sphingolipid synthesis

Trends in Cell Biology

Volumn 15, Issue 6, 2005, Pages 312-318

  Futerman, Anthony H ^a   Riezman, Howard ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; CERAMIDE DERIVATIVE; CERAMIDE GLUCOSYLTRANSFERASE; FATTY ACID; OXIDOREDUCTASE; PHOSPHATASE; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; SPHINGOSINE KINASE;

CELL MEMBRANE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; EUKARYOTIC CELL; GOLGI COMPLEX; HUMAN; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; DIAZEPAM BINDING INHIBITOR; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HUMANS; SPHINGOLIPIDS;

EUKARYOTA;

EID: 20444363393     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2005.04.006     Document Type: Review

References (59)

1. S. Ichikawa, and Y. Hirabayashi Glucosylceramide synthase and glycosphingolipid synthesis Trends Cell Biol. 8 1998 198 202
2. K. Venkataraman, and A.H. Futerman Ceramide as a second messenger: sticky solutions to sticky problems Trends Cell Biol. 10 2000 408 412
3. D.L. Marks, and R.E. Pagano Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease Trends Cell Biol. 12 2002 605 613
4. Y.A. Hannun, and C. Luberto Ceramide in the eukaryotic stress response Trends Cell Biol. 10 2000 73 80
5. S. Spiegel Sphingosine 1-phosphate signaling: providing cells with a sense of direction Trends Cell Biol. 12 2002 236 242
6. A.H. Futerman, and Y.A. Hannun The complex life of simple sphingolipids EMBO Rep. 5 2004 777 782
7. K. Hanada Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism Biochim. Biophys. Acta 1632 2003 16 30
8. K. Hanada Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques J. Biol. Chem. 275 2000 8409 8415
9. S. Yasuda Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells J. Biol. Chem. 278 2003 4176 4183
10. G. Han The topology of the Lcb1p subunit of yeast serine palmitoyltransferase J. Biol. Chem. 279 2004 53707 53716
11. K. Tamura Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis Plant Cell Physiol. 42 2001 1274 1281
12. K. Gable Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity J. Biol. Chem. 275 2000 7597 7603
13. E. Monaghan Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae Yeast 19 2002 659 670
14. A. Kihara, and Y. Igarashi FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane J. Biol. Chem. 279 2004 49243 49250
15. E.C. Mandon Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver J. Biol. Chem. 267 1992 11144 11148
16. J.D. Saba, and T. Hla Point-counterpoint of sphingosine 1-phosphate metabolism Circ. Res. 94 2004 724 734
17. M.M. Nagiec The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases J. Biol. Chem. 273 1998 19437 19442
18. K. Funato Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae J. Biol. Chem. 278 2003 7325 7334
19. N.C. Hait Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes FEBS Lett. 532 2002 97 102
20. A. Billich Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases J. Biol. Chem. 278 2003 47408 47415
21. C. Delon Sphingosine kinase 1 is an intracellular effector of phosphatidic acid J. Biol. Chem. 279 2004 44763 44774
22. N. Igarashi Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis J. Biol. Chem. 278 2003 46832 46839
23. A. Kihara Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p Genes Cells 8 2003 525 535
24. M. Ikeda Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol Biochem. Biophys. Res. Commun. 325 2004 338 343
25. A.H. Merrill Jr De novo sphingolipid biosynthesis. A necessary, but dangerous, pathway J. Biol. Chem. 277 2002 25843 25846
26. I. Guillas C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p EMBO J. 20 2001 2655 2665
27. S. Schorling Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisiae Mol. Biol. Cell 12 2001 3417 3427
28. B.F. Brandwagt Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants Mol. Plant Microbe Interact. 15 2002 35 42
29. K. Venkataraman Upstream of Growth and Differentiation Factor 1 (uog1), a mammalian homolog of the yeast Longevity Assurance Gene 1 (LAG1), regulates N-Stearoyl-sphinganine (C18-(Dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells J. Biol. Chem. 277 2002 35642 35649
30. K. Venkataraman, and A. Futerman Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis? FEBS Lett. 528 2002 3 4
31. E. Winter, and C.P. Ponting TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? Trends Biochem. Sci. 27 2002 381 383
32. C. Riebeling Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors J. Biol. Chem. 278 2003 43452 43459
33. I. Guillas Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast J. Biol. Chem. 278 2003 37083 37091
34. B. Vallee, and H. Riezman Lip1p: a novel subunit of acyl-CoA ceramide synthase EMBO J. 24 2005 730 741
35. L. Qie Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids J. Biol. Chem. 272 1997 16110 16117
36. N.L. Alderson The human FA2H gene encodes a fatty acid 2-hydroxylase J. Biol. Chem. 279 2004 48562 48568
37. N.J. Faergeman Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae Biochem. J. 380 2004 907 918
38. N.J. Faergeman, and J. Knudsen Acyl-CoA binding protein is an essential protein in mammalian cell lines Biochem. J. 368 2002 679 682
39. P. Ternes Identification and characterization of a sphingolipid delta 4-desaturase family J. Biol. Chem. 277 2002 25512 25518
40. C. Michel, and G. van Echten-Deckert Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum FEBS Lett. 416 1997 153 155
41. Y. Mizutani Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation FEBS Lett. 563 2004 93 97
42. C. Beckmann Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism Org. Biomol. Chem. 1 2003 2448 2454
43. H. Sprong UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum J. Biol. Chem. 273 1998 25880 25888
44. H. Sprong Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum Mol. Biol. Cell 14 2003 3482 3493
45. K. Huitema Identification of a family of animal sphingomyelin synthases EMBO J. 23 2004 33 44
46. S. Yamaoka Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells J. Biol. Chem. 279 2004 18688 18693
47. S. Ichikawa Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis Proc. Natl. Acad. Sci. U. S. A. 93 1996 4638 4643
48. A. Kohyama-Koganeya Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors J. Biol. Chem. 279 2004 35995 36002
49. I. Hillig Formation of glucosylceramide and sterol glucoside by a UDP-glucose-dependent glucosylceramide synthase from cotton expressed in Pichia pastoris FEBS Lett. 553 2003 365 369
50. K. Hanada Molecular machinery for non-vesicular trafficking of ceramide Nature 426 2003 803 809
51. K. Kumagai CERT mediates intermembrane transfer of various molecular species of ceramides J. Biol. Chem. 280 2005 6488 6495
52. M. Fukasawa Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells J. Cell Biol. 144 1999 673 685
53. H. Riezman, and G. van Meer Lipid pickup and delivery Nat. Cell Biol. 6 2004 15 16
54. F.X. Contreras Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes J. Biol. Chem. 278 2003 37169 37174
55. F.X. Contreras Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes Biophys. J. 88 2004 348 359
56. H. Lannert Functional organization of the Golgi apparatus in glycosphingolipid biosynthesis. Lactosylceramide and subsequent glycosphingolipids are formed in the lumen of the late Golgi J. Biol. Chem. 273 1998 2939 2946
57. C.G. Giraudo, and H.J. Maccioni Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells J. Biol. Chem. 278 2003 40262 40271
58. X. Buton Transbilayer movement of monohexosylsphingolipids in endoplasmic reticulum and Golgi membranes Biochemistry 41 2002 13106 13115
59. M.F. De Rosa Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis J. Biol. Chem. 279 2004 7867 7876