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Volumn 171, Issue 2, 2003, Pages 971-978

Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: Control by CD4+ regulatory T cells and IL-10

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 10;

EID: 0038783387     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.2.971     Document Type: Article
Times cited : (154)

References (67)
  • 1
    • 0032707898 scopus 로고    scopus 로고
    • Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
    • Blumberg, R. S., L. J. Saubermann, and W. Strober. 1999. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr. Opin. Immunol. 11:648.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 648
    • Blumberg, R.S.1    Saubermann, L.J.2    Strober, W.3
  • 2
    • 0038248520 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease
    • A. N. Theofilopoulos and C. A. Bona, eds. Taylor & Francis, New York
    • Powrie, F., and M. W. Leach. 2001. Experimental models of inflammatory bowel disease. In The Molecular Pathology of Autoimmune Diseases. A. N. Theofilopoulos and C. A. Bona, eds. Taylor & Francis, New York.
    • (2001) The Molecular Pathology of Autoimmune Diseases
    • Powrie, F.1    Leach, M.W.2
  • 4
    • 0029993786 scopus 로고    scopus 로고
    • Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12
    • Duchmann, R., E. Schmitt, P. Knolle, K. H. Meyer zum Buschenfelde, and M. Neurath. 1996. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 26:934.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 934
    • Duchmann, R.1    Schmitt, E.2    Knolle, P.3    Meyer zum Buschenfelde, K.H.4    Neurath, M.5
  • 6
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon, R. K., S. Tonkonogy, M. Schultz, L. A. Dieleman, W. Grenther, E. Balish, D. M. Rennick, and R. B. Sartor. 1998. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66:5224.
    • (1998) Infect. Immun. , vol.66 , pp. 5224
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3    Dieleman, L.A.4    Grenther, W.5    Balish, E.6    Rennick, D.M.7    Sartor, R.B.8
  • 8
    • 0027441514 scopus 로고
    • Interleukin-2- and interferon-γ-secreting T cells in normal and diseased human intestinal mucosa
    • Breese, E., C. P. Braegger, C. J. Corrigan, J. A. Walker-Smith, and T. T. MacDonald. 1993. Interleukin-2- and interferon-γ-secreting T cells in normal and diseased human intestinal mucosa. Immunology 78:127.
    • (1993) Immunology , vol.78 , pp. 127
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3    Walker-Smith, J.A.4    MacDonald, T.T.5
  • 9
    • 0030209985 scopus 로고    scopus 로고
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157:1261.
    • (1996) J. Immunol. , vol.157 , pp. 1261
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    De la Motte, C.5    Strong, S.A.6    Fiocchi, C.7    Strober, W.8
  • 10
  • 13
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
    • Simpson, S. J., S. Shah, M. Comiskey, Y. P. de Jong, B. Wang, E. Mizoguchi, A. K. Bhan, and C. Terhorst. 1998. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J. Exp. Med. 187:1225.
    • (1998) J. Exp. Med. , vol.187 , pp. 1225
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3    De Jong, Y.P.4    Wang, B.5    Mizoguchi, E.6    Bhan, A.K.7    Terhorst, C.8
  • 15
    • 0035337241 scopus 로고    scopus 로고
    • CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice
    • Malmstrom, V., D. Shipton, B. Singh, A. Al-Shamkhani, M. J. Puklavec, A. N. Barclay, and F. Powrie. 2001. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 166:6972.
    • (2001) J. Immunol. , vol.166 , pp. 6972
    • Malmstromm, V.1    Shipton, D.2    Singh, B.3    Al-Shamkhani, A.4    Puklavec, M.J.5    Barclay, A.N.6    Powrie, F.7
  • 17
    • 0031255003 scopus 로고    scopus 로고
    • + T cells in the regulation of inflammatory responses in the intestine
    • + T cells in the regulation of inflammatory responses in the intestine. Res. Immunol. 148:576.
    • (1997) Res. Immunol. , vol.148 , pp. 576
    • Powrie, F.1    Mauze, S.2    Coffman, R.L.3
  • 18
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
    • (2000) J. Exp. Med. , vol.192 , pp. 295
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 19
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
    • (1996) J. Exp. Med. , vol.184 , pp. 387
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 22
    • 0033571105 scopus 로고    scopus 로고
    • + T cells: A common basis between tumor immunity and autoimmunity
    • + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211.
    • (1999) J. Immunol. , vol.163 , pp. 5211
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 24
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
    • (1998) J. Exp. Med. , vol.188 , pp. 287
    • Thomton, A.E.1    Shevach, E.M.2
  • 26
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immun. 2:816.
    • (2001) Nat. Immun. , vol.2 , pp. 816
    • Maloy, K.J.1    Powrie, F.2
  • 27
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389
    • Shevach, E.M.1
  • 29
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
    • (1999) J. Exp. Med. , vol.190 , pp. 995
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 33
    • 0032442035 scopus 로고    scopus 로고
    • SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis
    • Li, X., J. G. Fox, M. T. Whary, L. Yan, B. Shames, and Z. Zhao. 1998. SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis. Infect. Immun. 66:5477.
    • (1998) Infect. Immun. , vol.66 , pp. 5477
    • Li, X.1    Fox, J.G.2    Whary, M.T.3    Yan, L.4    Shames, B.5    Zhao, Z.6
  • 34
    • 0013880752 scopus 로고
    • Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response
    • Monaco, A. P., M. L. Wood, J. G. Gray, and P. S. Russell. 1966. Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response. J. Immunol. 96:229.
    • (1966) J. Immunol. , vol.96 , pp. 229
    • Monaco, A.P.1    Wood, M.L.2    Gray, J.G.3    Russell, P.S.4
  • 35
    • 0021723276 scopus 로고
    • Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
    • Cobbold, S. P., A. Jayasuriya, A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548.
    • (1984) Nature , vol.312 , pp. 548
    • Cobbold, S.P.1    Jayasuriya, A.2    Nash, A.3    Prospero, T.D.4    Waldmann, H.5
  • 36
    • 0020593691 scopus 로고
    • Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development
    • Coffman. R. L. 1982. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69:5.
    • (1982) Immunol. Rev. , vol.69 , pp. 5
    • Coffman, R.L.1
  • 37
    • 0032481383 scopus 로고    scopus 로고
    • IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways
    • O'Farrell, A. M., Y. Liu, K. W. Moore, and A. L. Mui. 1998. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 17:1006.
    • (1998) EMBO J. , vol.17 , pp. 1006
    • O'Farrell, A.M.1    Liu, Y.2    Moore, K.W.3    Mui, A.L.4
  • 38
    • 0028877056 scopus 로고
    • Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
    • Openshaw, P., E. E. Murphy, N. A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182: 1357.
    • (1995) J. Exp. Med. , vol.182 , pp. 1357
    • Openshaw, P.1    Murphy, E.E.2    Hosken, N.A.3    Maino, V.4    Davis, K.5    Murphy, K.6    O'Garra, A.7
  • 39
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
    • (1993) Cell , vol.75 , pp. 263
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 41
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and γ interferon-dependent mechanism
    • Kullberg, M. C., J. M. Ward, P. L. Gorelick, P. Caspar, S. Hieny, A. Cheever, D. Jankovic, and A. Sher. 1998. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and γ interferon-dependent mechanism. Infect. Immun. 66:5157.
    • (1998) Infect. Immun. , vol.66 , pp. 5157
    • Kullberg, M.C.1    Ward, J.M.2    Gorelick, P.L.3    Caspar, P.4    Hieny, S.5    Cheever, A.6    Jankovic, D.7    Sher, A.8
  • 42
    • 0024346410 scopus 로고
    • A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines
    • Bottomly, K., M. Luqman, L. Greenbaum, S. Carding, J. West, T. Pasqualini, and D. B. Murphy. 1989. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur. J. Immunol. 19:617.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 617
    • Bottomly, K.1    Luqman, M.2    Greenbaum, L.3    Carding, S.4    West, J.5    Pasqualini, T.6    Murphy, D.B.7
  • 43
    • 0026816125 scopus 로고
    • Function of CD4 T cell subsets in vivo: Expression of CD45R isoforms
    • Bell, E. B. 1992. Function of CD4 T cell subsets in vivo: expression of CD45R isoforms. Semin. Immunol. 4:43.
    • (1992) Semin. Immunol. , vol.4 , pp. 43
    • Bell, E.B.1
  • 44
    • 0021337379 scopus 로고
    • Thymus cell migration: Analysis of thymus emigrants with markers that distinguish medullary thymocytes from peripheral T cells
    • Scollay, R., A. Wilson, and K. Shortman. 1984. Thymus cell migration: analysis of thymus emigrants with markers that distinguish medullary thymocytes from peripheral T cells. J. Immunol. 132:1089.
    • (1984) J. Immunol. , vol.132 , pp. 1089
    • Scollay, R.1    Wilson, A.2    Shortman, K.3
  • 45
    • 0030844377 scopus 로고    scopus 로고
    • Recent thymic emigrants are distinct from most medullary thymocytes
    • Gabor, M. J., D. I. Godfrey, and R. Scollay. 1997. Recent thymic emigrants are distinct from most medullary thymocytes. Eur. J. Immunol. 27:2010.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2010
    • Gabor, M.J.1    Godfrey, D.I.2    Scollay, R.3
  • 46
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmunity
    • Shevach, E. M. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18:423.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423
    • Shevach, E.M.1
  • 48
    • 0001138830 scopus 로고
    • Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation
    • Birkeland, M. L., P. Johnson, I. S. Trowbridge, and E. Pure. 1989. Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation. Proc. Natl. Acad. Sci. USA 86:6734.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6734
    • Birkeland, M.L.1    Johnson, P.2    Trowbridge, I.S.3    Pure, E.4
  • 50
    • 0028179230 scopus 로고
    • + T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179:589.
    • (1994) J. Exp. Med. , vol.179 , pp. 589
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 52
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629.
    • (2001) J. Exp. Med. , vol.194 , pp. 629
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 57
    • 0035879091 scopus 로고    scopus 로고
    • Regulation of TGF-β response during T cell activation is modulated by IL-10
    • Cottrez, F., and H. Groux. 2001. Regulation of TGF-β response during T cell activation is modulated by IL-10. J. Immunol. 167:773.
    • (2001) J. Immunol. , vol.167 , pp. 773
    • Cottrez, F.1    Groux, H.2
  • 60
    • 0032529414 scopus 로고    scopus 로고
    • Low dose TGF-β attenuates IL-12 responsiveness in murine Th cells
    • Gorham, J. D., M. L. Guler, D. Fenoglio, U. Gubler, and K. M. Murphy. 1998. Low dose TGF-β attenuates IL-12 responsiveness in murine Th cells. J. Immunol. 161:1664.
    • (1998) J. Immunol. , vol.161 , pp. 1664
    • Gorham, J.D.1    Guler, M.L.2    Fenoglio, D.3    Gubler, U.4    Murphy, K.M.5
  • 62
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor β-induced inhibition of T helper type 1 differentiation
    • Gorelik, L., S. Constant, and R. A. Flavell. 2002. Mechanism of transforming growth factor β-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 195:1499.
    • (2002) J. Exp. Med. , vol.195 , pp. 1499
    • Gorelik, L.1    Constant, S.2    Flavell, R.A.3
  • 63
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 64
    • 0029831666 scopus 로고    scopus 로고
    • High level IL-12 production by murine dendritic cells: Up-regulation via MHC class II and CD40 molecules and down-regulation by IL-4 and IL-10
    • Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: up-regulation via MHC class II and CD40 molecules and down-regulation by IL-4 and IL-10. J. Exp. Med. 184:741.
    • (1996) J. Exp. Med. , vol.184 , pp. 741
    • Koch, F.1    Stanzl, U.2    Jennewein, P.3    Janke, K.4    Heufler, C.5    Kampgen, E.6    Romani, N.7    Schuler, G.8
  • 65
    • 0034600789 scopus 로고    scopus 로고
    • Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain down-regulation
    • Kitani, A., I. J. Fuss, K. Nakamura, O. M. Schwartz, T. Usui, and W. Strober. 2000. Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain down-regulation. J. Exp. Med. 192:41.
    • (2000) J. Exp. Med. , vol.192 , pp. 41
    • Kitani, A.1    Fuss, I.J.2    Nakamura, K.3    Schwartz, O.M.4    Usui, T.5    Strober, W.6
  • 66
    • 0037080032 scopus 로고    scopus 로고
    • The interrelated roles of TGF-β and IL-10 in the regulation of experimental colitis
    • Fuss, I. J., M. Boirivant, B. Lacy, and W. Strober. 2002. The interrelated roles of TGF-β and IL-10 in the regulation of experimental colitis. J. Immunol. 168:900.
    • (2002) J. Immunol. , vol.168 , pp. 900
    • Fuss, I.J.1    Boirivant, M.2    Lacy, B.3    Strober, W.4


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