Recent advances in the protein kinase B signaling pathway

Current Opinion in Cell Biology

Volumn 17, Issue 2, 2005, Pages 150-157

  Woodgett, James R ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; PHOSPHOINOSITIDE DEPENDENT KINASE 1; PHOSPHOTRANSFERASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 15044363028     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2005.02.010     Document Type: Review

References (56)

1. L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655 1657
2. J. Luo, B.D. Manning, and L.C. Cantley Targeting the PI3K-Akt pathway in human cancer: rationale and promise Cancer Cell 4 2003 257 262
3. M.L. Sulis, and R. Parsons PTEN: from pathology to biology Trends Cell Biol 13 2003 478 483
4. A. Bellacosa, J.R. Testa, S.P. Staal, and P.N. Tsichlis A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region Science 254 1991 274 277
5. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
6. D.A. Cross, D.R. Alessi, P. Cohen, M. Andjelkovich, and B.A. Hemmings Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785 789
7. B.W. Doble, and J.R. Woodgett GSK-3: tricks of the trade for a multi-tasking kinase J Cell Sci 116 2003 1175 1186
8. M.P. Scheid, and J.R. Woodgett Unravelling the activation mechanisms of protein kinase B/Akt FEBS Lett 546 2003 108 112
9. J. Xu, D. Liu, G. Gill, and Z. Songyang Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides J Cell Biol 154 2001 699 705
10. H. Stocker, M. Andjelkovic, S. Oldham, M. Laffargue, M.P. Wymann, B.A. Hemmings, and E. Hafen Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB Science 295 2002 2088 2091
11. A. Balendran, R.M. Biondi, P.C. Cheung, A. Casamayor, M. Deak, and D.R. Alessi A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC-related kinase 2 by PDK1 J Biol Chem 275 2000 20806 20813
12. M. Frodin, T.L. Antal, B.A. Dummler, C.J. Jensen, M. Deak, S. Gammeltoft, and R.M. Biondi A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation EMBO J 21 2002 5396 5407
13. R.M. Biondi, A. Kieloch, R.A. Currie, M. Deak, and D.R. Alessi The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB EMBO J 20 2001 4380 4390
14. J. Yang, P. Cron, V. Thompson, V.M. Good, D. Hess, B.A. Hemmings, and D. Barford Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation Mol Cell 9 2002 1227 1240
15. J. Yang, P. Cron, V.M. Good, V. Thompson, B.A. Hemmings, and D. Barford Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-P Nat Struct Biol 9 2002 940 944
16. A. Balendran, A. Casamayor, M. Deak, A. Paterson, P. Gaffney, R. Currie, C.P. Downes, and D.R. Alessi PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 Curr Biol 9 1999 393 404
17. M.R. Williams, J.S. Arthur, A. Balendran, J. van der Kaay, V. Poli, P. Cohen, and D.R. Alessi The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells Curr Biol 10 2000 439 448
18. M.A. Lawlor, A. Mora, P.R. Ashby, M.R. Williams, V. Murray-Tait, L. Malone, A.R. Prescott, J.M. Lucocq, and D.R. Alessi Essential role of PDK1 in regulating cell size and development in mice EMBO J 21 2002 3728 3738
19. A. Mora, A.M. Davies, L. Bertrand, I. Sharif, G.R. Budas, S. Jovanovic, V. Mouton, C.R. Kahn, J.M. Lucocq, and G.A. Gray Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia EMBO J 22 2003 4666 4676
20. F. Rintelen, H. Stocker, G. Thomas, and E. Hafen PDK1 regulates growth through Akt and S6K in Drosophila Proc Natl Acad Sci USA 98 2001 15020 15025
21. A. Mora, D. Komander, D.M. van Aalten, and D.R. Alessi PDK1, the master regulator of AGC kinase signal transduction Semin Cell Dev Biol 15 2004 161 170
22. M.P. Scheid, P.A. Marignani, and J.R. Woodgett Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B Mol Cell Biol 22 2002 6247 6260
23. B.J. Collins, M. Deak, J.S. Arthur, L.J. Armit, and D.R. Alessi In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation EMBO J 22 2003 4202 4211 This paper demonstrates, in an elegant manner, the importance of the PIF-pocket of PDK1 on phosphorylation of certain of its substrate proteins in embryonic stem cells.
24. M. Frodin, T.L. Antal, B.A. Dummler, C.J. Jensen, M. Deak, S. Gammeltoft, and R.M. Biondi A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation EMBO J 21 2002 5396 5407
25. F.M. Roelants, P.D. Torrance, and J. Thorner Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9 Microbiology 150 2004 3289 3304
26. T.O. Chan, and P.N. Tsichlis PDK2: a complex tail in one Akt Science STKE 2001 PE1
27. M.M. Hill, M. Andjelkovic, D.P. Brazil, S. Ferrari, D. Fabbro, and B.A. Hemmings Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase J Biol Chem 276 2001 25643 25646
28. S. Persad, and S. Dedhar The role of integrin-linked kinase (ILK) in cancer progression Cancer Metastasis Rev 22 2003 375 384
29. J.T. Deng, C. Sutherland, D.L. Brautigan, M. Eto, and M.P. Walsh Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase Biochem J 367 2002 517 524
30. A.A. Troussard, N.M. Mawji, C. Ong, A. Mui, R. St-Arnaud, and S. Dedhar Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation J Biol Chem 278 2003 22374 22378 This study provides genetic evidence for a role of ILK kinase activity in the phosphorylation of PKB at Ser473, using conditional knockout and siRNA approaches.
31. C.G. Zervas, S.L. Gregory, and N.H. Brown Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane J Cell Biol 152 2001 1007 1018
32. M.M. Hill, J. Feng, and B.A. Hemmings Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1 Curr Biol 12 2002 1251 1255
33. Y. Kawakami, H. Nishimoto, J. Kitaura, M. Maeda-Yamamoto, R.M. Kato, D.R. Littman, D.J. Rawlings, and T. Kawakami Protein kinase C βII regulates Akt phosphorylation on Ser-473 in a cell-type- and stimulus-specific fashion J Biol Chem 279 2004 47720 47725
34. R.C. Hresko, H. Murata, and M. Mueckler Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes J Biol Chem 278 2003 21615 21622
35. C.P. Hodgkinson, E.M. Sale, and G.J. Sale Characterization of PDK2 activity against protein kinase Bγ Biochemistry 41 2002 10351 10359
36. J. Feng, J. Park, P. Cron, D. Hess, and B.A. Hemmings Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase J Biol Chem 279 2004 41189 41196 One of several important papers characterizing putative PDK2 activities.
37. Y. Gao, J. Chaudhuri, C. Zhu, L. Davidson, D.T. Weaver, and F.W. Alt A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination Immunity 9 1998 367 376
38. Guinea Viniegra J, Martinez N, Modirassari P, Hernandez Losa J, Parada Cobo C, Sanchez-Arevalo Lobo VJ, Avceves-Luquero CI, Alavrez-Vallina L, Ramon Y Cajal S, Rojas JM, Sanchez-Prieto R: Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 2005, in press.
39. R. Loewith, E. Jacinto, S. Wullschleger, A. Lorberg, J.L. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, and M.N. Hall Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control Mol Cell 10 2002 457 468
40. E. Jacinto, R. Loewith, A. Schmidt, S. Lin, M.A. Ruegg, A. Hall, and M.N. Hall Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Nat Cell Biol 6 2004 1122 1128 This paper demonstrates the existence of a second mTOR complex in mammalian cells that is not inhibited by rapamycin, which raises the possibility of roles for mTOR in rapamycin-insensitive processes.
41. M.A. Lim, C.K. Kikani, M.J. Wick, and L.Q. Dong Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function Proc Natl Acad Sci USA 100 2003 14006 14011 This paper demonstrated that nuclear transport of PDK-1 has the potential to be regulated rather than being a passive process and identified a functional nuclear export sequence (NES) in the molecule.
42. Scheid MP, Parsons M, Woodgett JR: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol 2005, in press. This paper identifies PI3K-dependent phosphorylation of PDK-1 to be a means to regulate its nuclear entry and exit, providing another layer of the regulation to this protein kinase.
43. D.P. Brazil, Z.Z. Yang, and B.A. Hemmings Advances in protein kinase B signalling: AKTion on multiple fronts Trends Biochem Sci 29 2004 233 242
44. I. Mende, S. Malstrom, P.N. Tsichlis, P.K. Vogt, and M. Aoki Oncogenic transformation induced by membrane-targeted Akt2 and Akt3 Oncogene 20 2001 4419 4423
45. P.K. Majumder, J.J. Yeh, D.J. George, P.G. Febbo, J. Kum, Q. Xue, R. Bikoff, H. Ma, P.W. Kantoff, and T.R. Golub Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model Proc Natl Acad Sci USA 100 2003 7841 7846
46. J. Hutchinson, J. Jin, R.D. Cardiff, J.R. Woodgett, and W.J. Muller Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression Mol Cell Biol 21 2001 2203 2212
47. J.N. Hutchinson, J. Jin, R.D. Cardiff, J.R. Woodgett, and W.J. Muller Activation of Akt-1 (PKB-α) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion Cancer Res 64 2004 3171 3178
48. V.K. Rajasekhar, A. Viale, N.D. Socci, M. Wiedmann, X. Hu, and E.C. Holland Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes Mol Cell 12 2003 889 901
49. M.J. Arboleda, J.F. Lyons, F.F. Kabbinavar, M.R. Bray, B.E. Snow, R. Ayala, M. Danino, B.Y. Karlan, and D.J. Slamon Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells Cancer Res 63 2003 196 206 This study provides insight into the biological consequences of increased levels of the β isoform of PKB on tumor cell properties.
50. S.F. Barnett, D. Defeo-Jones, S. Fu, P.J. Hancock, K.M. Haskell, R.E. Jones, J.A. Kahana, A.M. Kral, K. Leander, and L.L. Lee Identification and characterization of pleckstrin homology domain dependent and isozyme specific Akt inhibitors Biochem J 385 2005 399 408 This paper from Merck introduces isoform-selective PKB inhibitors that act through binding to both the PH and protein kinase domains. These reagents should prove very useful in understanding PKB functions.
51. R. Dajani, E. Fraser, S.M. Roe, N. Young, V. Good, T.C. Dale, and L.H. Pearl Crystal structure of glycogen synthase kinase 3 β: structural basis for phosphate-primed substrate specificity and autoinhibition Cell 105 2001 721 732
52. E. ter Haar, J.T. Coll, D.A. Austen, H.M. Hsiao, L. Swenson, and J. Jain Structure of GSK3β reveals a primed phosphorylation mechanism Nat Struct Biol 8 2001 593 596
53. S. Frame, P. Cohen, and R.M. Biondi A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation Mol Cell 7 2001 1321 1327
54. A. Cole, S. Frame, and P. Cohen Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event Biochem J 377 2004 249 255
55. X. Fang, Y. Lu, S.X. Yu, Y. Lu, R.C. Bast, J.R. Woodgett, and G.B. Mills Phosphorylation and inactivation of glycogen synthase kinase-3 by both protein kinase A and protein kinase B Proc Natl Acad Sci USA 97 2000 11960 11965
56. X. Fang, S. Yu, J.L. Tanyi, Y. Lu, J.R. Woodgett, and G.B. Mills Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway Mol Cell Biol 22 2002 2099 2110