-
1
-
-
0038725685
-
Negative selection - Clearing out the bad apples from the T-cell repertoire
-
Palmer, E. Negative selection - clearing out the bad apples from the T-cell repertoire. Nature Rev. Immunol. 3, 383-391 (2003).
-
(2003)
Nature Rev. Immunol.
, vol.3
, pp. 383-391
-
-
Palmer, E.1
-
2
-
-
0025923305
-
Non-deletional mechanisms of peripheral and central tolerance: Studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen
-
Hammerling, G. J. et al. Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen. Immunol. Rev. 122, 47-67 (1991).
-
(1991)
Immunol. Rev.
, vol.122
, pp. 47-67
-
-
Hammerling, G.J.1
-
3
-
-
0032578459
-
Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation
-
Wang, F., Huang, C. Y. & Kanagawa, O. Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation. Proc. Natl Acad. Sci. USA 95, 11834-11839 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11834-11839
-
-
Wang, F.1
Huang, C.Y.2
Kanagawa, O.3
-
4
-
-
0034305741
-
Receptor editing in developing T cells
-
McGargill, M. A., Derbinski, J. M. & Hogquist, K. A. Receptor editing in developing T cells. Nature Immunol. 1, 336-341 (2000).
-
(2000)
Nature Immunol.
, vol.1
, pp. 336-341
-
-
McGargill, M.A.1
Derbinski, J.M.2
Hogquist, K.A.3
-
5
-
-
16844363097
-
A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
-
Fontenot, J. D. & Rudensky, A. Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nature Immunol. 6, 331-337 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 331-337
-
-
Fontenot, J.D.1
Rudensky, A.Y.2
-
6
-
-
16844365788
-
+ regulatory T cells in immunological tolerance to self and non-self
-
+ regulatory T cells in immunological tolerance to self and non-self. Nature Immunol. 6, 345-352 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 345-352
-
-
Sakaguchi, S.1
-
7
-
-
2542477129
-
Starting at the beginning: New perspectives on the biology of mucosal T cells
-
Cheroutre, H. Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu. Rev. Immunol. 22, 217-246 (2004).
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 217-246
-
-
Cheroutre, H.1
-
8
-
-
10644257558
-
2: A critical mediator in Vα14/ NKT cell differentiation
-
2: a critical mediator in Vα14/ NKT cell differentiation. Mol. Immunol. 42, 413-417 (2005).
-
(2005)
Mol. Immunol.
, vol.42
, pp. 413-417
-
-
Franki, A.S.1
-
9
-
-
9144259224
-
The fourth way? Harnessing aggressive tendencies in the thymus
-
Baldwin, T. A., Hogquist, K. A. & Jameson, S. C. The fourth way? Harnessing aggressive tendencies in the thymus. J. Immunol. 173, 6515-6520 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 6515-6520
-
-
Baldwin, T.A.1
Hogquist, K.A.2
Jameson, S.C.3
-
10
-
-
16244367143
-
AIRE and APECED: Molecular insights into an autoimmune disease
-
Villasenor, J., Benoist, C. & Mathis, D. AIRE and APECED: molecular insights into an autoimmune disease. Immunol. Rev. 204, 156-164 (2005).
-
(2005)
Immunol. Rev.
, vol.204
, pp. 156-164
-
-
Villasenor, J.1
Benoist, C.2
Mathis, D.3
-
11
-
-
0037103223
-
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo
-
Brewer, J. A., Kanagawa, O., Sleckman, B. P. & Muglia, L. J. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J. Immunol. 169, 1837-1843 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 1837-1843
-
-
Brewer, J.A.1
Kanagawa, O.2
Sleckman, B.P.3
Muglia, L.J.4
-
12
-
-
0030659110
-
Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection
-
Martin, S. & Bevan, M. J. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27, 2726-2736 (1997).
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 2726-2736
-
-
Martin, S.1
Bevan, M.J.2
-
15
-
-
22344450566
-
The timing of TCRα expression critically influences T cell development and selection
-
Baldwin, T. A., Sandau, M. M., Jameson, S. C. & Hogquist, K. A. The timing of TCRα expression critically influences T cell development and selection. J. Exp. Med. 202, 111-121 (2005). In this study, the authors developed a TCR-transgenic model system in which the TCR α-chain was expressed at the appropriate developmental stage. In this model, H-Y-specific clonal deletion occurs at the late (SP) stage of development, which is in contrast to conventional models, in which it occurs early. This indicates that early deletion is a non-physiological aspect of TCR-transgenic models.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 111-121
-
-
Baldwin, T.A.1
Sandau, M.M.2
Jameson, S.C.3
Hogquist, K.A.4
-
16
-
-
0037417978
-
Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation
-
Zhan, Y. et al. Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation. Proc. Natl Acad. Sci. USA 100, 1197-1202 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1197-1202
-
-
Zhan, Y.1
-
17
-
-
0028054017
-
T-cell apoptosis detected in situ during positive and negative selection in the thymus
-
Surh, C. D. & Sprent, J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103 (1994).
-
(1994)
Nature
, vol.372
, pp. 100-103
-
-
Surh, C.D.1
Sprent, J.2
-
18
-
-
0037223065
-
Identification of the targets of clonal deletion in an unmanipulated thymus
-
Cho, H. J. et al. Identification of the targets of clonal deletion in an unmanipulated thymus. J. Immunol. 170, 10-13 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 10-13
-
-
Cho, H.J.1
-
19
-
-
0023663430
-
T cell tolerance by clonal elimination in the thymus
-
Kappler, J. W., Roehm, N. & Marrack, P. T cell tolerance by clonal elimination in the thymus. Cell 49, 273-280 (1987).
-
(1987)
Cell
, vol.49
, pp. 273-280
-
-
Kappler, J.W.1
Roehm, N.2
Marrack, P.3
-
20
-
-
0037309260
-
Rules for gene usage inferred from a comparison of large-scale gene expression profiles of T and B lymphocyte development
-
Hoffmann, R., Bruno, L., Seidl, T., Rolink, A. & Melchers, F. Rules for gene usage inferred from a comparison of large-scale gene expression profiles of T and B lymphocyte development. J. Immunol. 170, 1339-1353 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 1339-1353
-
-
Hoffmann, R.1
Bruno, L.2
Seidl, T.3
Rolink, A.4
Melchers, F.5
-
21
-
-
6344274985
-
The regulated expression of a diverse set of genes during thymocyte positive selection in vivo
-
Mick, V. E., Starr, T. K., McCaughtry, T. M., McNeil, L. K. & Hogquist, K. A. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173, 5434-5444 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 5434-5444
-
-
Mick, V.E.1
Starr, T.K.2
McCaughtry, T.M.3
McNeil, L.K.4
Hogquist, K.A.5
-
22
-
-
1842737707
-
Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals
-
Huang, Y. H., Li, D., Winoto, A. & Robey, E. A. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl Acad. Sci. USA 101, 4936-4941 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4936-4941
-
-
Huang, Y.H.1
Li, D.2
Winoto, A.3
Robey, E.A.4
-
23
-
-
3142763848
-
Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation
-
Tabrizifard, S. et al. Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation. J. Immunol. 173, 1094-1102 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 1094-1102
-
-
Tabrizifard, S.1
-
24
-
-
0037036140
-
Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy
-
Bousso, P., Bhakta, N. R., Lewis, R. S. & Robey, E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296, 1876-1880 (2002).
-
(2002)
Science
, vol.296
, pp. 1876-1880
-
-
Bousso, P.1
Bhakta, N.R.2
Lewis, R.S.3
Robey, E.4
-
25
-
-
4344668118
-
CCR7 signals are essential for cortex-medulla migration of developing thymocytes
-
Ueno, T. et al. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J. Exp. Med. 200, 493-505 (2004).
-
(2004)
J. Exp. Med.
, vol.200
, pp. 493-505
-
-
Ueno, T.1
-
26
-
-
1642289268
-
CCR7 directs the migration of thymocytes into the thymic medulla
-
Kwan, J. & Killeen, N. CCR7 directs the migration of thymocytes into the thymic medulla. J. Immunol. 172, 3999-4007 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 3999-4007
-
-
Kwan, J.1
Killeen, N.2
-
27
-
-
0028817585
-
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
-
Weih, F. et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80, 331-340 (1995).
-
(1995)
Cell
, vol.80
, pp. 331-340
-
-
Weih, F.1
-
28
-
-
0028952482
-
Expression of relB is required for the development of thymic medulla and dendritic cells
-
Burkly, L. et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536 (1995).
-
(1995)
Nature
, vol.373
, pp. 531-536
-
-
Burkly, L.1
-
29
-
-
10744226628
-
NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
-
Kajiura, F. et al. NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 172, 2067-2075 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 2067-2075
-
-
Kajiura, F.1
-
30
-
-
0041884736
-
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR
-
Boehm, T., Scheu, S., Pfeffer, K. & Bleul, C. C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR. J. Exp. Med. 198, 757-769 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 757-769
-
-
Boehm, T.1
Scheu, S.2
Pfeffer, K.3
Bleul, C.C.4
-
31
-
-
0242624626
-
Lymphotoxin pathway directs thymic Aire expression
-
Chin, R. K. et al. Lymphotoxin pathway directs thymic Aire expression. Nature Immunol. 4, 1121-1127 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 1121-1127
-
-
Chin, R.K.1
-
32
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
Reg cells. T-cell-depleted thymic grafts were used to prove that these defects, and the resultant autoimmunity, were intrinsic to thymic stroma.
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
-
33
-
-
0029835390
-
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
-
Laufer, T. M., DeKoning, J., Markowitz, J. S., Lo, D. & Glimcher, L. H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383, 81-85 (1996).
-
(1996)
Nature
, vol.383
, pp. 81-85
-
-
Laufer, T.M.1
DeKoning, J.2
Markowitz, J.S.3
Lo, D.4
Glimcher, L.H.5
-
34
-
-
0031569124
-
Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice
-
DeKoning, J. et al. Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice. J. Immunol. 158, 2558-2566 (1997).
-
(1997)
J. Immunol.
, vol.158
, pp. 2558-2566
-
-
DeKoning, J.1
-
35
-
-
0038544169
-
NIK-dependent RelB activation defines a unique signaling pathway for the development of Vα14i NKT cells
-
Elewaut, D. et al. NIK-dependent RelB activation defines a unique signaling pathway for the development of Vα14i NKT cells. J. Exp. Med. 197, 1623-1633 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1623-1633
-
-
Elewaut, D.1
-
36
-
-
0141678952
-
TRAF6 is a critical factor for dendritic cell maturation and development
-
Kobayashi, T. et al. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19, 3 53-363 (2003).
-
(2003)
Immunity
, vol.19
, pp. 353-363
-
-
Kobayashi, T.1
-
37
-
-
0033006011
-
Development and maturation of secondary lymphoid tissues
-
Fu, Y. X. & Chaplin, D. D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999).
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 399-433
-
-
Fu, Y.X.1
Chaplin, D.D.2
-
38
-
-
0035164360
-
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development
-
Kumanogoh, A. et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J. Immunol. 166, 353-360 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 353-360
-
-
Kumanogoh, A.1
-
39
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson, M. S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
-
40
-
-
0141958180
-
T cell development in mice expressing CD1d directed by a classical MHC class II promoter
-
Forestier, C. et al. T cell development in mice expressing CD1d directed by a classical MHC class II promoter. J. Immunol. 171, 4096-4104 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 4096-4104
-
-
Forestier, C.1
-
42
-
-
0035525290
-
Cross-presentation in viral immunity and self-tolerance
-
Heath, W. R. & Carbone, F. R. Cross-presentation in viral immunity and self-tolerance. Nature Rev. Immunol. 1, 126-134 (2001).
-
(2001)
Nature Rev. Immunol.
, vol.1
, pp. 126-134
-
-
Heath, W.R.1
Carbone, F.R.2
-
43
-
-
7244227645
-
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
-
+ T cells.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1039-1049
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
44
-
-
0037514517
-
A Role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection
-
Buhlmann, J. E., Elkin, S. K. & Sharpe, A. H. A Role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection. J. Immunol. 170, 5421-5428 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 5421-5428
-
-
Buhlmann, J.E.1
Elkin, S.K.2
Sharpe, A.H.3
-
45
-
-
0037089616
-
Perinatal blockade of B7-1 and B7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells
-
Gao, J. X. et al. Perinatal blockade of B7-1 and B7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. J. Exp. Med. 195, 959-971 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 959-971
-
-
Gao, J.X.1
-
46
-
-
0028877057
-
An essential role for gp39, the ligand for CD40, in thymic selection
-
Foy, T. M. et al. An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182, 1377-1388 (1995).
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1377-1388
-
-
Foy, T.M.1
-
47
-
-
0033682056
-
+ immunoregulatory T cells that control autoimmune diabetes
-
+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
-
48
-
-
0347480215
-
+ T cells
-
+ T cells. Immunity 19, 877-889 (2003).
-
(2003)
Immunity
, vol.19
, pp. 877-889
-
-
Serra, R.1
-
49
-
-
4544258485
-
Self-representation in the thymus: An extended view
-
Kyewski, B. & Derbinski, J. Self-representation in the thymus: an extended view. Nature Rev. Immunol. 4, 688-698 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 688-698
-
-
Kyewski, B.1
Derbinski, J.2
-
50
-
-
0346599403
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
-
Aaltonen, J. et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nature Genet. 17, 399-403 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 399-403
-
-
Aaltonen, J.1
-
51
-
-
16944367194
-
Positional cloning of the APECED gene
-
Nagamine, K. et al. Positional cloning of the APECED gene. Nature Genet. 17, 393-398 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 393-398
-
-
Nagamine, K.1
-
52
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C. C. Aire regulates negative selection of organ-specific T cells. Nature Immunol. 4, 350-354 (2003). This was the first study to show that deficiency in the transcriptional regulator AIRE impairs clonal deletion of T cells that recognize tissue-specific antigens, in this case a model self-antigen that is expressed under the control of the RIP.
-
(2003)
Nature Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
Lesage, S.2
Wilson, J.3
Peltonen, L.4
Goodnow, C.C.5
-
53
-
-
7244227646
-
Gene dosage - Limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
-
Liston, A. et al. Gene dosage - limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200, 1015-1026 (2004).
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1015-1026
-
-
Liston, A.1
-
55
-
-
0035374352
-
Subcellular localization of the autoimmune regulator protein. Characterization of nuclear targeting and transcriptional activation domain
-
Pitkanen, J., Vahamurto, P., Krohn, K. & Peterson, P. Subcellular localization of the autoimmune regulator protein. Characterization of nuclear targeting and transcriptional activation domain. J. Biol. Chem. 276, 19597-19602 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19597-19602
-
-
Pitkanen, J.1
Vahamurto, P.2
Krohn, K.3
Peterson, P.4
-
56
-
-
0038824426
-
The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein
-
Pitkanen, J. et al. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275, 16802-16809 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16802-16809
-
-
Pitkanen, J.1
-
57
-
-
22344434168
-
Contrasting models of promiscuous gene expression by thymic epithelium
-
Gillard, G. O. & Fair, A. G. Contrasting models of promiscuous gene expression by thymic epithelium. J. Exp. Med. 202, 15-19 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 15-19
-
-
Gillard, G.O.1
Fair, A.G.2
-
58
-
-
0942288397
-
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
-
Gotter, J., Brors, B., Hergenhahn, M. & Kyewski, B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J. Exp. Med. 199, 155-166 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 155-166
-
-
Gotter, J.1
Brors, B.2
Hergenhahn, M.3
Kyewski, B.4
-
59
-
-
18844362882
-
Chromosomal clustering of genes controlled by the aire transcription factor
-
Johnnidis, J. B. et al. Chromosomal clustering of genes controlled by the aire transcription factor. Proc. Natl Acad. Sci. USA 102, 7233-7238 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7233-7238
-
-
Johnnidis, J.B.1
-
60
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
Derbinski, J. et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202, 33-45 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 33-45
-
-
Derbinski, J.1
-
61
-
-
1642500086
-
AIRE functions as an E3 ubiquitin ligase
-
Uchida, D. et al. AIRE functions as an E3 ubiquitin ligase. J. Exp. Med. 199, 167-172 (2004). In this study, the PHD1 domain of AIRE was shown to mediate ubiquitylation of substrates in vitro, indicating that AIRE might regulate the stability of proteins in the cell.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 167-172
-
-
Uchida, D.1
-
62
-
-
15744397285
-
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease
-
Bottomley, M. J. et al. NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. J. Biol. Chem. 280, 11505-11512 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11505-11512
-
-
Bottomley, M.J.1
-
63
-
-
0037188899
-
Recruitment of Nck by CD3εe reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
-
Gil, D., Schamel, W. W., Montoya, M., Sanchez-Madrid, F. & Alarcon, B. Recruitment of Nck by CD3εe reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109, 901-912 (2002).
-
(2002)
Cell
, vol.109
, pp. 901-912
-
-
Gil, D.1
Schamel, W.W.2
Montoya, M.3
Sanchez-Madrid, F.4
Alarcon, B.5
-
64
-
-
14244262563
-
T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD8 complex of thymocytes
-
Gil, D., Schrum, A. G., Alarcon, B. & Palmer, E. T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD8 complex of thymocytes. J. Exp. Med. 201, 517-522 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 517-522
-
-
Gil, D.1
Schrum, A.G.2
Alarcon, B.3
Palmer, E.4
-
65
-
-
0037076975
-
A LAT mutation that inhibits T cell development yet induces lymphoproliteration
-
Sommers, C. L. et al. A LAT mutation that inhibits T cell development yet induces lymphoproliteration. Science 296, 2040-2043 (2002).
-
(2002)
Science
, vol.296
, pp. 2040-2043
-
-
Sommers, C.L.1
-
66
-
-
0037077094
-
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
-
Aguado, E. et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296, 2036-2040 (2002).
-
(2002)
Science
, vol.296
, pp. 2036-2040
-
-
Aguado, E.1
-
67
-
-
20244365648
-
Mutation of the phospholipase C-γ1-binding site of LAT affects both positive and negative thymocyte selection
-
Sommers, C. L. et al. Mutation of the phospholipase C-γ1-binding site of LAT affects both positive and negative thymocyte selection. J. Exp. Med. 201, 1125-1134 (2005). This study provided a striking example of how attenuation of the TCR signal (in this case, by mutation of a tyrosine phosphorylation site in the adaptor protein LAT) can convert a negatively selecting signal to a positively selecting signal.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1125-1134
-
-
Sommers, C.L.1
-
68
-
-
0034720881
-
A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity
-
Werlen, G., Hausmann, B. & Palmer, E. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity. Nature 406, 422-426 (2000).
-
(2000)
Nature
, vol.406
, pp. 422-426
-
-
Werlen, G.1
Hausmann, B.2
Palmer, E.3
-
69
-
-
12344298492
-
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes
-
McCarty, N. et al. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nature Immunol. 6, 65-72 (2005). The authors of this study used RNA interference to show that the kinase MINK is required for clonal deletion in several models.
-
(2005)
Nature Immunol.
, vol.6
, pp. 65-72
-
-
McCarty, N.1
-
70
-
-
21244489949
-
The CD3ε proline-rich sequence, and its interaction with Nck, is not required for T cell development and function
-
Szymczak, A. L. et al. The CD3ε proline-rich sequence, and its interaction with Nck, is not required for T cell development and function. J. Immunol. 175, 270-275 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 270-275
-
-
Szymczak, A.L.1
-
71
-
-
0028008513
-
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
-
Woronicz, J. D., Calnan, B., Ngo, V. & Winoto, A. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 367, 277-281 (1994).
-
(1994)
Nature
, vol.367
, pp. 277-281
-
-
Woronicz, J.D.1
Calnan, B.2
Ngo, V.3
Winoto, A.4
-
72
-
-
0030977267
-
Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
-
Cheng, L. E., Chan, F. K., Cado, D. & Winoto, A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16, 1865-1875 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 1865-1875
-
-
Cheng, L.E.1
Chan, F.K.2
Cado, D.3
Winoto, A.4
-
73
-
-
0028807837
-
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
-
Calnan, B. J., Szychowski, S., Chan, F. K., Cado, D. & Winoto, A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3, 273-282 (1995).
-
(1995)
Immunity
, vol.3
, pp. 273-282
-
-
Calnan, B.J.1
Szychowski, S.2
Chan, F.K.3
Cado, D.4
Winoto, A.5
-
74
-
-
18344393786
-
Peptide-induced negative selection of thymocytes activates transcription of an NF-κB inhibitor
-
Fiorini, E. et al. Peptide-induced negative selection of thymocytes activates transcription of an NF-κB inhibitor. Mol. Cell 9, 637-648 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 637-648
-
-
Fiorini, E.1
-
75
-
-
15244338878
-
Defective central tolerance induction in NOD mice: Genomics and genetics
-
Zucchelli, S. et al. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 22, 385-396 (2005).
-
(2005)
Immunity
, vol.22
, pp. 385-396
-
-
Zucchelli, S.1
-
76
-
-
10344231974
-
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Birn
-
Liston, A. et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Birn. Immunity 21, 817-830 (2004). References 75 and 76 compared the gene-expression profiles of thymocytes undergoing deletion in TCR-transgenic NOD mice and control mice, and these papers described a general reduction in the level of gene expression that was induced by self-antigen. These studies also used a genetic-backcross approach to identify potentially relevant loci that regulate this process.
-
(2004)
Immunity
, vol.21
, pp. 817-830
-
-
Liston, A.1
-
77
-
-
0035175577
-
A defect in central tolerance in NOD mice
-
Kishimoto, H. & Sprent, J. A defect in central tolerance in NOD mice. Nature Immunol. 2, 1025-1031 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 1025-1031
-
-
Kishimoto, H.1
Sprent, J.2
-
78
-
-
0034974501
-
-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice
-
-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice. J. Autoimmun. 16, 105-113 (2001).
-
(2001)
J. Autoimmun.
, vol.16
, pp. 105-113
-
-
Bergman, M.L.1
-
79
-
-
0037496129
-
The control of apoptosis in lymphocyte selection
-
Strasser, A. & Bouillet, P. The control of apoptosis in lymphocyte selection. Immunol. Rev. 193, 82-92 (2003).
-
(2003)
Immunol. Rev.
, vol.193
, pp. 82-92
-
-
Strasser, A.1
Bouillet, P.2
-
80
-
-
0028117306
-
Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
-
Strasser, A., Harris, A. W., von Boehmer, H. & Cory, S. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc. Natl Acad. Sci. USA 91, 1376-1380 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1376-1380
-
-
Strasser, A.1
Harris, A.W.2
Von Boehmer, H.3
Cory, S.4
-
81
-
-
0037148840
-
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
-
Bouillet, P. et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415, 922-926 (2002).
-
(2002)
Nature
, vol.415
, pp. 922-926
-
-
Bouillet, P.1
-
82
-
-
0036794390
-
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
-
Rathmell, J. C., Lindsten, T., Zong, W. X., Cinalli, R. M. & Thompson, C. B. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature Immunol. 3, 932-939 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 932-939
-
-
Rathmell, J.C.1
Lindsten, T.2
Zong, W.X.3
Cinalli, R.M.4
Thompson, C.B.5
-
83
-
-
7444243152
-
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
-
Harada, H., Quearry, B., Ruiz-Vela, A. & Korsmeyer, S. J. Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc. Natl Acad. Sci. USA 101, 15313-15317 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15313-15317
-
-
Harada, H.1
Quearry, B.2
Ruiz-Vela, A.3
Korsmeyer, S.J.4
-
84
-
-
0034662906
-
Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED)
-
Zuklys, S. et al. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune- polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J. Immunol. 165, 1976-1983 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 1976-1983
-
-
Zuklys, S.1
-
85
-
-
0033939699
-
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse
-
Heino, M. et al. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 30, 1884-1893 (2000).
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 1884-1893
-
-
Heino, M.1
-
86
-
-
0001722505
-
+ dendritic cells
-
+ dendritic cells. Immunity 9, 839-847 (1998).
-
(1998)
Immunity
, vol.9
, pp. 839-847
-
-
Wu, L.1
-
87
-
-
6244280519
-
+ thymocytes associated with intact thymic structure
-
+ thymocytes associated with intact thymic structure. Proc. Natl Acad. Sci. USA 94, 2472-2477 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2472-2477
-
-
Nakagawa, K.1
-
88
-
-
0038544245
-
Differential requirement for Rel/nuclear factor κB family members in natural killer T cell development
-
Sivakumar, V., Hammond, K. J., Howells, N., Pfeffer, K. & Weih, F. Differential requirement for Rel/nuclear factor κB family members in natural killer T cell development. J. Exp. Med. 197, 1613-1621 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1613-1621
-
-
Sivakumar, V.1
Hammond, K.J.2
Howells, N.3
Pfeffer, K.4
Weih, F.5
-
89
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
Anderson, M. S. et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227-239 (2005).
-
(2005)
Immunity
, vol.23
, pp. 227-239
-
-
Anderson, M.S.1
-
90
-
-
13544262691
-
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
-
Kuroda, N. et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 174, 1862-1870 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 1862-1870
-
-
Kuroda, N.1
|