Cutting edge: Contact-mediated suppression by CD4+CD25 + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

Journal of Immunology

Volumn 174, Issue 4, 2005, Pages 1783-1786

  Gondek, David C ^a   Lu, Li Fan ^a   Quezada, Sergio A ^a   Sakaguchi, Shimon ^b,c   Noelle, Randolph J ^a,d  

^a NORRIS COTTON CANCER CENTER   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; PERFORIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; ENZYME INDUCTION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 13544271161     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.4.1783     Document Type: Article

References (27)

1. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
2. Levings, M. K., and M. G. Roncarolo. 2000. T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties. J. Allergy Clin. Immunol. 106:S109.
3. Roncarolo, M. G., R. Baccherta, C. Bordignon, S. Narula, and M. K. Levings. 2001. Type 1 T regulatory cells. Immunol. Rev. 182:68.
4. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629.
5. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:237.
6. + regulatory T cell activity in both humans and mice. J. Immunol. 172:834.
7. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
8. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
9. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 26:311.
10. Ji, H, B., G. Liao, W. A. Faubion, A. C. Abadia-Molina, C. Cozzo, F. S. Laroux, A. Caton, and C. Terhorst. 2004. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J. Immunol. 172:5823.
11. Lord, S. J., R. V. Rajotte, G. S. Korbutt, and R. C. Bleackley. 2003. Granzyme B: a natural born killer. Immunol. Rev. 193:31.
12. + CTLs ex vivo. J. Immunol. 168:5954.
13. +, cytomegalovirus- specific T cell subset after recovery of primary cytomegalovirus infection. J. Immunol. 173:1834.
14. + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421:388.
15. Grossman, W. J., J. W. Verbsky, B. L. Tollefsen, C. Kemper, J. P. Atkinson, and T. J. Ley. 2004. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104:2840.
16. Grossman, W. J., J. W. Verbsky, W. Barchet, M. Colonna, J. P. Atkinson, and T. J. Ley. 2004. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21:589.
17. + T regulatoty cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 199:1479.
18. Froelich, C. J., K. Orth, J. Turbov, P. Sech, R. Gottlieb, B. Babior, G. M. Shah, R. C. Bleackley, V. M. Dixit, and W. Hanna. 1996. New paradigm for lymphocyte granule-mediated cytotoxicity: target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J. Biol. Chem. 271:29073.
19. Browne, K. A., E. Blink, V. R. Sutton, C. J. Froelich, D. A. Jans, and J. A. Trapani. 1999. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perform. Mol Cell. Biol. 19:8604.
20. Trapani, J. A., V. R. Sutton, K. Y. Thia, Y. Q. Li, C. J. Froelich, D. A. Jans, M. S. Sandrin, and K. A. Browne. 2003. A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J. Cell Biol. 160:223.
21. Kurschus, F. C., M. Kleinschmidt, E. Fellows, K. Dornmair, R. Rudolph, H. Lilie, and D. E. Jenne. 2004. Killing of target cells by redirected granzyme B in the absence of perform. FEBS Lett. 562:87.
22. Choy, J. C., V. H. Hung, A. L. Hunter, P. K. Cheung, B. Motyka, I. S. Goping, T. Sawchuk, R. C. Bleackley, T. J. Podor, B. M. McManus, and D. J. Granville. 2004. Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler. Thromb. Vasc. Biol. 24:2245.
23. Somersalo, K., N. Anikeeva, T. N. Sims, V. K. Thomas, R. K. Strong, T. Spies, T. Lebedeva, Y. Sykulev, and M. L. Dustin. 2004. Cytotoxic T lymphocytes form an antigen-independent ring junction. J. Clin. Invest. 113:49.
24. 2+-dependent epitope stimulates lymphocyte adhesion. J. Cell Biol. 112:345.
25. Labadia, M. E., D. D. Jeanfavre, G. O. Caviness, and M. M. Morelock. 1998. Molecular regulation of the interaction between leukocyte function-associated antigen-1 and soluble ICAM-1 by divalent metal cations. J Immunol 161:836.
26. + T cells via a CD30-dependent mechanism. J. Clin. Invest 113:310.
27. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969.