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Volumn 13, Issue 5, 2007, Pages 210-217

Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; DAUNORUBICIN; ETOPOSIDE; FINGOLIMOD; LYASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; UNCLASSIFIED DRUG;

EID: 34247617182     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2007.03.005     Document Type: Review
Times cited : (101)

References (89)
  • 1
    • 32044448106 scopus 로고    scopus 로고
    • Emerging medicinal roles for lysophospholipid signaling
    • Gardell S.E., et al. Emerging medicinal roles for lysophospholipid signaling. Trends Mol. Med. 12 (2006) 65-75
    • (2006) Trends Mol. Med. , vol.12 , pp. 65-75
    • Gardell, S.E.1
  • 2
    • 16444380534 scopus 로고    scopus 로고
    • Mechanisms of cardioprotection by lysophospholipids
    • Karliner J.S. Mechanisms of cardioprotection by lysophospholipids. J. Cell. Biochem. 92 (2004) 1095-1103
    • (2004) J. Cell. Biochem. , vol.92 , pp. 1095-1103
    • Karliner, J.S.1
  • 3
    • 33644832772 scopus 로고    scopus 로고
    • Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics
    • Milstien S., and Spiegel S. Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. Cancer Cell 9 (2006) 148-150
    • (2006) Cancer Cell , vol.9 , pp. 148-150
    • Milstien, S.1    Spiegel, S.2
  • 4
    • 5644287793 scopus 로고    scopus 로고
    • In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights
    • McVerry B.J., and Garcia J. In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell. Signal. 17 (2005) 131-139
    • (2005) Cell. Signal. , vol.17 , pp. 131-139
    • McVerry, B.J.1    Garcia, J.2
  • 5
    • 3242656984 scopus 로고    scopus 로고
    • Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate
    • Oskouian B., and Saba J.D. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. Semin. Cell Dev. Biol. 15 (2004) 529-540
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 529-540
    • Oskouian, B.1    Saba, J.D.2
  • 6
    • 12544253058 scopus 로고    scopus 로고
    • Structural and functional characteristics of S1P receptors
    • Sanchez T., and Hla T. Structural and functional characteristics of S1P receptors. J. Cell. Biochem. 92 (2004) 913-922
    • (2004) J. Cell. Biochem. , vol.92 , pp. 913-922
    • Sanchez, T.1    Hla, T.2
  • 7
    • 23644456866 scopus 로고    scopus 로고
    • Chemical approaches to the lysophospholipid receptors
    • Rosen H. Chemical approaches to the lysophospholipid receptors. Prostaglandins Other Lipid Mediat. 77 (2005) 179-184
    • (2005) Prostaglandins Other Lipid Mediat. , vol.77 , pp. 179-184
    • Rosen, H.1
  • 8
    • 3142744111 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis
    • Kono M., et al. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J. Biol. Chem. 279 (2004) 29367-29373
    • (2004) J. Biol. Chem. , vol.279 , pp. 29367-29373
    • Kono, M.1
  • 9
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • Cyster J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23 (2005) 127-159
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 10
    • 33645278951 scopus 로고    scopus 로고
    • Sphingosine kinase: biochemical and cellular regulation and role in disease
    • Taha T.A., et al. Sphingosine kinase: biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol. 39 (2006) 113-131
    • (2006) J. Biochem. Mol. Biol. , vol.39 , pp. 113-131
    • Taha, T.A.1
  • 11
    • 14844284989 scopus 로고    scopus 로고
    • Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer
    • Brindley D.N. Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J. Cell. Biochem. 92 (2004) 900-912
    • (2004) J. Cell. Biochem. , vol.92 , pp. 900-912
    • Brindley, D.N.1
  • 12
    • 3242691277 scopus 로고    scopus 로고
    • Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases
    • Pyne S., et al. Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. Semin. Cell Dev. Biol. 15 (2004) 491-501
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 491-501
    • Pyne, S.1
  • 13
    • 33745442062 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide
    • Giussani P., et al. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol. Cell. Biol. 26 (2006) 5055-5069
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 5055-5069
    • Giussani, P.1
  • 14
    • 33847055467 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses
    • Mechtcheriakova D., et al. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell. Signal. 19 (2006) 748-760
    • (2006) Cell. Signal. , vol.19 , pp. 748-760
    • Mechtcheriakova, D.1
  • 15
    • 0032692148 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase
    • Merrill Jr. A.H., and Hannun Y.A. (Eds), Academic Press
    • Van Veldhoven P.P. Sphingosine-1-phosphate lyase. In: Merrill Jr. A.H., and Hannun Y.A. (Eds). Sphingolipid Metabolism and Cell Signaling Part A (2000), Academic Press 244-254
    • (2000) Sphingolipid Metabolism and Cell Signaling Part A , pp. 244-254
    • Van Veldhoven, P.P.1
  • 16
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition an disruption of S1P gradients
    • Schwab S.R., et al. Lymphocyte sequestration through S1P lyase inhibition an disruption of S1P gradients. Science 309 (2005) 1735-1739
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1
  • 17
    • 33751225686 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer
    • Oskouian B., et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 17384-17389
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 17384-17389
    • Oskouian, B.1
  • 18
    • 33847209549 scopus 로고    scopus 로고
    • Zhang, K. et al. (2007) Redirection of sphingolipid metabolism towards de novo synthesis of ethanolamine in Leishmania EMBO J. 26, 1094-1104
  • 19
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • Ogretmen B., and Hannun Y.A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. Cancer 4 (2004) 604-616
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 20
    • 26644434393 scopus 로고    scopus 로고
    • The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity
    • Bandhuvula P., et al. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J. Biol. Chem. 280 (2005) 33697-33700
    • (2005) J. Biol. Chem. , vol.280 , pp. 33697-33700
    • Bandhuvula, P.1
  • 21
    • 9444251152 scopus 로고    scopus 로고
    • Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]o ctanamide (GT11) in primary cultured cerebellar neurons
    • Triola G., et al. Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]o ctanamide (GT11) in primary cultured cerebellar neurons. Mol. Pharmacol. 66 (2004) 1671-1678
    • (2004) Mol. Pharmacol. , vol.66 , pp. 1671-1678
    • Triola, G.1
  • 22
    • 33947122667 scopus 로고    scopus 로고
    • Identification and characterization of a human ethanolaminephosphotransferase1 (hEPT1)
    • Horibata Y., and Hirabayashi Y. Identification and characterization of a human ethanolaminephosphotransferase1 (hEPT1). J. Lipid Res. 48 (2006) 503-508
    • (2006) J. Lipid Res. , vol.48 , pp. 503-508
    • Horibata, Y.1    Hirabayashi, Y.2
  • 23
    • 0037012907 scopus 로고    scopus 로고
    • Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila
    • Dobrosotskaya I.Y., et al. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science 296 (2002) 879-883
    • (2002) Science , vol.296 , pp. 879-883
    • Dobrosotskaya, I.Y.1
  • 24
    • 0030671394 scopus 로고    scopus 로고
    • The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase
    • Saba J.D., et al. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J. Biol. Chem. 272 (1997) 26087-26090
    • (1997) J. Biol. Chem. , vol.272 , pp. 26087-26090
    • Saba, J.D.1
  • 25
    • 0032567648 scopus 로고    scopus 로고
    • Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast
    • Zhou J., and Saba J. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem. Biophys. Res. Commun. 242 (1998) 502-507
    • (1998) Biochem. Biophys. Res. Commun. , vol.242 , pp. 502-507
    • Zhou, J.1    Saba, J.2
  • 26
    • 0034721549 scopus 로고    scopus 로고
    • Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22
    • Van Veldhoven P.P., et al. Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22. Biochim. Biophys. Acta 1487 (2000) 128-134
    • (2000) Biochim. Biophys. Acta , vol.1487 , pp. 128-134
    • Van Veldhoven, P.P.1
  • 27
    • 0037494996 scopus 로고    scopus 로고
    • Sply regulation of sphingolipid signaling molecules is essential for Drosophila development
    • Herr D.R., et al. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. Development 130 (2003) 2443-2453
    • (2003) Development , vol.130 , pp. 2443-2453
    • Herr, D.R.1
  • 28
    • 0037591003 scopus 로고    scopus 로고
    • Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans
    • Mendel J., et al. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J. Biol. Chem. 278 (2003) 22341-22349
    • (2003) J. Biol. Chem. , vol.278 , pp. 22341-22349
    • Mendel, J.1
  • 29
    • 0034786769 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
    • Li G., et al. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. Development 128 (2001) 3473-3483
    • (2001) Development , vol.128 , pp. 3473-3483
    • Li, G.1
  • 30
    • 0014586151 scopus 로고
    • Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase)
    • Stoffel W., et al. Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase). Hoppe Seylers Z. Physiol. Chem. 350 (1969) 1233-1241
    • (1969) Hoppe Seylers Z. Physiol. Chem. , vol.350 , pp. 1233-1241
    • Stoffel, W.1
  • 31
    • 0025743953 scopus 로고
    • Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver
    • Van Veldhoven P.P., and Mannaerts G.P. Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. J. Biol. Chem. 266 (1991) 12502-12507
    • (1991) J. Biol. Chem. , vol.266 , pp. 12502-12507
    • Van Veldhoven, P.P.1    Mannaerts, G.P.2
  • 32
    • 0346463027 scopus 로고    scopus 로고
    • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis
    • Reiss U., et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J. Biol. Chem. 279 (2004) 1281-1290
    • (2004) J. Biol. Chem. , vol.279 , pp. 1281-1290
    • Reiss, U.1
  • 33
    • 7444239039 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol
    • Ikeda M., et al. Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol. Biochem. Biophys. Res. Commun. 325 (2004) 338-343
    • (2004) Biochem. Biophys. Res. Commun. , vol.325 , pp. 338-343
    • Ikeda, M.1
  • 34
    • 33749185077 scopus 로고    scopus 로고
    • Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
    • Kohno M., et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell. Biol. 26 (2006) 7211-7223
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 7211-7223
    • Kohno, M.1
  • 35
    • 1842430830 scopus 로고    scopus 로고
    • Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system
    • Genter M.B., et al. Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system. Physiol. Genomics 16 (2003) 67-81
    • (2003) Physiol. Genomics , vol.16 , pp. 67-81
    • Genter, M.B.1
  • 36
    • 0031040704 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid
    • Yatomi Y., et al. Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. J. Biol. Chem. 272 (1997) 5291-5297
    • (1997) J. Biol. Chem. , vol.272 , pp. 5291-5297
    • Yatomi, Y.1
  • 37
    • 33646802252 scopus 로고    scopus 로고
    • Molecular biology of the nasal airways: how do we assess cellular and molecular responses in the nose?
    • Genter M.B. Molecular biology of the nasal airways: how do we assess cellular and molecular responses in the nose?. Toxicol. Pathol. 34 (2006) 274-280
    • (2006) Toxicol. Pathol. , vol.34 , pp. 274-280
    • Genter, M.B.1
  • 38
    • 0032976314 scopus 로고    scopus 로고
    • Sphingolipids in food and the emerging importance of sphingolipids to nutrition
    • Vesper H., et al. Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 129 (1999) 1239-1250
    • (1999) J. Nutr. , vol.129 , pp. 1239-1250
    • Vesper, H.1
  • 39
    • 20344379481 scopus 로고    scopus 로고
    • Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion
    • Cliffe L.J., et al. Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science 308 (2005) 1463-1465
    • (2005) Science , vol.308 , pp. 1463-1465
    • Cliffe, L.J.1
  • 40
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: two sides of a coin
    • Radtke F., and Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science 307 (2005) 1904-1909
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 41
    • 3242664708 scopus 로고    scopus 로고
    • Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila
    • Renault A.D., et al. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Mech. Dev. 119 Suppl. 1 (2002) S293-S301
    • (2002) Mech. Dev. , vol.119 , Issue.SUPPL. 1
    • Renault, A.D.1
  • 42
    • 0037853139 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm
    • Kihara A., et al. Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. J. Biol. Chem. 278 (2003) 14578-14585
    • (2003) J. Biol. Chem. , vol.278 , pp. 14578-14585
    • Kihara, A.1
  • 43
    • 0036608026 scopus 로고    scopus 로고
    • Making worm guts: the gene regulatory network of the Caenorhabditis elegans endoderm
    • Maduro M.F., and Rothman J.H. Making worm guts: the gene regulatory network of the Caenorhabditis elegans endoderm. Dev. Biol. 246 (2002) 68-85
    • (2002) Dev. Biol. , vol.246 , pp. 68-85
    • Maduro, M.F.1    Rothman, J.H.2
  • 44
    • 0034671733 scopus 로고    scopus 로고
    • The zinc finger-containing transcription factors GATA-4, -5, and -6
    • Molkentin J.D. The zinc finger-containing transcription factors GATA-4, -5, and -6. J. Biol. Chem. 275 (2000) 38949-38952
    • (2000) J. Biol. Chem. , vol.275 , pp. 38949-38952
    • Molkentin, J.D.1
  • 45
    • 24044478417 scopus 로고    scopus 로고
    • Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors
    • Oskouian B., et al. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. J. Biol. Chem. 280 (2005) 18403-18410
    • (2005) J. Biol. Chem. , vol.280 , pp. 18403-18410
    • Oskouian, B.1
  • 46
    • 1442336006 scopus 로고    scopus 로고
    • Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis
    • Chen W.V., et al. Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis. Nat. Genet. 36 (2004) 304-312
    • (2004) Nat. Genet. , vol.36 , pp. 304-312
    • Chen, W.V.1
  • 47
    • 33748175142 scopus 로고    scopus 로고
    • Biology of platelet-derived growth factor and its involvement in disease
    • Alvarez R.H., et al. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin. Proc. 81 (2006) 1241-1257
    • (2006) Mayo Clin. Proc. , vol.81 , pp. 1241-1257
    • Alvarez, R.H.1
  • 48
    • 33845894956 scopus 로고    scopus 로고
    • PDGF signaling specificity is mediated through multiple immediate early genes
    • Schmahl J., et al. PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 39 (2006) 52-60
    • (2006) Nat. Genet. , vol.39 , pp. 52-60
    • Schmahl, J.1
  • 49
    • 0027371722 scopus 로고
    • Sphingosine 1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
    • Olivera A., and Spiegel S. Sphingosine 1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365 (1993) 557-559
    • (1993) Nature , vol.365 , pp. 557-559
    • Olivera, A.1    Spiegel, S.2
  • 50
    • 0035793866 scopus 로고    scopus 로고
    • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
    • Hobson J.P., et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 291 (2001) 1800-1803
    • (2001) Science , vol.291 , pp. 1800-1803
    • Hobson, J.P.1
  • 51
    • 9444285520 scopus 로고    scopus 로고
    • Microarray and comparative genomic-based identification of genes and gene regulatory regions of the mouse immune system
    • Hutton J.J., et al. Microarray and comparative genomic-based identification of genes and gene regulatory regions of the mouse immune system. BMC Genomics 5 (2004) 82
    • (2004) BMC Genomics , vol.5 , pp. 82
    • Hutton, J.J.1
  • 52
    • 22344454807 scopus 로고    scopus 로고
    • mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival
    • Dannenberg J.H., et al. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev. 19 (2005) 1581-1595
    • (2005) Genes Dev. , vol.19 , pp. 1581-1595
    • Dannenberg, J.H.1
  • 53
    • 33745218278 scopus 로고    scopus 로고
    • Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry
    • Zhan X., and Desiderio D.M. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. Anal. Biochem. 354 (2006) 279-289
    • (2006) Anal. Biochem. , vol.354 , pp. 279-289
    • Zhan, X.1    Desiderio, D.M.2
  • 54
    • 23144434356 scopus 로고    scopus 로고
    • KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
    • Huang H., et al. KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites. Nucleic Acids Res. 33 (2005) W226-W229
    • (2005) Nucleic Acids Res. , vol.33
    • Huang, H.1
  • 55
    • 20944435137 scopus 로고    scopus 로고
    • Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis
    • Kariya Y., et al. Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. Genes Cells 10 (2005) 605-615
    • (2005) Genes Cells , vol.10 , pp. 605-615
    • Kariya, Y.1
  • 56
    • 33746297675 scopus 로고    scopus 로고
    • Ethanolamine modulates DNA synthesis through epidermal growth factor receptor in rat primary hepatocytes
    • Kume H., and Sasaki H. Ethanolamine modulates DNA synthesis through epidermal growth factor receptor in rat primary hepatocytes. In Vitro Cell. Dev. Biol. Anim. 42 (2006) 20-26
    • (2006) In Vitro Cell. Dev. Biol. Anim. , vol.42 , pp. 20-26
    • Kume, H.1    Sasaki, H.2
  • 57
    • 0034333407 scopus 로고    scopus 로고
    • Promitogenic effects of ethanol, methanol, and ethanolamine in insulin-treated fibroblasts
    • Crilly K.S., et al. Promitogenic effects of ethanol, methanol, and ethanolamine in insulin-treated fibroblasts. Biochem. Pharmacol. 60 (2000) 1391-1398
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1391-1398
    • Crilly, K.S.1
  • 58
    • 0033783522 scopus 로고    scopus 로고
    • Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    • Liu Y., et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106 (2000) 951-961
    • (2000) J. Clin. Invest. , vol.106 , pp. 951-961
    • Liu, Y.1
  • 59
    • 0030986587 scopus 로고    scopus 로고
    • Del(10)(q22.3q24. 1) associated with juvenile polyposis
    • Jacoby R., et al. Del(10)(q22.3q24. 1) associated with juvenile polyposis. Am. J. Med. Genet. 70 (1997) 361-364
    • (1997) Am. J. Med. Genet. , vol.70 , pp. 361-364
    • Jacoby, R.1
  • 60
    • 0033828148 scopus 로고    scopus 로고
    • Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium
    • Li G., et al. Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium. Microbiology 146 (2000) 2219-2227
    • (2000) Microbiology , vol.146 , pp. 2219-2227
    • Li, G.1
  • 61
    • 2942666365 scopus 로고    scopus 로고
    • Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs
    • Min J., et al. Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. Eukaryot. Cell 3 (2004) 795-805
    • (2004) Eukaryot. Cell , vol.3 , pp. 795-805
    • Min, J.1
  • 62
    • 18544390682 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner
    • Min J., et al. Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol. Cancer Res. 3 (2005) 287-296
    • (2005) Mol. Cancer Res. , vol.3 , pp. 287-296
    • Min, J.1
  • 63
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • Visentin B., et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9 (2006) 225-238
    • (2006) Cancer Cell , vol.9 , pp. 225-238
    • Visentin, B.1
  • 64
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy S., et al. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33 (2003) 49-54
    • (2003) Nat. Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1
  • 65
    • 3242813597 scopus 로고    scopus 로고
    • Differential gene expression in ovarian carcinoma: identification of potential biomarkers
    • Hibbs K., et al. Differential gene expression in ovarian carcinoma: identification of potential biomarkers. Am. J. Pathol. 165 (2004) 397-414
    • (2004) Am. J. Pathol. , vol.165 , pp. 397-414
    • Hibbs, K.1
  • 66
    • 0032746381 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells
    • Hong G., et al. Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells. FEBS Lett. 460 (1999) 513-518
    • (1999) FEBS Lett. , vol.460 , pp. 513-518
    • Hong, G.1
  • 67
    • 0035793032 scopus 로고    scopus 로고
    • The role and clinical applications of bioactive lysolipids in ovarian cancer
    • Xu Y., et al. The role and clinical applications of bioactive lysolipids in ovarian cancer. J. Soc. Gynecol. Investig. 8 (2001) 1-13
    • (2001) J. Soc. Gynecol. Investig. , vol.8 , pp. 1-13
    • Xu, Y.1
  • 68
    • 0036732415 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
    • Paris F., et al. Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat. Med. 8 (2002) 901-902
    • (2002) Nat. Med. , vol.8 , pp. 901-902
    • Paris, F.1
  • 69
    • 0034102433 scopus 로고    scopus 로고
    • Sphingolipid regulation of female gonadal cell apoptosis
    • Morita Y., and Tilly J.L. Sphingolipid regulation of female gonadal cell apoptosis. Ann. N. Y. Acad. Sci. 905 (2000) 209-220
    • (2000) Ann. N. Y. Acad. Sci. , vol.905 , pp. 209-220
    • Morita, Y.1    Tilly, J.L.2
  • 70
    • 0032869319 scopus 로고    scopus 로고
    • Sphingolipid signaling in gonadal development and function
    • Tilly J.L., and Kolesnick R.N. Sphingolipid signaling in gonadal development and function. Chem. Phys. Lipids 102 (1999) 149-155
    • (1999) Chem. Phys. Lipids , vol.102 , pp. 149-155
    • Tilly, J.L.1    Kolesnick, R.N.2
  • 71
    • 0037203319 scopus 로고    scopus 로고
    • Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility
    • Tilly J.L., and Kolesnick R. Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility. Biochim. Biophys. Acta 1585 (2002) 135-138
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 135-138
    • Tilly, J.L.1    Kolesnick, R.2
  • 72
    • 0037162025 scopus 로고    scopus 로고
    • Lysophospholipids and their G protein-coupled receptors in inflammation and immunity
    • Graler M.H., and Goetzl E.J. Lysophospholipids and their G protein-coupled receptors in inflammation and immunity. Biochim. Biophys. Acta 1582 (2002) 168-174
    • (2002) Biochim. Biophys. Acta , vol.1582 , pp. 168-174
    • Graler, M.H.1    Goetzl, E.J.2
  • 73
    • 23044459004 scopus 로고    scopus 로고
    • The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate
    • Pettus B.J., et al. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol. Pharmacol. 68 (2005) 330-335
    • (2005) Mol. Pharmacol. , vol.68 , pp. 330-335
    • Pettus, B.J.1
  • 74
    • 0032525049 scopus 로고    scopus 로고
    • FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats
    • Chiba K., et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. J. Immunol. 160 (1998) 5037-5044
    • (1998) J. Immunol. , vol.160 , pp. 5037-5044
    • Chiba, K.1
  • 75
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • Brinkmann V., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277 (2002) 21453-21457
    • (2002) J. Biol. Chem. , vol.277 , pp. 21453-21457
    • Brinkmann, V.1
  • 76
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • Mandala S., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 (2002) 346-349
    • (2002) Science , vol.296 , pp. 346-349
    • Mandala, S.1
  • 77
    • 3242683494 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
    • Webb M., et al. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J. Neuroimmunol. 153 (2004) 108-121
    • (2004) J. Neuroimmunol. , vol.153 , pp. 108-121
    • Webb, M.1
  • 78
    • 20144388413 scopus 로고    scopus 로고
    • Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate
    • Chiba K., et al. Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate. Transplant. Proc. 37 (2005) 102-106
    • (2005) Transplant. Proc. , vol.37 , pp. 102-106
    • Chiba, K.1
  • 79
    • 0344443651 scopus 로고    scopus 로고
    • Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    • Sanchez T., et al. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J. Biol. Chem. 278 (2003) 47281-47290
    • (2003) J. Biol. Chem. , vol.278 , pp. 47281-47290
    • Sanchez, T.1
  • 80
    • 2442679391 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors
    • Graler M.H., and Goetzl E.J. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors. FASEB J. 18 (2004) 551-553
    • (2004) FASEB J. , vol.18 , pp. 551-553
    • Graler, M.H.1    Goetzl, E.J.2
  • 81
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004) 355-360
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1
  • 82
    • 14044258490 scopus 로고    scopus 로고
    • Regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1
    • Chi H., and Flavell R. Regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. J. Immunol. 174 (2005) 2485-2488
    • (2005) J. Immunol. , vol.174 , pp. 2485-2488
    • Chi, H.1    Flavell, R.2
  • 83
    • 30044452394 scopus 로고    scopus 로고
    • Signals for lymphocyte egress
    • Ley K., and Morris M. Signals for lymphocyte egress. Nat. Immunol. 6 (2005) 1215-1216
    • (2005) Nat. Immunol. , vol.6 , pp. 1215-1216
    • Ley, K.1    Morris, M.2
  • 84
    • 0034120178 scopus 로고    scopus 로고
    • FTY720 immunosuppression impairs effector T-cell peripheral homing without affecting induction, expansion and memory
    • Pinschewer D.D., et al. FTY720 immunosuppression impairs effector T-cell peripheral homing without affecting induction, expansion and memory. J. Immunol. 164 (2000) 5761-5770
    • (2000) J. Immunol. , vol.164 , pp. 5761-5770
    • Pinschewer, D.D.1
  • 85
    • 33744929865 scopus 로고    scopus 로고
    • Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes
    • Zhi L., et al. Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes. J. Cell. Physiol. 208 (2006) 109-115
    • (2006) J. Cell. Physiol. , vol.208 , pp. 109-115
    • Zhi, L.1
  • 86
    • 0041703016 scopus 로고    scopus 로고
    • The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α
    • Pettus B.J., et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α. FASEB J. 17 (2003) 1411-1421
    • (2003) FASEB J. , vol.17 , pp. 1411-1421
    • Pettus, B.J.1
  • 87
    • 33746926779 scopus 로고    scopus 로고
    • Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice
    • Michaud J., et al. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett. 580 (2006) 4607-4612
    • (2006) FEBS Lett. , vol.580 , pp. 4607-4612
    • Michaud, J.1
  • 88
    • 33646124980 scopus 로고    scopus 로고
    • Identification of the target genes of atopic dermatitis by real-time PCR
    • Seo E.Y., et al. Identification of the target genes of atopic dermatitis by real-time PCR. J. Invest. Dermatol. 126 (2006) 1187-1189
    • (2006) J. Invest. Dermatol. , vol.126 , pp. 1187-1189
    • Seo, E.Y.1
  • 89
    • 33749049791 scopus 로고    scopus 로고
    • Epidermal sphingolipids: metabolism, function, and roles in skin disorders
    • Holleran W.M., et al. Epidermal sphingolipids: metabolism, function, and roles in skin disorders. FEBS Lett. 580 (2006) 5456-5466
    • (2006) FEBS Lett. , vol.580 , pp. 5456-5466
    • Holleran, W.M.1


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