Cutting edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis

Journal of Immunology

Volumn 178, Issue 5, 2007, Pages 2661-2665

  Kursar, Mischo ^a   Koch, Markus ^a   Mittrücker, Hans Willi ^c   Nouailles, Geraldine ^a   Bonhagen, Kerstin ^b   Kamradt, Thomas ^b   Kaufmann, Stefan H E ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; INFECTION CONTROL; LYMPHOCYTE FUNCTION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TUBERCULOSIS;

EID: 33847344205     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.5.2661     Document Type: Article

References (26)

1. World Health Organization. The World Health Report. 2004. Geneva, Switzerland. p. 120.
2. Flynn, J. L., and J. Chan. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19: 93-129.
3. Kaufmann, S. H., S. T. Cole, V. Mizrahi, E. Rubin, and C. Nathan. 2005. Mycobacterium tuberculosis and the host response. J. Exp. Med. 201: 1693-1697.
4. Kaufmann, S. H., and A. J. McMichael. 2005. Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis. Nat. Med. 11: S33-S44.
5. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141: 2407-2412.
6. Flesch, I. E., and S. H. Kaufmann. 1988. Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by γ-interferon- activated bone marrow macrophages. Infect. Immun. 56: 1464-1469.
7. Cooper, A. M., J. E. Pearl, J. V. Brooks, S. Ehlers, and I. M. Orme. 2000. Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung. Infect. Immun. 68: 6879-6882.
8. phox-/- mice. Infect. Immun. 68: 1231-1234.
9. MacMicking, J., Q. W. Xie, and C. Nathan. 1997. Nitric oxide and macrophage funcrion. Annu. Rev. Immunol. 15: 323-350.
10. MacMicking, J. D., R. J. North, R. LaCourse, J. S. Mudgett, S. K. Shah, and C. F. Nathan. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA 94: 5243-5248.
11. Mittrucker, H. W., and S. H. Kaufmann. 2004. Mini-review: regulatory T cells and infection: suppression revisited. Eur. J. Immunol. 34: 306-312.
12. + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
13. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
14. + regulatory T cells. Curr. Opin. Immunol. 16: 203-208.
15. Collins, H. L., and S. H. Kaufmann. 2001. The many faces of host responses to tuberculosis. Immunology 103: 1-9.
16. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 178: 2243-2247.
17. + T cells causes reactivation of murine persistent tuberculosis despite continued expression of incerferon γ and nitric oxide synthase 2. J. Exp. Med. 192: 347-358.
18. Mohan, V. P., C. A. Scanga, K. Yu, H. M. Scott, K. E. Tanaka, E. Tsang, M. M. Tsai, J. L. Flynn, and J. Chan. 2001. Effects of tumor necrosis factor α on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect. Immun. 69: 1847-1855.
19. Olobo, J. O., M. Geletu, A. Demissie, T. Eguale, K. Hiwot, G. Aderaye, and S. Britton. 2001. Circulating TNF-α, TGF-β, and IL-10 in tuberculosis patients and healthy contacts. Scand. J. Immunol. 53: 85-91.
20. Jozefowski, S., R. Biedron, M. Bobek, and J. Marcinkiewicz. 2005. Leukotrienes modulate cytokine release from dendritic cells. Immunology 116: 418-428.
21. Pengal, R. A., L. P. Ganesan, G. Wei, H. Fang, M. C. Ostrowski, and S. Tridandapani. 2006. Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt. Mol. Immunol. 43: 1557-1564.
22. Smith, S. M., and H. M. Dockrell. 2000. Role of CD8 T cells in mycobacterial infections. Immunol. Cell Biol. 78: 325-333.
23. + regulatory T cells. Nat. Med. 10: 29-30.
24. + regulatory T cells control Leishmania major persistence and immunity. Nature 420: 502-507.
25. -/- setting. Immunity 16: 429-439.
26. + regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity 23: 287-296.