Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

Immunity

Volumn 12, Issue 2, 2000, Pages 171-181

  Gorelik, Leonid ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; CD4 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN G; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; C3H MOUSE; C57BL MOUSE; CYTOLOGY; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; ANTIGENS, CD4; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; CYTOKINES; HUMANS; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034131557     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80170-3     Document Type: Article

References (41)

1. Abdollah, S., Macias-Silva, M., Tsukazaki, T., Hayashi, H., Attisano, L., and Wrana, J.L. (1997). TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272, 27678-27685.
2. Adelstein, S., Pritchard-Briscoe, H., Andersen, T.A., Crosbie, J., Gammon, G., Loblay, R.H., Basten, A., and Goodnow, C.C. (1991). Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science 251, 1223-1225.
3. Akkaraju, S., Canaan, K., and Goodnow, C.C. (1997). Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells. J. Exp. Med. 186, 2005-2012.
4. Amendt, C., Schirmacher, P., Weber, H., and Blessing, M. (1998). Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 17, 25-34.
5. Arai, K.-I., Sporn, M.B., Roberts, A.B., and Battey, J.F. (1990). Peptide Growth Factors and their Receptors (Berlin; New York: Springer-Verlag).
6. Bottinger, E.P., Jakubczak, J.L., Haines, D.C., Bagnall, K., and Wakefield, L.M. (1997). Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. CanCer Res. 57, 5564-5570.
7. Chen, R.H., Ebner, R., and Derynck, R. (1993). Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. Science 260, 1335-1338.
8. Christ, M., McCartney-Francis, N.L., Kulkarni, A.B., Ward, J.M., Mizel, D.E., Mackall, C.L., Gress, R.E., Mines, K.L., Tian, H., Karlsson, S., et al. (1994). Immune dysregulation in TGF-beta 1-deficient mice. J. Immunol. 153, 1936-1946.
9. Cousins, S.W., McCabe, M.M., Danielpour, D., and Streilein, J.W. (1991). Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 32, 2201-2211.
10. Diebold, R.J., Eis, M.J., Yin, M., Ormsby, I., Boivin, G.P., Darrow, B.J., Saffitz, J.E., and Doetschman, T. (1995). Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. USA 92, 12215-12219.
11. Dixon, F.J., Andrews, B.S., Eisenberg, R.A., McConahey, P.J., Theofilopoulos, A.N., and Wilson, C.B. (1978). Etiology and pathogenesis of a spontaneous lupus-like syndrome in mice. Arthritis Rheum. 21, S64-S67.
12. Erlebacher, A., Filvaroff, E.H., Ye, J.Q., and Derynck, R. (1998). Osteoblastic responses to TGF-beta during bone remodeling. Mol. Biol. Cell. 9, 1903-1918.
13. Geiser, A.G., Letterio, J.J., Kulkarni, A.B., Karlsson, S., Roberts, A.B., and Sporn, M.B. (1993). Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: Aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. Proc. Natl. Acad. Sci. USA 90, 9944-9948.
14. Gorelik, L., and Mokyr, M.B. (1995). Low-dose-melphalan-induced up-regulation of type-1 cytokine expression in the s.c. tumor nodule of MOPC-315 tumor bearers and the role of interferon gamma in the therapeutic outcome. Cancer Immunol. Immunother. 41, 363-374.
15. Kaartinen, V., Voncken, J.W., Shuler, C., Warburton, D., Bu, D., Heisterkamp, N., and Groffen, J. (1995). Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11, 415-421.
16. Kehrl, J.H., Wakefield, L.M., Roberts, A.B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., Sporn, M.B., and Fauci, A.S. (1986). Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163, 1037-1050.
17. Kim, P.H., and Kagnoff, M.F. (1990). Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. J. Immunol. 145, 3773-3778.
18. Kulkarni, A.B., Huh, C.G., Becker, D., Geiser, A., Lyght, M., Flanders, K.C., Roberts, A.B., Sporn, M.B., Ward, J.M., and Karlsson, S. (1993). Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90, 770-774.
19. Kulkarni, A.B., Ward, J.M., Yaswen, L., Mackall, C.L., Bauer, S.R., Huh, C.G., Gress, R.E., and Karlsson, S. (1995). Transforming growth factor-beta 1 null mice. An animal model for inflammatory disorders. Am. J. Pathol. 146, 264-275.
20. Lee, Y.J., Han, Y., Lu, H.T., Nguyen, V., Qin, H., Howe, P.H., Hocevar, B.A., Boss, J.M., Ransohoff, R.M., and Benveniste, E.N. (1997). TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J. Immunol. 158, 2065-2075.
21. Letterio, J.J., Geiser, A.G., Kulkarni, A.B., Dang, H., Kong, L., Nakabayashi, T., Mackall, C.L., Gress, R.E., and Roberts, A.B. (1996). Autoimmunity associated with TGF-beta 1-deficiency in mice is dependent on MHC class II antigen expression. J. Clin. Invest. 98, 2109-2119.
22. Letterio, J.J., and Roberts, A.B. (1998). Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16, 137-161.
23. Martin, J.S., Dickson, M.C., Cousins, F.M., Kulkarni, A.B., Karlsson, S., and Akhurst, R.J. (1995). Analysis of homozygous TGF beta 1 null mouse embryos demonstrates defects in yolk sac vasculogenesis and hematopoiesis. Ann. NY Acad. Sci. 752, 300-308.
24. Massague, J. (1990). The transforming growth factor-beta family. Annu. Rev. Cell. Biol. 6, 597-641.
25. McIntyre, T.M., Kehry, M.R., and Snapper, C.M. (1995). Novel in vitro model for high-rate IgA class switching. J. Immunol. 154, 3156-3161.
26. Millan, F.A., Denhez, F., Kondaiah, P., and Akhurst, R.J. (1991). Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo. Development 111, 131-143.
27. Miyazono, K., Ten Dijke, P., Ichijo, H., and Heldin, C.H. (1994). Receptors for transforming growth factor-beta. Adv. Immunol. 55, 181-220.
28. Panek, R.B., Lee, Y.J., and Benveniste, E.N. (1995). TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression. J. Immunol. 154, 610-619.
29. Pelton, R.W., Nomura, S., Moses, H.L., and Hogan, B.L. (1989). Expression of transforming growth factor beta 2 RNA during murine embryogenesis. Development 106, 759-767.
30. Proetzel, G., Pawlowski, S.A., Wiles, M.V., Yin, M., Boivin, G.P., Howles, P.N., Ding, J., Ferguson, M.W., and Doetschman, T. (1995). Transforming growth factor-beta 3 is required for secondary palate fusion. Nat. Genet. 11, 409-414.
31. Qian, S.W., Burmester, J.K., Tsang, M.L.S., Weatherbee, J.A., Hinck, A.P., Ohlsen, D.J., Sporn, M.B., and Roberts, A.B. (1996). Binding affinity of transforming growth factor-beta for its type II receptor is determined by the C-terminal region of the molecule. J. Biol. Chem. 271, 30656-30662.
32. Sanford, L.P., Ormsby, I., Gittenberger-De Groot, A.C., Sariola, H., Friedman, R., Boivin, G.P., Cardell, E.L., and Doetschman, T. (1997). TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124, 2659-2670.
33. Sawada, S., Scarborough, J.D., Killeen, N., and Littman, D.R. (1994). A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77, 917-929.
34. Schmid, P., Cox, D., Bilbe, G., Maier, R., and McMaster, G.K. (1991). Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis. Development 111, 117-130.
35. Schreiber, E., Matthias, P., Muller, M.M., and Schaffner, W. (1989). Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acids Res. 17, 6419.
36. Shull, M.M., Ormsby, I., Kier, A.B., Pawlowski, S., Diebold, R.J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992). Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359, 693-699.
37. van Ginkel, F.W., Wahl, S.M., Kearney, J.F., Kweon, M.N., Fujihashi, K., Burrows, P.D., Kiyono, H., and McGhee, J.R. (1999). Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice. J. Immunol. 163, 1951-1957.
38. Wieser, R., Attisano, L., Wrana, J.L., and Massague, J. (1993). Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Mol. Cell. Biol. 13, 7239-7247.
39. Williams, A.O., Knapton, A.D., Geiser, A., Letterio, J.J., and Roberts, A.B. (1996). The liver in transforming growth factor-beta-1 (TGF-beta 1) null mutant mice. Ultrastruct. Pathol. 20, 477-490.
40. Wrana, J.L., Attisano, L., Wieser, R., Ventura, F., and Massague, J. (1994). Mechanism of activation of the TGF-beta receptor. Nature 370, 341-347.
41. Yaswen, L., Kulkarni, A.B., Fredrickson, T., Mittleman, B., Schiffman, R., Payne, S., Longenecker, G., Mozes, E., and Karlsson, S. (1996). Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood 87, 1439-1445.