Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 2, 2005, Pages 419-424

  Chen, Mei Ling ^a   Pittet, Mikaël J ^a,b   Gorelik, Leonid ^c,e   Flavell, Richard A ^c,d   Weissleder, Ralph ^b   Von Boehmer, Harald ^a   Khazaie, Khashayarsha ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY   (United States)

^e BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; TUMOR ANTIGEN;

ANIMAL BEHAVIOR; ANIMAL CELL; ARTICLE; CANCER INHIBITION; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; IMMUNE RESPONSE; IN VIVO STUDY; LYMPHATIC DRAINAGE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR REJECTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CYTOTOXICITY, IMMUNOLOGIC; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 12244285937     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408197102     Document Type: Article

References (41)

1. Shevach, E. M. (2004) Semin. Immunol. 16, 69-71.
2. Sakaguchi, S. (2004) Annu. Rev. Immunol. 22, 531-562.
3. Suri-Payer, E., Amar, A. Z., Thornton, A. M. & Shevach, E. M. (1998) J. Immunol. 160, 1212-1218.
4. von Boehmer, H. (2003) J. Exp. Med. 198, 845-849.
5. Walker, L. S., Chodos, A., Eggena, M., Dooms, H. & Abbas, A. K. (2003) J. Exp. Med. 198, 249-258.
6. Fisson, S., Darrasse-Jeze, G., Litvinova, E., Septier, F., Klatzmann, D., Liblau, R. & Salomon, B. L. (2003) J. Exp. Med. 198, 737-746.
7. Yamazaki, S., Iyoda, T., Tarbell, K., Olson, K., Velinzon, K., Inaba, K. & Steinman, R. M. (2003) J. Exp. Med. 198, 235-247.
8. Suvas, S., Kumaraguru, U., Pack, C. D., Lee, S. & Rouse, B. T. (2003) J. Exp. Med. 198, 889-901.
9. Dittmer, U., He, H., Messer, R. J., Schimmer, S., Olbrich, A. R., Ohlen, C., Greenberg, P. D., Stromnes, I. M., Iwashiro, M., Sakaguchi, S., et al. (2004) Immunity 29, 293-303.
10. Kursar, M., Bonhagen, K., Fensterle, J., Kohler, A., Hurwitz, R., Kamradt, T., Kaufmann, S. H. & Mittrucker, H. W. (2002) J. Exp. Med. 196, 1585-1592.
11. Lin, C. Y., Graca, L., Cobbold, S. P. & Waldmann, H. (2002) Nat. Immunol. 3, 1208-1213.
12. Dai, Z., Li, Q., Wang, Y., Gao, G., Diggs, L. S., Tellides, G. & Lakkis, F. G. (2004) J. Clin. Invest. 113, 310-317.
13. Malek, T. R., Yu, A., Vincek, V., Scibelli, P. & Kong, L. (2002) Immunity 17, 167-178.
14. Murakami, M., Sakamoto, A., Bender, J., Kappler, J. & Marrack, P. (2002) Proc. Natl. Acad. Sci. USA 99, 8832-8837.
15. Zippelius, A., Batard, P., Rubio-Godoy, V., Bioley, G., Lienard, D., Lejeune, F., Rimoldi, D., Guillaume, P., Meidenbauer, N., Mackensen, A., et al. (2004) Cancer Res. 64, 2865-2873.
16. Wang, H. Y., Lee, D. A., Peng, G., Guo, Z., Li, Y., Kiniwa, Y., Shevach, E. M. & Wang, R. F. (2004) Immunity 20, 107-118.
17. Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) Nat. Med. 10, 942-949.
18. Piccirillo, C. A., Letterio, J. J., Thornton, A. M., McHugh, R. S., Mamura, M., Mizuhara, H. & Shevach, E. M. (2002) J. Exp. Med. 196, 237-246.
19. Peng, Y., Laouar, Y., Li, M. O., Green, E. A. & Flavell, R. A. (2004) Proc. Natl. Acad. Sci. USA 101, 4572-4577.
20. Green, E. A., Gorelik, L., McGregor, C. M., Tran, E. H. & Flavell, R. A. (2003) Proc. Natl. Acad. Sci. USA 100, 10878-10883.
21. Kirberg, J., Baron, A., Jakob, S., Rolink, A., Karjalainen, K. & von Boehmer, H. (1994) J. Exp. Med. 180, 25-34.
22. Morgan, D. J., Liblau, R., Scott, B., Fleck, S., McDevitt, H. O., Sarvetnick, N., Lo, D. & Sherman, L. A. (1996) J. Immunol. 157, 978-983.
23. Klein, L., Trautman, L., Psarras, S., Schnell, S., Siermann, A., Liblau, R., von Boehmer, H. & Khazaie, K. (2003) Eur. J. Immunol. 33, 806-814.
24. Gorelik, L. & Flavell, R. A. (2000) Immunity 12, 171-181.
25. Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. & Von Andrian, U. H. (2003) Nature 424, 88-93.
26. Klein, L., Khazaie, K. & von Boehmer, H. (2003) Proc. Natl. Acad. Sci. USA 100, 8886-8891.
27. Lyman, M. A., Aung, S., Biggs, J. A. & Sherman, L. A. (2004) J. Immunol. 172, 6558-6567.
28. Piccirillo, C. A. & Shevach, E. M. (2001) J. Immunol. 167, 1137-1140.
29. Trapani, J. A. & Smyth, M. J. (2002) Nat. Rev. Immunol. 2, 735-747.
30. Shankaran, V., Ikeda, H., Bruce, A. T., White, J. M., Swanson, P. E., Old, L. J. & Schreiber, R. D. (2001) Nature 410, 1107-1111.
31. Somasundaram, R., Jacob, L., Swoboda, R., Caputo, L., Song, H., Basak, S., Monos, D., Peritt, D., Marincola, F., Cai, D., et al. (2002) Cancer Res. 62, 5267-5272.
32. Qin, Z., Schwartzkopff, J., Pradera, F., Kammertoens, T., Seliger, B., Pircher, H. & Blankenstein, T. (2003) Cancer Res. 63, 4095-4100.
33. Blankenstein, T. & Qin, Z. (2003) Curr. Opin. Immunol. 15, 148-154.
34. Veiga-Fernandes, H., Walter, U., Bourgeois, C., McLean, A. & Rocha, B. (2000) Nat. Immunol. 1, 47-53.
35. Snyder, J. E., Bowers, W. J., Livingstone, A. M., Lee, F. E., Federoff, H. J. & Mosmann, T. R. (2003) Nat. Med. 9, 231-235.
36. Hernandez, J., Aung, S., Marquardt, K. & Sherman, L. A. (2002) J. Exp. Med. 196, 323-333.
37. Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. (2002) Nat. Immunol. 3, 756-763.
38. Valitutti, S., Muller, S., Dessing, M. & Lanzavecchia, A. (1996) J. Exp. Med. 183, 1917-1921.
39. Gorelik, L. & Flavell, R. A. (2001) Nat. Med. 7, 1118-1122.
40. Erard, F., Garcia-Sanz, J. A., Moriggl, R. & Wild, M. T. (1999) J. Immunol. 162, 209-214.
41. Smyth, M. J., Strobl, S. L., Young, H. A., Ortaldo, J. R. & Ochoa, A. C. (1991) J. Immunol. 146, 3289-3297.