Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HI-60 cells

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 15-16, 2007, Pages 1310-1318

  Son, Jung Hyun ^a   Yoo, Hye Hyun ^a   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CERAMIDE 1 PHOSPHATE; CYCLOSERINE; DAUNORUBICIN; FUMONISIN B1; HYDROGEN PEROXIDE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TRANSFERASE;

APOPTOSIS; CELL LEVEL; CELL STRAIN; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPOGENESIS; PRIORITY JOURNAL;

APOPTOSIS; BIOSYNTHETIC PATHWAYS; CERAMIDES; HL-60 CELLS; HUMANS; HYDROGEN PEROXIDE; REACTIVE OXYGEN SPECIES;

EID: 34547156711     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390701434364     Document Type: Conference Paper

References (39)

1. Andrieu-Abadie, N., Gouazé, V., Salvayre, R., and Levade, T. 2001. Ceramide in apoptosis signaling: relationship with oxidative stress. Free Radic. Biol. Med. 31:717-728.
2. Andrieu-Abadie, N., and Levade, T. 2002. Sphingomyelin hydrolysis during apoptosis. Biochim. Biophys. Acta. 1585:126-134.
3. Buttke, T. M., and Sandstrom, P. A. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7-10.
4. Chalfant C. E., and Spiegel S. 2005. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell Sci. 118:4605-4612.
5. Chan, C., and Goldkorn, T. 2000. Ceramide path in human lung cell death. Am. J. Respir. Cell Mol. Biol. 22:460-468.
6. Deigner, H. P., Claus, R., Bonaterra, G. A., Gehrke, C., Bibak, N., Blaess, M., Cantz, M., Metz, J., and Kinscherf, R. 2001. Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis. FASEB J. 15:807-814.
7. Dressler, K. A., and Kolesnick, R. N. 1990. Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin. J. Biol. Chem. 265:14917-14921.
8. Escargueil-Blanc, I., Andrieu-Abadie, N., Caspar-Bauguil, S., Brossmer, R., Levade, T., Nègre-Salvayre, A., and Salvayre, R. 1998. Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. J. Biol. Chem. 273:27389-27395.
9. 2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J. Cell Sci. 111:3209-3220.
10. Gomez-Muñoz, A. 2004. Ceramide-1-phosphate: a novel regulator of cell activation. FEBS Lett. 562:5-10.
11. Gomez-Muñoz A. 2006. Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim. Biophys. Acta. in press.
12. Gomez-Muñoz, A., Waggoner, D. W., O'Brien, L., and Brindley, D. N. 1995. Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J. Biol. Chem. 270:26318-26325
13. Hannun, Y. A., and Luberto, C. 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10:73-80.
14. Hannun, Y. A., and Obeid L. M. 1995. Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci. 20:73-77.
15. Harada-Shiba, M., Kinoshita, M., Kamido, H., and Shimokado, K. 1998. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. J. Biol. Chem. 273:9681-9687.
16. Huwiler, A., Pfeilschifter, J., and van den Bosch, H. 1999. Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J. Biol. Chem. 274:7190-7195.
17. Jayadev, S., Liu, B., Bielawska, A. F., Lee, J. Y., Nazaire, F., Pushkareva, M. Y., Obeid, L. M., and Hannun, Y. A. 1995. Role for ceramide in cell cycle arrest. J. Biol. Chem. 270:2047-2052.
18. Kolesnick, R. N., and Kronke, M. 1998. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60:643-665.
19. Li, W., Riley, R. T., Voss, K. A., and Norred, W. P. 2000. Role of proliferation in the toxicity of fumonisin B1: enhanced hepatotoxic response in the partially hepatectomized rat. J. Toxicol. Environ. Health. A 60:441-457.
20. Maceyka, M., Payne, S. G., Milstien, S., and Spiegel, S. 2002. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim. Biophys. Acta. 1585:193-201.
21. Nakane, M., Kubota, M., Nakagomi, T., Tamura, A., Hisaki, H., Shimasaki, H., and Ueta, N. 2000. Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus. Neurosci. Lett. 296:89-92.
22. Okazaki, T., Bell, R. M., and Hannun, Y. A. 1989. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. J. Biol. Chem. 264:19076-19080.
23. Okazaki, T., Kondo, T., Kitano, T., and Tashima, M. 1998. Diversity and complexity of ceramide signalling in apoptosis. Cell. Signal. 10:685-692.
24. Osawa, Y., Uchinami, H., Bielawski, J., Schwabe, R. F., Hannun, Y. A., and Brenner, D. A. 2005. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factoralpha. J. Biol. Chem. 280:27879-27887.
25. Pena, L. A., Fuks, Z., and Kolesnick, R. 1997. Stress-induced apoptosis and the sphingomyelin pathway. Biochem. Pharmacol. 53:615-621.
26. Perry, D. K., Carton, J., Shah, A. K., Meredith, F., Uhlinger, D. J., and Hannun, Y. A. 2000. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem. 275:9078-9084.
27. Pettus, B. J., Chalfant, C. E., and Hannun, Y. A., 2002. Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta. 1585:114-125.
28. Riboni, L., Prinetti, A., Bassi, R., Caminiti, A., and Tettamanti, G. 1995. A mediator role of ceramide in the regulation of neuroblastoma neuro2a cell differentiation. J. Biol. Chem. 270:26868-26875.
29. Shi X., Castranova V., Halliwell B., and Vallyathan V. 1998. Reactive oxygen species and silica-induced carcinogenesis. J. Toxicol. Environ. Health. B 1:181-197.
30. Sultan, I., Senkal, C. E., Ponnusamy, S., Bielawski, J., Szulc, Z., Bielawska, A., Hannun, Y. A., and Ogretmen, B. 2006. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem. J. 393:513-521.
31. Thannickal, V. J., and Fanburg, B. L. 2000. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 279:L1005-L1028.
32. Ueda, N., Kaushal, G. P., Hong, X., and Shah, S. V. 1998. Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Kidney Int. 54:399-406.
33. Venable, M. E., Lee, J. Y., Smyth, M. J., Bielawska, A., and Obeid, L. M. 1995. Role of ceramide in cellular senescence. J. Biol. Chem. 270:30701-30708.
34. Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. N. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75-79.
35. Won, J.-S., and Singh, I. 2006. Sphingolipid signaling and redox regulation. Free Radic Biol Med. 40:1875-1888.
36. Woodcock, J. 2006. Sphingosine and ceramide signaling in apoptosis. IUBMB Life. 58:462-466.
37. Yoo, H. H., Son, J., and Kim, D. H. 2006. Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 843:327-333.
38. Yoshimura, S., Banno, Y., Nakashima, S., Takenaka, K., Sakai, H., Nishimura, Y., Sakai, N., Shimizu, S., Eguchi, Y., Tsujimoto, Y., and Nozawa, Y. 1998. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J. Biol. Chem. 273:6921-6927.
39. Yu, M. U., Yoo, J. M., Lee, Y. S., Lee, Y. M., Hong, J. T., Oh, K. W., Song, S., Yun, Y. P., Yoo, H. S., and Oh, S. 2004. Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells. J. Toxicol. Environ. Health. A 67:2085-2094.