Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells

Immunological Reviews

Volumn 182, Issue , 2001, Pages 207-214

  Weiner, Howard L ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; CELL DIFFERENTIATION; DENDRITIC CELL; HELPER CELL; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TARGET ORGAN; TRANSGENIC MOUSE;

ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; MOUTH; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035186416     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1820117.x     Document Type: Review

References (81)

1. Increased frequency of IL-2 responsive T-cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
2. Autoimmunity, microbial immunity and the immunological homunculus
3. Tolerance, danger, and the extended family
4. Regulatory T-cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
5. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy
6. Peripheral deletion of antigen-reactive T-cells in oral tolerance
7. Oral tolerance to ovalbumin in mice: Studies of chemically modified and 'biologically filtered' antigen
8. Oral tolerance induced by gut-processed antigen
9. Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T-cells in vivo
10. Antigen presentation by epithelial cells of the rat small intestine. II Selective induction of suppressor T-cells
11. Evidence for function of Ia molecules on gut epithelial cells in man
12. Oral tolerance to haptens: Intestinal epithelial cells from 2,4-dinitrochlorobenzene-fed mice inhibit hapten-specific T-cell activation in vitro
13. The role of small intestinal antigen-presenting cells in the induction of T-cell reactivity to soluble protein antigens: Association between aberrant presentation in the lamina propria and oral tolerance
14. Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function
15. 2 cells in murine Peyer's patches by oral immunization
16. Functional diversity of helper T lymphocytes
17. In situ immune response in gut associated lymphoid tissue (GALT) following oral antigen in TcR transgenic mice
18. FACS-sorted spleen and Peyer's patch dendritic cells induce different responses in Th0 clones
19. Expanding dendritic cells in vivo enhances the induction of oral tolerance
20. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
21. CTLA-4 is required for the induction of high dose oral tolerance
22. + T-cell-depleted mice
23. B cell-deficient (μMT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance
24. The regulation of immune responses to dietary protein antigens
25. Immunosuppression caused by antigen feeding. I. Evidence for the activation of a feedback suppressor pathway in the spleens of antigen-fed mice
26. Oral administration of the contact sensitizer trinitrochlorobenzene: Initial sensitization and subsequent appearance of a suppressor population
27. Regulation of the primary in vitro response to TNP-polymerized ovalbumin by T suppressor cells induced by ovalbumin feeding
28. Enterically induced immunological tolerance. I. Induction of suppressor T lymphocytes by intragastric administration of soluble proteins
29. Immunological responses to fed protein antigens in mice. II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen
30. Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin
31. Stigma variations: Observations on suppressor T-cells and leprosy
32. The distinctive specificity of antigen-specific suppressor T-cells
33. Immunological response to fed protein antigens in mice: I. Reversal of oral tolerance to ovalbumin by cyclophosphamide
34. Inhibition of specific immune responses by feeding protein antigens. V. Induction of the tolerant state in the absence of specific suppressor T-cells
35. Oral tolerance: Mechanism and therapeutic applications
36. + T lymphocytes
37. Suppressor T-cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGF-β following antigen specific triggering
38. Epitopes of myelin basic protein that trigger TGF-β release following oral tolerization are distinct from encephalitogenic epitopes and mediate epitope driven bystander suppression
39. Oral tolerance to myelin basic protein induces regulatory TGF-β-secreting T-cells in Peyer's patches of SJL mice
40. + cells mediate active suppression
41. Helper T-cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
42. Immunosuppressive and anti-inflammatory properties of interleukin 10
43. + T-cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production
44. On the mechanisms by which transforming growth factor-β2 alters antigen-presenting abilities of macrophages on T-cell activation
45. TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells
46. IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis
47. + T-cells
48. A critical role for transforming growth factor-β in donor transfusion-induced allograft tolerance
49. Alterations in cytokine production following intraocular injection of soluble protein antigen: Impairment in IFN-γ and induction of TGF-β and IL-4 production
50. Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T-cells engineered to express latent TGF-β1
51. + T cells
52. - thymocytes
53. T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction
54. Prevention of lung eosinophilic inflammation by oral tolerance
55. Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction
56. induction of oral tolerance in TGF-β 1 null mice
57. Oral tolerance to low dose B2-glycoprotein I: Immunomodulation of experimental antiphospholipid syndrome
58. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance
59. TGF-β induced by oral tolerance ameliorates experimental tracheal eosinophilia
60. Oral delivery of group A streptococcal cell walls augments circulating TGF-β and suppresses streptococcal cell wall arthritis
61. Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: Identification of regulatory cells
62. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shift
63. Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells
64. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T-cells by oral administration of myelin in multiple sclerosis patients
65. A transforming growth factor-β1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura
66. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
67. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
68. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
69. + regulatory T cells induced by an agonist self-peptide
70. + regulatory T cells is mediated by cell surface-bound transforming growth factor-β
71. + regulatory T cells from human peripheral blood
72. + T cells in ovalbumin TCR transgenic mice
73. + T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen
74. + regulatory cells?
75. Regulation of immune responses by TGF-β
76. The inhibitory effects of transforming growth factor-β1 (TGF-β1) in autoimmune diseases
77. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
78. Essential role of TGF-β in the natural resistance to experimental allergic encephalomyelitis in rats
79. Mucosal immunity and inflammation. I. Mucosal dendritic cells: Their specialized role in initiating T cell responses
80. The mucosal milieu creates tolerogenic dendritic cells and Tr1 and Th3 regulatory cells