The development and function of regulatory T cells

Cellular and Molecular Life Sciences

Volumn 66, Issue 16, 2009, Pages 2603-2622

  Workman, Creg J ^a   Szymczak Workman, Andrea L ^a   Collison, Lauren W ^a   Pillai, Meenu R ^a   Vignali, Dario A A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Allergy; Foxp3; Inflammatory bowel disease; Multiple sclerosis; Peripheral tolerance; Regulatory T cells; Tumors; Type 1 diabetes

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLERGY; ASTHMA; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL MATURATION; ENTERITIS; HOMEOSTASIS; HUMAN; IMMUNOLOGICAL TOLERANCE; INFECTION; INSULIN DEPENDENT DIABETES MELLITUS; MULTIPLE SCLEROSIS; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; TH3 CELL; TUMOR; ANIMAL; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; MICE; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY;

EID: 68549110270     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0026-2     Document Type: Review

References (217)

1. RK Gershon 1975 A disquisition on suppressor T cells Transplant Rev 26 170 185 1101469 1:STN:280:DyaE28%2FjsVGksg%3D%3D
2. RK Gershon P Cohen R Hencin SA Liebhaber 1972 Suppressor T cells J Immunol 108 586 590 4401006 1:CAS:528:DyaE38Xht1Ggsr4%3D
3. S Sakaguchi N Sakaguchi M Asano M Itoh M Toda 1995 Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 1151 1164 7636184 1:CAS:528: DyaK2MXntFWnurs%3D
4. S Hori T Nomura S Sakaguchi 2003 Control of regulatory T cell development by the transcription factor Foxp3 Science 299 1057 1061 12522256 1:CAS:528:DC%2BD3sXhtFarsbw%3D 10.1126/science.1079490 (Pubitemid 36222930)
5. JD Fontenot MA Gavin AY Rudensky 2003 Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 330 336 12612578 1:CAS:528:DC%2BD3sXitlyqs74%3D 10.1038/ni904 (Pubitemid 36432314)
6. R Khattri T Cox SA Yasayko F Ramsdell 2003 An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat Immunol 4 337 342 12612581 1:CAS:528:DC%2BD3sXitlyqs7s%3D 10.1038/ni909 (Pubitemid 36432315)
7. CL Bennett J Christie F Ramsdell ME Brunkow PJ Ferguson L Whitesell TE Kelly FT Saulsbury PF Chance HD Ochs 2001 The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat Genet 27 20 21 11137993 1:CAS:528:DC%2BD3MXis1yluw%3D%3D 10.1038/83713 (Pubitemid 32044513)
8. E Gambineri TR Torgerson HD Ochs 2003 Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis Curr Opin Rheumatol 15 430 435 12819471 1:CAS:528: DC%2BD3sXltFKjsb8%3D 10.1097/00002281-200307000-00010 (Pubitemid 36774255)
9. S Sakaguchi 2004 Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses Annu Rev Immunol 22 531 562 15032588 1:CAS:528:DC%2BD2cXktlOgsLo%3D 10.1146/annurev. immunol.21.120601.141122 (Pubitemid 38680433)
10. M Asano M Toda N Sakaguchi S Sakaguchi 1996 Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation J Exp Med 184 387 396 8760792 1:CAS:528:DyaK28XltVCrsrw%3D 10.1084/jem.184.2.387
11. W Liu AL Putnam Z Xu-Yu GL Szot MR Lee S Zhu PA Gottlieb P Kapranov TR Gingeras B Fazekas de St Groth C Clayberger DM Soper SF Ziegler JA Bluestone 2006 CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells J Exp Med 203 1701 1711 16818678 1:CAS:528: DC%2BD28XntVCgs70%3D 10.1084/jem.20060772 (Pubitemid 44036276)
12. S Paust L Lu N McCarty H Cantor 2004 Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease Proc Natl Acad Sci USA 101 10398 10403 15235129 1:CAS:528:DC%2BD2cXmtVyrs7s%3D 10.1073/pnas.0403342101 (Pubitemid 38924937)
13. LC Ndhlovu I Takeda K Sugamura N Ishii 2004 Expanding role of T-cell costimulators in regulatory T-cell function: recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells Crit Rev Immunol 24 251 266 15588225 1:CAS:528:DC%2BD2MXotFOksg%3D%3D 10.1615/CritRevImmunol.v24.i4.30 (Pubitemid 40052427)
14. DA Vignali LW Collison CJ Workman 2008 How regulatory T cells work Nat Rev Immunol 8 523 532 18566595 1:CAS:528:DC%2BD1cXns1ehs7g%3D 10.1038/nri2343
15. SF Ziegler 2006 FOXP3: of mice and men Annu Rev Immunol 24 209 226 16551248 1:CAS:528:DC%2BD28XkvFSqt7s%3D 10.1146/annurev.immunol.24.021605.090547
16. ME Keir AH Sharpe 2005 The B7/CD28 costimulatory family in autoimmunity Immunol Rev 204 128 143 15790355 1:CAS:528:DC%2BD2MXkslGns70%3D 10.1111/j.0105-2896.2005.00242.x (Pubitemid 40460498)
17. TR Malek A Yu V Vincek P Scibelli L Kong 2002 CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2 Immunity 17 167 178 12196288 1:CAS:528: DC%2BD38Xms1yqu7k%3D 10.1016/S1074-7613(02)00367-9 (Pubitemid 35245959)
18. L Su RJ Creusot EM Gallo SM Chan PJ Utz CG Fathman J Ermann 2004 Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene J Immunol 173 4994 5001 15470042 1:CAS:528:DC%2BD2cXotFCqur0%3D
19. L Gorelik RA Flavell 2000 Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease Immunity 12 171 181 10714683 1:CAS:528:DC%2BD3cXhslKqsLg%3D 10.1016/S1074-7613(00)80170-3
20. JC Marie JJ Letterio M Gavin AY Rudensky 2005 TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells J Exp Med 201 1061 1067 15809351 1:CAS:528:DC%2BD2MXjtFWlsrY%3D 10.1084/jem.20042276 (Pubitemid 40524674)
21. KA Hogquist TA Baldwin SC Jameson 2005 Central tolerance: learning self-control in the thymus Nat Rev Immunol 5 772 782 16200080 1:CAS:528:DC%2BD2MXhtVGrurjN 10.1038/nri1707 (Pubitemid 41400851)
22. M Kronenberg A Rudensky 2005 Regulation of immunity by self-reactive T cells Nature 435 598 604 15931212 1:CAS:528:DC%2BD2MXks1Oguro%3D 10.1038/nature03725 (Pubitemid 40825499)
23. MS Jordan A Boesteanu AJ Reed AL Petrone AE Holenbeck MA Lerman A Naji AJ Caton 2001 Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide Nat Immunol 2 301 306 11276200 1:CAS:528: DC%2BD3MXis1aktLg%3D 10.1038/86302 (Pubitemid 33706340)
24. R Pacholczyk H Ignatowicz P Kraj L Ignatowicz 2006 Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells Immunity 25 249 259 16879995 1:CAS:528:DC%2BD28XpvVGjsrw%3D 10.1016/j.immuni.2006.05.016 (Pubitemid 44224144)
25. R Pacholczyk J Kern N Singh M Iwashima P Kraj L Ignatowicz 2007 Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells Immunity 27 493 504 17869133 1:CAS:528:DC%2BD2sXhtFWmu7fK 10.1016/j.immuni.2007. 07.019 (Pubitemid 47418672)
26. M Takahashi K Nakamura K Honda Y Kitamura T Mizutani Y Araki T Kabemura Y Chijiiwa N Harada H Nawata 2006 An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis Dig Dis Sci 51 677 686 16614988 10.1007/s10620-006-3191-2
27. AM Thornton EM Shevach 2000 Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific J Immunol 164 183 190 10605010 1:CAS:528:DC%2BD3cXisVyk
28. T Takahashi Y Kuniyasu M Toda N Sakaguchi M Itoh M Iwata J Shimizu S Sakaguchi 1998 Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state Int Immunol 10 1969 1980 9885918 1:CAS:528:DyaK1MXmtFehtQ%3D%3D 10.1093/intimm/10.12.1969
29. Szymczak-Workman AL, Workman CJ, Vignali DAA (2009) Cutting edge: regulatory T cells do not require stimulation through their T cell receptor to suppress. J Immunol (in press)
30. CS Hsieh Y Liang AJ Tyznik SG Self D Liggitt AY Rudensky 2004 Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors Immunity 21 267 277 15308106 1:CAS:528:DC%2BD2cXnsVKlt7c%3D 10.1016/j.immuni. 2004.07.009 (Pubitemid 39094055)
31. CC Picca AJ Caton 2005 The role of self-peptides in the development of CD4+ CD25+ regulatory T cells Curr Opin Immunol 17 131 136 15766671 1:CAS:528:DC%2BD2MXit1Cht7s%3D 10.1016/j.coi.2005.01.003 (Pubitemid 40343098)
32. R Pacholczyk P Kraj L Ignatowicz 2002 Peptide specificity of thymic selection of CD4+CD25+ T cells J Immunol 168 613 620 11777953 1:CAS:528:DC%2BD38XksFWmsw%3D%3D
33. DJ Pennington B Silva-Santos T Silberzahn M Escorcio-Correia MJ Woodward SJ Roberts AL Smith PJ Dyson AC Hayday 2006 Early events in the thymus affect the balance of effector and regulatory T cells Nature 444 1073 1077 17190001 1:CAS:528:DC%2BD28XhtlemtLnE 10.1038/nature06051
34. HM van Santen C Benoist D Mathis 2004 Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells J Exp Med 200 1221 1230 15534371 10.1084/jem.20041022 1:CAS:528:DC%2BD2cXhtVSisr%2FN (Pubitemid 39552564)
35. MS Anderson ES Venanzi L Klein Z Chen SP Berzins SJ Turley H von Boehmer R Bronson A Dierich C Benoist D Mathis 2002 Projection of an immunological self shadow within the thymus by the aire protein Science 298 1395 1401 12376594 1:CAS:528:DC%2BD38Xos1Wnsb8%3D 10.1126/science.1075958 (Pubitemid 35346134)
36. B Kyewski L Klein 2006 A central role for central tolerance Annu Rev Immunol 24 571 606 16551260 1:CAS:528:DC%2BD28XkvFSqtLk%3D 10.1146/annurev. immunol.23.021704.115601
37. K Aschenbrenner LM D'Cruz EH Vollmann M Hinterberger J Emmerich LK Swee A Rolink L Klein 2007 Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells Nat Immunol 8 351 358 17322887 1:CAS:528:DC%2BD2sXjt1SqsL0%3D 10.1038/ni1444 (Pubitemid 46745410)
38. MA Gavin JP Rasmussen JD Fontenot V Vasta VC Manganiello JA Beavo AY Rudensky 2007 Foxp3-dependent programme of regulatory T-cell differentiation Nature 445 771 775 17220874 1:CAS:528:DC%2BD2sXhslSqs74%3D 10.1038/nature05543 (Pubitemid 46279714)
39. W Lin D Haribhai LM Relland N Truong MR Carlson CB Williams TA Chatila 2007 Regulatory T cell development in the absence of functional Foxp3 Nat Immunol 8 359 368 17273171 1:CAS:528:DC%2BD2sXjt1SqsLo%3D 10.1038/ni1445 (Pubitemid 46745411)
40. MS Anderson ES Venanzi Z Chen SP Berzins C Benoist D Mathis 2005 The cellular mechanism of Aire control of T cell tolerance Immunity 23 227 239 16111640 1:CAS:528:DC%2BD2MXpvVCnu7s%3D 10.1016/j.immuni.2005.07.005 (Pubitemid 41169291)
41. N Kuroda T Mitani N Takeda N Ishimaru R Arakaki Y Hayashi Y Bando K Izumi T Takahashi T Nomura S Sakaguchi T Ueno Y Takahama D Uchida S Sun F Kajiura Y Mouri H Han A Matsushima G Yamada M Matsumoto 2005 Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice J Immunol 174 1862 1870 15699112 1:CAS:528: DC%2BD2MXhtV2rsr8%3D
42. JD Fontenot JP Rasmussen MA Gavin AY Rudensky 2005 A function for interleukin 2 in Foxp3-expressing regulatory T cells Nat Immunol 6 1142 1151 16227984 1:CAS:528:DC%2BD2MXhtFamsb%2FI 10.1038/ni1263 (Pubitemid 41541792)
43. N Watanabe YH Wang HK Lee T Ito W Cao YJ Liu 2005 Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus Nature 436 1181 1185 16121185 1:CAS:528:DC%2BD2MXovVOgtrw%3D 10.1038/nature03886 (Pubitemid 41232298)
44. H Kurobe C Liu T Ueno F Saito I Ohigashi N Seach R Arakaki Y Hayashi T Kitagawa M Lipp RL Boyd Y Takahama 2006 CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance Immunity 24 165 177 16473829 1:CAS:528:DC%2BD28XitVOks7o%3D 10.1016/j.immuni.2005.12.011 (Pubitemid 43214586)
45. A Liston KM Nutsch AG Farr JM Lund JP Rasmussen PA Koni AY Rudensky 2008 Differentiation of regulatory Foxp3+ T cells in the thymic cortex Proc Natl Acad Sci USA 105 11903 11908 18695219 1:CAS:528:DC%2BD1cXhtVCnurjI 10.1073/pnas.0801506105
46. CW Lio CS Hsieh 2008 A two-step process for thymic regulatory T cell development Immunity 28 100 111 18199417 1:CAS:528:DC%2BD1cXht1Ont78%3D 10.1016/j.immuni.2007.11.021
47. JC Marie D Liggitt AY Rudensky 2006 Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor Immunity 25 441 454 16973387 1:CAS:528:DC%2BD28XhtVOjtLzP 10.1016/j.immuni.2006.07.012 (Pubitemid 44354215)
48. GD Sempowski SJ Cross CS Heinly RM Scearce BF Haynes 2004 CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis J Immunol 172 787 794 14707048 1:CAS:528:DC%2BD2cXnvVeh
49. Q Tang KJ Henriksen EK Boden AJ Tooley J Ye SK Subudhi XX Zheng TB Strom JA Bluestone 2003 Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells J Immunol 171 3348 3352 14500627 1:CAS:528:DC%2BD3sXnvFSrsbs%3D
50. A Vella JD Cooper CE Lowe N Walker S Nutland B Widmer R Jones SM Ring W McArdle ME Pembrey DP Strachan DB Dunger RC Twells DG Clayton JA Todd 2005 Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms Am J Hum Genet 76 773 779 15776395 1:CAS:528:DC%2BD2MXjs12rt7k%3D 10.1086/429843 (Pubitemid 40563099)
51. AL Bayer A Yu D Adeegbe TR Malek 2005 Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period J Exp Med 201 769 777 15753210 1:CAS:528:DC%2BD2MXitl2rt7o%3D 10.1084/jem.20041179 (Pubitemid 40403028)
52. S Sakaguchi 2005 Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self Nat Immunol 6 345 352 15785760 1:CAS:528:DC%2BD2MXisVyitLY%3D 10.1038/ni1178 (Pubitemid 41716771)
53. JA Bluestone AK Abbas 2003 Natural versus adaptive regulatory T cells Nat Rev Immunol 3 253 257 12658273 1:CAS:528:DC%2BD3sXitleqtLg%3D 10.1038/nri1032 (Pubitemid 37323210)
54. H Groux A O'Garra M Bigler M Rouleau S Antonenko JE de Vries MG Roncarolo 1997 A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature 389 737 742 9338786 1:CAS:528:DyaK2sXmvVSgtb0%3D 10.1038/39614 (Pubitemid 27458961)
55. PL Vieira JR Christensen S Minaee EJ O'Neill FJ Barrat A Boonstra T Barthlott B Stockinger DC Wraith A O'Garra 2004 IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells J Immunol 172 5986 5993 15128781 1:CAS:528:DC%2BD2cXjs1OjtLg%3D
56. HL Weiner 2001 Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells Immunol Rev 182 207 214 11722636 1:CAS:528:DC%2BD3MXpt1eisbo%3D 10.1034/j.1600-065X.2001.1820117.x (Pubitemid 33070220)
57. A Skapenko JR Kalden PE Lipsky H Schulze-Koops 2005 The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors J Immunol 175 6107 6116 16237107 1:CAS:528:DC%2BD2MXhtFahurfK
58. SG Zheng 2008 The critical role of TGF-beta1 in the development of induced Foxp3+ regulatory T cells Int J Clin Exp Med 1 192 202 19079658 1:CAS:528:DC%2BD1cXht1amu7fP
59. W Chen W Jin N Hardegen Kj Lei L Li N Marinos G McGrady SM Wahl 2003 Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-{beta} induction of transcription factor Foxp3 J Exp Med 198 1875 1886 14676299 1:CAS:528:DC%2BD3sXpvFaktLg%3D 10.1084/jem.20030152 (Pubitemid 38032120)
60. AP Kohm PA Carpentier HA Anger SD Miller 2002 Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis J Immunol 169 4712 4716 12391178 1:CAS:528: DC%2BD38XosVSjsr8%3D
61. KJ Maloy L Salaun R Cahill G Dougan NJ Saunders F Powrie 2003 CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms J Exp Med 197 111 119 12515818 1:CAS:528:DC%2BD3sXjslWltg%3D%3D 10.1084/jem.20021345 (Pubitemid 36110262)
62. SG Zheng JH Wang MN Koss F Quismorio Jr JD Gray DA Horwitz 2004 CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-{beta} suppress a stimulatory graft-versus-host disease with a lupus-like syndrome J Immunol 172 1531 1539 14734731 1:CAS:528:DC%2BD2cXptlyqsg%3D%3D
63. I Apostolou H von Boehmer 2004 In vivo instruction of suppressor commitment in naive T cells J Exp Med 199 1401 1408 15148338 1:CAS:528:DC%2BD2cXkt1Chu78%3D 10.1084/jem.20040249 (Pubitemid 38685731)
64. K Kretschmer I Apostolou D Hawiger K Khazaie MC Nussenzweig H von Boehmer 2005 Inducing and expanding regulatory T cell populations by foreign antigen Nat Immunol 6 1219 1227 16244650 1:CAS:528:DC%2BD2MXhtlShur3J 10.1038/ni1265 (Pubitemid 43045633)
65. I Apostolou A Sarukhan L Klein H von Boehmer 2002 Origin of regulatory T cells with known specificity for antigen Nat Immunol 3 756 763 12089509 1:CAS:528:DC%2BD38Xls1SnurY%3D
66. PA Taylor CJ Lees BR Blazar 2002 The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality Blood 99 3493 3499 11986199 1:CAS:528:DC%2BD38XjvVGnsrs%3D 10.1182/blood.V99.10.3493 (Pubitemid 34534513)
67. MJ Benson K Pino-Lagos M Rosemblatt RJ Noelle 2007 All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation J Exp Med 204 1765 1774 17620363 1:CAS:528:DC%2BD2sXptVyjs7Y%3D 10.1084/jem.20070719 (Pubitemid 47236315)
68. S Floess J Freyer C Siewert U Baron S Olek J Polansky K Schlawe HD Chang T Bopp E Schmitt S Klein-Hessling E Serfling A Hamann J Huehn 2007 Epigenetic control of the foxp3 locus in regulatory T cells PLoS Biol 5 e38 17298177 10.1371/journal.pbio.0050038 1:CAS:528:DC%2BD2sXhslOru7k%3D (Pubitemid 46256667)
69. K Steinbrink E Graulich S Kubsch J Knop AH Enk 2002 CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity Blood 99 2468 2476 11895781 1:CAS:528:DC%2BD38XisFyhsb8%3D 10.1182/blood.V99.7.2468 (Pubitemid 34525434)
70. V Verhasselt O Vosters C Beuneu C Nicaise P Stordeur M Goldman 2004 Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells Eur J Immunol 34 762 772 14991606 1:CAS:528:DC%2BD2cXitlGgt7o%3D 10.1002/eji.200324552 (Pubitemid 39255924)
71. J Masuyama S Kaga S Kano S Minota 2002 A novel costimulation pathway via the 4C8 antigen for the induction of CD4+ regulatory T cells J Immunol 169 3710 3716 12244164 1:CAS:528:DC%2BD38XnsFeltrk%3D
72. S Grundstrom L Cederbom A Sundstedt P Scheipers F Ivars 2003 Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo J Immunol 170 5008 5017 12734345
73. MR Walker DJ Kasprowicz VH Gersuk A Benard M Van Landeghen JH Buckner SF Ziegler 2003 Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells J Clin Invest 112 1437 1443 14597769 1:CAS:528:DC%2BD3sXovVGqsL4%3D
74. MK Levings R Sangregorio F Galbiati S Squadrone R de Waal Malefyt MG Roncarolo 2001 IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells J Immunol 166 5530 5539 11313392 1:CAS:528:DC%2BD3MXjtFyrtbc%3D
75. C Kemper AC Chan JM Green KA Brett KM Murphy JP Atkinson 2003 Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype Nature 421 388 392 12540904 1:CAS:528:DC%2BD3sXlsVansQ%3D%3D 10.1038/nature01315 (Pubitemid 36157938)
76. D Mucida Y Park G Kim O Turovskaya I Scott M Kronenberg H Cheroutre 2007 Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid Science 317 256 260 17569825 1:CAS:528:DC%2BD2sXnsFaqt78%3D 10.1126/science. 1145697 (Pubitemid 47076203)
77. CM Sun JA Hall RB Blank N Bouladoux M Oukka JR Mora Y Belkaid 2007 Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid J Exp Med 204 1775 1785 17620362 1:CAS:528:DC%2BD2sXptVyjs7c%3D 10.1084/jem.20070602 (Pubitemid 47236316)
78. EA Moseman X Liang AJ Dawson A Panoskaltsis-Mortari AM Krieg YJ Liu BR Blazar W Chen 2004 Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells J Immunol 173 4433 4442 15383574 1:CAS:528:DC%2BD2cXnslWmtr0%3D
79. P Verginis HS Li G Carayanniotis 2005 Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells J Immunol 174 7433 7439 15905592 1:CAS:528:DC%2BD2MXkt1OlsL4%3D
80. JL Coombes KRR Siddiqui CV Rancibia-Carcamo J Hall CM Sun Y Belkaid F Powrie 2007 A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-{beta} and retinoic acid dependent mechanism J Exp Med 204 1757 1764 17620361 1:CAS:528:DC%2BD2sXptVyjs7k%3D 10.1084/jem.20070590 (Pubitemid 47236314)
81. F Ghiringhelli PE Puig S Roux A Parcellier E Schmitt E Solary G Kroemer F Martin B Chauffert L Zitvogel 2005 Tumor cells convert immature myeloid dendritic cells into TGF-{beta}-secreting cells inducing CD4+CD25+ regulatory T cell proliferation J Exp Med 202 919 929 16186184 1:CAS:528:DC%2BD2MXhtVygt73F 10.1084/jem.20050463 (Pubitemid 41396892)
82. WP Min D Zhou TE Ichim GH Strejan X Xia J Yang X Huang B Garcia D White P Dutartre AM Jevnikar R Zhong 2003 Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance J Immunol 170 1304 1312 12538690 1:CAS:528:DC%2BD3sXnvVOlsQ%3D%3D
83. TL Denning YC Wang SR Patel IR Williams B Pulendran 2007 Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses Nat Immunol 8 1086 1094 17873879 1:CAS:528:DC%2BD2sXhtVCkurnN 10.1038/ni1511 (Pubitemid 47423756)
84. K Roelofs-Haarhuis X Wu E Gleichmann 2004 Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells J Immunol 173 1043 1050 15240692 1:CAS:528:DC%2BD2cXlsVGju7k%3D
85. R Liu CA La XF Bai Y Jee M Price DI Campagnolo P Christadoss TL Vollmer KL Van FD Shi 2005 Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia J Immunol 175 7898 7904 16339525 1:CAS:528:DC%2BD2MXht12jtrfJ
86. S Qin SP Cobbold H Pope J Elliott D Kioussis J Davies H Waldmann 1993 "Infectious" transplantation tolerance Science 259 974 977 8094901 1:CAS:528:DyaK3sXhsVKjt7s%3D 10.1126/science.8094901
87. SP Cobbold R Castejon E Adams D Zelenika L Graca S Humm H Waldmann 2004 Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants J Immunol 172 6003 6010 15128783 1:CAS:528:DC%2BD2cXjs1OjtLY%3D
88. D Dieckmann CH Bruett H Ploettner MB Lutz G Schuler 2002 Human CD4+CD25+ regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells J Exp Med 196 247 253 12119349 1:CAS:528:DC%2BD38XlsV2ms7g%3D 10.1084/jem.20020642 (Pubitemid 34787514)
89. H Jonuleit E Schmitt H Kakirman M Stassen J Knop AH Enk 2002 Infectious tolerance: human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ T helper cells J Exp Med 196 255 260 12119350 1:CAS:528:DC%2BD38XlsV2ms7k%3D 10.1084/jem.20020394 (Pubitemid 34787515)
90. Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 Cells. Annu Rev Immunol (in press)
91. E Bettelli Y Carrier W Gao T Korn TB Strom M Oukka HL Weiner VK Kuchroo 2006 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 235 238 16648838 1:CAS:528: DC%2BD28XksVGns7g%3D 10.1038/nature04753
92. L Xu A Kitani I Fuss W Strober 2007 Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta J Immunol 178 6725 6729 17513718 1:CAS:528:DC%2BD2sXlsVOnt7w%3D
93. MG Roncarolo S Gregori M Battaglia R Bacchetta K Fleischhauer MK Levings 2006 Interleukin-10-secreting type 1 regulatory T cells in rodents and humans Immunol Rev 212 28 50 16903904 1:CAS:528:DC%2BD28XpvFegtr4%3D 10.1111/j.0105-2896.2006.00420.x (Pubitemid 44116698)
94. R Bacchetta C Sartirana MK Levings C Bordignon S Narula MG Roncarolo 2002 Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines Eur J Immunol 32 2237 2245 12209636 1:CAS:528:DC%2BD38XmslSltL8%3D 10.1002/1521-4141(200208)32:8<2237:: AID-IMMU2237>3.0.CO;2-2 (Pubitemid 34965886)
95. FJ Barrat DJ Cua A Boonstra DF Richards C Crain HF Savelkoul R de Waal-Malefyt RL Coffman CM Hawrylowicz A O'Garra 2002 In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines J Exp Med 195 603 616 11877483 1:CAS:528:DC%2BD38XitV2nu7w%3D 10.1084/jem.20011629 (Pubitemid 34461505)
96. C Burkhart GY Liu SM Anderton B Metzler DC Wraith 1999 Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10 Int Immunol 11 1625 1634 10508180 1:CAS:528:DyaK1MXmvFaqu7o%3D 10.1093/intimm/11.10.1625 (Pubitemid 29481729)
97. MA Curotto de Lafaille N Kutchukhidze S Shen Y Ding H Yee JJ Lafaille 2008 Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation Immunity 29 114 126 18617425 1:CAS:528: DC%2BD1cXptF2mtb4%3D 10.1016/j.immuni.2008.05.010
98. MA Curotto de Lafaille AC Lino N Kutchukhidze JJ Lafaille 2004 CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion J Immunol 173 7259 7268 15585848 1:CAS:528:DC%2BD2cXhtVCqur%2FL
99. D Mucida N Kutchukhidze A Erazo M Russo JJ Lafaille MA Curotto de Lafaille 2005 Oral tolerance in the absence of naturally occurring Tregs J Clin Invest 115 1923 1933 15937545 1:CAS:528:DC%2BD2MXlvF2qtLw%3D 10.1172/JCI24487 (Pubitemid 40979732)
100. H Fukaura SC Kent MJ Pietrusewicz SJ Khoury HL Weiner DA Hafler 1996 Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients J Clin Invest 98 70 77 8690806 1:CAS:528:DyaK28XktFWgsb4%3D 10.1172/JCI118779
101. MO Li YY Wan RA Flavell 2007 T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation Immunity 26 579 591 17481928 1:CAS:528:DC%2BD2sXmt1ajs7k%3D 10.1016/j.immuni.2007.03.014 (Pubitemid 46756347)
102. M Mamura W Lee TJ Sullivan A Felici AL Sowers JP Allison JJ Letterio 2004 CD28 disruption exacerbates inflammation in Tgf-{beta}1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-{beta}1 Blood 103 4594 4601 15016653 1:CAS:528:DC%2BD2cXlt1Krt7w%3D 10.1182/blood-2003-08-2897 (Pubitemid 38745988)
103. L Fahlen S Read L Gorelik SD Hurst RL Coffman RA Flavell F Powrie 2005 T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells J Exp Med 201 737 746 15753207 1:CAS:528:DC%2BD2MXitl2rt7w%3D 10.1084/jem.20040685 (Pubitemid 40395119)
104. ML Chen MJ Pittet L Gorelik RA Flavell R Weissleder BH von K Khazaie 2005 Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo Proc Natl Acad Sci USA 102 419 424 15623559 1:CAS:528:DC%2BD2MXptFSrsg%3D%3D 10.1073/pnas.0408197102 (Pubitemid 40116782)
105. A Hamann DP Andrew D Jablonski-Westrich B Holzmann EC Butcher 1994 Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo J Immunol 152 3282 3293 7511642 1:CAS:528:DyaK2cXis1yitLs%3D
106. M Iwata A Hirakiyama Y Eshima H Kagechika C Kato SY Song 2004 Retinoic acid imprints gut-homing specificity on T cells Immunity 21 527 538 15485630 1:CAS:528:DC%2BD2cXpvVygtLw%3D 10.1016/j.immuni.2004.08.011 (Pubitemid 39370508)
107. MW Carroll WW Overwijk DR Surman K Tsung B Moss NP Restifo 1998 Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen J Natl Cancer Inst 90 1881 1887 9862625 1:CAS:528:DyaK1MXjtFyksQ%3D%3D 10.1093/jnci/90.24.1881
108. D Vignali 2008 How many mechanisms do regulatory T cells need? Eur J Immunol 38 908 911 18395857 1:CAS:528:DC%2BD1cXlvFems7o%3D 10.1002/eji.200738114
109. Q Tang JA Bluestone 2008 The Foxp3+ regulatory T cell: a jack of all trades, master of regulation Nat Immunol 9 239 244 18285775 1:CAS:528: DC%2BD1cXitVOjt7o%3D 10.1038/ni1572 (Pubitemid 351267321)
110. DK Sojka YH Huang DJ Fowell 2008 Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target Immunology 124 13 22 18346152 1:CAS:528:DC%2BD1cXltlens7s%3D 10.1111/j.1365-2567.2008.02813.x
111. DC Gondek LF Lu SA Quezada S Sakaguchi RJ Noelle 2005 Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism J Immunol 174 1783 1786 15699103 1:CAS:528:DC%2BD2MXhtV2ku7w%3D
112. X Cao SF Cai TA Fehniger J Song LI Collins DR Piwnica-Worms TJ Ley 2007 Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance Immunity 27 635 646 17919943 1:CAS:528:DC%2BD2sXht1ygurzJ 10.1016/j.immuni.2007.08.014 (Pubitemid 47628832)
113. AL Mellor DH Munn 2004 IDO expression by dendritic cells: tolerance and tryptophan catabolism Nat Rev Immunol 4 762 774 15459668 1:CAS:528: DC%2BD2cXotVSlsLg%3D 10.1038/nri1457 (Pubitemid 39336293)
114. C Mottet HH Uhlig F Powrie 2003 Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells J Immunol 170 3939 3943 12682220 1:CAS:528:DC%2BD3sXislektbk%3D
115. LW Collison CJ Workman TT Kuo K Boyd Y Wang KM Vignali R Cross D Sehy RS Blumberg DA Vignali 2007 The inhibitory cytokine IL-35 contributes to regulatory T-cell function Nature 450 566 569 18033300 1:CAS:528:DC%2BD2sXhtlCrtbzI 10.1038/nature06306 (Pubitemid 350190247)
116. R Kuhn J Lohler D Rennick K Rajewsky W Muller 1993 Interleukin-10- deficient mice develop chronic enterocolitis Cell 75 263 274 8402911 1:STN:280:DyaK2c%2Fgs1Gmug%3D%3D 10.1016/0092-8674(93)80068-P (Pubitemid 23320290)
117. F Powrie R Correa-Oliveira S Mauze RL Coffman 1994 Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity J Exp Med 179 589 600 7905019 1:CAS:528:DyaK2cXhtVCltLw%3D 10.1084/jem.179.2.589
118. C Asseman S Mauze MW Leach RL Coffman F Powrie 1999 An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation J Exp Med 190 995 1004 10510089 1:CAS:528:DyaK1MXmsVClt7s%3D 10.1084/jem.190.7.995 (Pubitemid 29480828)
119. C Asseman S Read F Powrie 2003 Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10 J Immunol 171 971 978 12847269 1:CAS:528:DC%2BD3sXltFylsr4%3D
120. YP Rubtsov JP Rasmussen EY Chi J Fontenot L Castelli X Ye P Treuting L Siewe A Roers WR Henderson Jr W Muller AY Rudensky 2008 Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces Immunity 28 546 558 18387831 1:CAS:528:DC%2BD1cXkvV2it7c%3D 10.1016/j.immuni. 2008.02.017
121. HH Uhlig J Coombes C Mottet A Izcue C Thompson A Fanger A Tannapfel JD Fontenot F Ramsdell F Powrie 2006 Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis J Immunol 177 5852 5860 17056509 1:CAS:528:DC%2BD28XhtFSns77E
122. CL Hvas J Kelsen J Agnholt P Hollsberg M Tvede JK Moller JF Dahlerup 2007 Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria Scand J Gastroenterol 42 592 601 17454880 1:CAS:528:DC%2BD2sXmt12qsbo%3D 10.1080/00365520601013754 (Pubitemid 46633815)
123. AB Kulkarni CG Huh D Becker A Geiser M Lyght KC Flanders AB Roberts MB Sporn JM Ward S Karlsson 1993 Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death Proc Natl Acad Sci USA 90 770 774 8421714 1:CAS:528:DyaK3sXhtVShtrY%3D 10.1073/pnas.90.2.770 (Pubitemid 23028947)
124. L Fahlen S Read L Gorelik SD Hurst RL Coffman RA Flavell F Powrie 2005 T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells J Exp Med 201 737 746 15753207 1:CAS:528:DC%2BD2MXitl2rt7w%3D 10.1084/jem.20040685 (Pubitemid 40395119)
125. F Powrie J Carlino MW Leach S Mauze RL Coffman 1996 A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells J Exp Med 183 2669 2674 8676088 1:CAS:528:DyaK28Xjslait78%3D 10.1084/jem.183.6.2669 (Pubitemid 26192376)
126. T Oida X Zhang M Goto S Hachimura M Totsuka S Kaminogawa HL Weiner 2003 CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism J Immunol 170 2516 2522 12594277 1:CAS:528:DC%2BD3sXht12ht7w%3D
127. MC Kullberg V Hay AW Cheever M Mamura A Sher JJ Letterio EM Shevach CA Piccirillo 2005 TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation Eur J Immunol 35 2886 2895 16180248 1:CAS:528:DC%2BD2MXhtFKjt7vP 10.1002/eji.200526106 (Pubitemid 41555084)
128. SG Kang HW Lim OM Andrisani HE Broxmeyer CH Kim 2007 Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells J Immunol 179 3724 3733 17785809 1:CAS:528:DC%2BD2sXpvFKlsLg%3D
129. Collison LW, Pillai MR, Chaturvedi V, Vignali DAA (2009) Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol (in press)
130. E Bardel F Larousserie P Charlot-Rabiega A Coulomb-L'Hermine O Devergne 2008 Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35 J Immunol 181 6898 6905 18981109 1:CAS:528:DC%2BD1cXhtlaisr3M
131. IP Lewkowich NS Herman KW Schleifer MP Dance BL Chen KM Dienger AA Sproles JS Shah J Kohl Y Belkaid M Wills-Karp 2005 CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function J Exp Med 202 1549 1561 16314437 1:CAS:528: DC%2BD2MXhtlSqtLbP 10.1084/jem.20051506 (Pubitemid 41746601)
132. EM Ling T Smith XD Nguyen C Pridgeon M Dallman J Arbery VA Carr DS Robinson 2004 Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease Lancet 363 608 615 14987885 1:CAS:528:DC%2BD2cXhsVOnsLY%3D 10.1016/S0140-6736(04)15592-X (Pubitemid 38264178)
133. LS Ou E Goleva C Hall DY Leung 2004 T regulatory cells in atopic dermatitis and subversion of their activity by superantigens J Allergy Clin Immunol 113 756 763 15100684 1:CAS:528:DC%2BD2cXjt1alt7w%3D 10.1016/j.jaci.2004. 01.772 (Pubitemid 38530433)
134. D Hartl B Koller AT Mehlhorn D Reinhardt T Nicolai DJ Schendel M Griese S Krauss-Etschmann 2007 Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma J Allergy Clin Immunol 119 1258 1266 17412402 1:CAS:528:DC%2BD2sXkslersrg%3D 10.1016/j.jaci.2007.02.023 (Pubitemid 46654192)
135. CA Akdis T Blesken M Akdis B Wuthrich K Blaser 1998 Role of interleukin 10 in specific immunotherapy J Clin Invest 102 98 106 9649562 1:CAS:528:DyaK1cXktlWhtbk%3D 10.1172/JCI2250
136. J Kearley JE Barker DS Robinson CM Lloyd 2005 Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent J Exp Med 202 1539 1547 16314435 1:CAS:528:DC%2BD2MXhtlSqtLbO 10.1084/jem.20051166 (Pubitemid 41746600)
137. M Ostroukhova C Seguin-Devaux TB Oriss B Dixon-McCarthy L Yang BT Ameredes TE Corcoran A Ray 2004 Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3 J Clin Invest 114 28 38 15232609 1:CAS:528:DC%2BD2cXls1altL8%3D
138. O Akbari GJ Freeman EH Meyer EA Greenfield TT Chang AH Sharpe G Berry RH DeKruyff DT Umetsu 2002 Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity Nat Med 8 1024 1032 12145647 1:CAS:528:DC%2BD38Xms1aitr4%3D 10.1038/nm745 (Pubitemid 35033708)
139. JW Oh CM Seroogy EH Meyer O Akbari G Berry CG Fathman RH Dekruyff DT Umetsu 2002 CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation J Allergy Clin Immunol 110 460 468 12209095 1:CAS:528:DC%2BD38XnvVSru70%3D 10.1067/mai.2002.127512
140. G Hansen JJ McIntire VP Yeung G Berry GJ Thorbecke L Chen RH DeKruyff DT Umetsu 2000 CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation J Clin Invest 105 61 70 10619862 1:CAS:528:DC%2BD3cXislSrsQ%3D%3D 10.1172/JCI7589
141. K Presser D Schwinge M Wegmann S Huber S Schmitt A Quaas JH Maxeiner S Finotto AW Lohse M Blessing C Schramm 2008 Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity J Immunol 181 7751 7758 19017964 1:CAS:528:DC%2BD1cXhtl2gsL7N
142. F Meiler J Zumkehr S Klunker B Ruckert CA Akdis M Akdis 2008 In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure J Exp Med 205 2887 2898 19001136 1:CAS:528:DC%2BD1cXhsVClt7jP 10.1084/jem.20080193
143. F Meiler S Klunker M Zimmermann CA Akdis M Akdis 2008 Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors Allergy 63 1455 1463 18925882 1:CAS:528:DC%2BD1cXhsVemsbnM 10.1111/j.1398-9995.2008.01774.x
144. MS Wilson JT Pesce TR Ramalingam RW Thompson A Cheever TA Wynn 2008 Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells J Immunol 181 6942 6954 18981114 1:CAS:528:DC%2BD1cXhtlaisr3J
145. O Boyman CD Surh J Sprent 2006 Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease Expert Opin Biol Ther 6 1323 1331 17223740 1:CAS:528:DC%2BD28Xht1eks7vK 10.1517/14712598.6. 12.1323 (Pubitemid 44875686)
146. JF Bach L Chatenoud 2001 Tolerance to islet autoantigens in type 1 diabetes Annu Rev Immunol 19 131 161 11244033 1:CAS:528:DC%2BD3MXivFKgtbs%3D 10.1146/annurev.immunol.19.1.131 (Pubitemid 32368032)
147. S You MA Alyanakian B Segovia D Damotte J Bluestone JF Bach L Chatenoud 2008 Immunoregulatory pathways controlling progression of autoimmunity in NOD mice Ann NY Acad Sci 1150 300 310 19120317 1:CAS:528:DC%2BD1MXhsFGqtrw%3D
148. AJ Wu H Hua SH Munson HO McDevitt 2002 Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice Proc Natl Acad Sci USA 99 12287 12292 12221281 1:CAS:528:DC%2BD38XntlCksL4%3D 10.1073/pnas.172382999
149. V Szanya J Ermann C Taylor C Holness CG Fathman 2002 The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 J Immunol 169 2461 2465 12193715 1:CAS:528:DC%2BD38XmsF2gurw%3D
150. S You M Belghith S Cobbold MA Alyanakian C Gouarin S Barriot C Garcia H Waldmann JF Bach L Chatenoud 2005 Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells Diabetes 54 1415 1422 15855328 1:CAS:528:DC%2BD2MXktVCksLo%3D 10.2337/diabetes.54.5.1415 (Pubitemid 40586672)
151. JM Lawson J Tremble C Dayan H Beyan RD Leslie M Peakman TI Tree 2008 Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes Clin Exp Immunol 154 353 359 19037920 1:CAS:528:DC%2BD1MXjs1Kqsg%3D%3D 10.1111/j.1365-2249.2008.03810.x
152. S You B Leforban C Garcia JF Bach JA Bluestone L Chatenoud 2007 Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment Proc Natl Acad Sci USA 104 6335 6340 17389382 1:CAS:528:DC%2BD2sXks1aqsrw%3D 10.1073/pnas.0701171104 (Pubitemid 47186095)
153. F Billiard E Litvinova D Saadoun F Djelti D Klatzmann JL Cohen G Marodon BL Salomon 2006 Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation J Immunol 177 2167 2174 16887976 1:CAS:528:DC%2BD28Xns1KhtLo%3D
154. KV Tarbell S Yamazaki K Olson P Toy RM Steinman 2004 CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes J Exp Med 199 1467 1477 15184500 1:CAS:528:DC%2BD2cXkvV2jsLk%3D 10.1084/jem.20040180 (Pubitemid 38780402)
155. B Salomon DJ Lenschow L Rhee N Ashourian B Singh A Sharpe JA Bluestone 2000 B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes Immunity 12 431 440 10795741 1:CAS:528:DC%2BD3cXivFyrsbg%3D 10.1016/S1074-7613(00)80195-8
156. KC Herold W Hagopian JA Auger E Poumian-Ruiz L Taylor D Donaldson SE Gitelman DM Harlan D Xu RA Zivin JA Bluestone 2002 Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus N Engl J Med 346 1692 1698 12037148 1:CAS:528:DC%2BD38XktVansLY%3D 10.1056/NEJMoa012864 (Pubitemid 34547482)
157. KC Herold SE Gitelman U Masharani W Hagopian B Bisikirska D Donaldson K Rother B Diamond DM Harlan JA Bluestone 2005 A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes Diabetes 54 1763 1769 15919798 1:CAS:528:DC%2BD2MXltVait7o%3D 10.2337/diabetes.54.6.1763 (Pubitemid 40770766)
158. M Battaglia A Stabilini E Draghici B Migliavacca S Gregori E Bonifacio MG Roncarolo 2006 Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells Diabetes 55 1571 1580 16731819 1:CAS:528:DC%2BD28XlsF2rtLY%3D 10.2337/db05-1576 (Pubitemid 44324109)
159. Q Tang KJ Henriksen M Bi EB Finger G Szot J Ye EL Masteller H McDevitt M Bonyhadi JA Bluestone 2004 In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes J Exp Med 199 1455 1465 15184499 1:CAS:528:DC%2BD2cXkvV2jsLg%3D 10.1084/jem.20040139 (Pubitemid 38780401)
160. HF McFarland R Martin 2007 Multiple sclerosis: a complicated picture of autoimmunity Nat Immunol 8 913 919 17712344 1:CAS:528:DC%2BD2sXptlSku7Y%3D 10.1038/ni1507 (Pubitemid 47300005)
161. V Viglietta C Baecher-Allan HL Weiner DA Hafler 2004 Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 199 971 979 15067033 1:CAS:528:DC%2BD2cXjtVejurw%3D 10.1084/jem.20031579 (Pubitemid 38481088)
162. J Haas A Hug A Viehover B Fritzsching CS Falk A Filser T Vetter L Milkova M Korporal B Fritz B Storch-Hagenlocher PH Krammer E Suri-Payer B Wildemann 2005 Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis Eur J Immunol 35 3343 3352 16206232 1:CAS:528: DC%2BD2MXht1ylu7jF 10.1002/eji.200526065 (Pubitemid 41672538)
163. K Venken N Hellings K Hensen JL Rummens R Medaer M D'Hooghe B Dubois J Raus P Stinissen 2006 Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression J Neurosci Res 83 1432 1446 16583400 1:CAS:528: DC%2BD28XmtlOqtrY%3D 10.1002/jnr.20852 (Pubitemid 43844989)
164. J Huan N Culbertson L Spencer R Bartholomew GG Burrows YK Chou D Bourdette SF Ziegler H Offner AA Vandenbark 2005 Decreased FOXP3 levels in multiple sclerosis patients J Neurosci Res 81 45 52 15952173 1:CAS:528:DC%2BD2MXlvFCksrY%3D 10.1002/jnr.20522 (Pubitemid 41139109)
165. MJ McGeachy LA Stephens SM Anderton 2005 Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system J Immunol 175 3025 3032 16116190 1:CAS:528:DC%2BD2MXos1Gitbo%3D
166. X Zhang DN Koldzic L Izikson J Reddy RF Nazareno S Sakaguchi VK Kuchroo HL Weiner 2004 IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells Int Immunol 16 249 256 14734610 1:CAS:528:DC%2BD2cXmtlyqug%3D%3D 10.1093/intimm/dxh029 (Pubitemid 38195655)
167. KM Spach FE Nashold BN Dittel CE Hayes 2006 IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis J Immunol 177 6030 6037 17056528 1:CAS:528:DC%2BD28XhtFSns7zL
168. T Korn J Reddy W Gao E Bettelli A Awasthi TR Petersen BT Backstrom RA Sobel KW Wucherpfennig TB Strom M Oukka VK Kuchroo 2007 Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation Nat Med 13 423 431 17384649 1:CAS:528:DC%2BD2sXjvVaqurw%3D 10.1038/nm1564 (Pubitemid 46559831)
169. GZ Liu AC Gomes P Putheti V Karrenbauer K Kostulas R Press J Hillert P Hjelmstrom XG Gao 2006 Increased soluble 4-1BB ligand (4-1BBL) levels in peripheral blood of patients with multiple sclerosis Scand J Immunol 64 412 419 16970683 1:CAS:528:DC%2BD28XhtF2qtr7L 10.1111/j.1365-3083.2006.01796.x (Pubitemid 44408797)
170. X Zhang J Reddy H Ochi D Frenkel VK Kuchroo HL Weiner 2006 Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells Int Immunol 18 495 503 16540527 1:CAS:528:DC%2BD28XivVKisrs%3D 10.1093/intimm/dxh390
171. ML Chen BS Yan Y Bando VK Kuchroo HL Weiner 2008 Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis J Immunol 180 7327 7337 18490732 1:CAS:528: DC%2BD1cXmtVanurw%3D
172. DJ Mekala RS Alli TL Geiger 2005 IL-10-dependent suppression of experimental allergic encephalomyelitis by Th2-differentiated, anti-TCR redirected T lymphocytes J Immunol 174 3789 3797 15749920 1:CAS:528: DC%2BD2MXitVehtb4%3D
173. M Viguier F Lemaitre O Verola MS Cho G Gorochov L Dubertret H Bachelez P Kourilsky L Ferradini 2004 Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells J Immunol 173 1444 1453 15240741 1:CAS:528:DC%2BD2cXlsVGhs70%3D
174. ZZ Yang AJ Novak MJ Stenson TE Witzig SM Ansell 2006 Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma Blood 107 3639 3646 16403912 1:CAS:528: DC%2BD28Xkt1Giuro%3D 10.1182/blood-2005-08-3376
175. EY Woo CS Chu TJ Goletz K Schlienger H Yeh G Coukos SC Rubin LR Kaiser CH June 2001 Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer Cancer Res 61 4766 4772 11406550 1:CAS:528:DC%2BD3MXks1GrtbY%3D
176. TJ Curiel G Coukos L Zou X Alvarez P Cheng P Mottram M Evdemon-Hogan JR Conejo-Garcia L Zhang M Burow Y Zhu S Wei I Kryczek B Daniel A Gordon L Myers A Lackner ML Disis KL Knutson L Chen W Zou 2004 Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Nat Med 10 942 949 15322536 1:CAS:528:DC%2BD2cXntFSkt7g%3D 10.1038/nm1093 (Pubitemid 39273735)
177. E Sato SH Olson J Ahn B Bundy H Nishikawa F Qian AA Jungbluth D Frosina S Gnjatic C Ambrosone J Kepner T Odunsi G Ritter S Lele YT Chen H Ohtani LJ Old K Odunsi 2005 Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer Proc Natl Acad Sci USA 102 18538 18543 16344461 1:CAS:528:DC%2BD28Xpt1Om 10.1073/pnas.0509182102 (Pubitemid 43011261)
178. UK Liyanage TT Moore HG Joo Y Tanaka V Herrmann G Doherty JA Drebin SM Strasberg TJ Eberlein PS Goedegebuure DC Linehan 2002 Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma J Immunol 169 2756 2761 12193750 1:CAS:528:DC%2BD38XmsF2ns7k%3D
179. H Kawaida K Kono A Takahashi H Sugai K Mimura N Miyagawa H Omata A Ooi H Fujii 2005 Distribution of CD4+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer J Surg Res 124 151 157 15734494 1:CAS:528:DC%2BD2MXhslWrsbc%3D 10.1016/j.jss.2004.10.004 (Pubitemid 40269816)
180. T Sasada M Kimura Y Yoshida M Kanai A Takabayashi 2003 CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression Cancer 98 1089 1099 12942579 10.1002/cncr.11618 (Pubitemid 37022112)
181. LA Ormandy T Hillemann H Wedemeyer MP Manns TF Greten F Korangy 2005 Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma Cancer Res 65 2457 2464 15781662 1:CAS:528: DC%2BD2MXisFGnsL0%3D 10.1158/0008-5472.CAN-04-3232 (Pubitemid 40490158)
182. Salama P, Phillips M, Grieu F, Morris M, Zeps N, Joseph D, Platell C, Iacopetta B (2008) Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 14:8228-8235
183. J Carreras A Lopez-Guillermo BC Fox L Colomo A Martinez G Roncador E Montserrat E Campo AH Banham 2006 High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma Blood 108 2957 2964 16825494 1:CAS:528:DC%2BD28XhtFygtrvK 10.1182/blood-2006-04-018218 (Pubitemid 44776932)
184. T Alvaro M Lejeune MT Salvado R Bosch JF Garcia J Jaen AH Banham G Roncador C Montalban MA Piris 2005 Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells Clin Cancer Res 11 1467 1473 15746048 10.1158/1078-0432.CCR-04-1869 (Pubitemid 40315228)
185. ME Morgan JH van Bilsen AM Bakker B Heemskerk MW Schilham FC Hartgers BG Elferink ZL van der RR de Vries TW Huizinga TH Ottenhoff RE Toes 2005 Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans Hum Immunol 66 13 20 15620457 1:CAS:528:DC%2BD2cXhtFGhsLrJ 10.1016/j.humimm.2004.05. 016 (Pubitemid 40037706)
186. SE Allan SQ Crome NK Crellin L Passerini TS Steiner R Bacchetta MG Roncarolo MK Levings 2007 Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production Int Immunol 19 345 354 17329235 1:CAS:528:DC%2BD2sXjsleku7Y%3D 10.1093/intimm/dxm014 (Pubitemid 46523383)
187. DQ Tran H Ramsey EM Shevach 2007 Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype Blood 110 2983 2990 17644734 1:CAS:528:DC%2BD2sXht1Smu7%2FO 10.1182/blood-2007-06-094656 (Pubitemid 350006952)
188. S Onizuka I Tawara J Shimizu S Sakaguchi T Fujita E Nakayama 1999 Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody Cancer Res 59 3128 3133 10397255 1:CAS:528: DyaK1MXksVCks7s%3D
189. J Shimizu S Yamazaki S Sakaguchi 1999 Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity J Immunol 163 5211 5218 10553041 1:CAS:528:DyaK1MXntlKktbw%3D
190. F Ghiringhelli C Menard M Terme C Flament J Taieb N Chaput PE Puig S Novault B Escudier E Vivier A Lecesne C Robert JY Blay J Bernard S Caillat-Zucman A Freitas T Tursz O Wagner-Ballon C Capron W Vainchencker F Martin L Zitvogel 2005 CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner J Exp Med 202 1075 1085 16230475 1:CAS:528:DC%2BD2MXhtFelu7rL 10.1084/jem.20051511 (Pubitemid 41464501)
191. L Gil-Guerrero J Dotor IL Huibregtse N Casares AB Lopez-Vazquez F Rudilla JI Riezu-Boj J Lopez-Sagaseta J Hermida DS Van J Bezunartea D Llopiz P Sarobe J Prieto F Borras-Cuesta JJ Lasarte 2008 In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1 J Immunol 181 126 135 18566377 1:CAS:528:DC%2BD1cXnsVGjs70%3D
192. K Loser J Apelt M Voskort M Mohaupt S Balkow T Schwarz S Grabbe S Beissert 2007 IL-10 controls ultraviolet-induced carcinogenesis in mice J Immunol 179 365 371 17579057 1:CAS:528:DC%2BD2sXmsF2gsr0%3D
193. L Strauss C Bergmann M Szczepanski W Gooding JT Johnson TL Whiteside 2007 A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment Clin Cancer Res 13 4345 4354 17671115 1:CAS:528: DC%2BD2sXotlGqsLg%3D 10.1158/1078-0432.CCR-07-0472 (Pubitemid 47219698)
194. I Kryczek S Wei L Zou G Zhu P Mottram H Xu L Chen W Zou 2006 Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells J Immunol 177 40 44 16785496 1:CAS:528:DC%2BD28XlvV2nt7o%3D
195. I Kryczek L Zou P Rodriguez G Zhu S Wei P Mottram M Brumlik P Cheng T Curiel L Myers A Lackner X Alvarez A Ochoa L Chen W Zou 2006 B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma J Exp Med 203 871 881 16606666 1:CAS:528:DC%2BD28Xjsl2is74%3D 10.1084/jem.20050930
196. K Wing Y Onishi P Prieto-Martin T Yamaguchi M Miyara Z Fehervari T Nomura S Sakaguchi 2008 CTLA-4 control over Foxp3+ regulatory T cell function Science 322 271 275 18845758 1:CAS:528:DC%2BD1cXht1Slu7%2FJ 10.1126/science.1160062
197. F Fallarino C sselin-Paturel C Vacca R Bianchi S Gizzi MC Fioretti G Trinchieri U Grohmann P Puccetti 2004 Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement J Immunol 173 3748 3754 15356121 1:CAS:528: DC%2BD2cXnsVWltbY%3D
198. MD Sharma B Baban P Chandler DY Hou N Singh H Yagita M Azuma BR Blazar AL Mellor DH Munn 2007 Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase J Clin Invest 117 2570 2582 17710230 1:CAS:528:DC%2BD2sXhtVCms7jJ 10.1172/JCI31911 (Pubitemid 47494358)
199. F Fallarino U Grohmann KW Hwang C Orabona C Vacca R Bianchi ML Belladonna MC Fioretti ML Alegre P Puccetti 2003 Modulation of tryptophan catabolism by regulatory T cells Nat Immunol 4 1206 1212 14578884 1:CAS:528: DC%2BD3sXpt1Sntrs%3D 10.1038/ni1003 (Pubitemid 37547898)
200. Y Belkaid BT Rouse 2005 Natural regulatory T cells in infectious disease Nat Immunol 6 353 360 15785761 1:CAS:528:DC%2BD2MXisVyitb8%3D 10.1038/ni1181 (Pubitemid 41716772)
201. Y Belkaid CA Piccirillo S Mendez EM Shevach DL Sacks 2002 CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity Nature 420 502 507 12466842 1:CAS:528:DC%2BD38Xpt1Whs7w%3D 10.1038/nature01152 (Pubitemid 35477041)
202. H Hisaeda Y Maekawa D Iwakawa H Okada K Himeno K Kishihara S Tsukumo K Yasutomo 2004 Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells Nat Med 10 29 30 14702631 1:CAS:528:DC%2BD2cXlsFGg 10.1038/nm975 (Pubitemid 38524694)
203. MG Netea R Sutmuller C Hermann CA Van der Graaf JW Van der Meer JH van Krieken T Hartung G Adema BJ Kullberg 2004 Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells J Immunol 172 3712 3718 15004175 1:CAS:528:DC%2BD2cXhvVKis7k%3D
204. M Kursar K Bonhagen J Fensterle A Kohler R Hurwitz T Kamradt SH Kaufmann HW Mittrucker 2002 Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses J Exp Med 196 1585 1592 12486101 1:CAS:528:DC%2BD38XpslWlu74%3D 10.1084/jem.20011347 (Pubitemid 36026470)
205. M Kursar M Koch HW Mittrucker G Nouailles K Bonhagen T Kamradt SH Kaufmann 2007 Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis J Immunol 178 2661 2665 17312107 1:CAS:528: DC%2BD2sXhvFSju7Y%3D
206. V Guyot-Revol JA Innes S Hackforth T Hinks A Lalvani 2006 Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis Am J Respir Crit Care Med 173 803 810 16339919 1:CAS:528:DC%2BD28Xms1Cgtr0%3D 10.1164/rccm.200508-1294OC
207. S Suvas U Kumaraguru CD Pack S Lee BT Rouse 2003 CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses J Exp Med 198 889 901 12975455 1:CAS:528:DC%2BD3sXnsV2ntLo%3D 10.1084/jem.20030171 (Pubitemid 37152926)
208. S Suvas AK Azkur BS Kim U Kumaraguru BT Rouse 2004 CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions J Immunol 172 4123 4132 15034024 1:CAS:528:DC%2BD2cXitlOqsL0%3D
209. R Cabrera Z Tu Y Xu RJ Firpi HR Rosen C Liu DR Nelson 2004 An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection Hepatology 40 1062 1071 15486925 1:CAS:528:DC%2BD2cXhtVCgt73P 10.1002/hep.20454 (Pubitemid 39425561)
210. JN Stoop RG van der Molen CC Baan LJ van der Laan EJ Kuipers JG Kusters HL Janssen 2005 Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection Hepatology 41 771 778 15791617 1:CAS:528:DC%2BD2MXjsV2msLs%3D 10.1002/hep.20649 (Pubitemid 40462939)
211. EM Aandahl J Michaelsson WJ Moretto FM Hecht DF Nixon 2004 Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens J Virol 78 2454 2459 14963140 1:CAS:528:DC%2BD2cXhs1SltLw%3D 10.1128/JVI.78.5.2454-2459.2004 (Pubitemid 38228938)
212. AL Kinter M Hennessey A Bell S Kern Y Lin M Daucher M Planta M McGlaughlin R Jackson SF Ziegler AS Fauci 2004 CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status J Exp Med 200 331 343 15280419 1:CAS:528:DC%2BD2cXmsVCkur8%3D 10.1084/jem.20032069 (Pubitemid 39031252)
213. L Weiss V Donkova-Petrini L Caccavelli M Balbo C Carbonneil Y Levy 2004 Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients Blood 104 3249 3256 15271794 1:CAS:528:DC%2BD2cXhtVWhurrP 10.1182/blood-2004-01-0365 (Pubitemid 39507143)
214. JP Scott-Browne S Shafiani G Tucker-Heard K Ishida-Tsubota JD Fontenot AY Rudensky MJ Bevan KB Urdahl 2007 Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis J Exp Med 204 2159 2169 17709423 1:CAS:528:DC%2BD2sXhtVWnurnO 10.1084/jem.20062105 (Pubitemid 47360876)
215. JM Lund L Hsing TT Pham AY Rudensky 2008 Coordination of early protective immunity to viral infection by regulatory T cells Science 320 1220 1224 18436744 1:CAS:528:DC%2BD1cXmt1Oisrk%3D 10.1126/science.1155209 (Pubitemid 351929511)
216. Y Belkaid 2008 Role of Foxp3-positive regulatory T cells during infection Eur J Immunol 38 918 921 18395860 1:CAS:528:DC%2BD1cXlvFems7k%3D 10.1002/eji.200738120
217. CF Anderson M Oukka VJ Kuchroo D Sacks 2007 CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis J Exp Med 204 285 297 17283207 1:CAS:528:DC%2BD2sXitVekt7c%3D 10.1084/jem.20061886 (Pubitemid 46294545)