메뉴 건너뛰기




Volumn 200, Issue 3, 2004, Pages 331-343

CD25+CD4+ regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4+ and CD8+ HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status

Author keywords

Cytokine; FoxP3; Human; Proliferation; Suppression

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; VIRUS DNA;

EID: 3543098686     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032069     Document Type: Article
Times cited : (390)

References (78)
  • 1
    • 0023544875 scopus 로고
    • The validity of immunological studies in human immunodeficiency virus infection: A three-year follow-up of 235 homo- or bisexual persons
    • Antonen, J., A. Ranki, S.L. Valle, E. Seppala, H. Vapaatalo, J. Suni, and K. Krohn. 1987. The validity of immunological studies in human immunodeficiency virus infection: a three-year follow-up of 235 homo- or bisexual persons. Acta Pathol. Microbiol. Immunol. Scand. [C]. 95:275-282.
    • (1987) Acta Pathol. Microbiol. Immunol. Scand. [C] , vol.95 , pp. 275-282
    • Antonen, J.1    Ranki, A.2    Valle, S.L.3    Seppala, E.4    Vapaatalo, H.5    Suni, J.6    Krohn, K.7
  • 2
    • 0024786954 scopus 로고
    • Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging
    • Clerici, M., N.I. Stocks, R.A. Zajac, R.N. Boswell, D.R. Lucey, C.S. Via, and G.M. Shearer. 1989. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J. Clin. Invest. 84:1892-1899.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1892-1899
    • Clerici, M.1    Stocks, N.I.2    Zajac, R.A.3    Boswell, R.N.4    Lucey, D.R.5    Via, C.S.6    Shearer, G.M.7
  • 3
    • 0026653197 scopus 로고
    • Immunological abnormalities in the natural history of HIV infection: Mechanisms and clinical relevance
    • Miedema, F. 1992. Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance. Immunodefic. Rev. 3:173-193.
    • (1992) Immunodefic. Rev. , vol.3 , pp. 173-193
    • Miedema, F.1
  • 6
    • 0035095255 scopus 로고    scopus 로고
    • Cellular immune response to human immunodeficiency virus
    • Norris, P.J., and E.S. Rosenberg. 2001. Cellular immune response to human immunodeficiency virus. AIDS. 15:S16-S21.
    • (2001) AIDS , vol.15
    • Norris, P.J.1    Rosenberg, E.S.2
  • 9
    • 0034633829 scopus 로고    scopus 로고
    • Exploitation of cellular signaling by HIV-1: Unwelcome guests with master keys that signal their entry
    • Popik, W., and P.M. Pitha. 2000. Exploitation of cellular signaling by HIV-1: unwelcome guests with master keys that signal their entry. Virology. 276:1-6.
    • (2000) Virology , vol.276 , pp. 1-6
    • Popik, W.1    Pitha, P.M.2
  • 10
    • 0036899797 scopus 로고    scopus 로고
    • Premature ageing of the immune system: The cause of AIDS?
    • Appay, V., and S.L. Rowland-Jones. 2002. Premature ageing of the immune system: the cause of AIDS? Trends Immunol. 23:580-585.
    • (2002) Trends Immunol. , vol.23 , pp. 580-585
    • Appay, V.1    Rowland-Jones, S.L.2
  • 11
    • 0035885920 scopus 로고    scopus 로고
    • Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection
    • Lieberman, J., P. Shankar, N. Manjunath, and J. Andersson. 2001. Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood. 98:1667-1677.
    • (2001) Blood , vol.98 , pp. 1667-1677
    • Lieberman, J.1    Shankar, P.2    Manjunath, N.3    Andersson, J.4
  • 12
    • 0034767911 scopus 로고    scopus 로고
    • Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection
    • Lawn, S.D., S.T. Butera, and T.M. Folks. 2001. Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection. Clin. Microbiol. Rev. 14:753-777.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 753-777
    • Lawn, S.D.1    Butera, S.T.2    Folks, T.M.3
  • 13
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 14
    • 0031939403 scopus 로고    scopus 로고
    • CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
    • Suri-Payer, E., A.Z. Amar, A.M. Thornton, and E.M. Shevach. 1998. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212-1218.
    • (1998) J. Immunol. , vol.160 , pp. 1212-1218
    • Suri-Payer, E.1    Amar, A.Z.2    Thornton, A.M.3    Shevach, E.M.4
  • 15
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • Shevach, E.M. 2002. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 16
    • 0037236815 scopus 로고    scopus 로고
    • Regulatory T cells: Mediating compromises between host and parasite
    • Sakaguchi, S. 2003. Regulatory T cells: mediating compromises between host and parasite. Nat. Immunol. 4:10-11.
    • (2003) Nat. Immunol. , vol.4 , pp. 10-11
    • Sakaguchi, S.1
  • 17
    • 1242345130 scopus 로고    scopus 로고
    • Antigen-specific regulatory T cells-their induction and role in infection
    • Mills, K.H., and P. McGuirk. 2004. Antigen-specific regulatory T cells-their induction and role in infection. Semin. Immunol. 16:107-117.
    • (2004) Semin. Immunol. , vol.16 , pp. 107-117
    • Mills, K.H.1    McGuirk, P.2
  • 18
    • 0037436121 scopus 로고    scopus 로고
    • Immunology. Regulating the regulators
    • Powrie, F., and K.J. Maloy. 2003. Immunology. Regulating the regulators. Science. 299:1030-1031.
    • (2003) Science , vol.299 , pp. 1030-1031
    • Powrie, F.1    Maloy, K.J.2
  • 19
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu, J., S. Yamazaki, and S. Sakaguchi. 1999. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211-5218.
    • (1999) J. Immunol. , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 20
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59:3128-3133.
    • (1999) Cancer Res. , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 21
    • 0036467522 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    • Kingsley, C.I., M. Karim, A.R. Bushell, and K.J. Wood. 2002. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168:1080-1086.
    • (2002) J. Immunol. , vol.168 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 22
    • 0036498560 scopus 로고    scopus 로고
    • Tracking the immunoregulatory mechanisms active during allograft tolerance
    • Sanchez-Fueyo, A., M. Weber, C. Domenig, T.B. Strom, and X.X. Zheng. 2002. Tracking the immunoregulatory mechanisms active during allograft tolerance. J. Immunol. 168:2274-2281.
    • (2002) J. Immunol. , vol.168 , pp. 2274-2281
    • Sanchez-Fueyo, A.1    Weber, M.2    Domenig, C.3    Strom, T.B.4    Zheng, X.X.5
  • 23
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    • Belkaid, Y., C.A. Piccirillo, S. Mendez, E.M. Shevach, and D.L. Sacks. 2002. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 420:502-507.
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 25
    • 0037292478 scopus 로고    scopus 로고
    • Influence of CD4+CD25+ T cells on Plasmodium berghei NK65 infection in BALB/c mice
    • Long, T.T., S. Nakazawa, S. Onizuka, M.C. Huaman, and H. Kanbara. 2003. Influence of CD4+CD25+ T cells on Plasmodium berghei NK65 infection in BALB/c mice. Int. J. Parasitol. 33:175-183.
    • (2003) Int. J. Parasitol. , vol.33 , pp. 175-183
    • Long, T.T.1    Nakazawa, S.2    Onizuka, S.3    Huaman, M.C.4    Kanbara, H.5
  • 27
    • 0036107373 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice
    • Hori, S., T.L. Carvalho, and J. Demengeot. 2002. CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur. J. Immunol. 32: 1282-1291.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1282-1291
    • Hori, S.1    Carvalho, T.L.2    Demengeot, J.3
  • 28
    • 0036884607 scopus 로고    scopus 로고
    • B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans
    • Montagnoli, C., A. Bacci, S. Bozza, R. Gaziano, P. Mosci, A.H. Sharpe, and L. Romani. 2002. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J. Immunol. 169:6298-6308.
    • (2002) J. Immunol. , vol.169 , pp. 6298-6308
    • Montagnoli, C.1    Bacci, A.2    Bozza, S.3    Gaziano, R.4    Mosci, P.5    Sharpe, A.H.6    Romani, L.7
  • 36
    • 2142815649 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo
    • Baecher-Allan, C., J.A. Brown, G.J. Freeman, and D.A. Hafler. 2003. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 252:67-88.
    • (2003) Novartis Found Symp. , vol.252 , pp. 67-88
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 38
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells
    • Fontenot, J.D., M.A. Gavin, and A.Y. Rudensky. 2003. Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat. Immunol. 4:330-336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 39
    • 0037383757 scopus 로고    scopus 로고
    • Twenty-first century Foxp3
    • O'Garra, A., and P. Vieira. 2003. Twenty-first century Foxp3. Nat. Immunol. 4:304-306.
    • (2003) Nat. Immunol. , vol.4 , pp. 304-306
    • O'Garra, A.1    Vieira, P.2
  • 40
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri, R., T. Cox, S.A. Yasayko, and F. Ramsdell. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4:337-342.
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 41
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 43
    • 0036284229 scopus 로고    scopus 로고
    • Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood
    • Wing, K., A. Ekmark, H. Karlsson, A. Rudin, and E. Suri-Payer. 2002. Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood. Immunology. 106:190-199.
    • (2002) Immunology , vol.106 , pp. 190-199
    • Wing, K.1    Ekmark, A.2    Karlsson, H.3    Rudin, A.4    Suri-Payer, E.5
  • 44
    • 0037261145 scopus 로고    scopus 로고
    • Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis
    • Cao, D., V. Malmstrom, C. Baecher-Allan, D. Hafler, L. Klareskog, and C. Trollmo. 2003. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33:215-223.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 215-223
    • Cao, D.1    Malmstrom, V.2    Baecher-Allan, C.3    Hafler, D.4    Klareskog, L.5    Trollmo, C.6
  • 45
  • 47
    • 0035806323 scopus 로고    scopus 로고
    • + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:1295-1302.
    • (2001) J. Exp. Med. , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 50
    • 1642575975 scopus 로고    scopus 로고
    • Human CD(4+)CD(25+) regulatory T cells and infectious tolerance
    • Stassen, M., E. Schmitt, and H. Jonuleit. 2004. Human CD(4+)CD(25+) regulatory T cells and infectious tolerance. Transplantation. 77:S23-S25.
    • (2004) Transplantation , vol.77
    • Stassen, M.1    Schmitt, E.2    Jonuleit, H.3
  • 52
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629-644.
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 53
    • 0036886390 scopus 로고    scopus 로고
    • The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells
    • Levings, M.K., R. Bacchetta, U. Schulz, and M.G. Roncarolo. 2002. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. 129:263-276.
    • (2002) Int. Arch. Allergy Immunol. , vol.129 , pp. 263-276
    • Levings, M.K.1    Bacchetta, R.2    Schulz, U.3    Roncarolo, M.G.4
  • 54
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 55
    • 0035421654 scopus 로고    scopus 로고
    • Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    • Piccirillo, C.A., and E.M. Shevach. 2001. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 167:1137-1140.
    • (2001) J. Immunol. , vol.167 , pp. 1137-1140
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 56
    • 10744227590 scopus 로고    scopus 로고
    • Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
    • Aandahl, E.M., J. Michaelsson, W.J. Moretto, F.M. Hecht, and D.F. Nixon. 2004. Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J. Virol. 78:2454-2459.
    • (2004) J. Virol. , vol.78 , pp. 2454-2459
    • Aandahl, E.M.1    Michaelsson, J.2    Moretto, W.J.3    Hecht, F.M.4    Nixon, D.F.5
  • 59
    • 0023028190 scopus 로고
    • The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
    • Maddon, P.J., A.G. Dalgleish, J.S. McDougal, P.R. Clapham, R.A. Weiss, and R. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 47:333-348.
    • (1986) Cell , vol.47 , pp. 333-348
    • Maddon, P.J.1    Dalgleish, A.G.2    McDougal, J.S.3    Clapham, P.R.4    Weiss, R.A.5    Axel, R.6
  • 61
    • 0029655470 scopus 로고    scopus 로고
    • The role of CD4 in HIV envelope-mediated pathogenesis
    • Siliciano, R.F. 1996. The role of CD4 in HIV envelope-mediated pathogenesis. Curr. Top. Microbiol. Immunol. 205:159-179.
    • (1996) Curr. Top. Microbiol. Immunol. , vol.205 , pp. 159-179
    • Siliciano, R.F.1
  • 62
    • 0025069873 scopus 로고
    • The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1
    • Fahey, J.L., J.M. Taylor, R. Detels, B. Hofmann, R. Melmed, P. Nishanian, and J.V. Giorgi. 1990. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N. Engl. J. Med. 322: 166-172.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 166-172
    • Fahey, J.L.1    Taylor, J.M.2    Detels, R.3    Hofmann, B.4    Melmed, R.5    Nishanian, P.6    Giorgi, J.V.7
  • 64
    • 1642480365 scopus 로고    scopus 로고
    • Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells
    • Vahlenkamp, T.W., M.B. Tompkins, and W.A. Tompkins. 2004. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells. J. Immunol. 172:4752-4761.
    • (2004) J. Immunol. , vol.172 , pp. 4752-4761
    • Vahlenkamp, T.W.1    Tompkins, M.B.2    Tompkins, W.A.3
  • 66
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • Sugimoto, K., F. Ikeda, J. Stadanlick, F.A. Nunes, H.J. Alter, and K.M. Chang. 2003. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology. 38:1437-1448.
    • (2003) Hepatology , vol.38 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 67
    • 0141677716 scopus 로고    scopus 로고
    • Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2
    • Iyasere, C., J.C. Tilton, A.J. Johnson, S. Younes, B. Yassine-Diab, R.P. Sekaly, W.W. Kwok, S.A. Migueles, A.C. Laborico, W.L. Shupert, et al. 2003. Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J. Virol. 77:10900-10909.
    • (2003) J. Virol. , vol.77 , pp. 10900-10909
    • Iyasere, C.1    Tilton, J.C.2    Johnson, A.J.3    Younes, S.4    Yassine-Diab, B.5    Sekaly, R.P.6    Kwok, W.W.7    Migueles, S.A.8    Laborico, A.C.9    Shupert, W.L.10
  • 69
    • 1642321982 scopus 로고    scopus 로고
    • IL-2, regulatory T cells, and tolerance
    • Nelson, B.H. 2004. IL-2, regulatory T cells, and tolerance. J. Immunol. 172:3983-3988.
    • (2004) J. Immunol. , vol.172 , pp. 3983-3988
    • Nelson, B.H.1
  • 70
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., and R. Medzhitov. 2003. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 71
    • 2442655250 scopus 로고    scopus 로고
    • Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    • Yang, Y., C.T. Huang, X. Huang, and D.M. Pardoll. 2004. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol. 5:508-515.
    • (2004) Nat Immunol. , vol.5 , pp. 508-515
    • Yang, Y.1    Huang, C.T.2    Huang, X.3    Pardoll, D.M.4
  • 72
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197:403-411.
    • (2003) J. Exp. Med. , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 75
    • 0037220923 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    • Xu, D., H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F.Y. Liew. 2003. CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J. Immunol. 170:394-399.
    • (2003) J. Immunol. , vol.170 , pp. 394-399
    • Xu, D.1    Liu, H.2    Komai-Koma, M.3    Campbell, C.4    McSharry, C.5    Alexander, J.6    Liew, F.Y.7
  • 76
    • 1642305619 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells control the severity of viral immunoinflammatory lesions
    • Suvas, S., A.K. Azkur, B.S. Kim, U. Kumaraguru, and B.T. Rouse. 2004. CD4(+)CD25(+) regulatory T cells control the severity of viral immunoinflammatory lesions. J. Immunol. 172:4123-4132.
    • (2004) J. Immunol. , vol.172 , pp. 4123-4132
    • Suvas, S.1    Azkur, A.K.2    Kim, B.S.3    Kumaraguru, U.4    Rouse, B.T.5
  • 77
    • 2142713131 scopus 로고    scopus 로고
    • The immune response to AIDS virus infection: Good, bad, or both?
    • Deeks, S.G., and B.D. Walker. 2004. The immune response to AIDS virus infection: good, bad, or both? J. Clin. Invest. 113:808-810.
    • (2004) J. Clin. Invest. , vol.113 , pp. 808-810
    • Deeks, S.G.1    Walker, B.D.2
  • 78
    • 0036430999 scopus 로고    scopus 로고
    • Attenuated signaling associated with immune activation in HIV-1-infected individuals
    • Leng, Q., G. Borkow, and Z. Bentwich. 2002. Attenuated signaling associated with immune activation in HIV-1-infected individuals. Biochem. Biophys. Res. Commun. 298:464-467.
    • (2002) Biochem. Biophys. Res. Commun. , vol.298 , pp. 464-467
    • Leng, Q.1    Borkow, G.2    Bentwich, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.