Induction of foxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants

Journal of Immunology

Volumn 172, Issue 10, 2004, Pages 6003-6010

  Cobbold, Stephen P ^a   Castejon, Raquel ^a,b   Adams, Elizabeth ^a   Zelenika, Diana ^a,c   Graca, Luis ^a   Humm, Susan ^a   Waldmann, Herman ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^c CENTRE NATIONAL DE GÉNOTYPAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GRAFT REJECTION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN GRAFT; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE; TRANSPLANTATION TOLERANCE;

EID: 2442425262     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.10.6003     Document Type: Article

References (57)

1. Qin, S. X., M. Wise, S. P. Cobbold, L. Leong, Y. C. Kong, J. R. Parnes, and H. Waldmann. 1990. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur. J. Immunol. 20:2737.
2. Chen, Z. K., S. P. Cobbold, H. Waldmann, and S. Metcalfe. 1996. Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation 62:1200.
3. + T cell function but not expansion. Nat. Immunol. 3:1208.
4. Davies, J. D., G. Martin, J. Phillips, S. E. Marshall, S. P. Cobbold, and H. Waldmann. 1996. T cell regulation in adult transplantation tolerance. J. Immunol. 157:529.
5. Davies, J. D., L. Y. Leong, A. Mellor, S. P. Cobbold, and H. Waldmann. 1996. T cell suppression in transplantation tolerance through linked recognition. J. Immunol 156:3602.
6. + T cell tolerance and linked suppression. J. Immunol. 163:4805.
7. Qin, S., S. P. Cobbold, H. Pope, J. Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
8. Graca, L., K. Honey, E. Adams, S. P. Cobbold, and H. Waldmann. 2000. Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J. Immunol. 165:4783.
9. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
10. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212.
11. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
12. Singh, B., S. Read, C. Asseman, V. Malmstrom, C. Mottet, L. A. Stephens, R. Stepankova, H. Tlaskalova, and F. Powrie. 2001. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182:190.
13. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
14. + T regulatory cells. Nat. Immunol. 4:337.
15. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor foxp3. Science 299:1057.
16. + regulatory T cells. Nat. Immunol. 4:330.
17. + suppressor T cells. Immunol. Rev. 182:58.
18. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
19. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168:1080.
20. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
21. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
22. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
23. - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:5558.
24. Graca, L., S. P. Cobbold, and H. Waldmann. 2002. Identification of regulatory T cells in tolerated allografts. J. Exp. Med 195:1641.
25. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
26. Zelenika, D., E. Adams, S. Humm, L. Graca, S. Thompson, S. P. Cobbold, and H. Waldmann. 2002. Regulatory T cells overexpress a subset of Th2 gene transcripts. J. Immunol. 168:1069.
27. Cobbold, S., E. Adams, L. Graca, and H. Waldmann. 2003. Serial analysis of gene expression provides new insights into regulatory T cells. Semin. Immunol. 15:209.
28. Cobbold, S. P., K. N. Nolan, L. Graca, R. Castejon, A. Le Moine, M. R. Frewin, S. Humm, E. Adams, S. Thompson, D. Zelenika, et al. 2003. Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms. Immunol. Rev. 196:109.
29. + T cells or B cells. J. Immunol. 161:1868.
30. Durie, F. H., R. A. Fava, T. M. Foy, A. Aruffo, J. A. Ledbetter, and R. J. Noelle. 1993. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261:1328.
31. Dasch, J. R., D. R. Pace, W. Waegell, D. Inenaga, and L. Ellingsworth. 1989. Monoclonal antibodies recognizing transforming growth factor-β: bioactivity neutralization and transforming growth factor β2 affinity purification. J. Immunol. 142:1536.
32. O'Farrell, A. M., Y. Liu, K. W. Moore, and A. L. Mui. 1998. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 17:1006.
33. Tone, M., Y. Tone, E. Adams, S. F. Yates, M. R. Frewin, S. P. Cobbold, and H. Waldmann. 2003. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. USA 100:15059.
34. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
35. + regulatory T cells by TGF-β induction of transcription factor FoxP3. J. Exp. Med. 198:1875.
36. Cobbold, S. P., E. Adams, S. E. Marshall, J. D. Davies, and H. Waldmann. 1996. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol. Rev. 149:5.
37. Miaw, S. C., A. Choi, E. Yu, H. Kishikawa, and I. C. Ho. 2000. ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 12:323.
38. + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 99:8213.
39. + regulatory cells? Immunity 14:399.
40. + T-cell development is regulated by at least 2 distinct mechanisms. Blood 99:555.
41. + regulatory T cells. J. Immunol. 168:1644.
42. + T cells. J. Immunol. 168:613.
43. + regulatory T calls from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol 168:4399.
44. + T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196:505.
45. Waidmann, M., Y. Allemand, J. Lehmann, S. di Genaro, N. Bucheler, A. Hamann, and I. B. Autenrieth. 2002. Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN-γ and TNF-α production. Gut 50:170.
46. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756.
47. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197:111.
48. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
49. Barthlott, T., G. Kassiotis, and B. Stockinger. 2003. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197:451.
50. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30:1538.
51. Min, W. P., D. Zhou, T. E. Ichim, G. H. Strejan, X. Xia, J. Yang, X. Huang, B. Garcia, D. White, P. Dutartre, et al. 2003. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J. Immunol. 170:1304.
52. + T-cell subsets in determining transplantation rejection or tolerance. Immunol. Rev. 182:164.
53. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629.
54. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:237.
55. Josien, R., P. Douillard, C. Guillot, M. Muschen, I. Anegon, J. Chetritt, S. Menoret, C. Vignes, J. P. Soulillou, and M. C. Cuturi. 1998. A critical role for transforming growth factor-β in donor transfusion-induced allograft tolerance. J. Clin. Invest. 102:1920.
56. Ludviksson, B. R., R. O. Ehrhardt, and W. Strober. 1997. TGF-β production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. J. Immunol. 159:3622.
57. Belghith, M., J. A. Bluestone, S. Barriot, J. Megret, J. F. Bach, and L. Chatenoud. 2003. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 9:1202.