Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Immunity

Volumn 25, Issue 3, 2006, Pages 441-454

  Marie, Julien C ^a   Liggitt, Denny ^a   Rudensky, Alexander Y ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

CELLIMMUNO; DEVBIO

Indexed keywords

CD1 ANTIGEN; FAS LIGAND; GAMMA INTERFERON; PERFORIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FATALITY; FLOW CYTOMETRY; LYMPHOCYTE DIFFERENTIATION; MORTALITY; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TARGET CELL; TH1 CELL;

ANIMALS; ANTIGENS, SURFACE; AUTOIMMUNE DISEASES; CELLS, CULTURED; IMMUNE TOLERANCE; LECTINS, C-TYPE; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; T-LYMPHOCYTES; TIME FACTORS;

EID: 33748465396     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2006.07.012     Document Type: Article

References (43)

1. Beima K.M., Miazgowicz M.M., Lewis M.D., Yan P.S., Huang T.H., and Weinmann A.S. T-bet binding to newly identified target gene promoters is cell-type independent, but results in variable context-dependent functional effects. J. Biol. Chem. 281 (2006) 11992-12000
2. Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., and Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
3. Chen M.L., Pittet M.J., Gorelik L., Flavell R.A., Weissleder R., von Boehmer H., and Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc. Natl. Acad. Sci. USA 102 (2005) 419-424
4. Cobbold S.P., Castejon R., Adams E., Zelenika D., Graca L., Humm S., and Waldmann H. Induction of FoxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172 (2004) 6003-6010
5. Cui J., Shin T., Kawano T., Sato H., Kondo E., Toura I., Kaneko Y., Koseki H., Kanno M., and Taniguchi M. Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 278 (1997) 1623-1626
6. Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425 (2003) 577-584
7. Fahlen L., Read S., Gorelik L., Hurst S.D., Coffman R.L., Flavell R.A., and Powrie F. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J. Exp. Med. 201 (2005) 737-746
8. Fantini M.C., Becker C., Monteleone G., Pallone F., Galle P.R., and Neurath M.F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172 (2004) 5149-5153
9. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22 (2005) 329-341
10. Gorelik L., and Flavell R.A. Abrogation of TGF-beta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12 (2000) 171-181
11. Gorelik L., Constant S., and Flavell R.A. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 195 (2002) 1499-1505
12. Grubin C.E., Kovats S., deRoos P., and Rudensky A.Y. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7 (1997) 197-208
13. Intlekofer A.M., Takemoto N., Wherry E.J., Longworth S.A., Northrup J.T., Palanivel V.R., Mullen A.C., Gasink C.R., Kaech S.M., Miller J.D., et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat. Immunol. 6 (2005) 1236-1244
14. Kulkarni A.B., Huh C.G., Becker D., Geiser A., Lyght M., Flanders K.C., Roberts A.B., Sporn M.B., Ward J.M., and Karlsson S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90 (1993) 770-774
15. Larsson J., Goumans M.J., Sjostrand L.J., van Rooijen M.A., Ward D., Leveen P., Xu X., ten Dijke P., Mummery C.L., and Karlsson S. Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 20 (2001) 1663-1673
16. Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., Perez-Melgosa M., Sweetser M.T., Schlissel M.S., Nguyen S., et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15 (2001) 763-774
17. Letterio J.J., and Roberts A.B. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16 (1998) 137-161
18. Letterio J.J., Geiser A.G., Kulkarni A.B., Roche N.S., Sporn M.B., and Roberts A.B. Maternal rescue of transforming growth factor-beta 1 null mice. Science 264 (1994) 1936-1938
19. Leveen P., Larsson J., Ehinger M., Cilio C.M., Sundler M., Sjostrand L.J., Holmdahl R., and Karlsson S. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood 100 (2002) 560-568
20. Leveen P., Carlsen M., Makowska A., Oddsson S., Larsson J., Goumans M.J., Cilio C.M., and Karlsson S. TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo. Blood 106 (2005) 4234-4240
21. Lin J.T., Martin S.L., Xia L., and Gorham J.D. TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J. Immunol. 174 (2005) 5950-5958
22. Lord G.M., Rao R.M., Choe H., Sullivan B.M., Lichtman A.H., Luscinskas F.W., and Glimcher L.H. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood 106 (2005) 3432-3439
23. Lucas P.J., Kim S.J., Melby S.J., and Gress R.E. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J. Exp. Med. 191 (2000) 1187-1196
24. Ma B., Zhu Z., Homer R.J., Gerard C., Strieter R., and Elias J.A. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol. 172 (2004) 1872-1881
25. Marie J.C., Astier A.L., Rivailler P., Rabourdin-Combe C., Wild T.F., and Horvat B. Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Nat. Immunol. 3 (2002) 659-666
26. Marie J.C., Letterio J.J., Gavin M., and Rudensky A.Y. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J. Exp. Med. 201 (2005) 1061-1067
27. Massague J., Andres J., Attisano L., Cheifetz S., Lopez-Casillas F., Ohtsuki M., and Wrana J.L. TGF-beta receptors. Mol. Reprod. Dev. 32 (1992) 99-104
28. Mendiratta S.K., Martin W.D., Hong S., Boesteanu A., Joyce S., and Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6 (1997) 469-477
29. Nichols K.E., Hom J., Gong S.Y., Ganguly A., Ma C.S., Cannons J.L., Tangye S.G., Schwartzberg P.L., Koretzky G.A., and Stein P.L. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat. Med. 11 (2005) 340-345
30. Park H.B., Paik D.J., Jang E., Hong S., and Youn J. Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells. Int. Immunol. 16 (2004) 1203-1213
31. Pearce E.L., Mullen A.C., Martins G.A., Krawczyk C.M., Hutchins A.S., Zediak V.P., Banica M., DiCioccio C.B., Gross D.A., Mao C.A., et al. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science 302 (2003) 1041-1043
32. Peitz M., Pfannkuche K., Rajewsky K., and Edenhofer F. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc. Natl. Acad. Sci. USA 99 (2002) 4489-4494
33. Peng Y., Laouar Y., Li M.O., Green E.A., and Flavell R.A. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc. Natl. Acad. Sci. USA 101 (2004) 4572-4577
34. Schmidt-Supprian M., Tian J., Grant E.P., Pasparakis M., Maehr R., Ovaa H., Ploegh H.L., Coyle A.J., and Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc. Natl. Acad. Sci. USA 101 (2004) 4566-4571
35. Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., Allen R., Sidman C., Proetzel G., Calvin D., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359 (1992) 693-699
36. Smart N.G., Apelqvist A.A., Gu X., Harmon E.B., Topper J.N., MacDonald R.J., and Kim S.K. Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol. 4 (2006) e39 10.1371/journal.pbio.0040039
37. Srinivas S., Watanabe T., Lin C.S., William C.M., Tanabe Y., Jessell T.M., and Costantini F. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1 (2001) 4
38. Strengell M., Matikainen S., Siren J., Lehtonen A., Foster D., Julkunen I., and Sareneva T. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J. Immunol. 170 (2003) 5464-5469
39. Thomas D.A., and Massague J. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 8 (2005) 369-380
40. Wang J., Xu N., Feng X., Hou N., Zhang J., Cheng X., Chen Y., Zhang Y., and Yang X. Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ. Res. 97 (2005) 821-828
41. Wherry E.J., Blattman J.N., Murali-Krishna K., van der Most R., and Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77 (2003) 4911-4927
42. Wolfer A., Bakker T., Wilson A., Nicolas M., Ioannidis V., Littman D.R., Lee P.P., Wilson C.B., Held W., MacDonald H.R., and Radtke F. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8 T cell development. Nat. Immunol. 2 (2001) 235-241
43. Yaswen L., Kulkarni A.B., Fredrickson T., Mittleman B., Schiffman R., Payne S., Longenecker G., Mozes E., and Karlsson S. Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood 87 (1996) 1439-1445