Cutting edge: Regulatory T cells do not require stimulation through their TCR to suppress

Journal of Immunology

Volumn 182, Issue 9, 2009, Pages 1588-1592

  Szymczak Workman, Andrea L ^a   Workman, Creg J ^a   Vignali, Dario A A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; EPITOPE; H 2A(B) ANTIGEN, MOUSE; H-2A(B) ANTIGEN, MOUSE; HLA ANTIGEN CLASS 2; LYMPHOCYTE ANTIGEN RECEPTOR; OVA 323 339; OVA 323-339; OVALBUMIN; PEPTIDE FRAGMENT;

ALLOIMMUNITY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS REACTION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; COCULTURE; CYTOLOGY; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOSUPPRESSION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 70349566221     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803123     Document Type: Article

References (25)

1. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182: 18-32.
2. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
3. + T cells. Microbes Infect. 3: 919-927.
4. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
5. Shevach, E. M. 2006. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 25: 195-201. (Pubitemid 44224153)
6. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
7. Vignali, D. A., L. W. Collison, and C. J. Workman. 2008. How regulatory T cells work. Nat. Rev. Immunol. 8: 523-532.
8. Tang, Q., J. Y. Adams, A. J. Tooley, M. Bi, B. T. Fife, P. Serra, P. Santamaria, R. M. Locksley, M. F. Krummel, and J. A. Bluestone. 2006. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7: 83-92. (Pubitemid 41823872)
9. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004. (Pubitemid 29480828)
10. Collison, L. W., C. J. Workman, T. T. Kuo, K. Boyd, Y. Wang, K. M. Vignali, R. Cross, D. Sehy, R. S. Blumberg, and D. A. Vignali. 2007. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450: 566-569.
11. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 174: 1783-1786.
12. + T cells selectively kill B lymphocytes. Blood 107: 3925-3932.
13. + regulatory T cell activity. J. Immunol. 175: 7274-7280.
14. + regulatory T cells. J. Immunol. 177: 6952-6961.
15. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
16. Barnden, M. J., J. Allison, W. R. Heath, and F. R. Carbone. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76: 34-40.
17. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341: 746-749.
18. Hsieh, C. S., Y. Zheng, Y. Liang, J. D. Fontenot, and A. Y. Rudensky. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7: 401-410.
19. + T cells. Immunity 25: 249-259.
20. Wong, J., R. Obst, M. Correia-Neves, G. Losyev, D. Mathis, and C. Benoist. 2007. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J. Immunol. 178: 7032-7041. (Pubitemid 46847429)
21. + regulatory T cells. Immunity 27: 493-504.
22. + T cells. Cell. Mol. Immunol. 3: 189-195.
23. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302.
24. + T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 105: 2845-2851.
25. Huang, C. T., C. J. Workman, D. Flies, X. Pan, A. L. Marson, G. Zhou, E. L. Hipkiss, S. Ravi, J. Kowalski, H. I. Levitsky, et al. 2004. Role of LAG-3 in regulatory T cells. Immunity 21: 503-513.