In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines

Journal of Experimental Medicine

Volumn 195, Issue 5, 2002, Pages 603-616

  Barrat, Franck J ^a,e   Cua, Daniel J ^a   Boonstra, André ^a,b   Richards, David F ^c   Crain, Chad ^a   Savelkoul, Huub F ^b   De Waal Malefyt, René ^a   Coffman, Robert L ^a   Hawrylowicz, Catherine M ^c   O'Garra, Anne ^a,d  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^e NONE   (United States)

Author keywords

Autoimmunity; Dexamethasone; Experimental autoimmune encephalomyelitis; T regulatory lymphocyte; Vitamin D3

Indexed keywords

COLECALCIFEROL; DEXAMETHASONE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOTHERAPY; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CHOLECALCIFEROL; CYTOKINES; DEXAMETHASONE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-10; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTORS;

EID: 0037018104     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011629     Document Type: Article

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