Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation

Journal of Immunology

Volumn 177, Issue 4, 2006, Pages 2167-2174

  Billiard, Fabienne ^a   Litvinova, Elena ^a   Saadoun, David ^a   Djelti, Fathia ^a,b   Klatzmann, David ^a   Cohen, José L ^a   Marodon, Gilles ^a   Salomon, Benoît L ^a  

^a CNRS   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DISEASE EXACERBATION; DISEASE MODEL; EFFECTOR CELL; IMMUNIZATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 33746933464     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.4.2167     Document Type: Article

References (52)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
2. + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196: 401-406.
3. +high regulatory T cell function. J. Immunol. 169: 6210-6217.
4. George, T. C., J. Bilshorough, J. L. Viney, and A. M. Norment. 2003. High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell-mediated suppression in vitro. Eur. J. Immunol. 33: 502-511.
5. - T cell-mediated suppression by dendritic cells. Science 299: 1033-1036.
6. Kubo, T., R. D. Hatton, J. Oliver, X. Liu, C. O. Elson, and C. T. Weaver. 2004. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J. Immunol. 173: 7249-7258.
7. + regulatory cell activation and function by dendritic cells. Int. Immunol. 16: 1769-1780.
8. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
9. + T cells. J. Immunol. 173: 5008-5020.
10. Barthlott, T., G. Kassiotis, and B. Stockinger. 2003. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197: 451-460.
11. Papiernik, M., M. do Carmo Leite-de-Moraes, C. Pontoux, A. M. Joret, B. Rocha, C. Penit, and M. Dy. 1997. T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive. IL-10-producing T cell population with infectious capacity. J. Immunol. 158: 4642-4653.
12. + regulatory T cells in the steady state. J. Exp. Med. 198: 737-746.
13. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
14. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
15. Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody, Cancer Res. 59: 3128-3133.
16. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168: 5979-5983.
17. + T cell responses. J. Exp. Med. 198: 889-901.
18. + regulatory T cells. Nat. Med. 10: 29-30.
19. + cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum. 48: 1452-1460.
20. + regulatory T cells play no apparent role in the acute humoral response to intact Streptococcus pneumoniae. Infect. Immun. 73: 4427-4431.
21. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 101: 15434-15439.
22. Klein, L., K. Khazaie, and H. von Boehmer. 2003. In vivo dynamics of antigen-spceitic regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100: 8886-8891.
23. + regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J. Immunol. 172: 6539-6544.
24. + regulatory T cells in vivo. J. Exp. Med. 198: 249-258.
25. + T cells. Eur. J. Immunol. 22: 1013-1022.
26. Scott, B., R. Liblau, S. Degermann, L. A. Marconi, L. Ogata, A. J. Caton, H. O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1: 73-83.
27. + regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunol. Lett. 102: 106-109.
28. + immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J. Immunol. 176: 1266-1273.
29. Refaeli, Y., L. Van Parijs, S. I. Alexander, and A. K. Abbas. 2002. Interferon γ is required for activation-induced death of T lymphocytes. J. Exp. Med. 196: 999-1005.
30. Martin-Fontecha, A., L. L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, and F. Sallusto. 2004. Induced recruitment of NK cells to lymph nodes provides IFN-γ for Th1 priming. Nat. Immunol. 5: 1260-1265.
31. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440.
32. Bour-Jordan, H., B. L. Salomon, H. L. Thompson, G. L. Szot, M. R. Bernhard, and J. A. Bluestone. 2004. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J. Clin. Invest. 114: 979-987.
33. Signore, A., E. Procaccini, A. M. Toscano, E. Ferretti, A. J. Williams, P. E. Beales, P. Cugini, and P. Pozzilli. 1994. Histological study of pancreatic β-cell loss in relation to the insulitis process in the non-obese diabetic mouse. Histochemistry 101: 263-269.
34. Fox, C. J., and J. S. Danska. 1997. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J Immunol. 158: 2414-2424.
35. Green, E. A., E. E. Eynon, and R. A. Flavell. 1998. Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 9: 733-743.
36. + regulatory T cells during autoimmune diabetes. J. Exp. Med. 201: 1333-1346.
37. + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 199: 1479-1489.
38. + T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J. Immunol. 174: 3344-3351.
39. Belkaid, Y., and B. T. Rouse. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6: 353-354.
40. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198: 235-247.
41. + T cells without reversing their suppressive function. J. Immunol 175: 7332-7340.
42. Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197: 403-411.
43. Lohr, J., B. Knoechel, S. Jiang, A. H. Sharpe, and A. K. Abbas. 2003. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat. Immunol. 4: 664-669.
44. + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J. Exp, Med. 198: 259-266.
45. Luhder, F., P. Hoglund, J. P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187: 427-432.
46. Kaufman, D. L., M. Clare-Salzler, J. Tian, T. Forsthuber, G. S. Ting, P. Robinson, M. A. Atkinson, E. E. Sercarz, A. J. Tobin, and P. V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72.
47. Tisch, R., X. D. Yang, S. M. Singer, R. S. Liblau, L. Fugger, and H. O. McDevitt. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75.
48. + Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16: 183-191.
49. Tang, Q., K. J. Henriksen, M. Bi, E. B. Finger, G. Szot, J. Ye, E. L. Masteller, H. McDevitt, M. Bonyhadi, and J. A. Bluestone. 2004. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 199: 1455-1465.
50. + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199: 1467-1477.
51. Gregori, S., N. Giarratana, S. Smiroldo, and L. Adorini. 2003. Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J. Immunol. 171: 4040-4047.
52. You, S., M. Belghith, S. Cobbold, M. A. Alyanakian, C. Gouarin, S. Barriot, C. Garcia, H. Waldmann, J. F. Bach, and L. Chatenoud. 2005. Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes 54: 1415-1422.