메뉴 건너뛰기




Volumn 10, Issue 12, 1996, Pages 1388-1397

Sphingolipid metabolism and cell growth regulation

Author keywords

cell growth death; fumonisins; signal transduction; sphingosine; sphingosine 1 phosphate

Indexed keywords

CALCIUM; CERAMIDE; CYCLIC AMP; CYTOKINE; DNA; GROWTH FACTOR; INOSITOL TRISPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDIC ACID; PROTEIN KINASE; PROTEIN KINASE C; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE DERIVATIVE; TRANSCRIPTION FACTOR AP 1;

EID: 0029862561     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.12.8903509     Document Type: Review
Times cited : (670)

References (130)
  • 1
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich, A., and Schlessinger, J. (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 2
    • 0027397544 scopus 로고
    • Inositol trisphosphates and calcium signalling
    • Berridge, M. J. (1993) Inositol trisphosphates and calcium signalling. Nature (London) 361,315-325
    • (1993) Nature (London) , vol.361 , pp. 315-325
    • Berridge, M.J.1
  • 3
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258,607-614
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 4
    • 0025077629 scopus 로고
    • Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions
    • Hakomori, S.-I. (1991) Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions. J. Biol. Chem. 265,18713-18716.
    • (1991) J. Biol. Chem. , vol.265 , pp. 18713-18716
    • Hakomori, S.-I.1
  • 6
    • 0027994349 scopus 로고
    • The sphingomyelin cycle and the second messenger function of ceramide
    • Hannun, Y. A. (1994) The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 69,3125-3128
    • (1994) J. Biol. Chem. , vol.69 , pp. 3125-3128
    • Hannun, Y.A.1
  • 7
    • 0028297068 scopus 로고
    • The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
    • Kolesnick, R., and Golde, D. W. ( 1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328
    • (1994) Cell , vol.77 , pp. 325-328
    • Kolesnick, R.1    Golde, D.W.2
  • 8
    • 0028333052 scopus 로고
    • Tumor necrosis factor receptor-mediated signaling pathways
    • Heller, R. A., and Krönke, M. (1994) Tumor necrosis factor receptor-mediated signaling pathways. J. Cell Biol. 26, 5-9
    • (1994) J. Cell Biol. , vol.26 , pp. 5-9
    • Heller, R.A.1    Krönke, M.2
  • 9
    • 0000411422 scopus 로고
    • Bioactive properties of sphingosine and structurally related compounds
    • Bell, R. M., ed
    • Merrill, A. H., Jr., Liotta, D. C., and Riley, R. E. (1995) Bioactive properties of sphingosine and structurally related compounds In Handbook of Lipid Research (Bell, R. M., ed) 8,205-237
    • (1995) Handbook of Lipid Research , vol.8 , pp. 205-237
    • Merrill Jr., A.H.1    Liotta, D.C.2    Riley, R.E.3
  • 10
    • 0027434784 scopus 로고
    • The role of sphingosine in cell growth regulation and transmembrane signaling
    • Spiegel, S., Olivera, A., and Carlson, R. O. (1993) The role of sphingosine in cell growth regulation and transmembrane signaling. Adv. Lipid. Res, 5, 105-129
    • (1993) Adv. Lipid. Res , vol.5 , pp. 105-129
    • Spiegel, S.1    Olivera, A.2    Carlson, R.O.3
  • 11
    • 0027991078 scopus 로고
    • Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway
    • Mattie, M., Brooker, G., and Spiegel, S. (1994) Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J Biol. Chem. 69, 3181-3188
    • (1994) J Biol. Chem. , vol.69 , pp. 3181-3188
    • Mattie, M.1    Brooker, G.2    Spiegel, S.3
  • 12
    • 0028128763 scopus 로고
    • Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
    • Chosh, T. K., Bian, J., and Gill, D. L. (1994) Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J. Biol. Chem. 269,22628-22635
    • (1994) J. Biol. Chem. , vol.269 , pp. 22628-22635
    • Chosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 14
    • 0025253532 scopus 로고
    • A specific enhancing effect of N,N-dimethyl-sphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubslituted sphingosine) in human epidermoid carcinoma A431 cells
    • Igarashi, Y., Kilamura, K., Toyokuni, T., Dean, B., Fenderson, B., Ogawass, T., and Hakomori, S. (1990) A specific enhancing effect of N,N-dimethyl-sphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubslituted sphingosine) in human epidermoid carcinoma A431 cells. J. Biol Chem. 65,5385-5389
    • (1990) J. Biol Chem. , vol.65 , pp. 5385-5389
    • Igarashi, Y.1    Kilamura, K.2    Toyokuni, T.3    Dean, B.4    Fenderson, B.5    Ogawass, T.6    Hakomori, S.7
  • 15
    • 0027074149 scopus 로고
    • Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturaled by cultured cells
    • Rother, J., van Echten, G., Schwarzmann, G., and Sandhoff, K. (1992) Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturaled by cultured cells. Biochem. Biophys. Res. Commun. 89, 14-20
    • (1992) Biochem. Biophys. Res. Commun. , vol.89 , pp. 14-20
    • Rother, J.1    Van Echten, G.2    Schwarzmann, G.3    Sandhoff, K.4
  • 16
    • 0029098277 scopus 로고
    • Differential roles of de now sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivalives, that occurs upon changing the medium of cells in culture
    • Smith, E. R., and Merrill, A. H., Jr. (1995) Differential roles of de now sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivalives, that occurs upon changing the medium of cells in culture. J. Biol. Chem. 270, 18749-18758
    • (1995) J. Biol. Chem. , vol.270 , pp. 18749-18758
    • Smith, E.R.1    Merrill Jr., A.H.2
  • 17
    • 0027346611 scopus 로고
    • Ganglioside metabolism - Topology and regulation
    • Sandhoff, K., and van Echten, G. (1993) Ganglioside metabolism - Topology and regulation. Adv. Lipid Res. 26, 119-142
    • (1993) Adv. Lipid Res. , vol.26 , pp. 119-142
    • Sandhoff, K.1    Van Echten, G.2
  • 18
    • 0025323167 scopus 로고
    • Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus
    • Futerman, A. H., Stieger, B., Hubbard, A. L., and Pagano, R. E. (1990) Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. J. Biol. Chem. 65,8650-8657
    • (1990) J. Biol. Chem. , vol.65 , pp. 8650-8657
    • Futerman, A.H.1    Stieger, B.2    Hubbard, A.L.3    Pagano, R.E.4
  • 19
    • 0027353039 scopus 로고
    • Sphingomyelinases
    • Spence, M. W. (1993) Sphingomyelinases. Adv. Lipid Res. 26, 3-23
    • (1993) Adv. Lipid Res. , vol.26 , pp. 3-23
    • Spence, M.W.1
  • 20
    • 0028987552 scopus 로고
    • Neutral sphingomyelinase: Localization in rat liver nuclei and involvement in regeneration/proliferation
    • Alessenko, A., and Chatterjee, S. (1995) Neutral sphingomyelinase: Localization in rat liver nuclei and involvement in regeneration/proliferation. Mol. Cell. Biochem. 143, 169-174
    • (1995) Mol. Cell. Biochem. , vol.143 , pp. 169-174
    • Alessenko, A.1    Chatterjee, S.2
  • 21
    • 0027346613 scopus 로고
    • Ceramidases: Enzymology and metabolic roles
    • Hassler, D. G., and Bell, R. M. (1993) Ceramidases: Enzymology and metabolic roles. Adv. Lipid Res. 26,49-57.
    • (1993) Adv. Lipid Res. , vol.26 , pp. 49-57
    • Hassler, D.G.1    Bell, R.M.2
  • 22
    • 0027355756 scopus 로고
    • Sphingosine kinase: Properties and cellular functions
    • Buehrer, B. M., and Bell, R. M. (1993) Sphingosine kinase: properties and cellular functions, Adv. Lipid. Res. 6, 59-67
    • (1993) Adv. Lipid. Res. , vol.6 , pp. 59-67
    • Buehrer, B.M.1    Bell, R.M.2
  • 23
    • 0028198427 scopus 로고
    • Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: Evidence for the existence of a sphingosine phosphatase
    • Van Veldhoven, P. P., and Mannaerts, G. P. (1994) Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: Evidence for the existence of a sphingosine phosphatase. Biochem. J. 299, 597-601
    • (1994) Biochem. J. , vol.299 , pp. 597-601
    • Van Veldhoven, P.P.1    Mannaerts, G.P.2
  • 25
    • 0025021423 scopus 로고
    • Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway
    • Zhang, H., Buckley, N. E., Gibson, K., and Spiegel, S. (1990) Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. ;. Biol. Chem. 65, 76-81
    • (1990) Biol. Chem. , vol.65 , pp. 76-81
    • Zhang, H.1    Buckley, N.E.2    Gibson, K.3    Spiegel, S.4
  • 26
    • 0027669148 scopus 로고
    • Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells
    • Jacobs, L. S., and Kester, M. (1993) Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells. Am. J. Physiol. 65, c740-c747
    • (1993) Am. J. Physiol. , vol.65
    • Jacobs, L.S.1    Kester, M.2
  • 27
    • 0025019387 scopus 로고
    • Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: Evidence for an involvement of protein kinase C
    • Stevens, V. L., Nimkar, S., Jamison, W. C., Liolta, D. C., and Merrill, A. H., Jr. (1990) Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. Biochim. Biophys. Acta 1051,37-45
    • (1990) Biochim. Biophys. Acta , vol.1051 , pp. 37-45
    • Stevens, V.L.1    Nimkar, S.2    Jamison, W.C.3    Liolta, D.C.4    Merrill Jr., A.H.5
  • 28
    • 0028339322 scopus 로고
    • Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts
    • Gómez-Munoz, A., Martin, A., O'Brien, L, and Brindley, D. N. (1994) Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J. Biol. Chem. 69, 8937-8943
    • (1994) J. Biol. Chem. , vol.69 , pp. 8937-8943
    • Gómez-Munoz, A.1    Martin, A.2    O'Brien, L.3    Brindley, D.N.4
  • 29
    • 0028234366 scopus 로고
    • Slereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation
    • Olivera, A., Zhang, H., Carlson, R. O., Maltie, M. E., Schmidt, R. R., and Spiegel, S. (1994) Slereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation. J. Biol. Chem. 89, 17924-17930
    • (1994) J. Biol. Chem. , vol.89 , pp. 17924-17930
    • Olivera, A.1    Zhang, H.2    Carlson, R.O.3    Maltie, M.E.4    Schmidt, R.R.5    Spiegel, S.6
  • 30
    • 0028222358 scopus 로고
    • Role of ceramide in mitogenesis induced by exogenous sphingoid bases
    • Hauser, J. M., Buehrer, B. M., and Bell, R. M. (1994) Role of ceramide in mitogenesis induced by exogenous sphingoid bases. J. Biol. Chem. 69, 6803-6809
    • (1994) J. Biol. Chem. , vol.69 , pp. 6803-6809
    • Hauser, J.M.1    Buehrer, B.M.2    Bell, R.M.3
  • 32
    • 0028107081 scopus 로고
    • Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin Bl. A molecular mechanism for carcinogenesis associated with Fusariwn moniliforme
    • Schroeder, J. J., Crane, H. M., Xia, J., Liotta, D. C., and Merrill, A. H., Jr. (1994) Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin Bl. A molecular mechanism for carcinogenesis associated with Fusariwn moniliforme. J. Biol. Chem. 69, 3475-3481
    • (1994) J. Biol. Chem. , vol.69 , pp. 3475-3481
    • Schroeder, J.J.1    Crane, H.M.2    Xia, J.3    Liotta, D.C.4    Merrill Jr., A.H.5
  • 33
    • 0028934898 scopus 로고
    • Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine
    • Pushkareva, M., Chao, R., Bielawska, A., Merrill, A. H., Jr., Crane, H. M., Lagu, B., Liotta, D. C., and Hannun, Y. A. (1995) Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry 34,1885-1892
    • (1995) Biochemistry , vol.34 , pp. 1885-1892
    • Pushkareva, M.1    Chao, R.2    Bielawska, A.3    Merrill Jr., A.H.4    Crane, H.M.5    Lagu, B.6    Liotta, D.C.7    Hannun, Y.A.8
  • 34
    • 0030071041 scopus 로고    scopus 로고
    • Suppression of bcl-2 gene expression by sphingosine intheapoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation
    • Sakakura, C., Sweeney, E. A., Shirahama, T., Hakomori, S., and Igarashi, Y. (1996) Suppression of bcl-2 gene expression by sphingosine intheapoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. FEES Leu. 379,177-180
    • (1996) FEES Leu. , vol.379 , pp. 177-180
    • Sakakura, C.1    Sweeney, E.A.2    Shirahama, T.3    Hakomori, S.4    Igarashi, Y.5
  • 35
    • 0029922118 scopus 로고    scopus 로고
    • Induction of apoptosis and potentiation of ceramide-mediated cytoloxicity by sphingoid bases in human myeloid leukemia cells
    • Jarvis, W. D., Fomari, F. A., Jr., Traylor, R. S., Martin, H. A., Kramer, L. B., Erukulla, R. K., Bittman, R., and Grant, C. (1996) Induction of apoptosis and potentiation of ceramide-mediated cytoloxicity by sphingoid bases in human myeloid leukemia cells. J. Biol. Chem. 271,8275-8284
    • (1996) J. Biol. Chem. , vol.271 , pp. 8275-8284
    • Jarvis, W.D.1    Fomari Jr., F.A.2    Traylor, R.S.3    Martin, H.A.4    Kramer, L.B.5    Erukulla, R.K.6    Bittman, R.7    Grant, C.8
  • 36
    • 0023865059 scopus 로고
    • Peptide growth factors are multifunctional
    • Sporn, M. B., and Roberts, A. B. (1988) Peptide growth factors are multifunctional. Nature (London) 332,217-221
    • (1988) Nature (London) , vol.332 , pp. 217-221
    • Sporn, M.B.1    Roberts, A.B.2
  • 37
    • 0025370129 scopus 로고
    • The bjmodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1
    • Buckley, N. E., Matyas, G. R., and Spiegel, S. (1990) The bjmodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1. Exp. Cell. Res. 89,13-21
    • (1990) Exp. Cell. Res. , vol.89 , pp. 13-21
    • Buckley, N.E.1    Matyas, G.R.2    Spiegel, S.3
  • 39
    • 0028825719 scopus 로고
    • Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity
    • Gómez-Muñoz, A., Waggoner, D. W., O'Brien, and Brindley, D. N. (1995) Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J. Biol. Chem. 270, 26318-26325.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26318-26325
    • Gómez-Muñoz, A.1    Waggoner, D.W.2    O'Brien3    Brindley, D.N.4
  • 42
    • 0026317132 scopus 로고
    • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fitsarium moniliforme
    • Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T., and Merrill, A. H., Jr. (1991) Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fitsarium moniliforme. J. Biol. Chem. 66, 14486-14490
    • (1991) J. Biol. Chem. , vol.66 , pp. 14486-14490
    • Wang, E.1    Norred, W.P.2    Bacon, C.W.3    Riley, R.T.4    Merrill Jr., A.H.5
  • 43
    • 0028934299 scopus 로고
    • Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungat encoded toxin which is a carcinogen
    • Huang, C., Dickman, M., Henderson, G., and Jones, C. (1995) Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungat encoded toxin which is a carcinogen. Cancer Res. 55,1655-1659
    • (1995) Cancer Res. , vol.55 , pp. 1655-1659
    • Huang, C.1    Dickman, M.2    Henderson, G.3    Jones, C.4
  • 44
    • 0001611677 scopus 로고
    • Liquid Chromatographie determination of sphinganine and sphingosine: Use of the free sphinganineto-sphingosine ratio as a biomarker for consumption of fumonisins
    • Riley, R. T., Wang, E., and Merrill, A. H., Jr. (1994) Liquid Chromatographie determination of sphinganine and sphingosine: use of the free sphinganineto-sphingosine ratio as a biomarker for consumption of fumonisins. J. Assoc. Off, Agric. Chem. 77, 533-540
    • (1994) J. Assoc. Off, Agric. Chem. , vol.77 , pp. 533-540
    • Riley, R.T.1    Wang, E.2    Merrill Jr., A.H.3
  • 48
    • 0027358029 scopus 로고
    • Fumonisins and other inhibitors of de novo sphingolipid biosynthesis
    • Merrill, A. H., Jr., Wang, E., Gilchrist, D. G., and Riley, R.T. (1993) Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. Adv. Lipid Res. 26,215-234
    • (1993) Adv. Lipid Res. , vol.26 , pp. 215-234
    • Merrill Jr., A.H.1    Wang, E.2    Gilchrist, D.G.3    Riley, R.T.4
  • 49
    • 0026473237 scopus 로고
    • Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase
    • Zweerink, M. M., Edison, A. M., Wells, C. B., Pinto, W., and Lester, R. L. (1992) Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J. Biol. Chem. 267,25032-25038
    • (1992) J. Biol. Chem. , vol.267 , pp. 25032-25038
    • Zweerink, M.M.1    Edison, A.M.2    Wells, C.B.3    Pinto, W.4    Lester, R.L.5
  • 50
    • 0029075192 scopus 로고
    • Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin
    • Miyake, Y., Kozutsumi, Y., Nakamura,S., Fujita, T., and Kawasaki,T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211, 396-03
    • (1995) Biochem. Biophys. Res. Commun. , vol.211 , pp. 396-403
    • Miyake, Y.1    Kozutsumi, Y.2    Nakamura, S.3    Fujita, T.4    Kawasaki, T.5
  • 51
    • 0029946264 scopus 로고    scopus 로고
    • Fumonisins: Fungal toxins that shed light on sphingotipid function
    • Merrill, A. H.Jr., Liotta, D. C., and Riley, R.T. (1996) Fumonisins: fungal toxins that shed light on sphingotipid function. Trends Cell Biol. 6,218-223
    • (1996) Trends Cell Biol. , vol.6 , pp. 218-223
    • Merrill Jr., A.H.1    Liotta, D.C.2    Riley, R.T.3
  • 52
    • 0030064134 scopus 로고    scopus 로고
    • Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2
    • Nakamura, S., Kozutsumi, Y., Sun, Y. D., Miyake, Y., Fujita, T., and Kawasaki, T. (1996) Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. J. Biol. Chem. 271,1255-1257
    • (1996) J. Biol. Chem. , vol.271 , pp. 1255-1257
    • Nakamura, S.1    Kozutsumi, Y.2    Sun, Y.D.3    Miyake, Y.4    Fujita, T.5    Kawasaki, T.6
  • 53
    • 0026648695 scopus 로고
    • Type C Niemann-Pick disease: A murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver
    • Goldin, E., Roff, C. F., Miller, S. P., Rodriguez-Lafrasse, C., Vanier, M. T., Brady, R. O., and Pentchev, P. G. (1992) Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver. Biochim. Biophys. Ada 1127, 303-311
    • (1992) Biochim. Biophys. Ada , vol.1127 , pp. 303-311
    • Goldin, E.1    Roff, C.F.2    Miller, S.P.3    Rodriguez-Lafrasse, C.4    Vanier, M.T.5    Brady, R.O.6    Pentchev, P.G.7
  • 54
    • 0023138332 scopus 로고
    • Lysosphingolipids inhibit protein kinase C: Implications for the sphingolipidoses
    • Hannun, Y. A., and Bell, R. M. (1987) Lysosphingolipids inhibit protein kinase C: Implications for the sphingolipidoses. Science 235, 670-674
    • (1987) Science , vol.235 , pp. 670-674
    • Hannun, Y.A.1    Bell, R.M.2
  • 55
    • 0029035478 scopus 로고
    • Sphingosylphosphorylcholine, a novel signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of AP-1
    • Berger, A., Rosenthal, D., and Spiegel, S. (1995) Sphingosylphosphorylcholine, a novel signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of AP-1. Proc. Natl. Acad. Sci. USA 92, 5885-5889.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5885-5889
    • Berger, A.1    Rosenthal, D.2    Spiegel, S.3
  • 56
    • 0025972399 scopus 로고
    • Long-chain (sphingoid) bases inhibit multistage Carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristale 13-acetate
    • Borek, C., Ong, A., Stevens, V. L., Wang, E., and Merrill, A. H., Jr. (1991) Long-chain (sphingoid) bases inhibit multistage Carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristale 13-acetate. Proc. Natl. Acad. Sci. USA 88, 1953-1957
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1953-1957
    • Borek, C.1    Ong, A.2    Stevens, V.L.3    Wang, E.4    Merrill Jr., A.H.5
  • 58
    • 0028304788 scopus 로고
    • Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice
    • Dillehay, D. L, Webb, S. J., Schmelz, E.-M., and Merrill, A. H., Jr. (1994) Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J. Nutr. 124, 615-620
    • (1994) J. Nutr. , vol.124 , pp. 615-620
    • Dillehay, D.L.1    Webb, S.J.2    Schmelz, E.-M.3    Merrill Jr., A.H.4
  • 59
    • 0029013314 scopus 로고
    • Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases
    • Merrill, A. H., Jr., Schmelz, E. M., Wang, E, Schroeder, J. J., Dillehay, D. L., and Riley, R. T. (1995) Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. J Nutr. 125,1677S-1682S
    • (1995) J Nutr. , vol.125
    • Merrill Jr., A.H.1    Schmelz, E.M.2    Wang, E.3    Schroeder, J.J.4    Dillehay, D.L.5    Riley, R.T.6
  • 60
    • 0029965928 scopus 로고    scopus 로고
    • Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)
    • Wright, S. C., Zheng, H., and Zhong, J. (1996) Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). FASEB J. 10,325-332
    • (1996) FASEB J. , vol.10 , pp. 325-332
    • Wright, S.C.1    Zheng, H.2    Zhong, J.3
  • 61
    • 0026049696 scopus 로고
    • Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
    • Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brooker, G., and Spiegel, S. (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol. 14,155-167
    • (1991) J. Cell Biol. , vol.14 , pp. 155-167
    • Zhang, H.1    Desai, N.N.2    Olivera, A.3    Seki, T.4    Brooker, G.5    Spiegel, S.6
  • 62
    • 0027371722 scopus 로고
    • Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDCF and FCS mitogens
    • Olivera, A., and Spiegel, S. (1993) Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDCF and FCS mitogens. Nature (London) 365, 557-560
    • (1993) Nature (London) , vol.365 , pp. 557-560
    • Olivera, A.1    Spiegel, S.2
  • 63
    • 0029027589 scopus 로고
    • Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemolactic signal transduction
    • Bornfeldt, K. E., Graves, L. M., Raines, E. W., Igarashi, Y., Wayman, G., Yamamura, S., Yatomi, Y., Sidhu, J. S., Krebs, E. G., Hakomori, S., and Ross, R. (1995) Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemolactic signal transduction. J. Cell Biol. 130, 193-206
    • (1995) J. Cell Biol. , vol.130 , pp. 193-206
    • Bornfeldt, K.E.1    Graves, L.M.2    Raines, E.W.3    Igarashi, Y.4    Wayman, G.5    Yamamura, S.6    Yatomi, Y.7    Sidhu, J.S.8    Krebs, E.G.9    Hakomori, S.10    Ross, R.11
  • 64
    • 0026774525 scopus 로고
    • Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness
    • Sadahira, Y., Ruan, F., Hakomori, S. & Igarashi, Y. (1992) Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Nail. Acad. Sci. USA 89, 9686-9690
    • (1992) Proc. Nail. Acad. Sci. USA , vol.89 , pp. 9686-9690
    • Sadahira, Y.1    Ruan, F.2    Hakomori, S.3    Igarashi, Y.4
  • 65
    • 0028268198 scopus 로고
    • Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells
    • Sadahira, Y., Zheng, M., Ruan, F., Hakomori, S., and Igarashi, Y. (1994) Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells. Fed. Eur. Biol. Soc. 340,99-103
    • (1994) Fed. Eur. Biol. Soc. , vol.340 , pp. 99-103
    • Sadahira, Y.1    Zheng, M.2    Ruan, F.3    Hakomori, S.4    Igarashi, Y.5
  • 66
    • 10244257751 scopus 로고
    • Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal Iransduclion, affects growth and invasiveness of human breast cancer cells
    • Spiegel, S., Olivera, A., Zhang, H., Thompson, E., Su, Y., and Berger, A. (1994) Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal Iransduclion, affects growth and invasiveness of human breast cancer cells. Breast Cancer Res. Treat. 1, 195-206
    • (1994) Breast Cancer Res. Treat. , vol.1 , pp. 195-206
    • Spiegel, S.1    Olivera, A.2    Zhang, H.3    Thompson, E.4    Su, Y.5    Berger, A.6
  • 67
    • 0025756765 scopus 로고
    • Cell membrane signaling as target in cancer therapy: Inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice
    • Endo, K., Igarashi, Y., Nisar, M., Zhou, Q. H., and Hakomori, S. (1991) Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res. 1, 1613-1618
    • (1991) Cancer Res. , vol.1 , pp. 1613-1618
    • Endo, K.1    Igarashi, Y.2    Nisar, M.3    Zhou, Q.H.4    Hakomori, S.5
  • 68
    • 0026717479 scopus 로고
    • Canglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways
    • Olivera, A., and Spiegel, S. (1992) Canglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways. Glycoconjugate J. 9, 109-117
    • (1992) Glycoconjugate J. , vol.9 , pp. 109-117
    • Olivera, A.1    Spiegel, S.2
  • 69
    • 0019961652 scopus 로고
    • How is the level of free arachidonic acid controlled in mammalian cells?
    • Irvine, R. (1982) How is the level of free arachidonic acid controlled in mammalian cells? Biochem. J. 204,3-16
    • (1982) Biochem. J. , vol.204 , pp. 3-16
    • Irvine, R.1
  • 70
    • 0025162155 scopus 로고
    • Signaling through phosphatidylcholine breakdown
    • Exton, J. H. (1990) Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 65, 1-4
    • (1990) J. Biol. Chem. , vol.65 , pp. 1-4
    • Exton, J.H.1
  • 71
    • 0022974603 scopus 로고
    • Sphingosine inhibition of protein kinase C activity and of phorbol bibutyrate binding in vitro and in human platelets
    • Hannun, Y. A., Loomis, C. R., Merrill, A. H., Jr., and Bell, R. M. (1986) Sphingosine inhibition of protein kinase C activity and of phorbol bibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261,12604-12609
    • (1986) J. Biol. Chem. , vol.261 , pp. 12604-12609
    • Hannun, Y.A.1    Loomis, C.R.2    Merrill Jr., A.H.3    Bell, R.M.4
  • 72
    • 0026457994 scopus 로고
    • Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation
    • Desai, N. N., Zhang, H., Olivera, A., Mattie, M. E., and Spiegel, S. (1992) Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation. J. Biol. Chem. 67, 23122-23128
    • (1992) J. Biol. Chem. , vol.67 , pp. 23122-23128
    • Desai, N.N.1    Zhang, H.2    Olivera, A.3    Mattie, M.E.4    Spiegel, S.5
  • 73
    • 0026644179 scopus 로고
    • Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors
    • Perry, D. K., Hand, W. L., Edmundson, D. E., and Lambeth, J. D. (1992) Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors J. Immunal. 149, 2749-2758
    • (1992) J. Immunal. , vol.149 , pp. 2749-2758
    • Perry, D.K.1    Hand, W.L.2    Edmundson, D.E.3    Lambeth, J.D.4
  • 74
    • 0025936424 scopus 로고
    • Inhibition of the insulin receptor tyrosine kinase by sphingosine
    • Arnold, R. S., and Newton, A. C. (1991) Inhibition of the insulin receptor tyrosine kinase by sphingosine. Biochemistry 30, 7747-7754
    • (1991) Biochemistry , vol.30 , pp. 7747-7754
    • Arnold, R.S.1    Newton, A.C.2
  • 75
    • 0023762958 scopus 로고
    • Sphingosine inhibits catmodulindependent enzymes
    • Jefferson, A. B., and Schulman, H. (1988) Sphingosine inhibits catmodulindependent enzymes J. Biol. Chem. 63,15241-15244
    • (1988) J. Biol. Chem. , vol.63 , pp. 15241-15244
    • Jefferson, A.B.1    Schulman, H.2
  • 77
    • 0023888568 scopus 로고
    • Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor
    • Davis, R. J., Girones, N., and Faucher, M. (1988) Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor. J. Biol. Chem. 63, 5373-5379
    • (1988) J. Biol. Chem. , vol.63 , pp. 5373-5379
    • Davis, R.J.1    Girones, N.2    Faucher, M.3
  • 79
    • 0028172435 scopus 로고
    • Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells
    • Seufferlein, T., and Rozengurl, E. (1994) Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells, J. Biol. Chem. 269,27610-27617
    • (1994) J. Biol. Chem. , vol.269 , pp. 27610-27617
    • Seufferlein, T.1    Rozengurl, E.2
  • 80
    • 0024841874 scopus 로고
    • Phoapholipase D activation by the mitogens platelet-derived growth factor, and 12-O-tetradecanoyl phorbol 13-acetate in NIH-3T3 cells
    • Ben-Av, P., and Liscovilch, M. (1989) Phoapholipase D activation by the mitogens platelet-derived growth factor, and 12-O-tetradecanoyl phorbol 13-acetate in NIH-3T3 cells. Fed. Eur. Biol. Soc. 59,64-66
    • (1989) Fed. Eur. Biol. Soc. , vol.59 , pp. 64-66
    • Ben-Av, P.1    Liscovilch, M.2
  • 81
    • 0025649545 scopus 로고
    • A cyloplasmic protein inhibits the CTPase activity of H-Ras in a phospholipid-dependent manner
    • Tsai, M., Yu, C., and Stacey, D. W. (1990) A cyloplasmic protein inhibits the CTPase activity of H-Ras in a phospholipid-dependent manner. Science 250,982-985.
    • (1990) Science , vol.250 , pp. 982-985
    • Tsai, M.1    Yu, C.2    Stacey, D.W.3
  • 82
    • 0026672998 scopus 로고
    • MAP kinases: Charting the regulatory pathways
    • Pelech, S. L., and Sanghera, J. S. (1992) MAP kinases: charting the regulatory pathways. Science 257, 1355-1356
    • (1992) Science , vol.257 , pp. 1355-1356
    • Pelech, S.L.1    Sanghera, J.S.2
  • 83
    • 0025611288 scopus 로고
    • Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells
    • Zhang, H., Desai, N. N., Murphey, J. M., and Spiegel, S. (1990) Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells. J. Biol. Chem. 65, 21309-21316
    • (1990) J. Biol. Chem. , vol.65 , pp. 21309-21316
    • Zhang, H.1    Desai, N.N.2    Murphey, J.M.3    Spiegel, S.4
  • 84
    • 0000057867 scopus 로고
    • Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells
    • Lavie, Y., and Liscovitch, M. (1990) Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells. Biochem. Biophys. Res. Commun. 67,607-613
    • (1990) Biochem. Biophys. Res. Commun. , vol.67 , pp. 607-613
    • Lavie, Y.1    Liscovitch, M.2
  • 85
    • 0011378011 scopus 로고
    • ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine
    • Kiss, Z., and Anderson, W. B. (1990) ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine. J. Biol. Chem. 65, 7188-7194
    • (1990) J. Biol. Chem. , vol.65 , pp. 7188-7194
    • Kiss, Z.1    Anderson, W.B.2
  • 86
    • 0028486763 scopus 로고
    • Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate
    • Natarajan, V., Jayaram, H. N., Scribner, W. M., and Garcia, J. G. (1994) Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. Am. J. Respir. Cell Mol. Biol. 11,221-229
    • (1994) Am. J. Respir. Cell Mol. Biol. , vol.11 , pp. 221-229
    • Natarajan, V.1    Jayaram, H.N.2    Scribner, W.M.3    Garcia, J.G.4
  • 87
    • 0025612307 scopus 로고
    • Inhibition of phosphalidic acid phosphohydrolase activity by sphingosine: Dual action of sphingosine in diacylglycerol signal termination
    • Lavie, Y., Piterman, O., and Liscovitch, M. (1990) Inhibition of phosphalidic acid phosphohydrolase activity by sphingosine: Dual action of sphingosine in diacylglycerol signal termination. Fed. Eur. Biol. Soc. 77, 7-10
    • (1990) Fed. Eur. Biol. Soc. , vol.77 , pp. 7-10
    • Lavie, Y.1    Piterman, O.2    Liscovitch, M.3
  • 88
    • 0025866050 scopus 로고
    • Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism
    • Mullmann, T. J., Siegel, M. L, Egan, R. W., and Billah, M. M. (1991) Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism. J. Biol. Chem. 66, 2013-2016
    • (1991) J. Biol. Chem. , vol.66 , pp. 2013-2016
    • Mullmann, T.J.1    Siegel, M.L.2    Egan, R.W.3    Billah, M.M.4
  • 89
    • 0025774977 scopus 로고
    • Plasma membrane fraction from rat liver contain a phosphalidate phosphohydrolase distinct from that in the endoplasmic reticutum and cytosol
    • Jamal, Z., Martin, A., Munoz, A. G., and Brindley, D. N. (1991) Plasma membrane fraction from rat liver contain a phosphalidate phosphohydrolase distinct from that in the endoplasmic reticutum and cytosol. J. Biol. Chem. 66,2988-2996
    • (1991) J. Biol. Chem. , vol.66 , pp. 2988-2996
    • Jamal, Z.1    Martin, A.2    Munoz, A.G.3    Brindley, D.N.4
  • 90
    • 0027192315 scopus 로고
    • Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases
    • Wu, W. I., Lin, Y. P., Wang, E., Merrill, A. H., Jr., and Carman, G. M. (1993) Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. J. Biol. Chem. 68,13830-13837
    • (1993) J. Biol. Chem. , vol.68 , pp. 13830-13837
    • Wu, W.I.1    Lin, Y.P.2    Wang, E.3    Merrill Jr., A.H.4    Carman, G.M.5
  • 91
    • 0027254840 scopus 로고
    • The different effects of sphingosine on diacylglycerol kinase isozymes in Jurkat cells, a human T-cell line
    • Yamada, K., and Sakane, F. (1993) The different effects of sphingosine on diacylglycerol kinase isozymes in Jurkat cells, a human T-cell line. Biochim. Biophys. Ada 1169, 211-216
    • (1993) Biochim. Biophys. Ada , vol.1169 , pp. 211-216
    • Yamada, K.1    Sakane, F.2
  • 93
    • 0026726492 scopus 로고
    • 2 production and sphingomyelin metabolism. Evidence for the regulation of cycoloxygenase gene expression by sphingosine and ceramide
    • 2 production and sphingomyelin metabolism. Evidence for the regulation of cycoloxygenase gene expression by sphingosine and ceramide. J. Biol. Chem. 267,20044-20050
    • (1992) J. Biol. Chem. , vol.267 , pp. 20044-20050
    • Ballou, L.R.1    Chao, C.P.2    Holness, M.S.3    Barker, S.C.4    Raghow, R.5
  • 94
    • 0025351642 scopus 로고
    • Intracellular calcium release mediated by sphingosine derivatives generated in cells
    • Ghosh, T. K., Bian, J., and Gill, D. L. (1990) Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248, 1653-1656
    • (1990) Science , vol.248 , pp. 1653-1656
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 95
    • 0028122243 scopus 로고
    • Sphingosine-medialed phosphatidylinositol metabolism and calcium mobilization
    • Chao, C. P., Laulederkind, S. J., and Ballou, L. R. (1994) Sphingosine-medialed phosphatidylinositol metabolism and calcium mobilization. J. Biol. Chem. 69,5849-5856
    • (1994) J. Biol. Chem. , vol.69 , pp. 5849-5856
    • Chao, C.P.1    Laulederkind, S.J.2    Ballou, L.R.3
  • 99
    • 0025900495 scopus 로고
    • Sphingosine stimulates calcium mobilization in rat parotid acinar cells
    • Sugiya, H., and Furuyama, S. (1991) Sphingosine stimulates calcium mobilization in rat parotid acinar cells. Fed. Eur. Biol. Soc. 86, 113-116
    • (1991) Fed. Eur. Biol. Soc. , vol.86 , pp. 113-116
    • Sugiya, H.1    Furuyama, S.2
  • 100
    • 0030051491 scopus 로고    scopus 로고
    • 2+ signaling in transformed oligodendrocytes
    • 2+ signaling in transformed oligodendrocytes. J. Biol. Chem. 271, 295-301
    • (1996) J. Biol. Chem. , vol.271 , pp. 295-301
    • Fatatis, A.1    Miller, R.J.2
  • 101
    • 0026757049 scopus 로고
    • Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine
    • Ritchie, T., Rosenberg, A., and Noble, E. P. (1992) Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine. Biochem. Biophys. Res. Commun. 86,790-795
    • (1992) Biochem. Biophys. Res. Commun. , vol.86 , pp. 790-795
    • Ritchie, T.1    Rosenberg, A.2    Noble, E.P.3
  • 102
    • 0024278736 scopus 로고
    • Regulation of the epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C
    • Wahl, M., and Carpenter, G. (1988) Regulation of the epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C.J. Biol. Chem 263, 7581-7590
    • (1988) J. Biol. Chem , vol.263 , pp. 7581-7590
    • Wahl, M.1    Carpenter, G.2
  • 103
    • 0027180151 scopus 로고
    • Sphingosine mobilizes intracellular calcium in human neutrophils
    • Wong, K., and Kwan, Y. L. (1993) Sphingosine mobilizes intracellular calcium in human neutrophils. Cell Calcium 14,493-505
    • (1993) Cell Calcium , vol.14 , pp. 493-505
    • Wong, K.1    Kwan, Y.L.2
  • 104
    • 0024428410 scopus 로고
    • Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins
    • Van Corven, E. J., Croenink, A., Jalink, K., Eicholtz, T., and Moolenaar, W. H. (1989) Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins. Cell 59, 45-54
    • (1989) Cell , vol.59 , pp. 45-54
    • Van Corven, E.J.1    Croenink, A.2    Jalink, K.3    Eicholtz, T.4    Moolenaar, W.H.5
  • 105
    • 0026725761 scopus 로고
    • Calcium and inositol 1,4,5-trisphosphate receptors: A complex relationship
    • Taylor, W., and Marshall, (1992) Calcium and inositol 1,4,5-trisphosphate receptors: A complex relationship. Trends Biochem. Sci. 7,403-407
    • (1992) Trends Biochem. Sci. , vol.7 , pp. 403-407
    • Taylor, W.1    Marshall2
  • 106
    • 0026777842 scopus 로고
    • The effects of sphingosine on sarcoplasmic reticulum membrane calcium release
    • Sabbadini, R. A., Betto, R., Teresi, A., Fachechi-Cassano, G., and Salviati, G. (1992) The effects of sphingosine on sarcoplasmic reticulum membrane calcium release. J. Biol. Chem. 267,15475-15484
    • (1992) J. Biol. Chem. , vol.267 , pp. 15475-15484
    • Sabbadini, R.A.1    Betto, R.2    Teresi, A.3    Fachechi-Cassano, G.4    Salviati, G.5
  • 108
    • 0028956049 scopus 로고
    • Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate
    • Goodemote, K. A., Mattie, M. E., Berger, A., and Spiegel, S. (1995) Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate. J. Biol. Chem. 270,10272-10277
    • (1995) J. Biol. Chem. , vol.270 , pp. 10272-10277
    • Goodemote, K.A.1    Mattie, M.E.2    Berger, A.3    Spiegel, S.4
  • 109
    • 0343562434 scopus 로고
    • Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C
    • Johnson, J. A., and Clark, R. B. (1990) Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C. J. Biol. Chem. 265, 9333-9339
    • (1990) J. Biol. Chem. , vol.265 , pp. 9333-9339
    • Johnson, J.A.1    Clark, R.B.2
  • 110
    • 0023025201 scopus 로고
    • Early signals in the mitogenic response
    • Rozengurt, E. (1986) Early signals in the mitogenic response. Science 234, 161-166
    • (1986) Science , vol.234 , pp. 161-166
    • Rozengurt, E.1
  • 111
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
    • Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M. J., and Sturgill, T. W. (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262,1065-1069
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5    Sturgill, T.W.6
  • 112
    • 0001597247 scopus 로고
    • Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation
    • Holt, J. T., Gopal, T. V., Moulton, A. D., and Nicnhuis, A. W. (1986) Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc. Nati Acad. Sci. USA 83,4794-4798
    • (1986) Proc. Nati Acad. Sci. USA , vol.83 , pp. 4794-4798
    • Holt, J.T.1    Gopal, T.V.2    Moulton, A.D.3    Nicnhuis, A.W.4
  • 113
    • 0026599596 scopus 로고
    • Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging
    • Riabowol, K. T., Schiff, J., and Oilman, M. Z. (1992) Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc. Natl. Acad. Sci USA 89,157-161
    • (1992) Proc. Natl. Acad. Sci USA , vol.89 , pp. 157-161
    • Riabowol, K.T.1    Schiff, J.2    Oilman, M.Z.3
  • 114
    • 0023938252 scopus 로고
    • Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells
    • Riabowol, K. T., Vosalka, R. J., Ziff, E. B., Lamb, N. J., and Feramisco, J. R. (1988) Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells. Mol. Cell. Biol. 8, 1670-1676
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 1670-1676
    • Riabowol, K.T.1    Vosalka, R.J.2    Ziff, E.B.3    Lamb, N.J.4    Feramisco, J.R.5
  • 115
    • 0028322142 scopus 로고
    • Sphingosine l-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent 3T3 fibroblasts
    • Su, Y., Rosenthal, D., Smulson, M., and Spiegel, S. (1994) Sphingosine l-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent 3T3 fibroblasts. J. Biol. Chem. 269,16512-16517
    • (1994) J. Biol. Chem. , vol.269 , pp. 16512-16517
    • Su, Y.1    Rosenthal, D.2    Smulson, M.3    Spiegel, S.4
  • 116
    • 0026661584 scopus 로고
    • Control of transcription factors by signal transduction pathways: The beginning of the end
    • Karin, M., and Smeal, T. (1992) Control of transcription factors by signal transduction pathways: the beginning of the end. Trends Biochem. Sci. 17, 418-422
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 418-422
    • Karin, M.1    Smeal, T.2
  • 118
    • 0028135464 scopus 로고
    • Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride
    • Ohta, H., Ruan, F. Hakomori, S., and Igarashi, Y. (1994) Quantification of free sphingosine in cultured cells by acylation with radioactive acetic anhydride. Anal. Biochem. 222, 489-494
    • (1994) Anal. Biochem. , vol.222 , pp. 489-494
    • Ohta, H.1    Ruan, F.2    Hakomori, S.3    Igarashi, Y.4
  • 119
    • 0028152929 scopus 로고
    • Sphingosine kinase from Swiss 3T3 fibroblasts: A convenient assay for the measurement of intracellular levels of free sphingoid bases
    • Olivera, A., Rosenthal, J., and Spiegel, S. (1994) Sphingosine kinase from Swiss 3T3 fibroblasts: A convenient assay for the measurement of intracellular levels of free sphingoid bases. Anal. Biochem. 223, 306-312
    • (1994) Anal. Biochem. , vol.223 , pp. 306-312
    • Olivera, A.1    Rosenthal, J.2    Spiegel, S.3
  • 120
    • 0029128576 scopus 로고
    • Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride
    • Yatomi, Y., Ruan, F. W., Ohta, H., and Welch, R. J. (1995) Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride. Anal. Biochem. 230, 315-320
    • (1995) Anal. Biochem. , vol.230 , pp. 315-320
    • Yatomi, Y.1    Ruan, F.W.2    Ohta, H.3    Welch, R.J.4
  • 121
    • 0026022563 scopus 로고
    • Cell regulation by sphingosine and more complex sphingolipids
    • Merrill, A. H., Jr. (1991) Cell regulation by sphingosine and more complex sphingolipids. J. Bioenerg. Biomembr. 23, 83-104
    • (1991) J. Bioenerg. Biomembr. , vol.23 , pp. 83-104
    • Merrill Jr., A.H.1
  • 123
    • 0023915234 scopus 로고
    • Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors
    • Wilson, E., Wang, E., Mullins, R. E., Liotta, D. C., Lambeth, J. D., and Merrill, A. H., Jr. (1988) Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors. J. Biol. Chem. 263, 9304-9309
    • (1988) J. Biol. Chem. , vol.263 , pp. 9304-9309
    • Wilson, E.1    Wang, E.2    Mullins, R.E.3    Liotta, D.C.4    Lambeth, J.D.5    Merrill Jr., A.H.6
  • 124
    • 0026079681 scopus 로고
    • Modulation of the free sphingosine levels in Epstein-Barr virus transformed human B lymphocytes by phorbol dibutyrate
    • Miccheli, A., Ricciolini, R., Lagana, A., Piccolella, E., and Conli, F. (1991) Modulation of the free sphingosine levels in Epstein-Barr virus transformed human B lymphocytes by phorbol dibutyrate. Biochim. Biophys. Acta 1095, 90-92
    • (1991) Biochim. Biophys. Acta , vol.1095 , pp. 90-92
    • Miccheli, A.1    Ricciolini, R.2    Lagana, A.3    Piccolella, E.4    Conli, F.5
  • 125
    • 0027930060 scopus 로고
    • On the presence of phosphorylated sphingoid bases in rat tissues: A mass-spectrometric approach
    • Van Veldboven, P. P., DeCeuster, P., Rozenberg, R., Mannaerts, G. P., and DeHoffmann, E. (1994) On the presence of phosphorylated sphingoid bases in rat tissues: A mass-spectrometric approach. FEBS Lett. 350, 91-95
    • (1994) FEBS Lett. , vol.350 , pp. 91-95
    • Van Veldboven, P.P.1    DeCeuster, P.2    Rozenberg, R.3    Mannaerts, G.P.4    DeHoffmann, E.5
  • 126
    • 0029079324 scopus 로고
    • Sphingosine 1-phosphate rapidly activates the milogen-activated protein kinase pathway by a G protein-dependent mechanism
    • Wu, J., Spiegel, S., and Sturgill, T. W. (1995) Sphingosine 1-phosphate rapidly activates the milogen-activated protein kinase pathway by a G protein-dependent mechanism. J Biol. Chem. 270,11484-11488
    • (1995) J Biol. Chem. , vol.270 , pp. 11484-11488
    • Wu, J.1    Spiegel, S.2    Sturgill, T.W.3
  • 127
    • 0029052921 scopus 로고
    • Sphingosine1-phosphate: A platelet-activating sphingolipid released from agonist-stimulated human platelets
    • Yatomi, Y., Ruan, F., Hakomori, S., and Igarashi, Y. (1995) Sphingosine1-phosphate: A platelet-activating sphingolipid released from agonist-stimulated human platelets. Blood 86, 193-202
    • (1995) Blood , vol.86 , pp. 193-202
    • Yatomi, Y.1    Ruan, F.2    Hakomori, S.3    Igarashi, Y.4
  • 129
    • 0028848344 scopus 로고
    • Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines-Implications for cellular proliferation and differentiation
    • Coroneos, E., Martinez, M., McKenna, S., and Kester, M. (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines-Implications for cellular proliferation and differentiation. J. Biol. Chem. 270, 23305-23309
    • (1995) J. Biol. Chem. , vol.270 , pp. 23305-23309
    • Coroneos, E.1    Martinez, M.2    McKenna, S.3    Kester, M.4
  • 130
    • 0028300922 scopus 로고
    • Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): Demonstration of cell type-specific response - A preliminary note
    • Mazurek, N., Megidish.T., Hakomori, S., and Igarashi, Y. (1994) Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response - a preliminary note. Biochem. Biophys. Res. Commun. 198,1-9
    • (1994) Biochem. Biophys. Res. Commun. , vol.198 , pp. 1-9
    • Mazurek, N.1    Megidish, T.2    Hakomori, S.3    Igarashi, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.