메뉴 건너뛰기




Volumn 110, Issue 3, 2002, Pages 460-468

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation

Author keywords

Airway hyperreactivity; Asthma; IL 10; Regulatory cells

Indexed keywords

ALLERGEN; CD4 ANTIGEN; INTERLEUKIN 10;

EID: 0036736840     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.127512     Document Type: Article
Times cited : (198)

References (49)
  • 1
    • 0030610055 scopus 로고    scopus 로고
    • Th1 and Th2 CD4+ cells in human allergic diseases
    • Umetsu DT, DeKruyff RH. Th1 and Th2 CD4+ cells in human allergic diseases. J Allergy Clin Immunol 1997;100:1-6.
    • (1997) J Allergy Clin Immunol , vol.100 , pp. 1-6
    • Umetsu, D.T.1    DeKruyff, R.H.2
  • 2
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: Central mediator of allergic asthma
    • Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-61.
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1    Luyimbazi, J.2    Xu, X.3
  • 3
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994;12:227-57.
    • (1994) Annu Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 4
    • 0031014668 scopus 로고    scopus 로고
    • The inverse association between tuberculin responses and atopic disorden
    • Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorden Science 1997;275:77-9.
    • (1997) Science , vol.275 , pp. 77-79
    • Shirakawa, T.1    Enomoto, T.2    Shimazu, S.3    Hopkin, J.M.4
  • 5
    • 0025918157 scopus 로고
    • Role of cytokines in the differentiation of CD4+ T-cell subsets in vivo
    • Coffman RL, Varkila K, Scott P, Chatelain R. Role of cytokines in the differentiation of CD4+ T-cell subsets in vivo. Immunol Rev 1991;123:189-207.
    • (1991) Immunol Rev , vol.123 , pp. 189-207
    • Coffman, R.L.1    Varkila, K.2    Scott, P.3    Chatelain, R.4
  • 6
    • 0032945548 scopus 로고    scopus 로고
    • Allergen-specific Thl cells fail to counterbalance Th2 cell-induced AHR but cause severe airway inflammation
    • Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Thl cells fail to counterbalance Th2 cell-induced AHR but cause severe airway inflammation. J Clin Invest 1999;103:175-83.
    • (1999) J Clin Invest , vol.103 , pp. 175-183
    • Hansen, G.1    Berry, G.2    DeKruyff, R.H.3    Umetsu, D.T.4
  • 7
    • 0034600789 scopus 로고    scopus 로고
    • Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-betal plasmid: TGF-betal-mediated suppression of T helper cell type I response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation
    • Kitani A, Fuss IJ, Nakamura K, Schwartz OM, Usui T, Strober W. Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-betal plasmid: TGF-betal-mediated suppression of T helper cell type I response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation. J Exp Med 2000;192:41-52.
    • (2000) J Exp Med , vol.192 , pp. 41-52
    • Kitani, A.1    Fuss, I.J.2    Nakamura, K.3    Schwartz, O.M.4    Usui, T.5    Strober, W.6
  • 8
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 9
    • 0028783962 scopus 로고
    • Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: Protection by transforming growth factor-beta and interleukin-10
    • Crisi G, Santambrogio L, Hochwald GM, Smith SR, Carlino JA, Thorbecke GJ. Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth factor-beta and interleukin-10. Eur J Immunol 1995;25:3035-40.
    • (1995) Eur J Immunol , vol.25 , pp. 3035-3040
    • Crisi, G.1    Santambrogio, L.2    Hochwald, G.M.3    Smith, S.R.4    Carlino, J.A.5    Thorbecke, G.J.6
  • 10
    • 0032522119 scopus 로고    scopus 로고
    • Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats
    • Xiao BG, Bai XF, Zhang GX, Link H. Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats. J Neuroimmunol 1998;84:230-7.
    • (1998) J Neuroimmunol , vol.84 , pp. 230-237
    • Xiao, B.G.1    Bai, X.F.2    Zhang, G.X.3    Link, H.4
  • 12
    • 0032031496 scopus 로고    scopus 로고
    • Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting interleukin-12 production
    • DeKruyff RH, Fang Y, Umetsu DT. Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting interleukin-12 production. J Immunol 1998;160:2231-7.
    • (1998) J Immunol , vol.160 , pp. 2231-2237
    • DeKruyff, R.H.1    Fang, Y.2    Umetsu, D.T.3
  • 13
    • 0032519450 scopus 로고    scopus 로고
    • Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help
    • Macaulay AE, DeKruyff RH, Umetsu DT. Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help. J Immunol 1998;160:1694-700.
    • (1998) J Immunol , vol.160 , pp. 1694-1700
    • Macaulay, A.E.1    DeKruyff, R.H.2    Umetsu, D.T.3
  • 14
    • 0034176856 scopus 로고    scopus 로고
    • Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
    • Costa GL, Benson JM, Seroogy CM, Achacoso P, Fathman CG, Nolan GP. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. J Immunol 2000;164:3581-90.
    • (2000) J Immunol , vol.164 , pp. 3581-3590
    • Costa, G.L.1    Benson, J.M.2    Seroogy, C.M.3    Achacoso, P.4    Fathman, C.G.5    Nolan, G.P.6
  • 15
    • 0030922681 scopus 로고    scopus 로고
    • Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal Th2 immune response and altered airway responsiveness
    • Tsuyuki S, Stuyuki J, Einsle K, Kopf M, Coyle AJ. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal Th2 immune response and altered airway responsiveness. J Exp Med 1997;185:1671-9.
    • (1997) J Exp Med , vol.185 , pp. 1671-1679
    • Tsuyuki, S.1    Stuyuki, J.2    Einsle, K.3    Kopf, M.4    Coyle, A.J.5
  • 16
    • 0029965236 scopus 로고    scopus 로고
    • Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
    • Murphy E, Shibuya K, Hosken N, et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J Exp Med 1996;183:901-13.
    • (1996) J Exp Med , vol.183 , pp. 901-913
    • Murphy, E.1    Shibuya, K.2    Hosken, N.3
  • 17
    • 0002691620 scopus 로고    scopus 로고
    • CD4+ Th cells engineered to produce latent TGF-b1 reverse allergen-induced airway hyperreactivity and inflammation
    • Hansen G, McIntire JJ, Yeung VP, et al. CD4+ Th cells engineered to produce latent TGF-b1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest 2000;11:89-96.
    • (2000) J Clin Invest , vol.11 , pp. 89-96
    • Hansen, G.1    McIntire, J.J.2    Yeung, V.P.3
  • 18
    • 0027222095 scopus 로고
    • Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses
    • Varney VA, Hamid QA, Gaga M, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92:644-51.
    • (1993) J Clin Invest , vol.92 , pp. 644-651
    • Varney, V.A.1    Hamid, Q.A.2    Gaga, M.3
  • 19
    • 0028821825 scopus 로고
    • Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
    • Gavett SH, O'Hearn DJ, Li X, Huang S-K, Finkelman PD, Wills-Karp M. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995;182:1527-36.
    • (1995) J Exp Med , vol.182 , pp. 1527-1536
    • Gavett, S.H.1    O'Hearn, D.J.2    Li, X.3    Huang, S.-K.4    Finkelman, P.D.5    Wills-Karp, M.6
  • 20
    • 0031134912 scopus 로고    scopus 로고
    • An OVA-IL-12 fusion protein is more effective than OVA plus rIL-12 in inducing a Thl-dominated immune response and inhibiting antigen-specific IgE production
    • Kim TS, DeKruyff RH, Rupper R, Maecker HT, Levy S, Umetsu DT. An OVA-IL-12 fusion protein is more effective than OVA plus rIL-12 in inducing a Thl-dominated immune response and inhibiting antigen-specific IgE production. J Immunol 1997;158:4137-44.
    • (1997) J Immunol , vol.158 , pp. 4137-4144
    • Kim, T.S.1    DeKruyff, R.H.2    Rupper, R.3    Maecker, H.T.4    Levy, S.5    Umetsu, D.T.6
  • 21
    • 0033557718 scopus 로고    scopus 로고
    • Modulation of airway inflammation by passive transfer of allergen-specific Thl and Th2 cells in a mouse model of asthma
    • Randolph DA, Carruthers CJ, Szabo SJ, Murphy KM, Chaplin DD. Modulation of airway inflammation by passive transfer of allergen-specific Thl and Th2 cells in a mouse model of asthma. J Immunol 1999;162:2375-83.
    • (1999) J Immunol , vol.162 , pp. 2375-2383
    • Randolph, D.A.1    Carruthers, C.J.2    Szabo, S.J.3    Murphy, K.M.4    Chaplin, D.D.5
  • 22
    • 0031093680 scopus 로고    scopus 로고
    • Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration
    • Hessel EM, Van Oosterhout AJ, Van Ark I, et al. Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration. Am J Respir Cell Mol Biol 1997;16:325-34.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 325-334
    • Hessel, E.M.1    Van Oosterhout, A.J.2    Van Ark, I.3
  • 23
    • 0033845105 scopus 로고    scopus 로고
    • Mechanisms preventing allergen-induced airways hyperreactivity: Role of immune deviation and tolerance
    • Tsitoura DC, Blumenthal RL, Berry G, DeKruyff RH, Umetsu DT. Mechanisms preventing allergen-induced airways hyperreactivity: role of immune deviation and tolerance. J Allergy Clin Immunol 2000;106:239-46.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 239-246
    • Tsitoura, D.C.1    Blumenthal, R.L.2    Berry, G.3    DeKruyff, R.H.4    Umetsu, D.T.5
  • 25
    • 0031893119 scopus 로고    scopus 로고
    • IL-10: Evolving concepts
    • Borish L. IL-10: evolving concepts. J Allergy Clin Immunol 1998;101:293-7.
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 293-297
    • Borish, L.1
  • 26
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 27
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-8.
    • (1993) J Exp Med , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 28
    • 0027239842 scopus 로고
    • IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
    • Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993;151:1224-34.
    • (1993) J Immunol , vol.151 , pp. 1224-1234
    • Ding, L.1    Linsley, P.S.2    Huang, L.Y.3    Germain, R.N.4    Shevach, E.M.5
  • 29
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal BM, Dwyer BK, Shevach EM. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 1998;187:537-46.
    • (1998) J Exp Med , vol.187 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 31
    • 12944267034 scopus 로고    scopus 로고
    • IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
    • Makela MJ, Kanehiro A, Borish L, et al. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci 2000;97:6007-12.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 6007-6012
    • Makela, M.J.1    Kanehiro, A.2    Borish, L.3
  • 32
    • 0029075489 scopus 로고
    • Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice
    • Zuany-Amorim C, Haile S, Leduc D, et al. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J Clin Invest 1995;95:2644-51.
    • (1995) J Clin Invest , vol.95 , pp. 2644-2651
    • Zuany-Amorim, C.1    Haile, S.2    Leduc, D.3
  • 33
    • 0033219725 scopus 로고    scopus 로고
    • Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice
    • Stampfli MR, Cwiartka M, Gajewska BU, et al. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Am J Resp Cell Mol Biol 1999;21:586-96.
    • (1999) Am J Resp Cell Mol Biol , vol.21 , pp. 586-596
    • Stampfli, M.R.1    Cwiartka, M.2    Gajewska, B.U.3
  • 34
    • 0034045109 scopus 로고    scopus 로고
    • Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness
    • Tournoy KG, Kips JC, Pauwels RA. Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin Exp Allergy 2000;30:775-83.
    • (2000) Clin Exp Allergy , vol.30 , pp. 775-783
    • Tournoy, K.G.1    Kips, J.C.2    Pauwels, R.A.3
  • 35
    • 0041652405 scopus 로고    scopus 로고
    • Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis
    • Grunig G, Corry DB, Leach MW, Seymour BW, Kurup VP, Rennick DM. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 1997;185:1089-99.
    • (1997) J Exp Med , vol.185 , pp. 1089-1099
    • Grunig, G.1    Corry, D.B.2    Leach, M.W.3    Seymour, B.W.4    Kurup, V.P.5    Rennick, D.M.6
  • 37
    • 0034890907 scopus 로고    scopus 로고
    • Pulmonary dendritic cells secreting IL-10 mediate T cell tolerance induced by respiratory exposure to antigen
    • Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells secreting IL-10 mediate T cell tolerance induced by respiratory exposure to antigen. Nat Immunol 2001;2:725-31.
    • (2001) Nat Immunol , vol.2 , pp. 725-731
    • Akbari, O.1    DeKruyff, R.H.2    Umetsu, D.T.3
  • 38
    • 0033198184 scopus 로고    scopus 로고
    • Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells
    • Tsitoura DC, DeKruyff RH, Lamb JR, Umetsu DT. Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells. J Immunol 1999;163:2592-600.
    • (1999) J Immunol , vol.163 , pp. 2592-2600
    • Tsitoura, D.C.1    DeKruyff, R.H.2    Lamb, J.R.3    Umetsu, D.T.4
  • 39
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-42.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 40
    • 0034327264 scopus 로고    scopus 로고
    • T regulatory cells 1 inhibit a Th2-specific response in vivo
    • Cottrez F, Hurst SD, Coffman RL, Groux H. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000;165:4848-53.
    • (2000) J Immunol , vol.165 , pp. 4848-4853
    • Cottrez, F.1    Hurst, S.D.2    Coffman, R.L.3    Groux, H.4
  • 41
    • 0029664297 scopus 로고    scopus 로고
    • Preferential induction of a Thl immune response and inhibition of specific IcE antibody formation by plasmid DNA immunization
    • Raz E, Tighe H, Sato Y, et al. Preferential induction of a Thl immune response and inhibition of specific IcE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci 1996;93:5141-5.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 5141-5145
    • Raz, E.1    Tighe, H.2    Sato, Y.3
  • 42
    • 0033979544 scopus 로고    scopus 로고
    • Vaccination with heat killed listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: Role of CD8+ T cells and IL-18
    • Hansen G, Yeung VP, Berry G, Umetsu DT, DeKruyff RH. Vaccination with heat killed listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: role of CD8+ T cells and IL-18. J Immunol 2000;164:223-30.
    • (2000) J Immunol , vol.164 , pp. 223-230
    • Hansen, G.1    Yeung, V.P.2    Berry, G.3    Umetsu, D.T.4    DeKruyff, R.H.5
  • 43
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237-40.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 44
    • 0034885046 scopus 로고    scopus 로고
    • The mucosal milieu creates tolerogenic dendritic cells and Tr1 and Th3 regulatory cells
    • Weiner HL. The mucosal milieu creates tolerogenic dendritic cells and Tr1 and Th3 regulatory cells. Nat Immunol 2001;2:671-2.
    • (2001) Nat Immunol , vol.2 , pp. 671-672
    • Weiner, H.L.1
  • 45
    • 0032538819 scopus 로고    scopus 로고
    • Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor b (TGF-b) production by murine CD4+ T cells
    • Chen W, Jin W, Wahl SM. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor b (TGF-b) production by murine CD4+ T cells. J Exp Med 1998;188:1849-57.
    • (1998) J Exp Med , vol.188 , pp. 1849-1857
    • Chen, W.1    Jin, W.2    Wahl, S.M.3
  • 46
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40-mediated antibody class switching
    • McAdam AJ, Greenwald RJ, Levin MA, et al. ICOS is critical for CD40-mediated antibody class switching. Nature 2001;409:102-5.
    • (2001) Nature , vol.409 , pp. 102-105
    • McAdam, A.J.1    Greenwald, R.J.2    Levin, M.A.3
  • 47
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell costimulator structurally and functionally related to CD28
    • Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T-cell costimulator structurally and functionally related to CD28. Nature 1999;397:263-6.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1    Dittrich, A.M.2    Beier, K.C.3
  • 48
    • 0037080032 scopus 로고    scopus 로고
    • The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis
    • Fuss IJ, Boirivant M, Lacy B, Strober W. The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis. J Immunol 2002;168:900-8.
    • (2002) J Immunol , vol.168 , pp. 900-908
    • Fuss, I.J.1    Boirivant, M.2    Lacy, B.3    Strober, W.4
  • 49
    • 0029984051 scopus 로고    scopus 로고
    • Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10
    • Gerosa F, Paganin C, Peritt D, et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 1996:2559-69.
    • (1996) J Exp Med , pp. 2559-2569
    • Gerosa, F.1    Paganin, C.2    Peritt, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.