Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγ1: Implication in stem cell factor radioprotective effect

Blood

Volumn 100, Issue 4, 2002, Pages 1294-1301

  Maddens, Stéphane ^a,b,c   Charruyer, Alexandra ^a,b,c   Plo, Isabelle ^a,b,c   Dubreuil, Patrice ^a,b,c   Berger, Stuart ^a,b,c   Salles, Bernard ^a,b,c   Laurent, Guy ^a,b,c   Jaffrézou, Jean Pierre ^a,b,c,d  

^a CHU PURPAN   (France)

^b INSERM   (France)

^c Arthritis and Immune Disorder Research Centre   (Canada)

^d INSTITUT CLAUDIUS REGAUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CD34 ANTIGEN; CERAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; ENZYME ACTIVATION; ENZYME INHIBITION; GENE ACTIVATION; GENE FUNCTION; GENE MUTATION; GENETIC TRANSFECTION; GENOTOXICITY; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION; SIGNAL TRANSDUCTION;

EID: 0037103184     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v100.4.1294.h81602001294_1294_1301     Document Type: Article

References (55)

1. Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells
2. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
3. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
4. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
5. Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling
6. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency
7. Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase C alpha
8. Loss of ceramide production confers resistance to radiation-induced apoptosis
9. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency
10. Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts
11. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
12. Lysosomal sphingomyelinase is not solicited for apoptosis signaling
13. Signalling sphingomyelinases: Which, where, how and why?
14. Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells
15. Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation
16. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
17. Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation
18. Radioprotection of mice by recombinant rat stem cell factor
19. Involvement of phospholipase Cgammal in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa
20. The Steel/W transduction pathway: Kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor
21. Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site
22. The c-kit receptor and its possible signaling transduction pathway in mouse spermatozoa
23. Isoforms of c-KIT differ in activation of signaling pathways and transformation of NIH3T3 fibroblasts
24. Regulation of phosphoinositide-specific phospholipase C isozymes
25. Activation of protein kinase C family members by the novel polyphosphoinositides Ptdlns-3,4-P2 and Ptdlns-3,4,5-P3
26. Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate
27. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
28. Coexpression of the c-kit and stem cell factor genes in breast carcinomas
29. Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential
30. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
31. Necrosis and apoptosis induced by oxidized low density lipoproteins occur through two calcium-dependent pathways in lymphoblastoid cells
32. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves
33. Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy
34. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
35. Protection from apoptosis by steel factor but not interleukin-3 is reversed through blockade of calcium influx
36. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: Basis for radiosensitivity of white spotting and steel mutant mice
37. Inhibition of c-kit ligand/steel factor by antibodies reduces survival of lethally irradiated mice
38. Stem cell factor enhances the survival of murine intestinal stem cells after photon irradiation
39. + hematopoietic progenitor cells
40. The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3′ kinase
41. The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2
42. Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells
43. Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
44. Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Racl and JNK activation in mast cell proliferation
45. Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways
46. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility
47. Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: Implication in drug-induced ceramide generation and apoptosis
48. Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells
49. Overexpression of phospholipase C-gamma1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 cells
50. Oxidative stress-induced phospholipase C-gamma 1 activation enhances cell survival
51. Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity
52. Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation
53. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes
54. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
55. 1-beta-D-arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells