An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis

Digestive Diseases and Sciences

Volumn 51, Issue 4, 2006, Pages 677-686

  Takahashi, Makoto ^a   Nakamura, Kazuhiko ^a   Honda, Kuniomi ^a   Kitamura, Yousuke ^a   Mizutani, Takahiro ^a   Araki, Yuzuru ^b   Kabemura, Teppei ^c   Chijiiwa, Yoshiharu ^d   Harada, Naohiko ^a,b   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA HIGASHI MEDICAL CENTER   (Japan)

^c SAISEIKAI FUKUOKA GENERAL HOSPITAL   (Japan)

^d HARASANSHIN HOSPITAL   (Japan)

Author keywords

CD4 positive T lymphocyte; Colitis; Inflammatory bowel disease; Interleukin 2 receptor ; Ulcerative

Indexed keywords

CD45RO ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLOGY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; ENTERITIS; FEMALE; FLOW CYTOMETRY; FREQUENCY ANALYSIS; GASTROINTESTINAL ENDOSCOPY; HUMAN; IMMUNE DEFICIENCY; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; ANTIGENS, CD45; BASE SEQUENCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COLITIS, ULCERATIVE; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROBABILITY; RECEPTORS, INTERLEUKIN-2; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY;

EID: 33645891652     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-3191-2     Document Type: Article

References (36)

1. Fiocchi C: Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115:182-205, 1998
2. Bouma G, Strober W: The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3:521-533, 2003
3. Strober W, Nakamura K, Kitani A: The SAMP1/Yit mouse: another step closer to modeling human inflammatory bowel disease. J Clin Invest 107:667-670, 2001
4. Asano M, Toda M, Sakaguchi N, Sakaguchi S: Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 184:387-396, 1996
5. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immuol 10:1969-1980, 1998
6. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188:287-296, 1998
7. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531-562, 2004
8. + suppressor T cells: more questions than answers. Nat Rev Immunol 2:389-400, 2002
9. + regulatory cells that control intestinal inflammation. J Exp Med 192:295-302, 2000
10. + regulatory T cells. J Immunol 170:3939-3943, 2003
11. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162:5317-5326, 1999
12. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 193:1285-1294, 2001
13. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193:1295-1301, 2001
14. + T cells with regulatory properties from human blood. J Exp Med 193:1303-1310, 2001
15. high regulatory cells in human peripheral blood. J Immunol 167:1245-1253, 2001
16. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99:3493-3499, 2002
17. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431-440, 2000
18. + T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 59:198-202, 2004
19. bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 172:6435-6443, 2004
20. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 33:215-223, 2003
21. + regulatory T cells in patients with multiple sclerosis. J Exp Med 199:971-979, 2004
22. Shimoyama T, Sawada K, Hiwatashi N, Sawada T, Matsueda K, Munakata A, Asakura H, Tanaka T, Kasukawa R, Kimura K, Suzuki Y, Nagamachi Y, Muto T, Nagawa H, Iizuka B, Baba S, Nasu M, Kataoka T, Kashiwagi N, Saniabadi AR: Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter study. J Clin Apheresis 16:1-9, 2001
23. Hanai H, Watanabe F, Takeuchi K, Iida T, Yamada M, Iwaoka Y, ABBY S, Matsushita I, Sato Y, Tozawa K, Arai H, Furuta T, Sugimoto K, Bjarnason I: Leukocyte adsorptive apheresis for the treatment of active ulcerative colitis: a prospective, uncontrolled, pilot study. Clin Gastroenterol Hepatol 1:28-35, 2003
24. Rachmilewitz D: Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomized trial. Br Med J 298:82-86, 1989
25. bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 173:3119-3130, 2004
26. + regulatory T cell activity in both humans and mice. J Immunol 172:834-842, 2004
27. + regulatory T cells. Eur J Immunol 32:1621-1630, 2002
28. Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor FoxP3. Science 299:1057-1061, 2003
29. + regulatory T cells. Nat Immunol 4:330-336, 2003
30. + T regulatory cells. Nat Immunol 4:337-342, 2003
31. Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM: JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 106:75-81, 2000
32. Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 27:18-20, 2001
33. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27:68-73, 2001
34. + regulatory T cells. Int Immunol 16:1643-1656, 2004
35. Asseman C, Mauze S, Leach MW Coffman RL, Powrie F: An essential role for Interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190:995-1004, 1999
36. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J Exp Med 194:629-644, 2001