In vivo instruction of suppressor commitment in naive T cells

Journal of Experimental Medicine

Volumn 199, Issue 10, 2004, Pages 1401-1408

  Apostolou, Irina ^a   Von Boehmer, Harald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Ag specific tolerance; Immunity; In vivo induction; Regulatory T cells; Subcutaneous infusion

Indexed keywords

ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; OSMOTIC PUMP; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; BASE SEQUENCE; DNA PRIMERS; FLOW CYTOMETRY; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN; T-LYMPHOCYTES;

EID: 2542420993     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20040249     Document Type: Article

References (42)

1. Bach, J.F. 2003. Regulatory T cells under scrutiny. Nat. Rev. Immunol. 3:189-198.
2. Apostolou, I., A. Sarukhan, L. Klein, and H. Von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
3. + and CD25-subpopulations. J. Immunol. 165:3105-3110.
4. + T cells that prevent spontaneous autoimmune encephalomyelitis. J. Immunol. 164:5499-5507.
5. + T suppressor cells are back to the game: are they players in autoimmunity? Autoimmun. Rev. 1:279-283.
6. Taniguchi, M., M. Harada, S. Kojo, T. Nakayama, and H. Wakao. 2003. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483-513.
7. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195:603-616.
8. + T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196:1335-1346.
9. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
10. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
11. + regulatory T cells. Nat. Immunol. 4:330-336.
12. + T regulatory cells. Nat. Immunol. 4:337-342.
13. - T cells. J. Clin. Invest. 112:1437-1443.
14. Brunkow, M.E., E.W. Jeffery, K.A. Hjerrild, B. Paeper, L.B. Clark, S.A. Yasayko, J.E. Wilkinson, D. Galas, S.F. Ziegler, and F. Ramsdell. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:68-73.
15. Bennett, C.L., J. Christie, F. Ramsdell, M.E. Brunkow, P.J. Ferguson, L. Whitesell, T.E. Kelly, F.T. Saulsbury, P.F. Chance, and H.D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27:20-21.
16. Wildin, R.S., F. Ramsdell, J. Peake, F. Faravelli, J.L. Casanova, N. Buist, E. Levy-Lahad, M. Mazzella, O. Goulet, L. Perroni, et al. 2001. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27:18-20.
17. Chatila, T.A., F. Blaeser, N. Ho, H.M. Lederman, C. Voulgaropoulos, C. Helms, and A.M. Bowcock. 2000. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 106:R75-R81.
18. + T cell responses to a self peptide. Eur. J. Immunol. 30:136-144.
19. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301-306.
20. Klein, L., K. Khazaie, and H. von Boehmer. 2003. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA. 100:8886-8891.
21. + regulatory T cells in the steady state. J. Exp. Med. 198:737-746.
22. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235-247.
23. + regulatory T cells in vivo. J. Exp. Med. 198:249-258.
24. Nagler-Anderson, C., A.K. Bhan, D.K. Podolsky, and C. Terhorst. 2004. Control freaks: immune regulatory cells. Nat. Immunol. 5:119-122.
25. +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167:188-195.
26. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198:1875-1886.
27. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180:25-34.
28. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
29. Mitchison, N.A. 1964. Induction of immunological paralysis in two zones of dosage. Proc. Roy. Soc. 161:275-292.
30. Chiller, J.M., G.S. Habicht, and W.O. Weigle. 1971. Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science. 171:813-815.
31. Chen, Y., V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1237-1240.
32. Weiner, H.L. 1997. Oral tolerance for the treatment of autoimmune diseases. Annu. Rev. Med. 48:341-351.
33. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192:1213-1222.
34. Sundstedt, A., E.J. O'Neill, K.S. Nicolson, and D.C. Wraith. 2003. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol. 170:1240-1248.
35. Miller, A., O. Lider, A.B. Roberts, M.B. Sporn, and H.L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc. Natl. Acad. Sci. USA. 89:421-425.
36. Horwitz, D.A., S.G. Zheng, J.D. Gray, J.H. Wang, K. Ohtsuka, and S. Yamagiwa. 2004. Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease. Semin. Immunol. 16:135-143.
37. + regulatory T cells generated ex vivo with IL-2 and TGF-β suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J. Immunol. 172:1531-1539.
38. Hemmi, H., M. Yoshino, H. Yamazaki, M. Naito, T. Iyoda, Y. Omatsu, S. Shimoyama, J.J. Letterio, T. Nakabayashi, H. Tagaya, et al. 2001. Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells. Int. Immunol. 13:695-704.
39. Akbari, O., R.H. DeKruyff, and D.T. Umetsu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:725-731.
40. Hawiger, D., K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J.V. Ravetch, R.M. Steinman, and M.C. Nussenzweig. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:769-779.
41. + autoreactive T cells after proliferation. J. Immunol. 168:1103-1112.
42. + T cell-mediated suppression by dendritic cells. Science. 299:1033-1036.