메뉴 건너뛰기




Volumn 197, Issue 1, 2003, Pages 111-119

CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms

Author keywords

Helicobacter; IL 10; Immune tolerance; Mucosal immunity; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0037243827     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021345     Document Type: Article
Times cited : (665)

References (48)
  • 1
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober, W., I.J. Fuss, and R.S. Blumberg. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495-549.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 2
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    • Duchmann, R., I. Kaiser, E. Hermann, W. Mayet, K. Ewe, and K.H. Meyer zum Buschenfelde. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102: 448-455.
    • (1995) Clin. Exp. Immunol. , vol.102 , pp. 448-455
    • Duchmann, R.1    Kaiser, I.2    Hermann, E.3    Mayet, W.4    Ewe, K.5    Meyer zum Buschenfelde, K.H.6
  • 3
    • 0031569530 scopus 로고    scopus 로고
    • + T cell down-regulation in human intestinal mucosa: Evidence for intestinal tolerance to luminal bacterial antigens
    • + T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J. Immunol. 158:3626-3634.
    • (1997) J. Immunol. , vol.158 , pp. 3626-3634
    • Khoo, U.Y.1    Proctor, I.E.2    Macpherson, A.J.3
  • 7
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 8
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K.J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816-822.
    • (2001) Nat. Immunol. , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 9
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach, E.M. 2000. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18:423-449.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 10
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 12
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.E.1    Shevach, E.M.2
  • 13
    • 0033985780 scopus 로고    scopus 로고
    • + immunoregulatory T cells is antigen nonspecific
    • + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183-190.
    • (2000) J. Immunol. , vol.164 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 14
    • 0034077559 scopus 로고    scopus 로고
    • + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
    • + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 30:1538-1543.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1538-1543
    • Cederbom, L.1    Hall, H.2    Ivars, F.3
  • 15
    • 0034254754 scopus 로고    scopus 로고
    • Anergic T cells inhibit the antigenpresenting function of dendritic cells
    • Vendetti, S., J.G. Chai, J. Dyson, E. Simpson, G. Lombardi, and R. Lechler. 2000. Anergic T cells inhibit the antigenpresenting function of dendritic cells. J. Immunol. 165:1175-1181.
    • (2000) J. Immunol. , vol.165 , pp. 1175-1181
    • Vendetti, S.1    Chai, J.G.2    Dyson, J.3    Simpson, E.4    Lombardi, G.5    Lechler, R.6
  • 17
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 18
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio, J.J., and A.B. Roberts. 1998. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16:137-161.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 21
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon, R.K., S. Tonkonogy, M. Schultz, L.A. Dieleman, W. Grenther, E. Balish, D.M. Rennick, and R.B. Sartor. 1998. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66:5224-5231.
    • (1998) Infect. Immun. , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3    Dieleman, L.A.4    Grenther, W.5    Balish, E.6    Rennick, D.M.7    Sartor, R.B.8
  • 22
    • 0030794060 scopus 로고    scopus 로고
    • Inflammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
    • Cahill, R.J., C.J. Foltz, J.G. Fox, C.A. Dangler, F. Powrie, and D.B. Schauer. 1997. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect. Immun. 65:3126-3131.
    • (1997) Infect. Immun. , vol.65 , pp. 3126-3131
    • Cahill, R.J.1    Foltz, C.J.2    Fox, J.G.3    Dangler, C.A.4    Powrie, F.5    Schauer, D.B.6
  • 23
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
    • Kullberg, M.C., J.M. Ward, P.L. Gorelick, P. Caspar, S. Hieny, A. Cheever, D. Jankovic, and A. Sher. 1998. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect. Immun. 66: 5157-5166.
    • (1998) Infect. Immun. , vol.66 , pp. 5157-5166
    • Kullberg, M.C.1    Ward, J.M.2    Gorelick, P.L.3    Caspar, P.4    Hieny, S.5    Cheever, A.6    Jankovic, D.7    Sher, A.8
  • 25
    • 0029781169 scopus 로고    scopus 로고
    • Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus
    • Fox, J.G., L. Yan, B. Shames, J. Campbell, J.C. Murphy, and X. Li. 1996. Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus. Infect. Immun. 64: 3673-3681.
    • (1996) Infect. Immun. , vol.64 , pp. 3673-3681
    • Fox, J.G.1    Yan, L.2    Shames, B.3    Campbell, J.4    Murphy, J.C.5    Li, X.6
  • 26
    • 0029873909 scopus 로고    scopus 로고
    • Inflanmnatory large bowel disease in inmmnodeficient mice naturally infected with Helicobacter hepaticus
    • Ward, J.M., M.R. Anver, D.C. Haines, J.M. Melhorn, P. Gorelick, L. Yan, and J.G. Fox. 1996. Inflanmnatory large bowel disease in inmmnodeficient mice naturally infected with Helicobacter hepaticus. Lab. Anim. Sci. 46:15-20.
    • (1996) Lab. Anim. Sci. , vol.46 , pp. 15-20
    • Ward, J.M.1    Anver, M.R.2    Haines, D.C.3    Melhorn, J.M.4    Gorelick, P.5    Yan, L.6    Fox, J.G.7
  • 27
    • 0032442035 scopus 로고    scopus 로고
    • SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis
    • Li, X., J.G. Fox, M.T. Whary, L. Yan, B. Shames, and Z. Zhao. 1998. SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis. Infect. Immun. 66:5477-5484.
    • (1998) Infect. Immun. , vol.66 , pp. 5477-5484
    • Li, X.1    Fox, J.G.2    Whary, M.T.3    Yan, L.4    Shames, B.5    Zhao, Z.6
  • 28
    • 0034874511 scopus 로고    scopus 로고
    • Cloning, expression, and catalytic activity of Helicobacter hepaticus urease
    • Beckwith, C.S., D.J. McGee, H.L. Mobley, and L.K. Riley. 2001. Cloning, expression, and catalytic activity of Helicobacter hepaticus urease. Infect. Immun. 69:5914-5920.
    • (2001) Infect. Immun. , vol.69 , pp. 5914-5920
    • Beckwith, C.S.1    McGee, D.J.2    Mobley, H.L.3    Riley, L.K.4
  • 29
    • 0034951122 scopus 로고    scopus 로고
    • Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus
    • Ge, Z., D.A. White, M.T. Whary, and J.G. Fox. 2001. Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus. J. Clin. Microbiol. 39: 2598-2602.
    • (2001) J. Clin. Microbiol. , vol.39 , pp. 2598-2602
    • Ge, Z.1    White, D.A.2    Whary, M.T.3    Fox, J.G.4
  • 30
    • 0035337241 scopus 로고    scopus 로고
    • Cd1341 expression on dendritic cells in the mesenteric lymph nodes drives colitis in t cell-restored scid mice
    • Malmstrom, V., D. Shipton, B. Singh, A. Al-Shamkhani, M.J. Puklavec, A.N. Barclay, and F. Powrie. 2001. Cd1341 expression on dendritic cells in the mesenteric lymph nodes drives colitis in t cell-restored scid mice. J. Immunol. 166: 6972-6981.
    • (2001) J. Immunol. , vol.166 , pp. 6972-6981
    • Malmstrom, V.1    Shipton, D.2    Singh, B.3    Al-Shamkhani, A.4    Puklavec, M.J.5    Barclay, A.N.6    Powrie, F.7
  • 31
    • 0030590652 scopus 로고    scopus 로고
    • Flow cytometric identification of murine neutrophils and monocytes
    • Lagasse, E., and I.L. Weissman. 1996. Flow cytometric identification of murine neutrophils and monocytes. J. Immunol. Methods, 197:139-150.
    • (1996) J. Immunol. Methods , vol.197 , pp. 139-150
    • Lagasse, E.1    Weissman, I.L.2
  • 32
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 33
    • 0034972172 scopus 로고    scopus 로고
    • Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: Cytokine requirements for the induction and maintenance of intestinal inflammation
    • Kullberg, M.C., A.G. Rothfuchs, D. Jankovic, P. Caspar, T.A. Wynn, P.L. Gorelick, A.W. Cheever, and A. Sher. 2001. Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Infect. Immun. 69:4232-4241.
    • (2001) Infect. Immun. , vol.69 , pp. 4232-4241
    • Kullberg, M.C.1    Rothfuchs, A.G.2    Jankovic, D.3    Caspar, P.4    Wynn, T.A.5    Gorelick, P.L.6    Cheever, A.W.7    Sher, A.8
  • 34
    • 0034503471 scopus 로고    scopus 로고
    • Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice
    • Chin, E.Y., C.A. Dangler, J.G. Fox, and D.B. Schauer. 2000. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice. Comp. Med. 50:586-594.
    • (2000) Comp. Med. , vol.50 , pp. 586-594
    • Chin, E.Y.1    Dangler, C.A.2    Fox, J.G.3    Schauer, D.B.4
  • 36
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 37
    • 0035554674 scopus 로고    scopus 로고
    • T cell regulation: A special job or everyone's responsibility?
    • Stockinger, G., T. Barthlott, and G. Kassiotis. 2001. T cell regulation: a special job or everyone's responsibility? Nat. Immunol. 2:757-758.
    • (2001) Nat. Immunol. , vol.2 , pp. 757-758
    • Stockinger, G.1    Barthlott, T.2    Kassiotis, G.3
  • 38
    • 0036107373 scopus 로고    scopus 로고
    • + T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice
    • + T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur. J. Immunol. 32:1282-1291.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1282-1291
    • Hori, S.1    Carvalho, T.L.2    Demengeot, J.3
  • 40
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda, K., B.E. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Forster, and S. Akira. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 10:39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 41
    • 0034019036 scopus 로고    scopus 로고
    • Chronic atrophic gastritis in SCID mice experimentally infected with Campylobacter fetus
    • Young, V.B., C.A. Dangler, J.G. Fox, and D.B. Schauer. 2000. Chronic atrophic gastritis in SCID mice experimentally infected with Campylobacter fetus. Infect. Immun. 68:2110-2118.
    • (2000) Infect. Immun. , vol.68 , pp. 2110-2118
    • Young, V.B.1    Dangler, C.A.2    Fox, J.G.3    Schauer, D.B.4
  • 42
    • 0036128828 scopus 로고    scopus 로고
    • Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
    • Vallance, B.A., W. Deng, L.A. Knodler, and B.B. Finlay. 2002. Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection. Infect. Immun. 70:2070-2081.
    • (2002) Infect. Immun. , vol.70 , pp. 2070-2081
    • Vallance, B.A.1    Deng, W.2    Knodler, L.A.3    Finlay, B.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.