Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

European Journal of Immunology

Volumn 32, Issue 8, 2002, Pages 2237-2245

  Bacchetta, Rosa ^a   Sartirana, Claudia ^a   Levings, Megan K ^a   Bordignon, Claudio ^a   Narula, Satwant ^b   Roncarolo, Maria Grazia ^a,c  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Activation marker; Cell proliferation; Cytokine; Suppression; T lymphocyte; Tolerance

Indexed keywords

CYTOKINE; GROWTH FACTOR; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR;

ARTICLE; BIOCHEMISTRY; CELL CLONING; CELL GROWTH; CELL SECRETION; CELL TYPE; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

CLONE CELLS; CYTOKINES; HUMANS; INTERLEUKIN-15; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

EID: 0036687184     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200208)32:8<2237::AID-IMMU2237>3.0.CO;2-2     Document Type: Article

References (37)

1. Type 1 T regulatory cells
2. + T cell subset inhibits antigen-specific T cell responses and prevents colitis
3. Regulatory T cells and inflammatory bowel disease
4. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
5. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
6. Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
7. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo
8. + T cell response to repetitive stimulation with antigen-presenting cells in vitro: Implications in designing antigen-presenting cell-based tumor vaccines
9. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
10. + T cell lines
11. + T cells
12. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
13. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
14. + T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses
15. Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells
16. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients
17. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift
18. The pleiotropic functions of interleukin 15: Not so interleukin 2-like after all
19. Cytokines: Shared receptors, distinct functions
20. Interleukin-2, interleukin-15, and their receptors
21. Interleukin-15 protects from lethal apoptosis in vivo
22. Stimulation of naive and memory T cells by cytokines
23. + memory T cells by opposing cytokines
24. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
25. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
26. + regulatory T cells. Their role in the control of superantigen responses
27. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
28. + T cells
29. +immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
30. T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive, IL-10-producing T cell population with infectious capacity
31. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
32. + T cells with regulatory properties from human blood
33. + T cell responsiveness to antigen
34. TCR-independent activation of extrathymically developed, self antigen-specific T cells by IL-2/IL-15
35. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
36. + T cell down-regulation in human intestinal mucosa: Evidence for intestinal tolerance to luminal bacterial antigens
37. Control of CD4 effector fate: Transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion