Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: Implications for dietary sphingolipids and colon carcinogenesis

Cancer Research

Volumn 56, Issue 21, 1996, Pages 4936-4941

  Schmelz, Eva M ^a   Dillehay, Dirck L ^a   Webb, Sonji K ^a   Reiter, Alex ^a   Adams, Jeanette ^a   Merrill Jr , Alfred H ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CARCINOGEN; SPHINGOLIPID; SPHINGOMYELIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER PREVENTION; COLON ADENOCARCINOMA; COLON ADENOMA; COLON CANCER; COLON CARCINOGENESIS; DIETARY INTAKE; FEMALE; GROWTH INHIBITION; INTESTINE CRYPT; MILK; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOYBEAN;

1,2-DIMETHYLHYDRAZINE; ADENOCARCINOMA; ADENOMA; ANIMALS; COLONIC NEOPLASMS; DIMETHYLHYDRAZINES; FEMALE; MICE; PRECANCEROUS CONDITIONS; SPHINGOMYELINS;

EID: 0029953485     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Vargas, P. A., and Alberts, D. S Primary prevention of colorectal cancer Cancer (Phila.), 70 1229-1235, 1992.
2. Herbsman, N, and Hornsby-Lewis, L The effects of diet on colon cancer Gastroenterology, 105: 604-605, 1993
3. Giovannucci, E., and Willett, W. C. Dietary factors and risk of colon cancer. Ann. Med, 26: 443-452, 1993.
4. Rogers, A, Zeisel, S H., and Groopman, J Diet and carcinogenesis. Carcinogenesis (Lond.), 14: 2205-2217, 1993
5. Nixon, D W. Diet and chemoprevention of colon polyps and colorectal cancer Semin Surg. Oncol, 11: 411-415, 1995.
6. Reddy, B. S. Nutritional factors and risk of colon cancer Crit. Rev. Food Sci Nutr., 35: 175-190, 1995.
7. Hannun, Y. A., and Linardic, C. M Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys. Acta. 1154: 223-236, 1993
8. Spiegel, S, and Merrill, A. H, Jr. Sphingolipid metabolism and growth regulation. FASEB J, in press, 1996
9. Zhang, H., Desai, N N, Olivera, A., Seki, T, Brooker, G, and Spiegel, S Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation J. Cell Biol., 114: 155-167, 1991
10. Stevens, V L, Nimkar, S., Jamison, W C, Liotta, D. C., and Merrill, A H., Jr. Characteristics of the growth inhibition and cytosoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells evidence for an involvement of protein kinase C Biochim Biophys Acta. 1051: 37-45, 1990.
11. Jayadev, S, Liu, B., Bielawska, A. E., Lee, J Y., Nazaire, F, Pushkareva, M Y., Obeid, L. M, and Hannun, Y A Role for ceramide in cell cycle arrest. J Biol. Chem., 270: 2047-2052, 1995.
12. Stevens, V. L., Owens, N. E, Wimon, E. F., Kinkade, J M., Jr, and Merrill, A. H. Jr Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine. Cancer Res., 50 222-226, 1990
13. Merrill, A. H., Jr., Sereni, A. M, Stevens, V. L., Hannun, Y. A., Bell, R. M., and Kinkade, J M, Jr Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem, 261: 12610-12615, 1986.
14. Hannun, Y. A., and Obeid, L. M Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci, 20: 73-77, 1995.
15. Merrill, A H., Jr., and Sweeley, C. C. Sphingolipid metabolism and cell signalling. In: D. E. Vance and J. Vance (eds.), Biochemistry of Lipids, Lipoproteins, and Membranes, Ed. 2, Vol 31, pp. 309-338, Amsterdam, the Netherlands: Elsevier Science Publishers, 1996.
16. Schmelz, E. M., Crall, K. J., Larocque, R., Dillehay, D. L., and Merrill, A. H., Jr. Uptake and metabolism of sphingolipids in isolated intestinal loops. J Nutr, 124: 702-712, 1994
17. Dillehay, D L, Webb, S. K., Schmelz, E M., and Merrill, A. H., Jr. Dietary sphinsomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J Nutr, 124: 615-620, 1994.
18. National Research Council. Guide for the Care and Use of Laboratory Animals, Publication No 88-23 (rev.). Bethesda, MD: National Institutes of Health, 1985.
19. Ann, Q., and Adams, J. Collision-induced decompositions of sphingomyelins for structural elucidation. Biol Mass Spectrom, 2: 285-294, 1993.
20. Strobel, F. H., and Adams, J How to measure the kinetic energy distribution of the precursor ion main beam in MIKES experiments. J. Am Soc. Mass Spectrom, 6: 1232-1242, 1995.
21. Rogers, A., and Nauss, K. M. Rodent models for carcinoma of the colon. Dig. Dis. Sci. 30 87S-102S, 1985.
22. Weisburger, J H., and Fiala, E. S. Experimental colon carcinogenesis and their mode of action. In H. Autrop and G. M Williams (eds.), Experimental Colon Carcinogenesis, pp. 27-50. Boca Raton, FL: CRC Press, 1982.
23. Merrill, A. H., Jr, Wang, E. Mullins, R. E., Jamison, W C L, Nimkar, S., and Liotta, D. C. Quantitation of free sphingosine in liver by high-performance liquid chromatography. Analyt Biochem, 171 373-381, 1988.
24. Bird, R. P. Observations and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett, 37: 147-151, 1987.
25. Elsayed, A M., and Shamsuddin, A. M Neoplasms of the colon. In. S F. Stinson, H. M. Schuller, and G Reynik (eds.), Atlas of Tumor Pathology of the Fisher Rat, Vol. 1, pp. 133-192 Boca Rota, FL: CRC Press, 1990.
26. Morrison, W. R. Polar lipids in bovine milk. I. Long-chain bases in sphingomyelin. Biochim. Biophys Acta, 176, 537-546, 1969
27. Hannun, Y A., Loomis, C. R., Merrill, A H., Jr., and Bell, R M. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol. Chem, 261: 12604-12609, 1986.
28. Borek, C, Ong, A., Stevens, V. L., Wang, E, and Merrill, A. H., Jr. Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. Proc. Natl Acad. Sci USA, 88: 1953-1957, 1991.
29. Borek, C., and Merrill, A. H, Jr. Sphingolipids inhibit multistage carcinogenesis and protein kinase C In: G Bronzetti, M Hayatsu, S. De Flora, M D. Waters, D. M. Shankel (eds.), Antimutagenesis and Anticarcinogenesis Mechanisms III, pp 367-371. New York. Plenum Publishing Corp., 1993.
30. Merrill, A. H, Jr, Liotta, D C., and Riley, R E Bioactive properties of sphingosine and structurally related compounds. In. R. M. Bell, J. H. Exton, and S M. Prescott, (eds.), Handbook of Lipid Research, Vol 8, pp. 205-237, New York: Plenum Publishing Corp, 1996.
31. Gupta, A. K, Fischer, G. J., Elder, J. T, Nickoloff, B. J., and Voorhees, J. J. Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin. J Invest. Dermatol. 91: 486-491, 1988.
32. Enkvetchakul, B, Merrill, A H., Jr., and Birt, D. F. Inhibition of ornithine decarboxylase activity in mouse epidermis by sphingosine sulfate. Carcinogenesis (Lond), 10 379-381, 1989.
33. Enkvetchakul, B., Barnett, T., Liotta, D C., Geisler, V., Menaldino, D, Merrill, A. H., Jr., and Birt, D F. Influences of sphingosine on two-stage skin tumorigenesis in SENCAR mice Cancer Lett., 62: 35-42, 1992.
34. Wertz, P. W., and Downing, D. T. Free sphingosines in porcine epidermis. Biochim. Biophys Acta, 1002: 213-217, 1989.
35. Endo, K, Igarashi, Y., Nisar, M., Zhou, Q, H., and Hakomori, S-I Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res., 51: 1613-1618, 1991
36. Okoshi, H., Hakomori, S-I., Nisar, M, Zhou, Q. H, Kimura, S, Tashiro, K, and Igarashi, Y Cell membrane signaling as target in cancer therapy. II Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. Cancer Res., 51, 6019-6024, 1991
37. Park, Y. S., Hakomori, S-I., Kawa, S, Ruan, F, and Igarashi, Y Liposomal N,N,N-trimethy Isphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target for cancer therapy III. Cancer Res., 54: 2213-2217, 1994.
38. McLellan, E. A. Medline, A., and Birt, R P. Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative neoplastic lesions Cancer Res, 51: 5270-5274, 1991.
39. Pretlow, T P, Barrow, B J, Ashton, W S, O'Riordan, M. A, Pretlow, T. G, Jurcisek, J. A, and Stellato, T A Aberrant crypts: putative neoplastic foci in human colonic mucosa Cancer Res., 51: 1564-1567, 1991
40. Bruce, W. R., Archer, M. C., Corpet, D E, Medline, A., Minkin, S., Stamp, D., Yin, Y., and Zhang, X. Diet, aberrant crypt foci and colorectal cancer. Mutat. Res, 290: 111-118, 1993.
41. Kristiansen, E, Thorup, I., and Meyer, O. Influence of different diets on development of DMH-induccd aberrant crypt foci and colon tumor incidence in Wistar rats. Nutr Cancer, 23: 151-159, 1995.
42. Magnuson, B. A., Carr, I, and Bird, R. P Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid. Cancer Res., 53: 4499-4504, 1993.
43. Vogelstein, B., and Kinzler, K. W. The multistep nature of cancer. Trends Genet., 9: 138-141, 1993
44. Zeisel, S H., Char, D, and Shear, N F. Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas. J. Nutr., 116: 50-58, 1986
45. Blank, M. L., Cress, E. A., Smith, Z L., and Snyder, F. Meats and fish consumed in the American diet contain substantial amounts of ether-linked phospholipids. J. Nutr., 122 1656-1661, 1992.
46. Ito, M, Kurita, T., and Kita, K. A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycosphingolipids as well as sphingomyelin to produce their lyso forms. J. Biol. Chem, 270: 24370-24374, 1995.
47. Desai, N. N, Carlson, R O., Mattie, M E, Olivera, A, Buckley, N. E, Seki, T, Brooker, G., and Spiegel, S. Signaling pathways for sphingosyl-phosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. J. Cell Biol, 121: 1385-1395, 1993.
48. Pushkareva, M., Chao, R., Bielawska, A, Merrill, A H., Jr., Crane, H M., Lagu, B, Liotta, D. C., and Hannun, Y A Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry, 34: 1885-1892, 1995.
49. Wolff, R. A, Dobrowsky, R. T, Bielawska, A, Obeid, L A., and Hannun, Y. A. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction J Biol Chem, 269: 19605-19609, 1994
50. Kolesnick, R N., and Golde, D. W The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalling Cell, 77, 325-328, 1994
51. Mattie, M, Brooker, G., and Spiegel, S Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J Biol. Chem., 269: 3181-3188, 1994.
52. Dudeja, P. K., Dahiya, R, and Brasitus, T A. The role of sphingomyelin synthase and sphingomyelinase in 1,2-dimethylhydrazine-induced lipid alterations of rat colonic plasma membranes Biochim. Biophys. Acta, 863: 309-312, 1986.
53. Wnght, S C., Zheng, H, and Zhong, J Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). FASEB J, 10: 325-332, 1996.