Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment. Implications for endothelial apoptosis

Cancer Biology and Therapy

Volumn 4, Issue 9, 2005, Pages 979-986

  Sathishkumar, Sabapathi ^a   Boyanovsky, Boris ^a   Karakashian, Alexander A ^a   Rozenova, Krassimira ^a   Giltiay, Natalia V ^a   Kudrimoti, Mahesh ^a   Mohiuddin, Mohammed ^a   Ahmed, Mansoor M ^a   Nikolova Karakashian, Mariana ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Ceramide; Endothelial cells; Grid radiation; Serum and secretory sphingomyelinase

Indexed keywords

CERAMIDE; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL DEATH; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; FRACTIONATION; GAMMA RADIATION; HUMAN; HUMAN CELL; INFORMATION PROCESSING; NICK END LABELING; RADIATION DOSE; REDUCTION;

EID: 27744607641     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.4.9.1915     Document Type: Article

References (49)

1. Camphausen K, Moses MA, Menard C, Sproull M, Beecken WD, Folkman J, et al. Radiation abscopal antitumor effect is mediated through p53. Cancer Res 2003; 63:1990-3.
2. Nagasawa H, Cremesti A, Kolesnick R, Fuks Z, Little JB. Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res 2002; 62:2531-4.
3. Albanese J, Dainiak N. Modulation of intercellular communication mediated at the cell surface and on extracellular, plasma membrane-derived vesicles by ionizing radiation. Exp Hematol 2003; 31:455-64.
4. Albanese J, Dainiak N. Ionizing radiation alters Fas antigen ligand at the cell surface and on exfoliated plasma membrane-derived vesicles: Implications for apoptosis and intercellular signaling. Radiat Res 2000; 153:49-61.
5. Komarova EA, Diatchenko L, Rokhlin OW, Hill JE, Wang ZJ, Krivokrysenko VI, et al. Stress-induced secretion of growth inhibitors: A novel tumor suppressor function of p53. Oncogene 1998; 17:1089-96.
6. Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004; 58:862-70.
7. Ohba K, Omagari K, Nakamura T, Ikuno N, Saeki S, Matsuo I, et al. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 1998; 43:575-7.
8. Uchida A, Mizutani Y, Nagamuta M, Ikenaga M. Effects of X-ray irradiation on natural killer (NK) cell system. I. Elevation of sensitivity of tumor cells and lytic function of NK cells. Immunopharmacol Immunotoxicol 1989; 11:507-19.
9. Mohiuddin M, Curtis DL, Grizos WT, Komarnicky L. Palliative treatment of advanced cancer using multiple nonconfluent pencil beam radiation. A pilot study. Cancer 1990; 66:114-8.
10. Reiff JE, Huq MS, Mohiuddin M, Suntharalingam N. Dosimetric properties of megavoltage grid therapy. Int J Radiat Oncol Biol Phys 1995; 33:937-42.
11. Mohiuddin M, Fujita M, Regine WF, Megooni AS, Ibbott GS, Ahmed MM. High-dose spatially-fractionated radiation (GRID): A new paradigm in the management of advanced cancers. Int J Radiat Oncol Biol Phys 1999; 45:721-7.
12. Sathishkumar S, Dey S, Meigooni AS, Regine WF, Kudrimoti MS, Ahmed MM, et al. The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation. Technol Cancer Res Treat 2002; 1:141-7.
13. Lin X, Fuks Z, Kolesnick R. Ceramide mediates radiation-induced death of endothelium. Crit Care Med 2000; 28:N87-93.
14. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 1994; 180:525-35.
15. Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003; 300:1155-9.
16. Reynolds CP, Maurer BJ, Kolesnick RN. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett 2004; 206:169-80.
17. Wong ML, Xie B, Beatini N, Phu P, Marathe S, Johns A, et al. Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis. Proc Natl Acad Sci USA 2000; 97:8681-6.
18. Schissel SL, Jiang X, Tweedie-Hardman J, Jeong T, Camejo EH, Najib J, et al. Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development. J Biol Chem 1998; 273:2738-46.
19. Tabas I. Secretory sphingomyelinase. Chem Phys Lipids 1999; 102:123-30.
20. Boyanovsky B, Karakashian A, King K, Giltiay N, Nikolova-Karakashian M. Uptake and metabolism of low density lipoproteins with elevated ceramide content by human microvascular endothelial cells: Implications for the regulation of apoptosis. J Biol Chem 2003; 278:26992-9.
21. Asakuma J, Sumitomo M, Asano T, Hayakawa M. Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel. Cancer Res 2003; 63:1365-70.
22. Nam SY, Amoscato AA, Lee YJ. Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. Oncogene 2002; 21:337-46.
23. Simstein R, Burow M, Parker A, Weldon C, Beckman B. Apoptosis, chemoresistance, and breast cancer: Insights from the MCF-7 cell model system. Exp Biol Med (Maywood) 2003; 228:995-1003.
24. Meigooni AS, Meli JA, Nath R. A comparison of solid phantoms with water for dosimetry of 1251 brachytherapy sources. Med Phys 1988; 15:695-701.
25. Merrill Jr AH, Wang E, Mullins RE, Jamison WC, Nimkar S, Liotta DC. Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal Biochem 1988; 171:373-81.
26. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34:1345-53.
27. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Med Sci 1959; 37:911-7.
28. Williams RD, Wang E, Merrill Jr AH. Enzymology of long-chain base synthesis by liver: Characterization of serine palmitoyltransferase in rat liver microsomes. Arch Biochem Biophys 1984; 228:282-91.
29. Nikolova-Karakashian M, Morgan ET, Alexander C, Liotta DC, Merrill Jr AH. Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11. J Biol Chem 1997; 272:18718-24.
30. Lightle S, Tosheva R, Lee A, Queen-Baker J, Boyanovsky B, Shedlofsky S, et al. Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: Role of serine-palmitoyl transferase. Arch Biochem Biophys 2003; 419:120-8.
31. Church LD, Hessler G, Goodall JE, Rider DA, Workman CJ, Vignali DAA, et al. TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing storeoperated Ca2+ influx. J Leukoc Biol 2005;jlb:1003456.
32. Kaplan EL, Meir P. Nanoparmertric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-81.
33. Horinouchi K, Erlich S, Perl DP, Ferlinz K, Bisgaier CL, Sandhoff K, et al. Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease. Nat Genet 1995; 10:288-93.
34. Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Iwama T, et al. p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Cell Death Differ 2004; 11:853-61.
35. Alphonse G, Bionda C, Aloy MT, Ardail D, Rousson R, Rodriguez-Lafrasse C. Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels. Oncogene 2004; 23:2703-15.
36. Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto M, McLoughlin M, Gallily R, et al. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med 1997; 186:1831-41.
37. Adam-Klages S, Schwandner R, Adam D, Kreder D, Bernardo K, Kronke M. Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. J Leukoc Biol 1998; 63:678-82.
38. Yatomi Y, Yamamura S, Hisano N, Nakahara K, Igarashi Y, Ozaki Y. Sphingosine 1-phosphate breakdown in platelets. J Biochem (Tokyo) 2004; 136:495-502.
39. Olivera A, Rivera J. Sphingolipids and the balancing of immune cell function: Lessons from the mast cell. J Immunol 2005; 174:1153-8.
40. Merrill Jr AH, Lingrell S, Wang E, Nikolova-Karakashian M, Vales TR, Vance DE. Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. J Biol Chem 1995; 270:13834-41.
41. Subbaiah PV, Subramanian VS, Wang K. Novel physiological function of sphingomyelin in plasma. Inhibition of lipid peroxidation in low density lipoproteins. J Biol Chem 1999; 274:36409-14.
42. Hembrough TA, Ruiz JF, Swerdlow BM, Swartz GM, Hammers HJ, Zhang L, et al. Identification and characterization of a very low density lipoprotein receptor-binding peptide from tissue factor pathway inhibitor that has antitumor and antiangiogenic activity. Blood 2004; 103:3374-80.
43. Weichselbaum RR, Hallahan D, Fuks Z, Kufe D. Radiation induction of immediate early genes: Effectors of the radiation-stress response. Int J Radiat Oncol Biol Phys 1994; 30:229-34.
44. Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, et al. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res 2003; 159:283-300.
45. Gupta S, Ahmed MM. A global perspective of radiation-induced signal transduction pathways in cancer therapeutics. Indian J Exp Biol 2004; 42:1153-76.
46. Schutze S, Wiegmann K, Machleidt T, Kronke M. TNF-induced activation of NF-kappa B. Immunobiology 1995; 193:193-203.
47. Ruvolo PP. Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol Res 2003; 47:383-92.
48. Fuss M, Thomas Jr CR. Stereotactic body radiation therapy: An ablative treatment option for primary and secondary liver tumors. Ann Surg Oncol 2004; 11:130-8.
49. Goggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schutze S, Gulbins E, Uhlig S. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 2004; 10(2):155-60.