-
2
-
-
0038725685
-
Negative selection-clearing out the bad apples from the T-cell repertoire
-
Palmer E. 2003. Negative selection-clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3:383-91
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 383-391
-
-
Palmer, E.1
-
3
-
-
0032806587
-
Peripheral T-cell tolerance: The contribution of permissive T-cell migration into parenchymal tissues of the neonate
-
Alferink J, Aigner S, Reibke R, Hammerling GJ, Arnold B. 1999. Peripheral T-cell tolerance: the contribution of permissive T-cell migration into parenchymal tissues of the neonate. Immunol. Rev. 169:255-61
-
(1999)
Immunol. Rev.
, vol.169
, pp. 255-261
-
-
Alferink, J.1
Aigner, S.2
Reibke, R.3
Hammerling, G.J.4
Arnold, B.5
-
4
-
-
0036360019
-
The enemy within: Keeping self-reactive T cells at bay in the periphery
-
Walker LS, Abbas AK. 2002. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2:11-19
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 11-19
-
-
Walker, L.S.1
Abbas, A.K.2
-
5
-
-
0036597371
-
+ suppressor T cells: More questions than answers
-
+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 389-400
-
-
Shevach, E.M.1
-
6
-
-
2442484053
-
+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
-
+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531-62
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
-
7
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S, et al. 2005. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202:33-45
-
(2005)
J. Exp. Med.
, vol.202
, pp. 33-45
-
-
Derbinski, J.1
Gabler, J.2
Brors, B.3
Tierling, S.4
Jonnakuty, S.5
-
8
-
-
0034055693
-
Self-antigen presentation by thymic stromal cells: A subtle division of labor
-
Klein L, Kyewski B. 2000. Self-antigen presentation by thymic stromal cells: a subtle division of labor. Curr. Opin. Immunol. 12:179-86
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 179-186
-
-
Klein, L.1
Kyewski, B.2
-
9
-
-
2442567829
-
Back to central tolerance
-
Mathis D, Benoist C. 2004. Back to central tolerance. Immunity 20:509-16
-
(2004)
Immunity
, vol.20
, pp. 509-516
-
-
Mathis, D.1
Benoist, C.2
-
10
-
-
16244367143
-
AIRE and APECED: Molecular insights into an autoimmune disease
-
Villasenor J, Benoist C, Mathis D. 2005. AIRE and APECED: molecular insights into an autoimmune disease. Immunol. Rev. 204:156-64
-
(2005)
Immunol. Rev.
, vol.204
, pp. 156-164
-
-
Villasenor, J.1
Benoist, C.2
Mathis, D.3
-
11
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
Derbinski J, Schulte A, Kyewski B, Klein L. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:1032-39
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1032-1039
-
-
Derbinski, J.1
Schulte, A.2
Kyewski, B.3
Klein, L.4
-
13
-
-
0035808785
-
The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice
-
Foss DL, Donskoy E, Goldschneider I. 2001. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J. Exp. Med. 193:365-74
-
(2001)
J. Exp. Med.
, vol.193
, pp. 365-374
-
-
Foss, D.L.1
Donskoy, E.2
Goldschneider, I.3
-
14
-
-
0141449952
-
Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice
-
Porritt HE, Gordon K, Petrie HT. 2003. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J. Exp. Med. 198:957-62
-
(2003)
J. Exp. Med.
, vol.198
, pp. 957-962
-
-
Porritt, H.E.1
Gordon, K.2
Petrie, H.T.3
-
15
-
-
0037304536
-
Thymic selection revisited: How essential is it?
-
von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, et al. 2003. Thymic selection revisited: how essential is it? Immunol. Rev. 191:62-78
-
(2003)
Immunol. Rev.
, vol.191
, pp. 62-78
-
-
Boehmer, H.1
Aifantis, I.2
Gounari, F.3
Azogui, O.4
Haughn, L.5
-
16
-
-
0028054017
-
T-cell apoptosis detected in situ during positive and negative selection in the thymus
-
Surh CD, Sprent J. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100-3
-
(1994)
Nature
, vol.372
, pp. 100-103
-
-
Surh, C.D.1
Sprent, J.2
-
17
-
-
0030935007
-
The MHC reactivity of the T cell repertoire prior to positive and negative selection
-
Zerrahn J, Held W, Raulet DH. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627-36
-
(1997)
Cell
, vol.88
, pp. 627-636
-
-
Zerrahn, J.1
Held, W.2
Raulet, D.H.3
-
18
-
-
0030846879
-
How many thymocytes audition for selection?
-
Merkenschlager M, Graf D, Lovatt M, Bommhardt U, Zamoyska R, et al. 1997. How many thymocytes audition for selection? Exp. Med. 186:1149-58
-
(1997)
Exp. Med.
, vol.186
, pp. 1149-1158
-
-
Merkenschlager, M.1
Graf, D.2
Lovatt, M.3
Bommhardt, U.4
Zamoyska, R.5
-
19
-
-
0022997960
-
The T cell repertoire may be biased in favor of MHC recognition
-
Blackman M, Yague J, Kubo R, Gay D, Coleclough C, et al. 1986. The T cell repertoire may be biased in favor of MHC recognition. Cell 47:349-57
-
(1986)
Cell
, vol.47
, pp. 349-357
-
-
Blackman, M.1
Yague, J.2
Kubo, R.3
Gay, D.4
Coleclough, C.5
-
20
-
-
0001937634
-
The somatic generation of immune recognition
-
Jerne NK. 1971. The somatic generation of immune recognition. Eur. J. Immunol. 1:1-9
-
(1971)
Eur. J. Immunol.
, vol.1
, pp. 1-9
-
-
Jerne, N.K.1
-
21
-
-
22744441535
-
How the T cell repertoire becomes peptide and MHC specific
-
Huseby ES, White J, Crawford F, Vass T, Becker D, et al. How the T cell repertoire becomes peptide and MHC specific. Cell 122:247-60
-
Cell
, vol.122
, pp. 247-260
-
-
Huseby, E.S.1
White, J.2
Crawford, F.3
Vass, T.4
Becker, D.5
-
22
-
-
0027220211
-
Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes
-
Petrie HT, Livak F, Schatz DG, Strasser A, Crispe IN, et al. 1993. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:615-22
-
(1993)
J. Exp. Med.
, vol.178
, pp. 615-622
-
-
Petrie, H.T.1
Livak, F.2
Schatz, D.G.3
Strasser, A.4
Crispe, I.N.5
-
23
-
-
0026030196
-
+) thymocytes as post-selection intermediates leading to mature T cells
-
+) thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173:323-32
-
(1991)
J. Exp. Med.
, vol.173
, pp. 323-332
-
-
Shortman, K.1
Vremec, D.2
Egerton, M.3
-
24
-
-
0025933951
-
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
-
Huesmann M, Scott B, Kisielow P, von Boehmer H. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66:533-40
-
(1991)
Cell
, vol.66
, pp. 533-540
-
-
Huesmann, M.1
Scott, B.2
Kisielow, P.3
Von Boehmer, H.4
-
25
-
-
0030058657
-
The repertoire of T cells shaped by a single MHC/peptide ligand
-
Ignatowicz L, Kappler J, Marrack P. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521-29
-
(1996)
Cell
, vol.84
, pp. 521-529
-
-
Ignatowicz, L.1
Kappler, J.2
Marrack, P.3
-
26
-
-
0030996826
-
+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus
-
+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 6:401-10
-
(1997)
Immunity
, vol.6
, pp. 401-410
-
-
Fukui, Y.1
Ishimoto, T.2
Utsuyama, M.3
Gyotoku, T.4
Koga, T.5
-
27
-
-
0031048826
-
Quantitative impact of thymic clonal deletion on the T cell repertoire
-
van Meerwijk JP, Marguerat S, Lees RK, Germain RN, Fowlkes BJ, et al. 1997. Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185:377-83
-
(1997)
J. Exp. Med.
, vol.185
, pp. 377-383
-
-
Van Meerwijk, J.P.1
Marguerat, S.2
Lees, R.K.3
Germain, R.N.4
Fowlkes, B.J.5
-
29
-
-
0032534666
-
Differential effects of peptide diversity and stromal cell type in positive and negative selection in the thymus
-
Anderson G, Partington KM, Jenkinson EJ. 1998. Differential effects of peptide diversity and stromal cell type in positive and negative selection in the thymus. J. Immunol. 161:6599-603
-
(1998)
J. Immunol.
, vol.161
, pp. 6599-6603
-
-
Anderson, G.1
Partington, K.M.2
Jenkinson, E.J.3
-
31
-
-
0028142707
-
Quantitative analysis of the efficiency of clonal deletion in the thymus
-
Spain LM, Berg LJ. 1994. Quantitative analysis of the efficiency of clonal deletion in the thymus. Dev. Immunol. 4:43-53
-
(1994)
Dev. Immunol.
, vol.4
, pp. 43-53
-
-
Spain, L.M.1
Berg, L.J.2
-
32
-
-
0031568068
-
Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen
-
Volkmann A, Zal T, Stockinger B. 1997. Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen. J. Immunol. 158:693-706
-
(1997)
J. Immunol.
, vol.158
, pp. 693-706
-
-
Volkmann, A.1
Zal, T.2
Stockinger, B.3
-
35
-
-
0032538986
-
Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells
-
Davey GM, Schober SL, Endrizzi BT, Dutcher AK, Jameson SC, et al. 1998. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med. 188:1867-74
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1867-1874
-
-
Davey, G.M.1
Schober, S.L.2
Endrizzi, B.T.3
Dutcher, A.K.4
Jameson, S.C.5
-
36
-
-
0028201732
-
Tolerance, danger, and the extended family
-
Matzinger P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 991-1045
-
-
Matzinger, P.1
-
37
-
-
0037066427
-
The danger model: A renewed sense of self
-
Matzinger P. 2002. The danger model: a renewed sense of self. Science 296:301-5
-
(2002)
Science
, vol.296
, pp. 301-305
-
-
Matzinger, P.1
-
38
-
-
0029659055
-
The shaping of the brain-specific T lymphocyte repertoire in the thymus
-
Wekerle H, Bradl M, Liningtori C, Kaab G, Kojima K. 1996. The shaping of the brain-specific T lymphocyte repertoire in the thymus. Immunol. Rev. 149:231-43
-
(1996)
Immunol. Rev.
, vol.149
, pp. 231-243
-
-
Wekerle, H.1
Bradl, M.2
Liningtori, C.3
Kaab, G.4
Kojima, K.5
-
39
-
-
0036219003
-
T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
-
Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, et al. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20:101-23
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 101-123
-
-
Kuchroo, V.K.1
Anderson, A.C.2
Waldner, H.3
Munder, M.4
Bettelli, E.5
-
40
-
-
0024968558
-
Are tissues a patch quilt of ectopic gene expression?
-
Linsk R, Gottesman M, Pernis B. 1989. Are tissues a patch quilt of ectopic gene expression? Science 246:261
-
(1989)
Science
, vol.246
, pp. 261
-
-
Linsk, R.1
Gottesman, M.2
Pernis, B.3
-
41
-
-
0025211921
-
Thymic epithelium tolerizes for histocompatibility antigens
-
Salaun J, Bandeira A, Khazaal I, Calman F, Coltey M, et al. 1990. Thymic epithelium tolerizes for histocompatibility antigens. Science 247:1471-74
-
(1990)
Science
, vol.247
, pp. 1471-1474
-
-
Salaun, J.1
Bandeira, A.2
Khazaal, I.3
Calman, F.4
Coltey, M.5
-
42
-
-
21444449127
-
Regulatory T cells in the establishment and maintenance of self-tolerance: Role of the thymic epithelium
-
Salaun J, Corbel C, Le Douarin NM. 2005. Regulatory T cells in the establishment and maintenance of self-tolerance: role of the thymic epithelium. Int. J. Dev. Biol. 49:137-42
-
(2005)
Int. J. Dev. Biol.
, vol.49
, pp. 137-142
-
-
Salaun, J.1
Corbel, C.2
Le Douarin, N.M.3
-
43
-
-
0029659049
-
Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells
-
Le Douarin N, Corbel C, Bandeira A, Thomas-Vaslin V, Modigliani Y, et al. 1996. Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. Immunol. Rev. 149:35-53
-
(1996)
Immunol. Rev.
, vol.149
, pp. 35-53
-
-
Le Douarin, N.1
Corbel, C.2
Bandeira, A.3
Thomas-Vaslin, V.4
Modigliani, Y.5
-
44
-
-
0023239988
-
Tolerance induced by thymic epithelial grafts in birds
-
Ohki H, Martin C, Corbel C, Coltey M, Le Douarin NM. 1987. Tolerance induced by thymic epithelial grafts in birds. Science 237:1032-35
-
(1987)
Science
, vol.237
, pp. 1032-1035
-
-
Ohki, H.1
Martin, C.2
Corbel, C.3
Coltey, M.4
Le Douarin, N.M.5
-
45
-
-
0029788211
-
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
-
Asano M, Toda M, Sakaguchi N, Sakaguchi S. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387-96
-
(1996)
J. Exp. Med.
, vol.184
, pp. 387-396
-
-
Asano, M.1
Toda, M.2
Sakaguchi, N.3
Sakaguchi, S.4
-
46
-
-
0029005494
-
Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein
-
Antonia SJ, Geiger T, Miller J, Flavell RA. 1995. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein. Int. Immunol. 7:715-25
-
(1995)
Int. Immunol.
, vol.7
, pp. 715-725
-
-
Antonia, S.J.1
Geiger, T.2
Miller, J.3
Flavell, R.A.4
-
47
-
-
0028301977
-
T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus
-
Jolicoeur C, Hanahan D, Smith KM. 1994. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA 91:6707-11
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6707-6711
-
-
Jolicoeur, C.1
Hanahan, D.2
Smith, K.M.3
-
48
-
-
0026688158
-
Autoimmune diabetes as a consequence of locally produced interleukin-2
-
Heath WR, Allison J, Hoffmann MW, Schonrich G, Hammerling G, et al. 1992. Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature 359:547-49
-
(1992)
Nature
, vol.359
, pp. 547-549
-
-
Heath, W.R.1
Allison, J.2
Hoffmann, M.W.3
Schonrich, G.4
Hammerling, G.5
-
49
-
-
0028446546
-
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
-
von Herrath MG, Dockter J, Oldstone MB. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1:231-42
-
(1994)
Immunity
, vol.1
, pp. 231-242
-
-
Von Herrath, M.G.1
Dockter, J.2
Oldstone, M.B.3
-
50
-
-
0031755882
-
Intrathymic expression of genes involved in organ specific autoimmune disease
-
Heath VL, Moore NC, Parnell SM, Mason DW. 1998. Intrathymic expression of genes involved in organ specific autoimmune disease. J. Autoimmun. 11:309-18
-
(1998)
J. Autoimmun.
, vol.11
, pp. 309-318
-
-
Heath, V.L.1
Moore, N.C.2
Parnell, S.M.3
Mason, D.W.4
-
51
-
-
0032490563
-
CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium
-
Klein L, Klein T, Ruther U, Kyewski B. 1998. CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium. J. Exp. Med. 188:5-16
-
(1998)
J. Exp. Med.
, vol.188
, pp. 5-16
-
-
Klein, L.1
Klein, T.2
Ruther, U.3
Kyewski, B.4
-
52
-
-
0032402315
-
Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens
-
Sospedra M, Ferrer-Francesch X, Dominguez O, Juan M, Foz-Sala M, et al. 1998. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens. J. Immunol. 161:5918-29
-
(1998)
J. Immunol.
, vol.161
, pp. 5918-5929
-
-
Sospedra, M.1
Ferrer-Francesch, X.2
Dominguez, O.3
Juan, M.4
Foz-Sala, M.5
-
53
-
-
0031937377
-
Aberrant expression of tissue-specific proteins in the thymus: A hypothesis for the development of central tolerance
-
Werdelin O, Cordes U, Jensen T. 1998. Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance. Scand. J. Immunol. 47:95-100
-
(1998)
Scand. J. Immunol.
, vol.47
, pp. 95-100
-
-
Werdelin, O.1
Cordes, U.2
Jensen, T.3
-
54
-
-
0022443333
-
The neuroendocrine thymus: Coexistence of oxytocin and neurophysin in the human thymus
-
52a. Geenen V, Legros JJ, Franchimont P, Baudrihaye M, Defresne MP, Boniver J. 1986. The neuroendocrine thymus: coexistence of oxytocin and neurophysin in the human thymus. Science 232:508-11
-
(1986)
Science
, vol.232
, pp. 508-511
-
-
Geenen, V.1
Legros, J.J.2
Franchimont, P.3
Baudrihaye, M.4
Defresne, M.P.5
Boniver, J.6
-
55
-
-
0032401760
-
Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
-
Hanahan D. 1998. Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. Curr. Opin. Immunol. 10:656-62
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 656-662
-
-
Hanahan, D.1
-
56
-
-
0030796631
-
Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
-
Smith KM, Olson DC, Hirose R, Hanahan D. 1997. Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. Int. Immunol. 9:1355-65
-
(1997)
Int. Immunol.
, vol.9
, pp. 1355-1365
-
-
Smith, K.M.1
Olson, D.C.2
Hirose, R.3
Hanahan, D.4
-
57
-
-
0942288397
-
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
-
Gotter J, Brors B, Hergenhalin M, Kyewski B. 2004. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J. Exp. Med. 199:155-66
-
(2004)
J. Exp. Med.
, vol.199
, pp. 155-166
-
-
Gotter, J.1
Brors, B.2
Hergenhalin, M.3
Kyewski, B.4
-
58
-
-
0036644686
-
Promiscuous gene expression and central T-cell tolerance: More than meets the eye
-
Kyewski B, Derbinski J, Gotter J, Klein L. 2002. Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol. 23:364-71
-
(2002)
Trends Immunol.
, vol.23
, pp. 364-371
-
-
Kyewski, B.1
Derbinski, J.2
Gotter, J.3
Klein, L.4
-
59
-
-
0036773624
-
Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus
-
Bruno R, Sabater L, Sospedra M, Ferrer-Francesch X, Escudero D, et al. 2002. Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus. Eur. J. Immunol. 32:2737-47
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 2737-2747
-
-
Bruno, R.1
Sabater, L.2
Sospedra, M.3
Ferrer-Francesch, X.4
Escudero, D.5
-
60
-
-
0035856960
-
Thymus medulla consisting of epithelial islets each derived from a single progenitor
-
Rodewald HR, Paul S, Haller C, Bluethmann H, Blum C. 2001. Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature 414:763-68
-
(2001)
Nature
, vol.414
, pp. 763-768
-
-
Rodewald, H.R.1
Paul, S.2
Haller, C.3
Bluethmann, H.4
Blum, C.5
-
61
-
-
0036063262
-
Identification and characterization of thymic epithelial progenitor cells
-
Bennett AR, Farley A, Blair NF, Gordon J, Sharp L, et al. 2002. Identification and characterization of thymic epithelial progenitor cells. Immunity 16:803-14
-
(2002)
Immunity
, vol.16
, pp. 803-814
-
-
Bennett, A.R.1
Farley, A.2
Blair, N.F.3
Gordon, J.4
Sharp, L.5
-
63
-
-
2442647655
-
Functional evidence for a single endodermal origin for the thymic epithelium
-
Gordon J, Wilson VA, Blair NF, Sheridan J, Farley A, et al. 2004. Functional evidence for a single endodermal origin for the thymic epithelium. Nat. Immunol. 5:546-53
-
(2004)
Nat. Immunol.
, vol.5
, pp. 546-553
-
-
Gordon, J.1
Wilson, V.A.2
Blair, N.F.3
Sheridan, J.4
Farley, A.5
-
64
-
-
1842631137
-
Developing a new paradigm for thymus organogenesis
-
Blackburn CC, Manley NR. 2004. Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. 4:278-89
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 278-289
-
-
Blackburn, C.C.1
Manley, N.R.2
-
65
-
-
0026749044
-
Two subsets of epithelial cells in the thymic medulla
-
Surh CD, Gao EK, Kosaka H, Lo D, Ahn C, et al. 1992. Two subsets of epithelial cells in the thymic medulla. J. Exp. Med. 176:495-505
-
(1992)
J. Exp. Med.
, vol.176
, pp. 495-505
-
-
Surh, C.D.1
Gao, E.K.2
Kosaka, H.3
Lo, D.4
Ahn, C.5
-
66
-
-
0027291690
-
Medullary thymic epithelium expresses a ligand for CTLA4in situ and in vitro
-
Nelson AJ, Hosier S, Brady W, Linsley PS, Farr AG. 1993. Medullary thymic epithelium expresses a ligand for CTLA4in situ and in vitro. J. Immunol. 151:2453-61
-
(1993)
J. Immunol.
, vol.151
, pp. 2453-2461
-
-
Nelson, A.J.1
Hosier, S.2
Brady, W.3
Linsley, P.S.4
Farr, A.G.5
-
67
-
-
0034857910
-
Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
-
Klein L, Roettinger B, Kyewski B. 2001. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol. 31:2476-86
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2476-2486
-
-
Klein, L.1
Roettinger, B.2
Kyewski, B.3
-
68
-
-
0041884736
-
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR
-
Boehm T, Scheu S, Pfeffer K, Bleul CC. 2003. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR. J. Exp. Med. 198:757-69
-
(2003)
J. Exp. Med.
, vol.198
, pp. 757-769
-
-
Boehm, T.1
Scheu, S.2
Pfeffer, K.3
Bleul, C.C.4
-
69
-
-
10744232942
-
An immunologically privileged retinal antigen elicits tolerance: Major role for central selection mechanisms
-
Avichezer D, Grajewski RS, Chan CC, Mattapallil MJ, Silver PB, et al. 2003. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J. Exp. Med. 198:1665-76
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1665-1676
-
-
Avichezer, D.1
Grajewski, R.S.2
Chan, C.C.3
Mattapallil, M.J.4
Silver, P.B.5
-
70
-
-
0035089893
-
Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
-
Pugliese A, Brown D, Garza D, Murchison D, Zeller M, et al. 2001. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J. Clin. Invest. 107:555-64
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 555-564
-
-
Pugliese, A.1
Brown, D.2
Garza, D.3
Murchison, D.4
Zeller, M.5
-
71
-
-
0034662906
-
Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED)
-
Zuklys S, Balciunaite G, Agarwal A, Fasler-Kan E, Palmer E, et al. 2000. Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis- ectodermal dystrophy (APECED). J. Immunol. 165:1976-83
-
(2000)
J. Immunol.
, vol.165
, pp. 1976-1983
-
-
Zuklys, S.1
Balciunaite, G.2
Agarwal, A.3
Fasler-Kan, E.4
Palmer, E.5
-
72
-
-
17144371855
-
The cornified envelope: A model of cell death in the skin
-
Candi E, Schmidt R, Melino G. 2005. The cornified envelope: a model of cell death in the skin. Nat. Rev. Mol. Cell Biol. 6:328-40
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 328-340
-
-
Candi, E.1
Schmidt, R.2
Melino, G.3
-
73
-
-
0141828565
-
Tight junction-related structures in the absence of a lumen: Occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas
-
Langbein L, Pape UF, Grund C, Kuhn C, Praetzel S, et al. 2003. Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas. Eur. J. Cell Biol. 82:385-400
-
(2003)
Eur. J. Cell Biol.
, vol.82
, pp. 385-400
-
-
Langbein, L.1
Pape, U.F.2
Grund, C.3
Kuhn, C.4
Praetzel, S.5
-
74
-
-
0036864744
-
Organization of thymic medullary epithelial heterogeneity: Implications for mechanisms of epithelial differentiation
-
Farr AG, Dooley JL, Erickson M. 2002. Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol. Rev. 189:20-27
-
(2002)
Immunol. Rev.
, vol.189
, pp. 20-27
-
-
Farr, A.G.1
Dooley, J.L.2
Erickson, M.3
-
75
-
-
22344434168
-
Contrasting models of promiscuous gene expression by thymic epithelium
-
Gillard GO, Farr AG. 2005. Contrasting models of promiscuous gene expression by thymic epithelium. J. Exp. Med. 202:15-19
-
(2005)
J. Exp. Med.
, vol.202
, pp. 15-19
-
-
Gillard, G.O.1
Farr, A.G.2
-
76
-
-
0037438387
-
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
-
Akashi K, He X, Chen J, Iwasaki H, Niu C, et al. 2003. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101:383-89
-
(2003)
Blood
, vol.101
, pp. 383-389
-
-
Akashi, K.1
He, X.2
Chen, J.3
Iwasaki, H.4
Niu, C.5
-
77
-
-
0036070180
-
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment
-
Miyamoto T, Iwasaki H, Reizis B, Ye M, Graf T, et al. 2002. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev. Cell 3:137-47
-
(2002)
Dev. Cell
, vol.3
, pp. 137-147
-
-
Miyamoto, T.1
Iwasaki, H.2
Reizis, B.3
Ye, M.4
Graf, T.5
-
78
-
-
85047689216
-
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
-
Thebault-Baumont K, Dubois-Laforgue D, Krief P, Briand JP, Halbout P, et al. 2003. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J. Clin. Invest. 111:851-57
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 851-857
-
-
Thebault-Baumont, K.1
Dubois-Laforgue, D.2
Krief, P.3
Briand, J.P.4
Halbout, P.5
-
79
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298:1395-401
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
Chen, Z.4
Berzins, S.P.5
-
80
-
-
0037790522
-
Autoimmune regulator: From loss of function to autoimmunity
-
Pitkanen J, Peterson P. 2003. Autoimmune regulator: from loss of function to autoimmunity. Genes Immun. 4:12-21
-
(2003)
Genes Immun.
, vol.4
, pp. 12-21
-
-
Pitkanen, J.1
Peterson, P.2
-
81
-
-
20744433548
-
Cooperative activation of transcription by autoimmune regulator AIRE and CBP
-
Pitkanen J, Rebane A, Rowell J, Murumagi A, Strobel P, et al. 2005. Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochem. Biophys. Res. Commun. 333:944-53
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.333
, pp. 944-953
-
-
Pitkanen, J.1
Rebane, A.2
Rowell, J.3
Murumagi, A.4
Strobel, P.5
-
83
-
-
0035798665
-
The autoimmune regulator (AIRE) is a DNA-binding protein
-
Kumar PG, Laloraya M, Wang CY, Ruan QG, Davoodi-Semiromi A, et al. 2001. The autoimmune regulator (AIRE) is a DNA-binding protein. J. Biol. Chem. 276:41357-64
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 41357-41364
-
-
Kumar, P.G.1
Laloraya, M.2
Wang, C.Y.3
Ruan, Q.G.4
Davoodi-Semiromi, A.5
-
84
-
-
7244227646
-
Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
-
Liston A, Gray DH, Lesage S, Fletcher AL, Wilson J, et al. 2004. Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200:1015-26
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1015-1026
-
-
Liston, A.1
Gray, D.H.2
Lesage, S.3
Fletcher, A.L.4
Wilson, J.5
-
85
-
-
23844558032
-
The cellular mechanism of Aire control of T cell tolerance
-
82a. Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23:227-39
-
(2005)
Immunity
, vol.23
, pp. 227-239
-
-
Anderson, M.S.1
Venanzi, E.S.2
Chen, Z.3
Berzins, S.P.4
Benoist, C.5
Mathis, D.6
-
86
-
-
18844362882
-
Chromosomal clustering of genes controlled by the aire transcription factor
-
Johnnidis JB, Venanzi ES, Taxman DJ, Ting JP, Benoist CO, et al. 2005. Chromosomal clustering of genes controlled by the aire transcription factor. Proc. Natl. Acad. Sci. USA 102:7233-38
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7233-7238
-
-
Johnnidis, J.B.1
Venanzi, E.S.2
Taxman, D.J.3
Ting, J.P.4
Benoist, C.O.5
-
87
-
-
3543018516
-
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
-
Murrell A, Heeson S, Reik W. 2004. Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat. Genet. 36:889-93
-
(2004)
Nat. Genet.
, vol.36
, pp. 889-893
-
-
Murrell, A.1
Heeson, S.2
Reik, W.3
-
88
-
-
5144231380
-
Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage
-
Sillanpaa N, Magureanu CG, Murumagi A, Reinikainen A, West A, et al. 2004. Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage. Mol. Immunol. 41:1185-98
-
(2004)
Mol. Immunol.
, vol.41
, pp. 1185-1198
-
-
Sillanpaa, N.1
Magureanu, C.G.2
Murumagi, A.3
Reinikainen, A.4
West, A.5
-
89
-
-
0036498116
-
Expression of AIRE gene in peripheral monocyte/dendritic cell lineage
-
Kogawa K, Nagafuchi S, Katsuta H, Kudoh J, Tamiya S, et al. 2002. Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol. Lett. 80:195-98
-
(2002)
Immunol. Lett.
, vol.80
, pp. 195-198
-
-
Kogawa, K.1
Nagafuchi, S.2
Katsuta, H.3
Kudoh, J.4
Tamiya, S.5
-
90
-
-
1842427830
-
The evolutionary dynamics of eukaryotic gene order
-
Hurst LD, Pal C, Lercher MJ. 2004. The evolutionary dynamics of eukaryotic gene order. Nat. Rev. Genet. 5:299-310
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 299-310
-
-
Hurst, L.D.1
Pal, C.2
Lercher, M.J.3
-
91
-
-
0035234557
-
Genomic imprinting: Parental influence on the genome
-
Reik W, Walter J. 2001. Genomic imprinting: parental influence on the genome. Nat. Rev. Genet. 2:21-32
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 21-32
-
-
Reik, W.1
Walter, J.2
-
92
-
-
0035158704
-
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
-
Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, et al. 2001. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat. Genet. 27:31-39
-
(2001)
Nat. Genet.
, vol.27
, pp. 31-39
-
-
Jackson-Grusby, L.1
Beard, C.2
Possemato, R.3
Tudor, M.4
Fambrough, D.5
-
93
-
-
7044220808
-
Regulating self-tolerance by deregulating gene expression
-
Gotter J, Kyewski B. 2004. Regulating self-tolerance by deregulating gene expression. Curr. Opin. Immunol. 16:741-45
-
(2004)
Curr. Opin. Immunol.
, vol.16
, pp. 741-745
-
-
Gotter, J.1
Kyewski, B.2
-
95
-
-
0021912204
-
Studies of the role of the thymic environment in the induction of tolerance to MHC antigens
-
Jenkinson EJ, Jhittay P, Kingston R, Owen JJ. 1985. Studies of the role of the thymic environment in the induction of tolerance to MHC antigens. Transplantation 39:331-33
-
(1985)
Transplantation
, vol.39
, pp. 331-333
-
-
Jenkinson, E.J.1
Jhittay, P.2
Kingston, R.3
Owen, J.J.4
-
96
-
-
0022467911
-
Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells
-
von Boehmer H, Hafen K. 1986. Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells. Nature 320:626-28
-
(1986)
Nature
, vol.320
, pp. 626-628
-
-
Von Boehmer, H.1
Hafen, K.2
-
97
-
-
0020754719
-
Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen
-
Good MF, Pyke KW, Nossal GJ. 1983. Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen. Proc. Natl. Acad. Sci. USA 80:3045-49
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 3045-3049
-
-
Good, M.F.1
Pyke, K.W.2
Nossal, G.J.3
-
98
-
-
0021970169
-
Thymic epithelium and the induction of transplantation tolerance in nude mice
-
Jordan RK, Robinson JH, Hopkinson NA, House KC, Bentley AL. 1985. Thymic epithelium and the induction of transplantation tolerance in nude mice. Nature 314:454-56
-
(1985)
Nature
, vol.314
, pp. 454-456
-
-
Jordan, R.K.1
Robinson, J.H.2
Hopkinson, N.A.3
House, K.C.4
Bentley, A.L.5
-
99
-
-
0025272416
-
Strong T cell tolerance in parent-F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy
-
Gao EK, Lo D, Sprent J. 1990. Strong T cell tolerance in parent-F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. J. Exp. Med. 171:1101-21
-
(1990)
J. Exp. Med.
, vol.171
, pp. 1101-1121
-
-
Gao, E.K.1
Lo, D.2
Sprent, J.3
-
100
-
-
0024381358
-
A nondeletional mechanism of thymic self tolerance
-
Ramsdell F, Lantz T, Fowlkes BJ. 1989. A nondeletional mechanism of thymic self tolerance. Science 246:1038-41
-
(1989)
Science
, vol.246
, pp. 1038-1041
-
-
Ramsdell, F.1
Lantz, T.2
Fowlkes, B.J.3
-
102
-
-
0027450835
-
Thymus epithelium induces tissue-specific tolerance
-
Bonomo A, Matzinger P. 1993. Thymus epithelium induces tissue-specific tolerance. J. Exp. Med. 177:1153-64
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1153-1164
-
-
Bonomo, A.1
Matzinger, P.2
-
103
-
-
14244259515
-
Directed migration of positively selected thymocytes visualized in real time
-
Witt CM, Raychaudhuri S, Schaefer B, Chakraborty AK, Robey EA. 2005. Directed migration of positively selected thymocytes visualized in real time. PLoS Biol. 3:e160
-
(2005)
PLoS Biol.
, vol.3
-
-
Witt, C.M.1
Raychaudhuri, S.2
Schaefer, B.3
Chakraborty, A.K.4
Robey, E.A.5
-
104
-
-
9644303116
-
Thymopoiesis in 4 dimensions
-
Witt CM, Robey EA. 2005. Thymopoiesis in 4 dimensions. Semin. Immunol. 17:95-102
-
(2005)
Semin. Immunol.
, vol.17
, pp. 95-102
-
-
Witt, C.M.1
Robey, E.A.2
-
105
-
-
0742323358
-
T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
-
Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I. 2004. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 101:998-1003
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 998-1003
-
-
Miller, M.J.1
Hejazi, A.S.2
Wei, S.H.3
Cahalan, M.D.4
Parker, I.5
-
106
-
-
0028988659
-
Thymic emigration: Conveyor belts or lucky dips?
-
discussion 73-74
-
Scollay R, Godfrey DI. 1995. Thymic emigration: conveyor belts or lucky dips? Immunol. Today 16:268-73; discussion 73-74
-
(1995)
Immunol. Today
, vol.16
, pp. 268-273
-
-
Scollay, R.1
Godfrey, D.I.2
-
107
-
-
7244227645
-
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
-
Gallegos AM, Bevan MJ. 2004. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200:1039-49
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1039-1049
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
108
-
-
0037446749
-
T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: The soluble form is more effective than the membrane-bound form
-
Zhang M, Vacchio MS, Vistica BP, Lesage S, Egwuagu CE, et al. 2003. T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form. J. Immunol. 170:3954-62
-
(2003)
J. Immunol.
, vol.170
, pp. 3954-3962
-
-
Zhang, M.1
Vacchio, M.S.2
Vistica, B.P.3
Lesage, S.4
Egwuagu, C.E.5
-
111
-
-
0032485487
-
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
-
Albert ML, Sauter B, Bhardwaj N. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86-89
-
(1998)
Nature
, vol.392
, pp. 86-89
-
-
Albert, M.L.1
Sauter, B.2
Bhardwaj, N.3
-
112
-
-
3543053363
-
Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
-
Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, et al. 1998. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188:1359-68
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1359-1368
-
-
Albert, M.L.1
Pearce, S.F.2
Francisco, L.M.3
Sauter, B.4
Roy, P.5
-
113
-
-
0031297434
-
Processing of engulfed apoptotic bodies yields T cell epitopes
-
Bellone M, Iezzi G, Rovere P, Galati G, Ronchetti A, et al. 1997. Processing of engulfed apoptotic bodies yields T cell epitopes. J. Immunol. 159:5391-99
-
(1997)
J. Immunol.
, vol.159
, pp. 5391-5399
-
-
Bellone, M.1
Iezzi, G.2
Rovere, P.3
Galati, G.4
Ronchetti, A.5
-
115
-
-
0035869278
-
Dendritic cells acquire antigens from live cells for cross-presentation to CTL
-
Harshyne LA, Watkins SC, Gambotto A, Barratt-Boyes SM. 2001. Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J. Immunol. 166:3717-23
-
(2001)
J. Immunol.
, vol.166
, pp. 3717-3723
-
-
Harshyne, L.A.1
Watkins, S.C.2
Gambotto, A.3
Barratt-Boyes, S.M.4
-
116
-
-
0028590184
-
Presentation and intercellular transfer of self antigen within the thymic microenvironment: Expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells
-
Humblet C, Rudensky A, Kyewski B. 1994. Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells. Int. Immunol. 6:1949-58
-
(1994)
Int. Immunol.
, vol.6
, pp. 1949-1958
-
-
Humblet, C.1
Rudensky, A.2
Kyewski, B.3
-
117
-
-
0032482173
-
Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells
-
Barlow AK, He X, Janeway C Jr. 1998. Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells. J. Exp. Med. 187:1403-15
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1403-1415
-
-
Barlow, A.K.1
He, X.2
Janeway Jr., C.3
-
118
-
-
0342360011
-
On the intrathymic intercellular transfer of self-determinants
-
Viret C, Barlow AK, Janeway CA Jr. 1999. On the intrathymic intercellular transfer of self-determinants. Immunol. Today 20:8-10
-
(1999)
Immunol. Today
, vol.20
, pp. 8-10
-
-
Viret, C.1
Barlow, A.K.2
Janeway Jr., C.A.3
-
119
-
-
14544292915
-
Cross-presentation by intercellular peptide transfer through gap junctions
-
Neijssen J, Herberts C, Drijfhout JW, Reits E, Janssen L, et al. 2005. Cross-presentation by intercellular peptide transfer through gap junctions. Nature 434:83-88
-
(2005)
Nature
, vol.434
, pp. 83-88
-
-
Neijssen, J.1
Herberts, C.2
Drijfhout, J.W.3
Reits, E.4
Janssen, L.5
-
120
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4:350-54
-
(2003)
Nat. Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
Lesage, S.2
Wilson, J.3
Peltonen, L.4
Goodnow, C.C.5
-
122
-
-
1642500086
-
AIRE functions as an E3 ubiquitin ligase
-
118a. Uchida D, Hatakeyama S, Matsushima A, Han H, Ishido S, et al. 2004. AIRE functions as an E3 ubiquitin ligase. J. Exp. Med. 199:167-72
-
(2004)
J. Exp. Med.
, vol.199
, pp. 167-172
-
-
Uchida, D.1
Hatakeyama, S.2
Matsushima, A.3
Han, H.4
Ishido, S.5
-
123
-
-
15744397285
-
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease
-
118b. Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, et al. 2005. NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. J. Biol. Chem. 280:11505-12
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11505-11512
-
-
Bottomley, M.J.1
Stier, G.2
Pennacchini, D.3
Legube, G.4
Simon, B.5
-
124
-
-
0033136302
-
+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
-
+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317-26
-
(1999)
J. Immunol.
, vol.162
, pp. 5317-5326
-
-
Itoh, M.1
Takahashi, T.2
Sakaguchi, N.3
Kuniyasu, Y.4
Shimizu, J.5
-
125
-
-
15244354286
-
Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
-
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, et al. 2005. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22:329-41
-
(2005)
Immunity
, vol.22
, pp. 329-341
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Williams, L.M.3
Dooley, J.L.4
Farr, A.G.5
-
128
-
-
0041806547
-
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
-
Klein L, Khazaie K, von Boehmer H. 2003. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100:8886-91
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8886-8891
-
-
Klein, L.1
Khazaie, K.2
Von Boehmer, H.3
-
129
-
-
0036568942
-
+ regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
-
+ regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168:4399-405
-
(2002)
J. Immunol.
, vol.168
, pp. 4399-4405
-
-
Kawahata, K.1
Misaki, Y.2
Yamauchi, M.3
Tsunekawa, S.4
Setoguchi, K.5
-
132
-
-
0029835390
-
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
-
Laufer TM, DeKoning J, Markowitz JS, Lo D, Glimcher LH. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383:81-85
-
(1996)
Nature
, vol.383
, pp. 81-85
-
-
Laufer, T.M.1
DeKoning, J.2
Markowitz, J.S.3
Lo, D.4
Glimcher, L.H.5
-
135
-
-
24744448656
-
Linking signalling pathways, thymic stroma integrity and autoimmunity
-
Derbinski J, Kyewski B. 2005. Linking signalling pathways, thymic stroma integrity and autoimmunity. Trends Immunol. 26:503-6
-
(2005)
Trends Immunol.
, vol.26
, pp. 503-506
-
-
Derbinski, J.1
Kyewski, B.2
-
136
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, et al. 2005. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308:248-51
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
Maeda, S.2
Yamane, S.3
Ogino, K.4
Kasai, M.5
-
137
-
-
10744226628
-
NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner
-
Kajiura F, Sun S, Nomura T, Izumi K, Ueno T, et al. 2004. NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 172:2067-75
-
(2004)
J. Immunol.
, vol.172
, pp. 2067-2075
-
-
Kajiura, F.1
Sun, S.2
Nomura, T.3
Izumi, K.4
Ueno, T.5
-
138
-
-
0035399985
-
+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen
-
+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167:188-95
-
(2001)
J. Immunol.
, vol.167
, pp. 188-195
-
-
Thorstenson, K.M.1
Khoruts, A.2
-
140
-
-
2542420993
-
In vivo instruction of suppressor commitment in naive T cells
-
Apostolou I, von Boehmer H. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199:1401-8
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1401-1408
-
-
Apostolou, I.1
Von Boehmer, H.2
-
141
-
-
29244435493
-
Inducing and expanding regulatory T cell populations by foreign antigen
-
133a. Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6:1219-27
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1219-1227
-
-
Kretschmer, K.1
Apostolou, I.2
Hawiger, D.3
Khazaie, K.4
Nussenzweig, M.C.5
Von Boehmer, H.6
-
142
-
-
0242624626
-
Lymphotoxin pathway directs thymic Aire expression
-
Chin RK, Lo JC, Kim O, Blink SE, Christiansen PA, et al. 2003. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4:1121-27
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1121-1127
-
-
Chin, R.K.1
Lo, J.C.2
Kim, O.3
Blink, S.E.4
Christiansen, P.A.5
-
143
-
-
0028952482
-
Expression of relB is required for the development of thymic medulla and dendritic cells
-
Burkly L, Hession C, Ogata L, Reilly C, Marconi LA, et al. 1995. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373:531-36
-
(1995)
Nature
, vol.373
, pp. 531-536
-
-
Burkly, L.1
Hession, C.2
Ogata, L.3
Reilly, C.4
Marconi, L.A.5
-
144
-
-
0028817585
-
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
-
Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, et al. 1995. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80:331-40
-
(1995)
Cell
, vol.80
, pp. 331-340
-
-
Weih, F.1
Carrasco, D.2
Durham, S.K.3
Barton, D.S.4
Rizzo, C.A.5
-
145
-
-
0033939699
-
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse
-
Heino M, Peterson P, Sillanpaa N, Guerin S, Wu L, et al. 2000. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 30:1884-93
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 1884-1893
-
-
Heino, M.1
Peterson, P.2
Sillanpaa, N.3
Guerin, S.4
Wu, L.5
-
146
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
Pugliese A, Zeller M, Fernandez A Jr., Zalcberg LJ, Bartlett RJ, et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15:293-97
-
(1997)
Nat. Genet.
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
Zeller, M.2
Fernandez Jr., A.3
Zalcberg, L.J.4
Bartlett, R.J.5
-
147
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15:289-92
-
(1997)
Nat. Genet.
, vol.15
, pp. 289-292
-
-
Vafiadis, P.1
Bennett, S.T.2
Todd, J.A.3
Nadeau, J.4
Grabs, R.5
-
148
-
-
0036315824
-
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
-
Chentoufi AA, Polychronakos C. 2002. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51:1383-90
-
(2002)
Diabetes
, vol.51
, pp. 1383-1390
-
-
Chentoufi, A.A.1
Polychronakos, C.2
-
149
-
-
0031255108
-
Thymic expression of autoantigens correlates with resistance to autoimmune disease
-
Egwuagu CE, Charukamnoetkanok P, Gery I. 1997. Thymic expression of autoantigens correlates with resistance to autoimmune disease. J. Immunol. 159:3109-12
-
(1997)
J. Immunol.
, vol.159
, pp. 3109-3112
-
-
Egwuagu, C.E.1
Charukamnoetkanok, P.2
Gery, I.3
-
150
-
-
0031812475
-
Expression of ocular autoantigens in the mouse thymus
-
Charukamnoetkanok P, Fukushima A, Whitcup SM, Gery I, Egwuagu CE. 1998. Expression of ocular autoantigens in the mouse thymus. Curr. Eye Res. 17:788-92
-
(1998)
Curr. Eye Res.
, vol.17
, pp. 788-792
-
-
Charukamnoetkanok, P.1
Fukushima, A.2
Whitcup, S.M.3
Gery, I.4
Egwuagu, C.E.5
-
151
-
-
0035795102
-
Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance
-
Liu H, MacKenzie-Graham AJ, Kim S, Voskuhl RR. 2001. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J. Neuroimmunol. 115:118-26
-
(2001)
J. Neuroimmunol.
, vol.115
, pp. 118-126
-
-
Liu, H.1
MacKenzie-Graham, A.J.2
Kim, S.3
Voskuhl, R.R.4
-
152
-
-
0033984067
-
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
-
Klein L, Klugmann M, Nave KA, Tuohy VK, Kyewski B. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6:56-61
-
(2000)
Nat. Med.
, vol.6
, pp. 56-61
-
-
Klein, L.1
Klugmann, M.2
Nave, K.A.3
Tuohy, V.K.4
Kyewski, B.5
-
153
-
-
0034610973
-
High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
-
Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, et al. 2000. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191:761-70
-
(2000)
J. Exp. Med.
, vol.191
, pp. 761-770
-
-
Anderson, A.C.1
Nicholson, L.B.2
Legge, K.L.3
Turchin, V.4
Zaghouani, H.5
-
154
-
-
17844411238
-
Detection of thyroglobulin mRNA as truncated isoform(s) in mouse thymus
-
Li HS, Carayanniotis G. 2005. Detection of thyroglobulin mRNA as truncated isoform(s) in mouse thymus. Immunology 115:85-89
-
(2005)
Immunology
, vol.115
, pp. 85-89
-
-
Li, H.S.1
Carayanniotis, G.2
-
155
-
-
1542500767
-
Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus
-
Bruno R, Sabater L, Tolosa E, Sospedra M, Ferrer-Francesch X, et al. 2004. Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus. J. Neuroimmunol. 149:147-59
-
(2004)
J. Neuroimmunol.
, vol.149
, pp. 147-159
-
-
Bruno, R.1
Sabater, L.2
Tolosa, E.3
Sospedra, M.4
Ferrer-Francesch, X.5
-
156
-
-
0035083648
-
Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen
-
Diez J, Park Y, Zeller M, Brown D, Garza D, et al. 2001. Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. Diabetes 50:895-900
-
(2001)
Diabetes
, vol.50
, pp. 895-900
-
-
Diez, J.1
Park, Y.2
Zeller, M.3
Brown, D.4
Garza, D.5
-
157
-
-
0027276929
-
Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues
-
Talib S, Okarma TB, Lebkowski JS. 1993. Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues. Nucleic Acids Res. 21:233-37
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 233-237
-
-
Talib, S.1
Okarma, T.B.2
Lebkowski, J.S.3
-
158
-
-
27144445820
-
Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells
-
149a. Allen S, Read S, DiPaolo R, McHugh RS, Shevach EM, et al. 2005. Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells. J. Immunol. 175:5759-64
-
(2005)
J. Immunol.
, vol.175
, pp. 5759-5764
-
-
Allen, S.1
Read, S.2
DiPaolo, R.3
McHugh, R.S.4
Shevach, E.M.5
-
159
-
-
0036919338
-
Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis
-
Backlund J, Treschow A, Bockermann R, Holm B, Holm L, et al. 2002. Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis. Eur. J. Immunol. 32:3776-84
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 3776-3784
-
-
Backlund, J.1
Treschow, A.2
Bockermann, R.3
Holm, B.4
Holm, L.5
-
160
-
-
0036236464
-
The genetic background of autoimmune polyendocrinopathy-candidiasis- ectodermal dystrophy and its autoimmune disease components
-
Vogel A, Strassburg CP, Obermayer-Straub P, Brabant G, Manns MP. 2002. The genetic background of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy and its autoimmune disease components. J. Mol. Med. 80:201-11
-
(2002)
J. Mol. Med.
, vol.80
, pp. 201-211
-
-
Vogel, A.1
Strassburg, C.P.2
Obermayer-Straub, P.3
Brabant, G.4
Manns, M.P.5
-
161
-
-
0034869235
-
APECED mutations in the autoimmune regulator (AIRE) gene
-
Heino M, Peterson P, Kudoh J, Shimizu N, Antonarakis SE, et al. 2001. APECED mutations in the autoimmune regulator (AIRE) gene. Hum. Mutat. 18:205-11
-
(2001)
Hum. Mutat.
, vol.18
, pp. 205-211
-
-
Heino, M.1
Peterson, P.2
Kudoh, J.3
Shimizu, N.4
Antonarakis, S.E.5
-
162
-
-
25144432460
-
Modifier loci condition autoimmunity provoked by Aire deficiency
-
152a. Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 202:805-15
-
(2005)
J. Exp. Med.
, vol.202
, pp. 805-815
-
-
Jiang, W.1
Anderson, M.S.2
Bronson, R.3
Mathis, D.4
Benoist, C.5
-
163
-
-
10744233772
-
Prevalence and clinical associations of 10 defined auto antibodies in autoimmune polyendocrine syndrome type I
-
Soderbergh A, Myhre AG, Ekwall O, Gebre-Medhin G, Hedstrand H, et al. 2004. Prevalence and clinical associations of 10 defined auto antibodies in autoimmune polyendocrine syndrome type I. J. Clin. Endocrinol. Metab. 89:557-62
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 557-562
-
-
Soderbergh, A.1
Myhre, A.G.2
Ekwall, O.3
Gebre-Medhin, G.4
Hedstrand, H.5
-
164
-
-
5444222000
-
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
-
Jaeckel E, Lipes MA, von Boehmer H. 2004. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat. Immunol. 5:1028-35
-
(2004)
Nat. Immunol.
, vol.5
, pp. 1028-1035
-
-
Jaeckel, E.1
Lipes, M.A.2
Von Boehmer, H.3
-
165
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, et al. 2005. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435:220-23
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
Babaya, N.4
Liu, E.5
-
166
-
-
18744385526
-
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
-
Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, et al. 2005. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435:224-28
-
(2005)
Nature
, vol.435
, pp. 224-228
-
-
Kent, S.C.1
Chen, Y.2
Bregoli, L.3
Clemmings, S.M.4
Kenyon, N.S.5
-
167
-
-
20444438369
-
Paths to understanding the genetic basis of autoimmune disease
-
Rioux JD, Abbas AK. 2005. Paths to understanding the genetic basis of autoimmune disease. Nature 435:584-89
-
(2005)
Nature
, vol.435
, pp. 584-589
-
-
Rioux, J.D.1
Abbas, A.K.2
-
168
-
-
27844563909
-
Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus
-
Sabater L, Ferrer-Francesch X, Sospedra M, Caro P, Juan M, Pujol-Borrell R. 2005. Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus. J. Autoimmun. 25:312-18
-
(2005)
J. Autoimmun.
, vol.25
, pp. 312-318
-
-
Sabater, L.1
Ferrer-Francesch, X.2
Sospedra, M.3
Caro, P.4
Juan, M.5
Pujol-Borrell, R.6
-
169
-
-
0037351401
-
Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide
-
Miyamoto K, Miyake S, Schachner M, Yamamura T. 2003. Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide. Eur. J. Immunol. 33:656-65
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 656-665
-
-
Miyamoto, K.1
Miyake, S.2
Schachner, M.3
Yamamura, T.4
-
170
-
-
23844439642
-
Thymic expression of peripheral tissue antigens in humans: A remarkable variability among individuals
-
Takase H, Yu CR, Mahdi RM, Douek DC, Dirusso GB, et al. 2005. Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals. Int. Immunol. 17:1131-40
-
(2005)
Int. Immunol.
, vol.17
, pp. 1131-1140
-
-
Takase, H.1
Yu, C.R.2
Mahdi, R.M.3
Douek, D.C.4
Dirusso, G.B.5
-
171
-
-
0031756654
-
Myelin protein expression in lymphoid tissues: Implications for peripheral tolerance
-
Voskuhl RR. 1998. Myelin protein expression in lymphoid tissues: implications for peripheral tolerance. Immunol. Rev. 164:81-92
-
(1998)
Immunol. Rev.
, vol.164
, pp. 81-92
-
-
Voskuhl, R.R.1
-
173
-
-
0034551737
-
Thymomas alter the T-cell subset composition in the blood: A potential mechanism for thymoma-associated autoimmune disease
-
Hoffacker V, Schultz A, Tiesinga JJ, Gold R, Schalke B, et al. 2000. Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood 96:3872-79
-
(2000)
Blood
, vol.96
, pp. 3872-3879
-
-
Hoffacker, V.1
Schultz, A.2
Tiesinga, J.J.3
Gold, R.4
Schalke, B.5
-
174
-
-
0037963689
-
Diversity of the inhibitory effects on fertilization by anti-sperm antibodies bound to the surface of ejaculated human sperm
-
Shibahara H, Shiraishi Y, Hirano Y, Suzuki T, Takamizawa S, et al. 2003. Diversity of the inhibitory effects on fertilization by anti-sperm antibodies bound to the surface of ejaculated human sperm. Hum. Reprod. 18:1469-73
-
(2003)
Hum. Reprod.
, vol.18
, pp. 1469-1473
-
-
Shibahara, H.1
Shiraishi, Y.2
Hirano, Y.3
Suzuki, T.4
Takamizawa, S.5
-
175
-
-
0033961572
-
Antisperm antibodies from infertile patients and their cognate sperm antigens: A review. Identity between SAGA-1, the H6-3C4 antigen, and CD52
-
Diekman AB, Norton EJ, Westbrook VA, Klotz KL, Naaby-Hansen S, et al. 2000. Antisperm antibodies from infertile patients and their cognate sperm antigens: a review. Identity between SAGA-1, the H6-3C4 antigen, and CD52. Am. J. Reprod. Immunol. 43:134-43
-
(2000)
Am. J. Reprod. Immunol.
, vol.43
, pp. 134-143
-
-
Diekman, A.B.1
Norton, E.J.2
Westbrook, V.A.3
Klotz, K.L.4
Naaby-Hansen, S.5
-
176
-
-
0041869608
-
Effects of sera from infertile women with sperm immobilizing antibodies on fertilization and embryo development in vitro in mice
-
Taneichi A, Shibahara H, Takahashi K, Sasaki S, Kikuchi K, et al. 2003. Effects of sera from infertile women with sperm immobilizing antibodies on fertilization and embryo development in vitro in mice. Am. J. Reprod. Immunol. 50:146-51
-
(2003)
Am. J. Reprod. Immunol.
, vol.50
, pp. 146-151
-
-
Taneichi, A.1
Shibahara, H.2
Takahashi, K.3
Sasaki, S.4
Kikuchi, K.5
-
177
-
-
20344365312
-
Autoimmune ovarian disease in day 3-thymectomized mice: The neonatal time window, antigen specificity of disease suppression, and genetic control
-
Tung KS, Setiady YY, Samy ET, Lewis J, Teuscher C. 2005. Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control. Curr. Top. Microbiol. Immunol. 293:209-47
-
(2005)
Curr. Top. Microbiol. Immunol.
, vol.293
, pp. 209-247
-
-
Tung, K.S.1
Setiady, Y.Y.2
Samy, E.T.3
Lewis, J.4
Teuscher, C.5
-
178
-
-
4243670795
-
Autoimmune hypogonadism as part of an autoimmune polyglandular syndrome
-
Maclaren N, Chen QY, Kukreja A, Marker J, Zhang CH, et al. 2001. Autoimmune hypogonadism as part of an autoimmune polyglandular syndrome. J. Soc. Gynecol. Investig. 8:S52-54
-
(2001)
J. Soc. Gynecol. Investig.
, vol.8
-
-
Maclaren, N.1
Chen, Q.Y.2
Kukreja, A.3
Marker, J.4
Zhang, C.H.5
-
179
-
-
0036749783
-
Genetic disorders in premature ovarian failure
-
Laml T, Preyer O, Umek W, Hengstschlager M, Hanzal H. 2002. Genetic disorders in premature ovarian failure. Hum. Reprod. Update 8:483-91
-
(2002)
Hum. Reprod. Update
, vol.8
, pp. 483-491
-
-
Laml, T.1
Preyer, O.2
Umek, W.3
Hengstschlager, M.4
Hanzal, H.5
-
181
-
-
0042470540
-
Does the immune system see tumors as foreign or self?
-
Pardoll D. 2003. Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21:807-39
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 807-839
-
-
Pardoll, D.1
-
183
-
-
4644324025
-
Cancer immunotherapy: Moving beyond current vaccines
-
Rosenberg SA, Yang JC, Restifo NP. 2004. Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10:909-15
-
(2004)
Nat. Med.
, vol.10
, pp. 909-915
-
-
Rosenberg, S.A.1
Yang, J.C.2
Restifo, N.P.3
-
185
-
-
0032880649
-
Human tumor antigens for cancer vaccine development
-
Wang RF, Rosenberg SA. 1999. Human tumor antigens for cancer vaccine development. Immunol. Rev. 170:85-100
-
(1999)
Immunol. Rev.
, vol.170
, pp. 85-100
-
-
Wang, R.F.1
Rosenberg, S.A.2
-
186
-
-
0028989971
-
Genes coding for tumor antigens recognized by cytolytic T lymphocytes
-
Van Pel A, van der Bruggen P, Coulie PG, Brichard VG, Lethe B, et al. 1995. Genes coding for tumor antigens recognized by cytolytic T lymphocytes. Immunol. Rev. 145:229-50
-
(1995)
Immunol. Rev.
, vol.145
, pp. 229-250
-
-
Van Pel, A.1
Van Der Bruggen, P.2
Coulie, P.G.3
Brichard, V.G.4
Lethe, B.5
-
187
-
-
4544258485
-
Self-representation in the thymus: An extended view
-
Kyewski B, Derbinski J. 2004. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4:688-98
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 688-698
-
-
Kyewski, B.1
Derbinski, J.2
-
192
-
-
0037174674
-
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
-
Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, et al. 2002. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298:850-54
-
(2002)
Science
, vol.298
, pp. 850-854
-
-
Dudley, M.E.1
Wunderlich, J.R.2
Robbins, P.F.3
Yang, J.C.4
Hwu, P.5
-
194
-
-
1842684987
-
The use of zebrafish to understand immunity
-
Trede NS, Langenau DM, Traver D, Look AT, Zon LI. 2004. The use of zebrafish to understand immunity. Immunity 20:367-79
-
(2004)
Immunity
, vol.20
, pp. 367-379
-
-
Trede, N.S.1
Langenau, D.M.2
Traver, D.3
Look, A.T.4
Zon, L.I.5
-
196
-
-
26844450449
-
How defects in central tolerance impinge on a deficiency in regulatory T cells
-
Chen Z, Benoist C, Mathis D. 2005. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc. Natl. Acad. Sci. USA 102:14735-40
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14735-14740
-
-
Chen, Z.1
Benoist, C.2
Mathis, D.3
-
197
-
-
0033590981
-
Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla
-
Heino M, Peterson P, Kudoh J, Nagamine K, Lagerstedt A, et al. 1999. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257:821-25
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.257
, pp. 821-825
-
-
Heino, M.1
Peterson, P.2
Kudoh, J.3
Nagamine, K.4
Lagerstedt, A.5
-
198
-
-
0038486459
-
Localization of the APECED protein in distinct nuclear structures
-
Bjorses P, Pelto-Huikko M, Kaukonen J, Aaltonen J, Peltonen L, et al. 1999. Localization of the APECED protein in distinct nuclear structures. Hum. Mol. Genet. 8:259-66
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 259-266
-
-
Bjorses, P.1
Pelto-Huikko, M.2
Kaukonen, J.3
Aaltonen, J.4
Peltonen, L.5
-
200
-
-
23444442192
-
Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion
-
Garcia CA, Prabakar KR, Diez J, Cao ZA, Allende G, et al. 2005. Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion. J. Immunol. 175:2111-22
-
(2005)
J. Immunol.
, vol.175
, pp. 2111-2122
-
-
Garcia, C.A.1
Prabakar, K.R.2
Diez, J.3
Cao, Z.A.4
Allende, G.5
-
201
-
-
9244255248
-
Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs
-
Zheng X, Yin L, Liu Y, Zheng P. 2004. Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs. Eur. J. Immunol. 34:3126-34
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 3126-3134
-
-
Zheng, X.1
Yin, L.2
Liu, Y.3
Zheng, P.4
-
202
-
-
0037301566
-
A central role for peripheral dendritic cells in the induction of acquired thymic tolerance
-
Goldschneider I, Cone RE. 2003. A central role for peripheral dendritic cells in the induction of acquired thymic tolerance. Trends Immunol. 24:77-81
-
(2003)
Trends Immunol.
, vol.24
, pp. 77-81
-
-
Goldschneider, I.1
Cone, R.E.2
-
203
-
-
0035041538
-
Age-dependent T cell tolerance and autoimmunity to myelin basic protein
-
Huseby ES, Sather B, Huseby PG, Goverman J. 2001. Age-dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity 14:471-81
-
(2001)
Immunity
, vol.14
, pp. 471-481
-
-
Huseby, E.S.1
Sather, B.2
Huseby, P.G.3
Goverman, J.4
-
204
-
-
0242636376
-
Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus
-
Petrie HT. 2003. Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus. Nat. Rev. Immunol. 3:859-66
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 859-866
-
-
Petrie, H.T.1
-
205
-
-
0034084162
-
Regulatory T cells in autoimmunity
-
Shevach EM. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18:423-50
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 423-450
-
-
Shevach, E.M.1
-
206
-
-
0035059416
-
Cross-presentation, dendritic cells, tolerance, and immunity
-
Heath WR, Carbone FR. 2001. Cross-presentation, dendritic cells, tolerance, and immunity. Annu. Rev. Immunol. 19:47-64
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 47-64
-
-
Heath, W.R.1
Carbone, F.R.2
-
208
-
-
17644361955
-
The NOD mouse: A model of immune dysregulation
-
Anderson MS, Bluestone JA. 2005. The NOD mouse: a model of immune dysregulation. Annu. Rev. Immunol. 23:447-86
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 447-486
-
-
Anderson, M.S.1
Bluestone, J.A.2
|