Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells

Journal of Biological Chemistry

Volumn 282, Issue 19, 2007, Pages 14213-14225

  Guan, Lingjie ^a   Song, Kyung ^b   Pysz, Marybeth A ^a   Curry, Kathryn J ^a   Hizli, A Asli ^a   Danielpour, David ^b   Black, Adrian R ^a   Black, Jennifer D ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GROWTH KINETICS; PHOSPHORYLATION; RATS;

CYCLIN D1; HYPOPHOSPHORYLATION; MOLECULAR MECHANISMS;

CELLS;

CYCLIN D1; INITIATION FACTOR 4E BINDING PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; CARRIER PROTEIN; CYCLIN D; CYCLINE; EIF4EBP1 PROTEIN, RAT; INITIATION FACTOR; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYPT CELL; DEPHOSPHORYLATION; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CULTURE; EPITHELIUM CELL; INTESTINE; INTESTINE MUCOSA; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CYCLINS; DOWN-REGULATION; EPITHELIAL CELLS; EUKARYOTIC INITIATION FACTORS; INTESTINAL MUCOSA; INTESTINES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 34250635347     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610513200     Document Type: Article

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