N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase

Cancer Research

Volumn 61, Issue 13, 2001, Pages 5102-5105

  Wang, Hongtao ^a   Cabot, Myles C ^a   Maurer, Barry J ^b,c,d   Patrick, C Patrick ^b,c,e  

^a SAINT JOHN'S HEALTH CENTER   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c Departments of Pediatrics   (United States)

^d Keck School of Medicine   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CYCLOSERINE; FENRETINIDE; FUMONISIN B1; PALMITIC ACID; SERINE PALMITOYLTRANSFERASE; SPHINGANINE; SPHINGOMYELIN; SPHINGOSINE ACYLTRANSFERASE;

ARTICLE; BIOSYNTHESIS; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ACYLTRANSFERASES; ANTINEOPLASTIC AGENTS; CERAMIDES; ENZYME ACTIVATION; ENZYME INDUCTION; FENRETINIDE; HUMANS; NEUROBLASTOMA; OXIDOREDUCTASES; SERINE C-PALMITOYLTRANSFERASE; SPHINGOSINE; TUMOR CELLS, CULTURED;

EID: 0035392960     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
2. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
3. Tamoxifen elicits rapid transmembrane lipid signal response in human breast cancer cells
4. Taxol-induced ceramide generation and apoptosis in human breast cancer cells
5. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
6. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)retinamide in neuroblastoma cell lines
7. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
8. Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
9. Apoptosis induced by N-hexanoyl-sphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis
10. Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells
11. Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells
12. N-Oleoylethanolamine inhibits glucosylation of natural ceramides in CHP-100 neuroepithelioma cells: Possible implications for apoptosis
13. 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for Taxol and vincristine
14. Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy
15. Serine-aplmitoyl transferase activity in cultured human keratinocytes
16. Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptosis KYM-1 cells
17. Production of ceramide causes apoptosis during early neural differentiation in vitro
18. The role of de novo ceramide synthesis in chemotherapy-induced apoptosis
19. Targeting ceramide metabolism: A strategy for overcoming drug resistance
20. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers Adriamycin resistance in human breast cancer cells
21. Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-α-induced apoptosis
22. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses Adriamycin resistance