Compartmentalization of Ceramide Signaling: Physical Foundations and Biological Effects

Journal of Cellular Physiology

Volumn 184, Issue 3, 2000, Pages 285-300

  Kolesnick, Richard N ^a   Goñi, Felix M ^b   Alonso, Alicia ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; DNA; FATTY ACID; PHOSPHOLIPID; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOSINE;

APOPTOSIS; CELL COMPARTMENTALIZATION; CELL MEMBRANE; DIFFERENTIAL SCANNING CALORIMETRY; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SOLUBILITY; X RAY DIFFRACTION;

ANIMALS; CELL COMPARTMENTATION; CERAMIDES; CHEMISTRY, PHYSICAL; DIGLYCERIDES; DRUG STABILITY; HUMANS; LIPID BILAYERS; MEMBRANE FUSION; PERMEABILITY; PHOSPHOLIPIDS; PROTEIN BINDING; SIGNAL TRANSDUCTION; STRESS;

EID: 0033884050     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4652(200009)184:3<285::AID-JCP2>3.0.CO;2-3     Document Type: Review

References (130)

1. Metabolic effects of short-chain ceramide and glucosylceramide on sphingolipids and protein kinase
2. Cell-permeable ceramides prevent the activation of phospholipase D by ADP-ribosylation factor and RhoA
3. Mechanisms by which short-chain ceramides cause apoptosis
4. Increase in size of sonicated phospholipid vesicles in the presence of detergents
5. The caveolae membrane system
6. Tracking of cell surface receptors by fluorescent digital imaging microscopy using a charge-coupled device camera. Low-density lipoprotein and influenza virus receptor mobility at 4°C
7. Measurements of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles
8. Morphological changes induced by phospholipase C and by sphingomyelinase on large unilamellar vesicles: A cryotransmission electron microscopy study of liposome fusion
9. Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion
10. Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs
11. Selectivity of ceramide-mediated biology. Lack of activity of erythrodihydroceramide
12. Association of p75(NTR) with caveolin and localization of neutrophin-induced sphingomyelin hydrolysis to caveolae
13. Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways
14. Inhibition of phosphatidylcholine and phosphatidylethanolamine biosynthesis in rat-2 fibroblasts by cell-permeable ceramides
15. Differential effects of ceramides upon adenylyl cyclase subtypes
16. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
17. Structure and origin of ordered lipid domains in biological membranes
18. ADP-Ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
19. Sphingolipid organization in biomembranes: What physical studies of model membranes reveal
20. Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures
21. Phase behaviour and molecular interactions in mixtures of ceramide with dipalmitoylphosphatidylcholine
22. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
23. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid
24. Ceramide formation during heat shock: A potential mediator of alpha B-crystallin transcription
25. Ceramide as modulator of endocytosis
26. Bending membranes to the task
27. Molecular arrangements in sphingolipids. Crystal structure of N-Tetracosanoylphytosphingosine
28. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
29. Sphingolipid signaling domains: Floating on rafts or buried in caves?
30. Ceramide activates heterotrimeric protein phosphatase 2Aδ
31. Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines
32. Lipid domains in the membrane: Thermotropic properties of sphingomyelin vesicles containing GM1 ganglioside and cholesterol
33. Use of N-([1-14C]hexanoyl)-D-erythro-sphingolipids to assay sphingolipid metabolism
34. Ceramide metabolism compartmentalized in the endoplasmic reticulum and Golgi apparatus
35. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species
36. Automated detection and tracking of individual and clustered cell surface low density lipoprotein receptor molecules
37. 2+)-ATPase reconstituted systems
38. Modulation of cell signalling by ceramides
39. Interfacial enzyme activation, non-lamellar phase formation and membrane fusion. Is there a conducting thread?
40. Structure and functional properties of diacylglycerols in membranes
41. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to proapoptotic stimuli
42. Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells
43. Chemistry of glycosphingolipids
44. Solubilization and localization of weakly polar lipids in unsonicated egg phosphatidylcholine: A 13C MAS NMR study
45. Phase properties of mixtures of ceramides
46. Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways
47. Functions of ceramide in coordinating cellular responses to stress
48. Ceramide induces apoptosis in PC12 cells
49. Cathepsin D targeted by acid sphingomyelinase-derived ceramide
50. Elastic properties of lipid bilayers: Theory and possible experiments
51. 2+-activated adenosine triphosphatase
52. Ceramides in apoptosis - Does it really matter?
53. Lipid microdomains in dimyristoylphoaphatidylcholine-ceramide liposomes
54. Sphingomyelinase induces lipid microdomains formation in a fluid phosphatidylcholine/sphingomyelin membrane
55. Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomes
56. Do glycolipid microdomains really exist?
57. 2
58. 2
59. Ceramides modulate protein kinase C activity and perturb the structure of phosphatidylcholine/phosphatidylserine bilayers
60. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase
61. Selective ceramide binding to protein kinase C-a and -d isoenzimes in renal mesangial cells
62. Calcium-independent activation of endothelial nitric oxide synthase by ceramide
63. Physical principles of membrane organization
64. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae
65. Tumor necrosis factor alpha increases tyrosine phosphorylation of a 23-kDa nuclear protein in U937 cells through ceramide signaling pathway
66. Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells
67. The role of endothelium in ceramide-induced vasodilation
68. Intracellular mechanisms of L-selectin induced capping
69. ARF Signaling: A potential role for phospholipase D in membrane traffic
70. Sphingolipid Metabolism
71. 2-ceramide
72. On the molecular level mechanisms of peripheral protein/membrane interactions induced by lipids forming nonlamellar phases
73. Early effects of PP60(v-scr) kinase activation on caveolae
74. TNF-a-mediated apoptosis is initiated in caveolae-like domains
75. Dihydroceramide biology. Structure-specific metabolism and intracellular localization
76. Regulation of ceramide production and apoptosis
77. Recent advances in the biochemistry of glycosphingolipid metabolism
78. Conversion of short-chain ceramides to short-chain ceramide GM3 in B16 melanoma cells
79. Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in chinese hamster ovary and mouse LM cell fibroblasts
80. Acetylation of sphingosine by PAF-dependent transacetylase
81. Biosynthesis of N-acetylsphingosine by platelet-activating factor: Sphingosine CoA-independent transacetylase in HL-60 cells
82. Characteristics of the binding of tacrine to acidic phospholipids
83. 6-ceramide
84. Organized endothelial cell surface signal transduction in caveolae distinct glycosylphosphatidylinositol-anchored protein domains
85. Compartmentalized production of ceramide at the cell surface
86. Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae
87. Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation
88. Signal transduction of stress via ceramide
89. FTIR spectroscopy studies of the conformational order and phase behavior of ceramides
90. VIP21/caveolin is a cholesterol-binding protein
91. Topological properties of two cubic phases of a phospholipid:CHolesterol:DIacylglycerol aqueous system and their possible implications in the phospholipase C-induced liposome fusion
92. The role of protein kinase C in cell surface signal transduction and tumor promotion
93. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane endothelium
94. Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts
95. Phase transition in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol
96. Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase
97. Crystal structures of membrane lipids
98. Molecular arrangements in sphingolipids: Crystal structure of the ceramide N-(2D,3D-dihydroxyoctadecanoyl)-phytosphingosine
99. Liposomes containing sphingomyelin and cholesterol: Detergent solubilization and infrared spectroscopic studies
100. Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts
101. The role of ceramide in cell signaling
102. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
103. Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells
104. Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae
105. Different effects of enzyme-generated ceramides and diacylglycerols in phospholipid membrane fusion and leakage
106. Vesicle membrane fusion induced by the concerted activities of sphingomyelinase and phospholipase C
107. Equilibrium and kinetic studies of the solubilization of phospholipid-cholesterol bilayers by C12E8. The influence of the lipid phase structure
108. Cedramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis
109. Separation of caveolae from associated microdomains of GPI-anchored proteins
110. Kinetics of melittin binding to phospholipid small unilamellar vesicles
111. Structural and thermotropic properties of synthetic C 16:0 (palmitoyl) ceramide: Effect of hydration
112. Physical properties of ceramides: Effect of fatty acid hydroxylation
113. The modified stalk mechanism of lamellar/inverted phase transitions and its implications for membrane fusion
114. 2-ceramide may be responsible for its ability to inhibit platelet aggregation
115. Functional rafts in cell membranes
116. Detection of temporary lateral confinement of membrane proteins using single-particle tracking analysis
117. Surface and bulk interaction of lipids and water with a classification of biologically active lipids based on those interactions
118. Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers
119. Hypothesis: Ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains
120. Ceramides in phospholipid membranes: Effects on bilayer stability and transition to nonlamellar phases
121. Ceramides in pig epidermis: Structure determination
122. Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labelling
123. Glycosphingolipids
124. Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle. Suppresion of sphingomyelin and higher-glycosphingolipid synthesis and accumulation of ceramide and glucosylceramide in mitotic cells
125. Sphingomyelinase treatment induces ATP-independent endocytosis
126. Kinase suppressor of Ras is ceramide-activated protein kinase
127. Caveolin-1 mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide