메뉴 건너뛰기




Volumn 4, Issue 1, 2009, Pages 101-128

Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine

Author keywords

Dopamine transporter; Fluorine 18 PET; Norepinephrine transporter; Serotonin transporter; Tropanes

Indexed keywords

1 [2 [(4 FLUOROPHENYL)(PHENYL)METHOXY]ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; 1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 6 NITROQUIPAZINE; CARBON 11; CITALOPRAM; COCAINE; DOPAMINE TRANSPORTER; FLUORINE 18; FLUOXETINE; NISOXETINE; NORADRENALIN TRANSPORTER; REBOXETINE; SEROTONIN TRANSPORTER; TRACER; TROPANE DERIVATIVE; TROPARIL; VANOXERINE;

EID: 68449097096     PISSN: 15568598     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cpet.2009.05.006     Document Type: Review
Times cited : (23)

References (297)
  • 1
    • 0027364736 scopus 로고
    • From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters
    • Rudnick G., and Clark J. From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim Biophys Acta 1144 (1993) 249-263
    • (1993) Biochim Biophys Acta , vol.1144 , pp. 249-263
    • Rudnick, G.1    Clark, J.2
  • 2
    • 0031753789 scopus 로고    scopus 로고
    • The family of Na+/Cl- neurotransmitter transporters
    • Nelson N. The family of Na+/Cl- neurotransmitter transporters. J Neurochem 71 (1998) 1785-1803
    • (1998) J Neurochem , vol.71 , pp. 1785-1803
    • Nelson, N.1
  • 3
    • 0035156972 scopus 로고    scopus 로고
    • The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines
    • Eisenhofer G. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol Ther 91 (2001) 35-62
    • (2001) Pharmacol Ther , vol.91 , pp. 35-62
    • Eisenhofer, G.1
  • 4
    • 0035910939 scopus 로고    scopus 로고
    • Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity
    • Miller G.M., Yatin S.M., De La Garza R., et al. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain Res Mol Brain Res 87 (2001) 124-143
    • (2001) Brain Res Mol Brain Res , vol.87 , pp. 124-143
    • Miller, G.M.1    Yatin, S.M.2    De La Garza, R.3
  • 6
    • 0037264650 scopus 로고    scopus 로고
    • Plasma membrane monoamine transporters: structure, regulation and function
    • Torres G.E., Gainetdinov R.R., and Caron M.G. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 4 (2003) 13-25
    • (2003) Nat Rev Neurosci , vol.4 , pp. 13-25
    • Torres, G.E.1    Gainetdinov, R.R.2    Caron, M.G.3
  • 7
    • 0030292906 scopus 로고    scopus 로고
    • Listening to neurotransmitter transporters
    • Lester H.A., Cao Y., and Mager S. Listening to neurotransmitter transporters. Neuron 17 (1996) 807-810
    • (1996) Neuron , vol.17 , pp. 807-810
    • Lester, H.A.1    Cao, Y.2    Mager, S.3
  • 8
    • 6944247728 scopus 로고    scopus 로고
    • Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation
    • Melikian H.E. Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation. Pharmacol Ther 104 (2004) 17-27
    • (2004) Pharmacol Ther , vol.104 , pp. 17-27
    • Melikian, H.E.1
  • 9
    • 0033938105 scopus 로고    scopus 로고
    • Neurotransmitter transporters: fruitful targets for CNS drug discovery
    • Iversen L. Neurotransmitter transporters: fruitful targets for CNS drug discovery. Mol Psychiatry 5 (2000) 357-362
    • (2000) Mol Psychiatry , vol.5 , pp. 357-362
    • Iversen, L.1
  • 10
    • 0033615028 scopus 로고    scopus 로고
    • Pharmacotherapies for treatment of cocaine abuse: preclinical aspects
    • Carroll F.I., Howell L.L., and Kuhar M.J. Pharmacotherapies for treatment of cocaine abuse: preclinical aspects. J Med Chem 42 (1999) 2721-2736
    • (1999) J Med Chem , vol.42 , pp. 2721-2736
    • Carroll, F.I.1    Howell, L.L.2    Kuhar, M.J.3
  • 11
    • 0038416872 scopus 로고    scopus 로고
    • 2002 Medicinal Chemistry Division award address: monoamine transporters and opioid receptors. Targets for addiction therapy
    • Carroll F.I. 2002 Medicinal Chemistry Division award address: monoamine transporters and opioid receptors. Targets for addiction therapy. J Med Chem 46 (2003) 1775-1794
    • (2003) J Med Chem , vol.46 , pp. 1775-1794
    • Carroll, F.I.1
  • 12
    • 0029738423 scopus 로고    scopus 로고
    • PET evaluation of the dopamine system of the human brain
    • Volkow N.D., Fowler J.S., Gatley S.J., et al. PET evaluation of the dopamine system of the human brain. J Nucl Med 37 (1996) 1242-1256
    • (1996) J Nucl Med , vol.37 , pp. 1242-1256
    • Volkow, N.D.1    Fowler, J.S.2    Gatley, S.J.3
  • 13
    • 0033786712 scopus 로고    scopus 로고
    • PET studies of brain monoamine transporters
    • Laakso A., and Hietala J. PET studies of brain monoamine transporters. Curr Pharm Des 6 (2000) 1611-1623
    • (2000) Curr Pharm Des , vol.6 , pp. 1611-1623
    • Laakso, A.1    Hietala, J.2
  • 14
    • 13844265749 scopus 로고    scopus 로고
    • Molecular imaging in the clinical arena
    • Jaffer F.A., and Weissleder R. Molecular imaging in the clinical arena. J Am Med Assoc 293 (2005) 855-862
    • (2005) J Am Med Assoc , vol.293 , pp. 855-862
    • Jaffer, F.A.1    Weissleder, R.2
  • 15
    • 34548695230 scopus 로고    scopus 로고
    • Molecular neuroimaging: from conventional to emerging techniques
    • Hammoud D.A., Hoffman J.M., and Pomper M.G. Molecular neuroimaging: from conventional to emerging techniques. Radiology 245 (2007) 21-42
    • (2007) Radiology , vol.245 , pp. 21-42
    • Hammoud, D.A.1    Hoffman, J.M.2    Pomper, M.G.3
  • 16
    • 34247137134 scopus 로고    scopus 로고
    • Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
    • Meyer J.H. Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci 32 (2007) 86-102
    • (2007) J Psychiatry Neurosci , vol.32 , pp. 86-102
    • Meyer, J.H.1
  • 17
    • 23844456320 scopus 로고    scopus 로고
    • Neuroimaging in Parkinson's disease
    • Brooks D.J. Neuroimaging in Parkinson's disease. NeuroRx 1 (2004) 243-254
    • (2004) NeuroRx , vol.1 , pp. 243-254
    • Brooks, D.J.1
  • 18
    • 0035282803 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography
    • Aboagye E.O., Price P.M., and Jones T. In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography. Drug Discov Today 6 (2001) 293-302
    • (2001) Drug Discov Today , vol.6 , pp. 293-302
    • Aboagye, E.O.1    Price, P.M.2    Jones, T.3
  • 19
    • 0036392074 scopus 로고    scopus 로고
    • Positron emission tomography: imaging and quantification of neurotransporter availability
    • Laruelle M., Slifstein M., and Huang Y. Positron emission tomography: imaging and quantification of neurotransporter availability. Methods 27 (2002) 287-299
    • (2002) Methods , vol.27 , pp. 287-299
    • Laruelle, M.1    Slifstein, M.2    Huang, Y.3
  • 20
    • 0036895218 scopus 로고    scopus 로고
    • The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development
    • Talbot P.S., and Laruelle M. The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. Eur Neuropsychopharmacol 12 (2002) 503-511
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 503-511
    • Talbot, P.S.1    Laruelle, M.2
  • 21
    • 24944570215 scopus 로고    scopus 로고
    • PET and SPECT exploration of central monoaminergic transporters for the development of new drugs and treatments in brain disorders
    • Guilloteau D., and Chalon S. PET and SPECT exploration of central monoaminergic transporters for the development of new drugs and treatments in brain disorders. Curr Pharm Des 11 (2005) 3237-3245
    • (2005) Curr Pharm Des , vol.11 , pp. 3237-3245
    • Guilloteau, D.1    Chalon, S.2
  • 22
    • 33745050401 scopus 로고    scopus 로고
    • Using positron emission tomography to facilitate CNS drug development
    • Lee C.M., and Farde L. Using positron emission tomography to facilitate CNS drug development. Trends Pharmacol Sci 27 (2006) 310-316
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 310-316
    • Lee, C.M.1    Farde, L.2
  • 23
    • 38349095953 scopus 로고    scopus 로고
    • The role of molecular imaging in drug discovery and development
    • Hargreaves R.J. The role of molecular imaging in drug discovery and development. Clin Pharmacol Ther 83 (2008) 349-353
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 349-353
    • Hargreaves, R.J.1
  • 24
    • 33645103129 scopus 로고    scopus 로고
    • A dose-finding study of duloxetine based on serotonin transporter occupancy
    • Takano A., Suzuki K., Kosaka J., et al. A dose-finding study of duloxetine based on serotonin transporter occupancy. Psychopharmacology 185 (2006) 395-399
    • (2006) Psychopharmacology , vol.185 , pp. 395-399
    • Takano, A.1    Suzuki, K.2    Kosaka, J.3
  • 25
    • 2542490139 scopus 로고    scopus 로고
    • PET tracers and radiochemistry
    • Schlyer D.J. PET tracers and radiochemistry. Ann Acad Med Singap 33 (2004) 146-154
    • (2004) Ann Acad Med Singap , vol.33 , pp. 146-154
    • Schlyer, D.J.1
  • 28
    • 84942802774 scopus 로고    scopus 로고
    • Wernick M.N., Aarsvold J., (Eds), Elsevier Academic Press, San Diego (CA); London, UK
    • In: Wernick M.N., Aarsvold J., (Eds). Emission tomography: the fundamentals of PET and SPECT (2004), Elsevier Academic Press, San Diego (CA); London, UK 179
    • (2004) Emission tomography: the fundamentals of PET and SPECT , pp. 179
  • 29
    • 0033059817 scopus 로고    scopus 로고
    • Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution
    • Levin C.S., and Hoffman E.J. Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution. Phys Med Biol 44 (1999) 781-799
    • (1999) Phys Med Biol , vol.44 , pp. 781-799
    • Levin, C.S.1    Hoffman, E.J.2
  • 30
    • 0034926661 scopus 로고    scopus 로고
    • Fluorine substituent effects (on bioactivity)
    • Smart B.E. Fluorine substituent effects (on bioactivity). J Fluor Chem 109 (2001) 3-11
    • (2001) J Fluor Chem , vol.109 , pp. 3-11
    • Smart, B.E.1
  • 31
    • 4444355871 scopus 로고    scopus 로고
    • Fluorine in medicinal chemistry
    • Böhm H.J., Banner D., Bendels S., et al. Fluorine in medicinal chemistry. Chembiochem 5 (2004) 637-643
    • (2004) Chembiochem , vol.5 , pp. 637-643
    • Böhm, H.J.1    Banner, D.2    Bendels, S.3
  • 32
    • 33746610484 scopus 로고    scopus 로고
    • The strength of weak interactions: aromatic fluorine in drug design
    • DiMagno S.G., and Sun H. The strength of weak interactions: aromatic fluorine in drug design. Curr Top Med Chem 6 (2006) 1473-1482
    • (2006) Curr Top Med Chem , vol.6 , pp. 1473-1482
    • DiMagno, S.G.1    Sun, H.2
  • 34
    • 33746631226 scopus 로고    scopus 로고
    • Fluorinated molecules as drugs and imaging agents in the CNS
    • Sun S., and Adejare A. Fluorinated molecules as drugs and imaging agents in the CNS. Curr Top Med Chem 6 (2006) 1457-1464
    • (2006) Curr Top Med Chem , vol.6 , pp. 1457-1464
    • Sun, S.1    Adejare, A.2
  • 35
    • 34848848499 scopus 로고    scopus 로고
    • Fluorine in pharmaceuticals: looking beyond intuition
    • Müller K., Faeh C., and Diederich F. Fluorine in pharmaceuticals: looking beyond intuition. Science 317 (2007) 1881-1886
    • (2007) Science , vol.317 , pp. 1881-1886
    • Müller, K.1    Faeh, C.2    Diederich, F.3
  • 36
    • 49449097238 scopus 로고    scopus 로고
    • The many roles for fluorine in medicinal chemistry
    • Hagmann W.K. The many roles for fluorine in medicinal chemistry. J Med Chem 51 (2008) 4359-4369
    • (2008) J Med Chem , vol.51 , pp. 4359-4369
    • Hagmann, W.K.1
  • 37
    • 35948949527 scopus 로고    scopus 로고
    • Selective fluoroalkylations with fluorinated sulfones, sulfoxides, and sulfides
    • Prakash G.K.S., and Hu J. Selective fluoroalkylations with fluorinated sulfones, sulfoxides, and sulfides. Acc Chem Res 40 (2007) 921-930
    • (2007) Acc Chem Res , vol.40 , pp. 921-930
    • Prakash, G.K.S.1    Hu, J.2
  • 38
    • 46149094509 scopus 로고    scopus 로고
    • Fluorination in medicinal chemistry: methods, strategies, and recent developments
    • Kirk K.L. Fluorination in medicinal chemistry: methods, strategies, and recent developments. Org Process Res Dev 12 (2008) 305-321
    • (2008) Org Process Res Dev , vol.12 , pp. 305-321
    • Kirk, K.L.1
  • 39
    • 0038108104 scopus 로고    scopus 로고
    • Chemistry of β+-emitting compounds based on fluorine-18
    • Lasne M.C., Perrio C., Rouden J., et al. Chemistry of β+-emitting compounds based on fluorine-18. Top Curr Chem 222 (2002) 201-258
    • (2002) Top Curr Chem , vol.222 , pp. 201-258
    • Lasne, M.C.1    Perrio, C.2    Rouden, J.3
  • 41
    • 58249114012 scopus 로고    scopus 로고
    • 18F]fluoride ion: nucleophilic fluorination as the detagging process
    • 18F]fluoride ion: nucleophilic fluorination as the detagging process. Angew Chem Int Ed Engl 48 (2009) 586-589
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 586-589
    • Bejot, R.1    Fowler, T.2    Carroll, L.3
  • 42
    • 0029743481 scopus 로고    scopus 로고
    • Distribution volume ratios without blood sampling from graphical analysis of PET data
    • Logan J., Fowler J.S., Volkow N.D., et al. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 16 (1996) 834-840
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 834-840
    • Logan, J.1    Fowler, J.S.2    Volkow, N.D.3
  • 43
    • 0029763029 scopus 로고    scopus 로고
    • Comparison of two compartmental models for describing receptor ligand kinetics and receptor availability in multiple injection PET studies
    • Morris E.D., Alpert N.M., and Fischman A.J. Comparison of two compartmental models for describing receptor ligand kinetics and receptor availability in multiple injection PET studies. J Cereb Blood Flow Metab 16 (1996) 841-853
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 841-853
    • Morris, E.D.1    Alpert, N.M.2    Fischman, A.J.3
  • 44
    • 0033729254 scopus 로고    scopus 로고
    • The role of model-based methods in the development of single scan techniques
    • Laruelle M. The role of model-based methods in the development of single scan techniques. Nucl Med Biol 27 (2000) 637-642
    • (2000) Nucl Med Biol , vol.27 , pp. 637-642
    • Laruelle, M.1
  • 45
    • 0033729522 scopus 로고    scopus 로고
    • Graphical analysis of PET data applied to reversible and irreversible tracers
    • Logan J. Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Biol 27 (2000) 661-670
    • (2000) Nucl Med Biol , vol.27 , pp. 661-670
    • Logan, J.1
  • 46
    • 0036895091 scopus 로고    scopus 로고
    • Radioligand studies: imaging and quantitative analysis
    • Lammertsma A.A. Radioligand studies: imaging and quantitative analysis. Eur Neuropsychopharmacol 12 (2002) 513-516
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 513-516
    • Lammertsma, A.A.1
  • 47
    • 57549096728 scopus 로고    scopus 로고
    • Tracer kinetic modeling in PET
    • Bentourkia M., and Zaidi H. Tracer kinetic modeling in PET. PET Clinics 2 (2007) 267-277
    • (2007) PET Clinics , vol.2 , pp. 267-277
    • Bentourkia, M.1    Zaidi, H.2
  • 48
    • 0021020662 scopus 로고
    • Relationship between lipophilicity and brain extraction of C-11-labeled radiopharmaceuticals
    • Dischino D.D., Welch M.J., Kilbourn M.R., et al. Relationship between lipophilicity and brain extraction of C-11-labeled radiopharmaceuticals. J Nucl Med 24 (1983) 1030-1038
    • (1983) J Nucl Med , vol.24 , pp. 1030-1038
    • Dischino, D.D.1    Welch, M.J.2    Kilbourn, M.R.3
  • 49
    • 0035452348 scopus 로고    scopus 로고
    • Binding characteristics of selective serotonin reuptake inhibitors with relation to emission tomography studies
    • Elfving B., Bjørnholm B., Ebert B., et al. Binding characteristics of selective serotonin reuptake inhibitors with relation to emission tomography studies. Synapse 41 (2001) 203-211
    • (2001) Synapse , vol.41 , pp. 203-211
    • Elfving, B.1    Bjørnholm, B.2    Ebert, B.3
  • 50
    • 0344121272 scopus 로고    scopus 로고
    • Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents
    • Waterhouse R.N. Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents. Mol Imaging Biol 5 (2003) 376-389
    • (2003) Mol Imaging Biol , vol.5 , pp. 376-389
    • Waterhouse, R.N.1
  • 51
    • 0026330894 scopus 로고
    • Cloning and expression of a cocaine-sensitive rat dopamine transporter
    • Kilty J.E., Lorang D., and Amara S.G. Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 254 (1991) 578-579
    • (1991) Science , vol.254 , pp. 578-579
    • Kilty, J.E.1    Lorang, D.2    Amara, S.G.3
  • 52
    • 0026315352 scopus 로고
    • Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA
    • Shimada S., Kitayama S., Lin C.L., et al. Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254 (1991) 576-578
    • (1991) Science , vol.254 , pp. 576-578
    • Shimada, S.1    Kitayama, S.2    Lin, C.L.3
  • 53
    • 0027049060 scopus 로고
    • Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter
    • Giros B., El Mestikawy S., Godinot N., et al. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol Pharmacol 42 (1992) 383-390
    • (1992) Mol Pharmacol , vol.42 , pp. 383-390
    • Giros, B.1    El Mestikawy, S.2    Godinot, N.3
  • 54
    • 0028936065 scopus 로고
    • The dopamine transporter: immunochemical characterization and localization in brain
    • Ciliax B.J., Heilman C., Demchyshyn L.L., et al. The dopamine transporter: immunochemical characterization and localization in brain. J Neurosci 15 (1995) 1714-1723
    • (1995) J Neurosci , vol.15 , pp. 1714-1723
    • Ciliax, B.J.1    Heilman, C.2    Demchyshyn, L.L.3
  • 55
    • 0030031457 scopus 로고    scopus 로고
    • The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
    • Nirenberg M.J., Vaughan R.A., Uhl G.R., et al. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. J Neurosci 16 (1996) 436-447
    • (1996) J Neurosci , vol.16 , pp. 436-447
    • Nirenberg, M.J.1    Vaughan, R.A.2    Uhl, G.R.3
  • 56
    • 0033591616 scopus 로고    scopus 로고
    • Immunocytochemical localization of the dopamine transporter in human brain
    • Ciliax B.J., Drash G.W., Staley J.K., et al. Immunocytochemical localization of the dopamine transporter in human brain. J Comp Neurol 409 (1999) 38-56
    • (1999) J Comp Neurol , vol.409 , pp. 38-56
    • Ciliax, B.J.1    Drash, G.W.2    Staley, J.K.3
  • 57
    • 0025721829 scopus 로고
    • Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT
    • Kaufman M.J., Spealman R.D., and Madras B.K. Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT. Synapse 9 (1991) 177-187
    • (1991) Synapse , vol.9 , pp. 177-187
    • Kaufman, M.J.1    Spealman, R.D.2    Madras, B.K.3
  • 58
    • 0025961180 scopus 로고
    • The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus
    • Niznik H.B., Fogel E.F., Fassos F.F., et al. The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus. J Neurochem 56 (1991) 192-198
    • (1991) J Neurochem , vol.56 , pp. 192-198
    • Niznik, H.B.1    Fogel, E.F.2    Fassos, F.F.3
  • 59
    • 0026633036 scopus 로고
    • Mesostriatal and mesolimbic dopamine uptake binding sites are reduced in Parkinson's disease and progressive supranuclear palsy: a quantitative autoradiographic study using [3H]Mazindol
    • Chinaglia G., Alvarez F.J., Probst A., et al. Mesostriatal and mesolimbic dopamine uptake binding sites are reduced in Parkinson's disease and progressive supranuclear palsy: a quantitative autoradiographic study using [3H]Mazindol. Neuroscience 49 (1992) 317-327
    • (1992) Neuroscience , vol.49 , pp. 317-327
    • Chinaglia, G.1    Alvarez, F.J.2    Probst, A.3
  • 60
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson T.M., and Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302 (2003) 819-822
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 61
    • 26944484406 scopus 로고    scopus 로고
    • Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder
    • Mazei-Robison M.S., Couch R.S., Shelton R.C., et al. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology 49 (2005) 724-736
    • (2005) Neuropharmacology , vol.49 , pp. 724-736
    • Mazei-Robison, M.S.1    Couch, R.S.2    Shelton, R.C.3
  • 62
    • 0025938404 scopus 로고
    • Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome
    • Singer H.S., Hahn I.H., and Moran T.H. Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. Ann Neurol 30 (1991) 558-562
    • (1991) Ann Neurol , vol.30 , pp. 558-562
    • Singer, H.S.1    Hahn, I.H.2    Moran, T.H.3
  • 63
    • 58349108690 scopus 로고    scopus 로고
    • Biomarkers for Parkinson's disease: tools to assess Parkinson's disease onset and progression
    • Marek K., Jennings D., Tamagnan G., et al. Biomarkers for Parkinson's disease: tools to assess Parkinson's disease onset and progression. Ann Neurol 64 Suppl (2008) S111-S121
    • (2008) Ann Neurol , vol.64 , Issue.SUPPL
    • Marek, K.1    Jennings, D.2    Tamagnan, G.3
  • 64
    • 0021127531 scopus 로고
    • Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake
    • Heikkila R.E., and Manzino L. Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur J Pharmacol 103 (1984) 241-248
    • (1984) Eur J Pharmacol , vol.103 , pp. 241-248
    • Heikkila, R.E.1    Manzino, L.2
  • 65
    • 0024960595 scopus 로고
    • The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action
    • Andersen P.H. The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol 166 (1989) 493-504
    • (1989) Eur J Pharmacol , vol.166 , pp. 493-504
    • Andersen, P.H.1
  • 68
    • 1842401194 scopus 로고
    • 18F]GBR 12909 for human studies of dopamine reuptake sites
    • [abstract]
    • 18F]GBR 12909 for human studies of dopamine reuptake sites. [abstract]. J Nucl Med 31 836 (1990) 901
    • (1990) J Nucl Med , vol.31 , Issue.836 , pp. 901
    • Haka, M.S.1    Kilbourn, M.R.2
  • 69
    • 0039576805 scopus 로고
    • Imaging and kinetic modeling of [F-18]GBR 12909, a dopamine uptake inhibitor
    • [abstract]
    • Koeppe R.A., Kilbourn M.R., Frey K.A., et al. Imaging and kinetic modeling of [F-18]GBR 12909, a dopamine uptake inhibitor. [abstract]. J Nucl Med 31 55 (1990) 720
    • (1990) J Nucl Med , vol.31 , Issue.55 , pp. 720
    • Koeppe, R.A.1    Kilbourn, M.R.2    Frey, K.A.3
  • 73
    • 0028989861 scopus 로고
    • 18F]NNC 12-0818: two potential radioligands for the dopamine transporter
    • 18F]NNC 12-0818: two potential radioligands for the dopamine transporter. Appl Radiat Isot 46 (1995) 323-328
    • (1995) Appl Radiat Isot , vol.46 , pp. 323-328
    • Müller, L.1    Halldin, C.2    Foged, C.3
  • 74
    • 0026007785 scopus 로고
    • Cocaine and serotonin neurochemistry
    • Wolf W.A., and Kuhn D.M. Cocaine and serotonin neurochemistry. Neurochem Int 18 (1991) 33-38
    • (1991) Neurochem Int , vol.18 , pp. 33-38
    • Wolf, W.A.1    Kuhn, D.M.2
  • 75
    • 85047700129 scopus 로고    scopus 로고
    • Cocaine, reward, movement and monoamine transporters
    • Uhl G.R., Hall F.S., and Sora I. Cocaine, reward, movement and monoamine transporters. Mol Psychiatry 7 (2002) 21-26
    • (2002) Mol Psychiatry , vol.7 , pp. 21-26
    • Uhl, G.R.1    Hall, F.S.2    Sora, I.3
  • 76
    • 0023265754 scopus 로고
    • Cocaine receptors on dopamine transporters are related to self-administration of cocaine
    • Ritz M.C., Lamb R.J., Goldberg S.R., et al. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237 (1987) 1219-1223
    • (1987) Science , vol.237 , pp. 1219-1223
    • Ritz, M.C.1    Lamb, R.J.2    Goldberg, S.R.3
  • 78
    • 0024855153 scopus 로고
    • 3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens
    • 3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens. Eur J Pharmacol 173 (1989) 215-217
    • (1989) Eur J Pharmacol , vol.173 , pp. 215-217
    • Boja, J.W.1    Kuhar, M.J.2
  • 79
    • 0024833426 scopus 로고
    • Mapping cocaine binding sites in human and baboon brain in vivo
    • Fowler J.S., Volkow N.D., Wolf A.P., et al. Mapping cocaine binding sites in human and baboon brain in vivo. Synapse 4 (1989) 371-377
    • (1989) Synapse , vol.4 , pp. 371-377
    • Fowler, J.S.1    Volkow, N.D.2    Wolf, A.P.3
  • 80
    • 0026471338 scopus 로고
    • Comparative PET studies of the kinetics and distribution of cocaine and cocaethylene in baboon brain
    • Fowler J.S., Volkow N.D., MacGregor R.R., et al. Comparative PET studies of the kinetics and distribution of cocaine and cocaethylene in baboon brain. Synapse 12 (1992) 220-227
    • (1992) Synapse , vol.12 , pp. 220-227
    • Fowler, J.S.1    Volkow, N.D.2    MacGregor, R.R.3
  • 81
    • 0026696704 scopus 로고
    • Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography
    • Yu D.W., Gatley S.J., Wolf A.P., et al. Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography. J Med Chem 35 (1992) 2178-2183
    • (1992) J Med Chem , vol.35 , pp. 2178-2183
    • Yu, D.W.1    Gatley, S.J.2    Wolf, A.P.3
  • 82
    • 0028084899 scopus 로고
    • 11C]cocaine metabolites contribute to PET images of the baboon brain
    • 11C]cocaine metabolites contribute to PET images of the baboon brain. J Neurochem 62 (1994) 1154-1162
    • (1994) J Neurochem , vol.62 , pp. 1154-1162
    • Gatley, S.J.1    Yu, D.W.2    Fowler, J.S.3
  • 83
    • 44649159527 scopus 로고    scopus 로고
    • Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys
    • Kimmel H.L., Negus S.S., Wilcox K.M., et al. Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. Pharmacol Biochem Behav 90 (2008) 453-462
    • (2008) Pharmacol Biochem Behav , vol.90 , pp. 453-462
    • Kimmel, H.L.1    Negus, S.S.2    Wilcox, K.M.3
  • 84
    • 0020632379 scopus 로고
    • N-demethylation of cocaine to norcocaine
    • Kloss M.W., Rosen G.M., and Rauckman E.J. N-demethylation of cocaine to norcocaine. Mol Pharmacol 23 (1983) 482-485
    • (1983) Mol Pharmacol , vol.23 , pp. 482-485
    • Kloss, M.W.1    Rosen, G.M.2    Rauckman, E.J.3
  • 85
    • 0024912569 scopus 로고
    • Mass spectrometric studies of cocaine disposition in animals and humans using stable isotope-labeled analogues
    • Jindal S.P., and Lutz T. Mass spectrometric studies of cocaine disposition in animals and humans using stable isotope-labeled analogues. J Pharm Sci 78 (1989) 1009-1014
    • (1989) J Pharm Sci , vol.78 , pp. 1009-1014
    • Jindal, S.P.1    Lutz, T.2
  • 87
    • 33645958909 scopus 로고    scopus 로고
    • Carboxylesterases: detoxifying enzymes and targets for drug therapy
    • Potter P.M., and Wadkins R.M. Carboxylesterases: detoxifying enzymes and targets for drug therapy. Curr Med Chem 13 (2006) 1045-1054
    • (2006) Curr Med Chem , vol.13 , pp. 1045-1054
    • Potter, P.M.1    Wadkins, R.M.2
  • 89
    • 0036142190 scopus 로고    scopus 로고
    • Crystal structure of a bacterial cocaine esterase
    • Larsen N.A., Turner J.M., Stevens J., et al. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol 9 (2002) 17-21
    • (2002) Nat Struct Biol , vol.9 , pp. 17-21
    • Larsen, N.A.1    Turner, J.M.2    Stevens, J.3
  • 90
    • 0015885558 scopus 로고
    • Compounds affecting the central nervous system. 4. 3β-Phenyltropane-2-carboxylic esters and analogs
    • Clarke R.L., Daum S.J., Gambino A.J., et al. Compounds affecting the central nervous system. 4. 3β-Phenyltropane-2-carboxylic esters and analogs. J Med Chem 16 (1973) 1260-1267
    • (1973) J Med Chem , vol.16 , pp. 1260-1267
    • Clarke, R.L.1    Daum, S.J.2    Gambino, A.J.3
  • 91
    • 0025108546 scopus 로고
    • New, potent cocaine analogs: ligand binding and transport studies in rat striatum
    • Boja J.W., Carroll F.I., Rahman M.A., et al. New, potent cocaine analogs: ligand binding and transport studies in rat striatum. Eur J Pharmacol 184 (1990) 329-332
    • (1990) Eur J Pharmacol , vol.184 , pp. 329-332
    • Boja, J.W.1    Carroll, F.I.2    Rahman, M.A.3
  • 92
    • 0026009418 scopus 로고
    • Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters
    • Carroll F.I., Gao Y., Rahman M.A., et al. Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters. J Med Chem 34 (1991) 2719-2725
    • (1991) J Med Chem , vol.34 , pp. 2719-2725
    • Carroll, F.I.1    Gao, Y.2    Rahman, M.A.3
  • 93
    • 0026566383 scopus 로고
    • Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter
    • Carroll F.I., Lewin A.H., Boja J.W., et al. Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter. J Med Chem 35 (1992) 969-981
    • (1992) J Med Chem , vol.35 , pp. 969-981
    • Carroll, F.I.1    Lewin, A.H.2    Boja, J.W.3
  • 94
    • 0032984327 scopus 로고    scopus 로고
    • Studies of selected phenyltropanes at monoamine transporters
    • Kuhar M.J., McGirr K.M., Hunter R.G., et al. Studies of selected phenyltropanes at monoamine transporters. Drug Alcohol Depend 56 (1999) 9-15
    • (1999) Drug Alcohol Depend , vol.56 , pp. 9-15
    • Kuhar, M.J.1    McGirr, K.M.2    Hunter, R.G.3
  • 95
    • 0036136662 scopus 로고    scopus 로고
    • Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat
    • Cook C.D., Carroll F.I., and Beardsley P.M. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology 159 (2001) 58-63
    • (2001) Psychopharmacology , vol.159 , pp. 58-63
    • Cook, C.D.1    Carroll, F.I.2    Beardsley, P.M.3
  • 96
    • 0001384546 scopus 로고    scopus 로고
    • Chemistry, design, and structure-activity relationship of cocaine antagonists
    • Singh S. Chemistry, design, and structure-activity relationship of cocaine antagonists. Chem Rev 100 (2000) 925-1024
    • (2000) Chem Rev , vol.100 , pp. 925-1024
    • Singh, S.1
  • 97
    • 47349119625 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter binding properties of 2β-[3'-(substituted benzyl)isoxazol-5-yl]- and 2β-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3β-(substituted phenyl)tropanes
    • Jin C., Navarro H.A., Page K., et al. Synthesis and monoamine transporter binding properties of 2β-[3'-(substituted benzyl)isoxazol-5-yl]- and 2β-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3β-(substituted phenyl)tropanes. Bioorg Med Chem 16 (2008) 6682-6688
    • (2008) Bioorg Med Chem , vol.16 , pp. 6682-6688
    • Jin, C.1    Navarro, H.A.2    Page, K.3
  • 98
    • 58149095805 scopus 로고    scopus 로고
    • Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter
    • Jin C., Navarro H.A., and Carroll F.I. Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter. J Med Chem 51 (2008) 8048-8056
    • (2008) J Med Chem , vol.51 , pp. 8048-8056
    • Jin, C.1    Navarro, H.A.2    Carroll, F.I.3
  • 99
  • 100
    • 0027468956 scopus 로고
    • Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging
    • Meltzer P.C., Liang A.Y., Brownell A.L., et al. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging. J Med Chem 36 (1993) 855-862
    • (1993) J Med Chem , vol.36 , pp. 855-862
    • Meltzer, P.C.1    Liang, A.Y.2    Brownell, A.L.3
  • 102
    • 0029670103 scopus 로고    scopus 로고
    • 18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography
    • 18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. Nucl Med Biol 23 (1996) 141-146
    • (1996) Nucl Med Biol , vol.23 , pp. 141-146
    • Wilson, A.A.1    DaSilva, J.N.2    Houle, S.3
  • 103
    • 0028178856 scopus 로고
    • 11C]β-CIT binding to monoamine transporters in the monkey and human brain
    • 11C]β-CIT binding to monoamine transporters in the monkey and human brain. Synapse 16 (1994) 93-103
    • (1994) Synapse , vol.16 , pp. 93-103
    • Farde, L.1    Halldin, C.2    Müller, L.3
  • 105
    • 4344618164 scopus 로고    scopus 로고
    • 18F]fluoroethyl)nortropane) as a dopamine transporter ligand: a PET study in the conscious monkey brain
    • 18F]fluoroethyl)nortropane) as a dopamine transporter ligand: a PET study in the conscious monkey brain. Synapse 54 (2004) 37-45
    • (2004) Synapse , vol.54 , pp. 37-45
    • Harada, N.1    Ohba, H.2    Fukumoto, D.3
  • 106
    • 0029658009 scopus 로고    scopus 로고
    • 18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: biodistribution in rats
    • 18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: biodistribution in rats. Synapse 23 (1996) 321-327
    • (1996) Synapse , vol.23 , pp. 321-327
    • Haaparanta, M.1    Bergman, J.2    Laakso, A.3
  • 107
    • 0031594290 scopus 로고    scopus 로고
    • 18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: characterization in human subjects
    • 18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: characterization in human subjects. Synapse 28 (1998) 244-250
    • (1998) Synapse , vol.28 , pp. 244-250
    • Laakso, A.1    Bergman, J.2    Haaparanta, M.3
  • 108
    • 0035371972 scopus 로고    scopus 로고
    • 18F]CFT are both sensitive PET markers to detect presynaptic dopaminergic hypofunction in early Parkinson's disease
    • 18F]CFT are both sensitive PET markers to detect presynaptic dopaminergic hypofunction in early Parkinson's disease. Synapse 40 (2001) 193-200
    • (2001) Synapse , vol.40 , pp. 193-200
    • Rinne, J.O.1    Nurmi, E.2    Ruottinen, H.M.3
  • 109
    • 0033752802 scopus 로고    scopus 로고
    • 11C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)
    • 11C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET). J Labelled Comp Radiopharm 43 (2000) 1235-1244
    • (2000) J Labelled Comp Radiopharm , vol.43 , pp. 1235-1244
    • Kämäräinen, E.L.1    Kyllönen, T.2    Airaksinen, A.3
  • 110
    • 38849196172 scopus 로고    scopus 로고
    • 18F]fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophen yl)nortropane in rats
    • 18F]fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophen yl)nortropane in rats. Nucl Med Biol 35 (2008) 177-183
    • (2008) Nucl Med Biol , vol.35 , pp. 177-183
    • Koivula, T.1    Marjamäki, P.2    Haaparanta, M.3
  • 111
    • 0031456987 scopus 로고    scopus 로고
    • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites
    • Owens M.J., Morgan W.N., Plott S.J., et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283 (1997) 1305-1322
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1305-1322
    • Owens, M.J.1    Morgan, W.N.2    Plott, S.J.3
  • 112
    • 0344110152 scopus 로고    scopus 로고
    • Pharmacokinetics of selective serotonin reuptake inhibitors
    • Hiemke C., and Härtter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol Ther 85 (2000) 11-28
    • (2000) Pharmacol Ther , vol.85 , pp. 11-28
    • Hiemke, C.1    Härtter, S.2
  • 113
    • 0030070681 scopus 로고    scopus 로고
    • N-substituted analogs of 2β-carbomethoxy-3β-(4'-iodophenyl)tropane (β-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain
    • Neumeyer J.L., Tamagnan G., Wang S., et al. N-substituted analogs of 2β-carbomethoxy-3β-(4'-iodophenyl)tropane (β-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. J Med Chem 39 (1996) 543-548
    • (1996) J Med Chem , vol.39 , pp. 543-548
    • Neumeyer, J.L.1    Tamagnan, G.2    Wang, S.3
  • 114
    • 0028241283 scopus 로고
    • N-ω-Fluoroalkyl analogs of (1 R)-2β-carbomethoxy-3β-(4-iodophenyl)-tropane (β-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters
    • Neumeyer J.L., Wang S., Gao Y., et al. N-ω-Fluoroalkyl analogs of (1 R)-2β-carbomethoxy-3β-(4-iodophenyl)-tropane (β-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters. J Med Chem 37 (1994) 1558-1561
    • (1994) J Med Chem , vol.37 , pp. 1558-1561
    • Neumeyer, J.L.1    Wang, S.2    Gao, Y.3
  • 115
    • 0026647629 scopus 로고
    • Isopropyl and phenyl esters of 3β-(4-substituted phenyl)tropan-2β-carboxylic acids: potent and selective compounds for the dopamine transporter
    • Carroll F.I., Abraham P., Lewin A.H., et al. Isopropyl and phenyl esters of 3β-(4-substituted phenyl)tropan-2β-carboxylic acids: potent and selective compounds for the dopamine transporter. J Med Chem 35 (1992) 2497-2500
    • (1992) J Med Chem , vol.35 , pp. 2497-2500
    • Carroll, F.I.1    Abraham, P.2    Lewin, A.H.3
  • 116
    • 0028939735 scopus 로고
    • 123I] N-ω-fluoroalkyl-2β-carboxy-3β-(4-iodophenyl)nortropane esters in baboons
    • 123I] N-ω-fluoroalkyl-2β-carboxy-3β-(4-iodophenyl)nortropane esters in baboons. Nucl Med Biol 22 (1995) 211-219
    • (1995) Nucl Med Biol , vol.22 , pp. 211-219
    • Baldwin, R.M.1    Zea-Ponce, Y.2    Al-Tikriti, M.3
  • 117
    • 0028933124 scopus 로고
    • Comparison of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane and 2β-carbomethoxy-3β-(4-iodophenyl)- N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain
    • Kuikka J.T., Bergström K.A., Ahonen A., et al. Comparison of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane and 2β-carbomethoxy-3β-(4-iodophenyl)- N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain. Eur J Nucl Med 22 (1995) 356-360
    • (1995) Eur J Nucl Med , vol.22 , pp. 356-360
    • Kuikka, J.T.1    Bergström, K.A.2    Ahonen, A.3
  • 118
    • 0029662277 scopus 로고    scopus 로고
    • 11C]β-CIT-FE, a radioligand for quantitation of the dopamine transporter in the living brain using positron emission tomography
    • 11C]β-CIT-FE, a radioligand for quantitation of the dopamine transporter in the living brain using positron emission tomography. Synapse 22 (1996) 386-390
    • (1996) Synapse , vol.22 , pp. 386-390
    • Halldin, C.1    Farde, L.2    Lundkvist, C.3
  • 120
    • 0030276777 scopus 로고    scopus 로고
    • 18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography
    • 18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography. Nucl Med Biol 23 (1996) 999-1004
    • (1996) Nucl Med Biol , vol.23 , pp. 999-1004
    • Chaly, T.1    Dhawan, V.2    Kazumata, K.3
  • 121
    • 0031689041 scopus 로고    scopus 로고
    • Dopamine transporter imaging with fluorine-18-FPCIT and PET
    • Kazumata K., Dhawan V., Chaly T., et al. Dopamine transporter imaging with fluorine-18-FPCIT and PET. J Nucl Med 39 (1998) 1521-1530
    • (1998) J Nucl Med , vol.39 , pp. 1521-1530
    • Kazumata, K.1    Dhawan, V.2    Chaly, T.3
  • 122
    • 0035983408 scopus 로고    scopus 로고
    • 18F]FPCIT binding in early stage Parkinson's disease: a PET study
    • 18F]FPCIT binding in early stage Parkinson's disease: a PET study. Synapse 45 (2002) 125-133
    • (2002) Synapse , vol.45 , pp. 125-133
    • Ma, Y.1    Dhawan, V.2    Mentis, M.3
  • 125
    • 34248185541 scopus 로고    scopus 로고
    • 18F]FP-CIT using a protic solvent system
    • 18F]FP-CIT using a protic solvent system. Nucl Med Biol 34 (2007) 345-351
    • (2007) Nucl Med Biol , vol.34 , pp. 345-351
    • Lee, S.J.1    Oh, S.J.2    Chi, D.Y.3
  • 126
    • 17344383647 scopus 로고    scopus 로고
    • Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters
    • Goodman M.M., Keil R., Shoup T.M., et al. Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters. J Nucl Med 38 (1997) 119-126
    • (1997) J Nucl Med , vol.38 , pp. 119-126
    • Goodman, M.M.1    Keil, R.2    Shoup, T.M.3
  • 127
    • 0033625020 scopus 로고    scopus 로고
    • 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters
    • 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nucl Med Biol 27 (2000) 1-12
    • (2000) Nucl Med Biol , vol.27 , pp. 1-12
    • Goodman, M.M.1    Kilts, C.D.2    Keil, R.3
  • 128
    • 0037097151 scopus 로고    scopus 로고
    • Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT
    • Votaw J.R., Howell L.L., Martarello L., et al. Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT. Synapse 44 (2002) 203-210
    • (2002) Synapse , vol.44 , pp. 203-210
    • Votaw, J.R.1    Howell, L.L.2    Martarello, L.3
  • 134
    • 33645998163 scopus 로고    scopus 로고
    • 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements
    • 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements. J Nucl Med 47 (2006) 520-527
    • (2006) J Nucl Med , vol.47 , pp. 520-527
    • Zoghbi, S.S.1    Shetty, U.2    Ichise, M.3
  • 135
    • 0032887820 scopus 로고    scopus 로고
    • Pharmacokinetics of radiotracers in human plasma during positron emission tomography
    • Cumming P., Yokoi F., Chen A., et al. Pharmacokinetics of radiotracers in human plasma during positron emission tomography. Synapse 34 (1999) 124-134
    • (1999) Synapse , vol.34 , pp. 124-134
    • Cumming, P.1    Yokoi, F.2    Chen, A.3
  • 136
    • 0035137440 scopus 로고    scopus 로고
    • Kinetics of the metabolism of four PET radioligands in living minipigs
    • Gillings N.M., Bender D., Falborg L., et al. Kinetics of the metabolism of four PET radioligands in living minipigs. Nucl Med Biol 28 (2001) 97-104
    • (2001) Nucl Med Biol , vol.28 , pp. 97-104
    • Gillings, N.M.1    Bender, D.2    Falborg, L.3
  • 138
    • 13244258485 scopus 로고    scopus 로고
    • 11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat
    • 11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat. Nucl Med Biol 32 (2005) 87-93
    • (2005) Nucl Med Biol , vol.32 , pp. 87-93
    • Luurtsema, G.1    Molthoff, C.F.M.2    Schuit, R.C.3
  • 141
    • 0032587811 scopus 로고    scopus 로고
    • 18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β(4' methylphenyl) nortropane (FPCMT)
    • 18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β(4' methylphenyl) nortropane (FPCMT). Appl Radiat Isot 51 (1999) 299-305
    • (1999) Appl Radiat Isot , vol.51 , pp. 299-305
    • Chaly Jr., T.1    Matacchieri, R.2    Dahl, R.3
  • 143
    • 0035803004 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter
    • Gu X.H., Zong R., Kula N.S., et al. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorg Med Chem Lett 11 (2001) 3049-3053
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 3049-3053
    • Gu, X.H.1    Zong, R.2    Kula, N.S.3
  • 144
    • 5144220557 scopus 로고    scopus 로고
    • Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents
    • Peng X., Zhang A., Kula N.S., et al. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorg Med Chem Lett 14 (2004) 5635-5639
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 5635-5639
    • Peng, X.1    Zhang, A.2    Kula, N.S.3
  • 145
    • 34248649591 scopus 로고    scopus 로고
    • 18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT)
    • 18F]MCL-322) as a PET radiotracer for imaging the dopamine transporter (DAT). Bioorg Med Chem 15 (2007) 4511-4519
    • (2007) Bioorg Med Chem , vol.15 , pp. 4511-4519
    • Wuest, F.1    Berndt, M.2    Strobel, K.3
  • 146
    • 10844272345 scopus 로고    scopus 로고
    • 18F]FE@CIT, a new potential tracer for the dopamine transporter
    • 18F]FE@CIT, a new potential tracer for the dopamine transporter. Synapse 55 (2005) 73-79
    • (2005) Synapse , vol.55 , pp. 73-79
    • Mitterhauser, M.1    Wadsak, W.2    Mien, L.K.3
  • 148
    • 17744415283 scopus 로고    scopus 로고
    • Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2β-Carbo-1'-fluoro-2-propoxy-3β-(4-chlorophenyl)tropanes: ligands for the imaging of dopamine transporters by positron emission tomography
    • Xing D., Chen P., Keil R., et al. Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2β-Carbo-1'-fluoro-2-propoxy-3β-(4-chlorophenyl)tropanes: ligands for the imaging of dopamine transporters by positron emission tomography. J Med Chem 43 (2000) 639-648
    • (2000) J Med Chem , vol.43 , pp. 639-648
    • Xing, D.1    Chen, P.2    Keil, R.3
  • 149
    • 0033938814 scopus 로고    scopus 로고
    • Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter
    • Mach R.H., Nader M.A., Ehrenkaufer R.L., et al. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse 37 (2000) 109-117
    • (2000) Synapse , vol.37 , pp. 109-117
    • Mach, R.H.1    Nader, M.A.2    Ehrenkaufer, R.L.3
  • 150
    • 0032810783 scopus 로고    scopus 로고
    • 18F]fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4-sub stituted-phenyl)nortropanes for imaging DAT by PET
    • 18F]fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4-sub stituted-phenyl)nortropanes for imaging DAT by PET. J Labelled Comp Radiopharm 42 Suppl 1 (1999) S400
    • (1999) J Labelled Comp Radiopharm , vol.42 , Issue.SUPPL. 1
    • Chen, P.1    Kilts, C.D.2    Camp, V.M.3
  • 151
    • 68449099873 scopus 로고    scopus 로고
    • Goodman MM, Chen P. Fluoroalkenyl Nortropanes. 2000:World Patent Application WO2000064490. Published November 2, 2000.
    • Goodman MM, Chen P. Fluoroalkenyl Nortropanes. 2000:World Patent Application WO2000064490. Published November 2, 2000.
  • 152
    • 33645119477 scopus 로고    scopus 로고
    • Pharmacological characterization of (E)- N-(4-Fluorobut-2-enyl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter
    • Chalon S., Hall H., Saba W., et al. Pharmacological characterization of (E)- N-(4-Fluorobut-2-enyl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter. J Pharmacol Exp Ther 317 (2006) 147-152
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 147-152
    • Chalon, S.1    Hall, H.2    Saba, W.3
  • 153
    • 30344480515 scopus 로고    scopus 로고
    • 11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET
    • 11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET. Bioorg Med Chem 14 (2006) 1115-1125
    • (2006) Bioorg Med Chem , vol.14 , pp. 1115-1125
    • Dollé, F.1    Emond, P.2    Mavel, S.3
  • 154
    • 33746917585 scopus 로고    scopus 로고
    • 18F]LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET
    • 18F]LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET. J Labelled Comp Radiopharm 49 (2006) 687-698
    • (2006) J Labelled Comp Radiopharm , vol.49 , pp. 687-698
    • Dollé, F.1    Hinnen, F.2    Emond, P.3
  • 155
    • 34548829186 scopus 로고    scopus 로고
    • 18F]LBT-999: a selective radioligand for the visualization of the dopamine transporter with PET
    • 18F]LBT-999: a selective radioligand for the visualization of the dopamine transporter with PET. J Labelled Comp Radiopharm 50 (2007) 716-723
    • (2007) J Labelled Comp Radiopharm , vol.50 , pp. 716-723
    • Dollé, F.1    Helfenbein, J.2    Hinnen, F.3
  • 156
    • 33845534740 scopus 로고    scopus 로고
    • 11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET
    • 11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET. Synapse 61 (2007) 17-23
    • (2007) Synapse , vol.61 , pp. 17-23
    • Saba, W.1    Valette, H.2    Schöllhorn-Peyronneau, M.A.3
  • 158
    • 0029063953 scopus 로고
    • Cocaine and 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid ester and amide analogues: new high-affinity and selective compounds for the dopamine transporter
    • Carroll F.I., Kotian P., Dehghani A., et al. Cocaine and 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid ester and amide analogues: new high-affinity and selective compounds for the dopamine transporter. J Med Chem 38 (1995) 379-388
    • (1995) J Med Chem , vol.38 , pp. 379-388
    • Carroll, F.I.1    Kotian, P.2    Dehghani, A.3
  • 159
    • 0031828427 scopus 로고    scopus 로고
    • RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter
    • Dworkin S.I., Lambert P., Sizemore G.M., et al. RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter. Synapse 30 (1998) 49-55
    • (1998) Synapse , vol.30 , pp. 49-55
    • Dworkin, S.I.1    Lambert, P.2    Sizemore, G.M.3
  • 160
    • 0037012668 scopus 로고    scopus 로고
    • RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeys
    • Cook C.D., Carroll F.I., and Beardsley P.M. RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeys. Eur J Pharmacol 442 (2002) 93-98
    • (2002) Eur J Pharmacol , vol.442 , pp. 93-98
    • Cook, C.D.1    Carroll, F.I.2    Beardsley, P.M.3
  • 161
    • 0036132414 scopus 로고    scopus 로고
    • Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys
    • Wilcox K.M., Lindsey K.P., Votaw J.R., et al. Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. Synapse 43 (2002) 78-85
    • (2002) Synapse , vol.43 , pp. 78-85
    • Wilcox, K.M.1    Lindsey, K.P.2    Votaw, J.R.3
  • 162
    • 0032734511 scopus 로고    scopus 로고
    • Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain
    • Tsukada H., Nishiyama S., Kakiuchi T., et al. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain Res 849 (1999) 85-96
    • (1999) Brain Res , vol.849 , pp. 85-96
    • Tsukada, H.1    Nishiyama, S.2    Kakiuchi, T.3
  • 163
    • 0033984457 scopus 로고    scopus 로고
    • Effects of ketamine, MK-801, and amphetamine on regional brain 2-deoxyglucose uptake in freely moving mice
    • Miyamoto S., Leipzig J.N., Lieberman J.A., et al. Effects of ketamine, MK-801, and amphetamine on regional brain 2-deoxyglucose uptake in freely moving mice. Neuropsychopharmacology 22 (2000) 400-412
    • (2000) Neuropsychopharmacology , vol.22 , pp. 400-412
    • Miyamoto, S.1    Leipzig, J.N.2    Lieberman, J.A.3
  • 164
    • 0033937455 scopus 로고    scopus 로고
    • 11c]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis
    • 11c]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: multiparametric PET studies combined with microdialysis analysis. Synapse 37 (2000) 95-103
    • (2000) Synapse , vol.37 , pp. 95-103
    • Tsukada, H.1    Harada, N.2    Nishiyama, S.3
  • 165
    • 17944382799 scopus 로고    scopus 로고
    • 11C]methamphetamine in monkeys in positron emission tomography (PET) study
    • 11C]methamphetamine in monkeys in positron emission tomography (PET) study. Brain Res 911 (2001) 173-175
    • (2001) Brain Res , vol.911 , pp. 173-175
    • Mizugaki, M.1    Nakagawa, N.2    Nakamura, H.3
  • 167
    • 0038376120 scopus 로고    scopus 로고
    • Interference of anaesthetics with radioligand binding in neuroreceptor studies
    • Elfving B., Bjørnholm B., and Knudsen G.M. Interference of anaesthetics with radioligand binding in neuroreceptor studies. Eur J Nucl Med Mol Imaging 30 (2003) 912-915
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 912-915
    • Elfving, B.1    Bjørnholm, B.2    Knudsen, G.M.3
  • 168
    • 7244220105 scopus 로고    scopus 로고
    • Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans
    • Votaw J.R., Byas-Smith M.G., Voll R., et al. Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans. Anesthesiology 101 (2004) 1128-1135
    • (2004) Anesthesiology , vol.101 , pp. 1128-1135
    • Votaw, J.R.1    Byas-Smith, M.G.2    Voll, R.3
  • 169
    • 0026350637 scopus 로고
    • Cloning of a serotonin transporter affected by antidepressants
    • Hoffman B.J., Mezey E., and Brownstein M.J. Cloning of a serotonin transporter affected by antidepressants. Science 254 (1991) 579-580
    • (1991) Science , vol.254 , pp. 579-580
    • Hoffman, B.J.1    Mezey, E.2    Brownstein, M.J.3
  • 170
    • 0023692068 scopus 로고
    • Autoradiography of antidepressant binding sites in the human brain: localization using [3h]imipramine and [3h]paroxetine
    • Cortés R., Soriano E., Pazos A., et al. Autoradiography of antidepressant binding sites in the human brain: localization using [3h]imipramine and [3h]paroxetine. Neuroscience 27 (1988) 473-496
    • (1988) Neuroscience , vol.27 , pp. 473-496
    • Cortés, R.1    Soriano, E.2    Pazos, A.3
  • 171
    • 0025019520 scopus 로고
    • 3H]imipramine localization and relationship to serotonin transporter
    • 3H]imipramine localization and relationship to serotonin transporter. J Pharmacol Exp Ther 252 (1990) 410-418
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 410-418
    • Hrdina, P.D.1    Foy, B.2    Hepner, A.3
  • 172
    • 0027425434 scopus 로고
    • Cellular localization of serotonin transporter mRNA in the rat brain
    • Fujita M., Shimada S., Maeno H., et al. Cellular localization of serotonin transporter mRNA in the rat brain. Neurosci Lett 162 (1993) 59-62
    • (1993) Neurosci Lett , vol.162 , pp. 59-62
    • Fujita, M.1    Shimada, S.2    Maeno, H.3
  • 173
    • 0028292581 scopus 로고
    • Expression of serotonin transporter messenger RNA in the human brain
    • Austin M.C., Bradley C.C., Mann J.J., et al. Expression of serotonin transporter messenger RNA in the human brain. J Neurochem 62 (1994) 2362-2367
    • (1994) J Neurochem , vol.62 , pp. 2362-2367
    • Austin, M.C.1    Bradley, C.C.2    Mann, J.J.3
  • 174
    • 0028535338 scopus 로고
    • Molecular physiology of norepinephrine and serotonin transporters
    • Blakely R.D., De Felice L.J., and Hartzell H.C. Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196 (1994) 263-281
    • (1994) J Exp Biol , vol.196 , pp. 263-281
    • Blakely, R.D.1    De Felice, L.J.2    Hartzell, H.C.3
  • 175
    • 0029666198 scopus 로고    scopus 로고
    • 3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain
    • 3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology 14 (1996) 309-323
    • (1996) Neuropsychopharmacology , vol.14 , pp. 309-323
    • Gurevich, E.V.1    Joyce, J.N.2
  • 176
    • 0030586373 scopus 로고    scopus 로고
    • Quantitative subregional distribution of serotonin-1A receptors and serotonin transporters in the human dorsal raphe
    • Stockmeier C.A., Shapiro L.A., Haycock J.W., et al. Quantitative subregional distribution of serotonin-1A receptors and serotonin
    • (1996) Brain Res , vol.727 , pp. 1-12
    • Stockmeier, C.A.1    Shapiro, L.A.2    Haycock, J.W.3
  • 177
    • 13844317450 scopus 로고    scopus 로고
    • Regional distribution of serotonin transporter protein in postmortem human brain. Is the cerebellum a SERT-free brain region?
    • Kish S.J., Furukawa Y., Chang L.J., et al. Regional distribution of serotonin transporter protein in postmortem human brain. Is the cerebellum a SERT-free brain region?. Nucl Med Biol 32 (2005) 123-128
    • (2005) Nucl Med Biol , vol.32 , pp. 123-128
    • Kish, S.J.1    Furukawa, Y.2    Chang, L.J.3
  • 179
    • 0022346881 scopus 로고
    • 3H]imipramine binding sites in control and parkinsonian brains
    • 3H]imipramine binding sites in control and parkinsonian brains. Eur J Pharmacol 117 (1985) 71-80
    • (1985) Eur J Pharmacol , vol.117 , pp. 71-80
    • Cash, R.1    Raisman, R.2    Ploska, A.3
  • 180
    • 0032819493 scopus 로고    scopus 로고
    • Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders
    • Blier P., and de Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 21 (1999) 91S-98S
    • (1999) Neuropsychopharmacology , vol.21
    • Blier, P.1    de Montigny, C.2
  • 182
    • 0032145210 scopus 로고    scopus 로고
    • The spectrum of behaviors influenced by serotonin
    • Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44 (1998) 151-162
    • (1998) Biol Psychiatry , vol.44 , pp. 151-162
    • Lucki, I.1
  • 183
    • 0032821347 scopus 로고    scopus 로고
    • Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior
    • Mann J.J. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 21 (1999) 99S-105S
    • (1999) Neuropsychopharmacology , vol.21
    • Mann, J.J.1
  • 184
    • 0035078362 scopus 로고    scopus 로고
    • The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system
    • Mann J.J., Brent D.A., and Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 24 (2001) 467-477
    • (2001) Neuropsychopharmacology , vol.24 , pp. 467-477
    • Mann, J.J.1    Brent, D.A.2    Arango, V.3
  • 185
    • 0028265462 scopus 로고
    • Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
    • Owens M.J., and Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40 (1994) 288-295
    • (1994) Clin Chem , vol.40 , pp. 288-295
    • Owens, M.J.1    Nemeroff, C.B.2
  • 186
    • 0031727557 scopus 로고    scopus 로고
    • The serotonin transporter and depression
    • Owens M.J., and Nemeroff C.B. The serotonin transporter and depression. Depress Anxiety 8 Suppl 1 (1998) 5-12
    • (1998) Depress Anxiety , vol.8 , Issue.SUPPL. 1 , pp. 5-12
    • Owens, M.J.1    Nemeroff, C.B.2
  • 187
    • 0038210320 scopus 로고    scopus 로고
    • Serotonin transporter: a potential substrate in the biology of suicide
    • Purselle D.C., and Nemeroff C.B. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology 28 (2003) 613-619
    • (2003) Neuropsychopharmacology , vol.28 , pp. 613-619
    • Purselle, D.C.1    Nemeroff, C.B.2
  • 188
    • 0033507575 scopus 로고    scopus 로고
    • Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level
    • Benmansour S., Cecchi M., Morilak D.A., et al. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J Neurosci 19 (1999) 10494-10501
    • (1999) J Neurosci , vol.19 , pp. 10494-10501
    • Benmansour, S.1    Cecchi, M.2    Morilak, D.A.3
  • 189
    • 0036703989 scopus 로고    scopus 로고
    • Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter
    • Benmansour S., Owens W.A., Cecchi M., et al. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. J Neurosci 22 (2002) 6766-6772
    • (2002) J Neurosci , vol.22 , pp. 6766-6772
    • Benmansour, S.1    Owens, W.A.2    Cecchi, M.3
  • 190
    • 0037177817 scopus 로고    scopus 로고
    • Serotonin transporter function and pharmacology are sensitive to expression level
    • Ramsey I.S., and De Felice L.J. Serotonin transporter function and pharmacology are sensitive to expression level. J Biol Chem 277 (2002) 14475-14482
    • (2002) J Biol Chem , vol.277 , pp. 14475-14482
    • Ramsey, I.S.1    De Felice, L.J.2
  • 191
    • 4644363462 scopus 로고    scopus 로고
    • Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors
    • Kugaya A., Sanacora G., Staley J.K., et al. Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors. Biol Psychiatry 56 (2004) 497-502
    • (2004) Biol Psychiatry , vol.56 , pp. 497-502
    • Kugaya, A.1    Sanacora, G.2    Staley, J.K.3
  • 192
    • 34247545605 scopus 로고    scopus 로고
    • Serotonin transporter density and anxiolytic-like effects of antidepressants in mice
    • Mirza N.R., Nielsen E., and Troelsen K.B. Serotonin transporter density and anxiolytic-like effects of antidepressants in mice. Prog Neuropsychopharmacol Biol Psychiatry 31 (2007) 858-866
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 858-866
    • Mirza, N.R.1    Nielsen, E.2    Troelsen, K.B.3
  • 193
    • 0031727818 scopus 로고    scopus 로고
    • Ten years of fluoxetine
    • Stokes P.E. Ten years of fluoxetine. Depress Anxiety 8 Suppl 1 (1998) 1-4
    • (1998) Depress Anxiety , vol.8 , Issue.SUPPL. 1 , pp. 1-4
    • Stokes, P.E.1
  • 195
    • 0031718019 scopus 로고    scopus 로고
    • 18F-fluoxetine in the rodent brain: an in vitro and in vivo study
    • 18F-fluoxetine in the rodent brain: an in vitro and in vivo study. Nucl Med Biol 25 (1998) 605-610
    • (1998) Nucl Med Biol , vol.25 , pp. 605-610
    • Mukherjee, J.1    Das, M.K.2    Yang, Z.Y.3
  • 196
    • 0024241568 scopus 로고
    • McN-5652: a highly potent inhibitor of serotonin uptake
    • Shank R.P., Vaught J.L., Pelley K.A., et al. McN-5652: a highly potent inhibitor of serotonin uptake. J Pharmacol Exp Ther 247 (1988) 1032-1038
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 1032-1038
    • Shank, R.P.1    Vaught, J.L.2    Pelley, K.A.3
  • 197
    • 0027390785 scopus 로고
    • A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z
    • Suehiro M., Scheffel U., Dannals R.F., et al. A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. J Nucl Med 34 (1993) 120-127
    • (1993) J Nucl Med , vol.34 , pp. 120-127
    • Suehiro, M.1    Scheffel, U.2    Dannals, R.F.3
  • 199
    • 0034741137 scopus 로고    scopus 로고
    • 18F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter
    • 18F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter. Nucl Med Biol 28 (2001) 857-863
    • (2001) Nucl Med Biol , vol.28 , pp. 857-863
    • Zessin, J.1    Eskola, O.2    Brust, P.3
  • 200
    • 0037211552 scopus 로고    scopus 로고
    • 18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats
    • 18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse 47 (2003) 45-53
    • (2003) Synapse , vol.47 , pp. 45-53
    • Marjamäki, P.1    Zessin, J.2    Eskola, O.3
  • 201
    • 10744224806 scopus 로고    scopus 로고
    • In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652
    • Brust P., Hinz R., Kuwabara H., et al. In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652. Neuropsychopharmacology 28 (2003) 2010-2019
    • (2003) Neuropsychopharmacology , vol.28 , pp. 2010-2019
    • Brust, P.1    Hinz, R.2    Kuwabara, H.3
  • 204
    • 0025194627 scopus 로고
    • 3H]6-nitroquipazine binding sites in rat brain
    • 3H]6-nitroquipazine binding sites in rat brain. Eur J Pharmacol 180 (1990) 273-281
    • (1990) Eur J Pharmacol , vol.180 , pp. 273-281
    • Hashimoto, K.1    Goromaru, T.2
  • 205
    • 18444405216 scopus 로고    scopus 로고
    • Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET
    • Karramkam M., Dollé F., Valette H., et al. Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET. Bioorg Med Chem 10 (2002) 2611-2623
    • (2002) Bioorg Med Chem , vol.10 , pp. 2611-2623
    • Karramkam, M.1    Dollé, F.2    Valette, H.3
  • 207
    • 0004301849 scopus 로고
    • Halogen substituted diphenylsulfides.
    • European Patent Application EP0 402 097 A1. Published December, 12, 1990
    • Mehta NB, Hollingsworth CEB, Brieaddy LE, et al. Halogen substituted diphenylsulfides. 1990: European Patent Application EP0 402 097 A1. Published December, 12, 1990.
    • (1990)
    • Mehta, N.B.1    Hollingsworth, C.E.B.2    Brieaddy, L.E.3
  • 208
    • 0029133762 scopus 로고
    • Pharmacological properties of 403U76, a new chemical class of 5-hydroxytryptamine and noradrenaline reuptake inhibitor
    • Ferris R.M., Brieaddy L., Mehta N., et al. Pharmacological properties of 403U76, a new chemical class of 5-hydroxytryptamine and noradrenaline reuptake inhibitor. J Pharm Pharmacol 47 (1995) 775-781
    • (1995) J Pharm Pharmacol , vol.47 , pp. 775-781
    • Ferris, R.M.1    Brieaddy, L.2    Mehta, N.3
  • 209
    • 0036842463 scopus 로고    scopus 로고
    • Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
    • Huang Y., Hwang D.R., Narendran R., et al. Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. J Cereb Blood Flow Metab 22 (2002) 1377-1398
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1377-1398
    • Huang, Y.1    Hwang, D.R.2    Narendran, R.3
  • 210
    • 20144388151 scopus 로고    scopus 로고
    • Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    • Jarkas N., Votaw J.R., Voll R.J., et al. Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters. Nucl Med Biol 32 (2005) 211-224
    • (2005) Nucl Med Biol , vol.32 , pp. 211-224
    • Jarkas, N.1    Votaw, J.R.2    Voll, R.J.3
  • 211
    • 19944432965 scopus 로고    scopus 로고
    • Synthesis and characterization of eadam: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography
    • Jarkas N., McConathy J., Votaw J.R., et al. Synthesis and characterization of eadam: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nucl Med Biol 32 (2005) 75-86
    • (2005) Nucl Med Biol , vol.32 , pp. 75-86
    • Jarkas, N.1    McConathy, J.2    Votaw, J.R.3
  • 213
    • 1542472726 scopus 로고    scopus 로고
    • 18F-ADAM): an improved PET radioligand for serotonin transporters
    • 18F-ADAM): an improved PET radioligand for serotonin transporters. J Nucl Med 44 (2003) 1890-1897
    • (2003) J Nucl Med , vol.44 , pp. 1890-1897
    • Shiue, G.G.1    Choi, S.R.2    Fang, P.3
  • 215
    • 10644257674 scopus 로고    scopus 로고
    • 11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    • 11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. Nucl Med Biol 31 (2004) 983-994
    • (2004) Nucl Med Biol , vol.31 , pp. 983-994
    • Zhu, Z.1    Guo, N.2    Narendran, R.3
  • 216
    • 17144418906 scopus 로고    scopus 로고
    • Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents
    • Huang Y., Bae S., Zhu Z., et al. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. J Med Chem 48 (2005) 2559-2570
    • (2005) J Med Chem , vol.48 , pp. 2559-2570
    • Huang, Y.1    Bae, S.2    Zhu, Z.3
  • 217
    • 4544366519 scopus 로고    scopus 로고
    • 18F(2-[2-Amino-5-fluorophenyl)thio]- N, N-dimethyl-benzenmethanamine as a PET imaging agent for serotonin transporters
    • 18F(2-[2-Amino-5-fluorophenyl)thio]- N, N-dimethyl-benzenmethanamine as a PET imaging agent for serotonin transporters. J Labelled Comp Radiopharm 46 Suppl 1 (2003) S164
    • (2003) J Labelled Comp Radiopharm , vol.46 , Issue.SUPPL. 1
    • Oya, S.1    Choi, S.R.2    Hou, C.3
  • 218
    • 0037057546 scopus 로고    scopus 로고
    • New PET imaging agent for the serotonin transporter: [18F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]- N, N-dimethyl-benzenmethanamine)
    • Oya S., Choi S.R., Coenen H., et al. New PET imaging agent for the serotonin transporter: [18F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]- N, N-dimethyl-benzenmethanamine). J Med Chem 45 (2002) 4716-4723
    • (2002) J Med Chem , vol.45 , pp. 4716-4723
    • Oya, S.1    Choi, S.R.2    Coenen, H.3
  • 219
    • 37349052384 scopus 로고    scopus 로고
    • 2-(2'-((Dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents
    • Parhi A.K., Wang J.L., Oya S., et al. 2-(2'-((Dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents. J Med Chem 50 (2007) 6673-6684
    • (2007) J Med Chem , vol.50 , pp. 6673-6684
    • Parhi, A.K.1    Wang, J.L.2    Oya, S.3
  • 220
    • 38349132686 scopus 로고    scopus 로고
    • Synthesis and in vivo evaluation of halogenated N, N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands
    • Jarkas N., Voll R.J., Williams L., et al. Synthesis and in vivo evaluation of halogenated N, N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands. J Med Chem 51 (2008) 271-281
    • (2008) J Med Chem , vol.51 , pp. 271-281
    • Jarkas, N.1    Voll, R.J.2    Williams, L.3
  • 221
    • 0034077167 scopus 로고    scopus 로고
    • 2-((2-((Dimethylamino)-methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand
    • Oya S., Choi S.R., Hou C., et al. 2-((2-((Dimethylamino)-methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 27 (2000) 249-254
    • (2000) Nucl Med Biol , vol.27 , pp. 249-254
    • Oya, S.1    Choi, S.R.2    Hou, C.3
  • 222
    • 0034632763 scopus 로고    scopus 로고
    • Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of 11C-labeled 2-(phenylthio)araalkylamines
    • Wilson A.A., Ginovart N., Schmidt M., et al. Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of 11C-labeled 2-(phenylthio)araalkylamines. J Med Chem 43 (2000) 3103-3110
    • (2000) J Med Chem , vol.43 , pp. 3103-3110
    • Wilson, A.A.1    Ginovart, N.2    Schmidt, M.3
  • 224
    • 0035200087 scopus 로고    scopus 로고
    • Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter: modeling strategies
    • Ginovart N., Wilson A.A., Meyer J.H., et al. Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter: modeling strategies. J Cereb Blood Flow Metab 21 (2001) 1342-1353
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1342-1353
    • Ginovart, N.1    Wilson, A.A.2    Meyer, J.H.3
  • 226
    • 20444418603 scopus 로고    scopus 로고
    • Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB
    • Frankle W.G., Narendran R., Huang Y., et al. Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB. Biol Psychiatry 57 (2005) 1510-1516
    • (2005) Biol Psychiatry , vol.57 , pp. 1510-1516
    • Frankle, W.G.1    Narendran, R.2    Huang, Y.3
  • 227
    • 57149102510 scopus 로고    scopus 로고
    • 11C-HOMADAM binding to the serotonin transporter in the healthy human brain
    • 11C-HOMADAM binding to the serotonin transporter in the healthy human brain. J Nucl Med 49 (2008) 2018-2025
    • (2008) J Nucl Med , vol.49 , pp. 2018-2025
    • Nye, J.A.1    Votaw, J.R.2    Jarkas, N.3
  • 228
    • 4544329318 scopus 로고    scopus 로고
    • Comparison of three F-18 labeled PET ligands for the serotonin transporter: radiosynthesis and in vivo imaging studies in baboon
    • Huang Y., Zhu Z., Bae S.A., et al. Comparison of three F-18 labeled PET ligands for the serotonin transporter: radiosynthesis and in vivo imaging studies in baboon. J Labelled Comp Radiopharm 46 Suppl 1 (2003) S57
    • (2003) J Labelled Comp Radiopharm , vol.46 , Issue.SUPPL. 1
    • Huang, Y.1    Zhu, Z.2    Bae, S.A.3
  • 229
    • 4544230544 scopus 로고    scopus 로고
    • 18F]-ADAM) as a serotonin transporter imaging agent
    • 18F]-ADAM) as a serotonin transporter imaging agent. Appl Radiat Isot 61 (2004) 1247-1254
    • (2004) Appl Radiat Isot , vol.61 , pp. 1247-1254
    • Fang, P.1    Shiue, G.G.2    Shimazu, T.3
  • 230
    • 43049168348 scopus 로고    scopus 로고
    • 18F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters
    • 18F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters. Nucl Med Biol 35 (2008) 447-458
    • (2008) Nucl Med Biol , vol.35 , pp. 447-458
    • Wang, J.L.1    Parhi, A.K.2    Oya, S.3
  • 231
    • 0035450364 scopus 로고    scopus 로고
    • Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine
    • Owens M.J., Knight D.L., and Nemeroff C.B. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50 (2001) 345-350
    • (2001) Biol Psychiatry , vol.50 , pp. 345-350
    • Owens, M.J.1    Knight, D.L.2    Nemeroff, C.B.3
  • 232
    • 13844289397 scopus 로고    scopus 로고
    • Binding of S-citalopram and paroxetine discriminates between species
    • Elfving B., and Wiborg O. Binding of S-citalopram and paroxetine discriminates between species. Synapse 55 (2005) 280-282
    • (2005) Synapse , vol.55 , pp. 280-282
    • Elfving, B.1    Wiborg, O.2
  • 233
    • 0026610297 scopus 로고
    • 3H]Nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding
    • 3H]Nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. J Pharmacol Exp Ther 260 (1992) 427-436
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 427-436
    • Tejani-Butt, S.M.1
  • 234
    • 0029670751 scopus 로고    scopus 로고
    • 3H]noradrenaline uptake and effects of DSP-4 lesioning and antidepressant treatments
    • 3H]noradrenaline uptake and effects of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 (1996) 63-70
    • (1996) Neuropharmacology , vol.35 , pp. 63-70
    • Cheetham, S.C.1    Viggers, J.A.2    Butler, S.A.3
  • 235
    • 33751002065 scopus 로고    scopus 로고
    • Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2β-carbomethoxy-3β-(3′-((Z)-2-haloethenyl)phenyl)nortrop anes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography
    • Stehouwer J.S., Jarkas N., Zeng F., et al. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2β-carbomethoxy-3β-(3′-((Z)-2-haloethenyl)phenyl)nortrop anes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem 49 (2006) 6760-6767
    • (2006) J Med Chem , vol.49 , pp. 6760-6767
    • Stehouwer, J.S.1    Jarkas, N.2    Zeng, F.3
  • 236
    • 17544404431 scopus 로고    scopus 로고
    • Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor
    • Wong E.H.F., Sonders M.S., Amara S.G., et al. Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol Psychiatry 47 (2000) 818-829
    • (2000) Biol Psychiatry , vol.47 , pp. 818-829
    • Wong, E.H.F.1    Sonders, M.S.2    Amara, S.G.3
  • 237
    • 0037435050 scopus 로고    scopus 로고
    • Synthesis and characterization of iodine-123 labeled 2β-carbomethoxy-3β-(4'-((Z)-2-iodoethenyl)phenyl)nortropane: a ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography
    • Goodman M.M., Chen P., Plisson C., et al. Synthesis and characterization of iodine-123 labeled 2β-carbomethoxy-3β-(4'-((Z)-2-iodoethenyl)phenyl)nortropane: a ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. J Med Chem 46 (2003) 925-935
    • (2003) J Med Chem , vol.46 , pp. 925-935
    • Goodman, M.M.1    Chen, P.2    Plisson, C.3
  • 238
    • 0020579207 scopus 로고
    • Interaction between noradrenergic and serotonergic brain systems as evidenced by behavioral and biochemical effects of microinjections of adrenergic agonists and antagonists into the medial raphe nucleus
    • Plaznik A., Danysz W., Kostowski W., et al. Interaction between noradrenergic and serotonergic brain systems as evidenced by behavioral and biochemical effects of microinjections of adrenergic agonists and antagonists into the medial raphe nucleus. Pharmacol Biochem Behav 19 (1983) 27-32
    • (1983) Pharmacol Biochem Behav , vol.19 , pp. 27-32
    • Plaznik, A.1    Danysz, W.2    Kostowski, W.3
  • 239
    • 0031054886 scopus 로고    scopus 로고
    • Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei
    • Ordway G.A., Stockmeier C.A., Cason G.W., et al. Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei. J Neurosci 17 (1997) 1710-1719
    • (1997) J Neurosci , vol.17 , pp. 1710-1719
    • Ordway, G.A.1    Stockmeier, C.A.2    Cason, G.W.3
  • 240
    • 0033765025 scopus 로고    scopus 로고
    • Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders
    • Ressler K.J., and Nemeroff C.B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12 Suppl 1 (2000) 2-19
    • (2000) Depress Anxiety , vol.12 , Issue.SUPPL. 1 , pp. 2-19
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 241
    • 0037075829 scopus 로고    scopus 로고
    • Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation
    • Emond P., Vercouillie J., Innis R., et al. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. J Med Chem 45 (2002) 1253-1258
    • (2002) J Med Chem , vol.45 , pp. 1253-1258
    • Emond, P.1    Vercouillie, J.2    Innis, R.3
  • 242
    • 34648823211 scopus 로고    scopus 로고
    • 18F]fluorobenzyl)methylamino)methylphenylsulfanyl)benzonitri le, an F-18 fluorobenzyl analogue of DASB: synthesis, in vitro binding, and in vivo biodistribution studies
    • 18F]fluorobenzyl)methylamino)methylphenylsulfanyl)benzonitri le, an F-18 fluorobenzyl analogue of DASB: synthesis, in vitro binding, and in vivo biodistribution studies. Bioconjug Chem 18 (2007) 1612-1618
    • (2007) Bioconjug Chem , vol.18 , pp. 1612-1618
    • Garg, S.1    Thopate, S.R.2    Minton, R.C.3
  • 243
    • 52949104404 scopus 로고    scopus 로고
    • Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging
    • Mavel S., Vercouillie J., Garreau L., et al. Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging. Bioorg Med Chem 16 (2008) 9050-9055
    • (2008) Bioorg Med Chem , vol.16 , pp. 9050-9055
    • Mavel, S.1    Vercouillie, J.2    Garreau, L.3
  • 244
    • 0028773367 scopus 로고
    • Secondary amine analogues of 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters
    • Boja J., Kuhar M.J., Kopajtic T., et al. Secondary amine analogues of 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters. J Med Chem 37 (1994) 1220-1223
    • (1994) J Med Chem , vol.37 , pp. 1220-1223
    • Boja, J.1    Kuhar, M.J.2    Kopajtic, T.3
  • 245
    • 0029796134 scopus 로고    scopus 로고
    • Synthesis and transporter binding properties of 3β-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2β-carboxylic acid methyl esters: serotonin transporter selective analogs
    • Blough B.E., Abraham P., Lewin A.H., et al. Synthesis and transporter binding properties of 3β-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2β-carboxylic acid methyl esters: serotonin transporter selective analogs. J Med Chem 39 (1996) 4027-4035
    • (1996) J Med Chem , vol.39 , pp. 4027-4035
    • Blough, B.E.1    Abraham, P.2    Lewin, A.H.3
  • 246
    • 0030729033 scopus 로고    scopus 로고
    • 3β-(4-Ethyl-3-iodophenyl)nortropane-2β-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter
    • Blogh B.E., Abraham P., Mills A.C., et al. 3β-(4-Ethyl-3-iodophenyl)nortropane-2β-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter. J Med Chem 40 (1997) 3861-3864
    • (1997) J Med Chem , vol.40 , pp. 3861-3864
    • Blogh, B.E.1    Abraham, P.2    Mills, A.C.3
  • 247
    • 0034698895 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter affinity of 2β-carbomethoxy-3β-(2'-, 3'- or 4'-substituted) biphenyltropanes
    • Tamagnan G., Baldwin R.M., Kula N.S., et al. Synthesis and monoamine transporter affinity of 2β-carbomethoxy-3β-(2'-, 3'- or 4'-substituted) biphenyltropanes. Bioorg Med Chem Lett 10 (2000) 1783-1785
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 1783-1785
    • Tamagnan, G.1    Baldwin, R.M.2    Kula, N.S.3
  • 248
    • 0034933346 scopus 로고    scopus 로고
    • Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands
    • Emond P., Helfenbein J., Chalon S., et al. Synthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands. Bioorg Med Chem 9 (2001) 1849-1855
    • (2001) Bioorg Med Chem , vol.9 , pp. 1849-1855
    • Emond, P.1    Helfenbein, J.2    Chalon, S.3
  • 249
    • 1842640037 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter affinity of 3'-analogs of 2-β-carbomethoxy-3-β-(4'-iodophenyl)tropane (β-CIT)
    • Bois F., Baldwin R.M., Kula N.S., et al. Synthesis and monoamine transporter affinity of 3'-analogs of 2-β-carbomethoxy-3-β-(4'-iodophenyl)tropane (β-CIT). Bioorg Med Chem Lett 14 (2004) 2117-2120
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 2117-2120
    • Bois, F.1    Baldwin, R.M.2    Kula, N.S.3
  • 250
    • 16244410784 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency
    • Tamagnan G., Alagille D., Fu X., et al. Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorg Med Chem Lett 15 (2005) 1131-1133
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 1131-1133
    • Tamagnan, G.1    Alagille, D.2    Fu, X.3
  • 251
    • 27744547705 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropanes
    • Tamagnan G., Alagille D., Fu X., et al. Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropanes. Bioorg Med Chem Lett 16 (2006) 217-220
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 217-220
    • Tamagnan, G.1    Alagille, D.2    Fu, X.3
  • 252
    • 0030764452 scopus 로고    scopus 로고
    • In vitro and in vivo characterisation of Nor-β-CIT: a potential radioligand for visualisation of the serotonin transporter in the brain
    • Bergström K.A., Halldin C., Hall H., et al. In vitro and in vivo characterisation of Nor-β-CIT: a potential radioligand for visualisation of the serotonin transporter in the brain. Eur J Nucl Med 24 (1997) 596-601
    • (1997) Eur J Nucl Med , vol.24 , pp. 596-601
    • Bergström, K.A.1    Halldin, C.2    Hall, H.3
  • 253
    • 0032773868 scopus 로고    scopus 로고
    • PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter
    • Helfenbein J., Sandell J., Halldin C., et al. PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter. Nucl Med Biol 26 (1999) 491-499
    • (1999) Nucl Med Biol , vol.26 , pp. 491-499
    • Helfenbein, J.1    Sandell, J.2    Halldin, C.3
  • 254
    • 27444439092 scopus 로고    scopus 로고
    • Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 (N-fluoroalkyl) labeled 2β-carbomethoxy-3β-(4'-(3-furyl)phenyl)-tropanes and -nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography
    • Stehouwer J.S., Plisson C., Jarkas N., et al. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 (N-fluoroalkyl) labeled 2β-carbomethoxy-3β-(4'-(3-furyl)phenyl)-tropanes and -nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem 48 (2005) 7080-7083
    • (2005) J Med Chem , vol.48 , pp. 7080-7083
    • Stehouwer, J.S.1    Plisson, C.2    Jarkas, N.3
  • 255
    • 32344439133 scopus 로고    scopus 로고
    • Evaluation of carbon-11-labeled 2β-carbomethoxy-3β-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET
    • Plisson C., Jarkas N., McConathy J., et al. Evaluation of carbon-11-labeled 2β-carbomethoxy-3β-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET. J Med Chem 49 (2006) 942-946
    • (2006) J Med Chem , vol.49 , pp. 942-946
    • Plisson, C.1    Jarkas, N.2    McConathy, J.3
  • 256
    • 34648830281 scopus 로고    scopus 로고
    • Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2β-carbo(2-fluoroethoxy)-3β-(4'-((Z)-2-iodoethenyl)phenyl)nort ropane as a candidate serotonin transporter imaging agent
    • Plisson C., Stehouwer J.S., Voll R.J., et al. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2β-carbo(2-fluoroethoxy)-3β-(4'-((Z)-2-iodoethenyl)phenyl)nort ropane as a candidate serotonin transporter imaging agent. J Med Chem 50 (2007) 4553-4560
    • (2007) J Med Chem , vol.50 , pp. 4553-4560
    • Plisson, C.1    Stehouwer, J.S.2    Voll, R.J.3
  • 257
    • 58149098059 scopus 로고    scopus 로고
    • Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2β-carbo(fluoroalkoxy)-3β-(3'-((Z)-2-haloethenyl)phenyl)nortro panes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography
    • Stehouwer J.S., Jarkas N., Zeng F., et al. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2β-carbo(fluoroalkoxy)-3β-(3'-((Z)-2-haloethenyl)phenyl)nortro panes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. J Med Chem 51 (2008) 7788-7799
    • (2008) J Med Chem , vol.51 , pp. 7788-7799
    • Stehouwer, J.S.1    Jarkas, N.2    Zeng, F.3
  • 258
    • 0026433037 scopus 로고
    • Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter
    • Pacholczyk T., Blakely R.D., and Amara S.G. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 350 (1991) 350-354
    • (1991) Nature , vol.350 , pp. 350-354
    • Pacholczyk, T.1    Blakely, R.D.2    Amara, S.G.3
  • 259
    • 0034194496 scopus 로고    scopus 로고
    • Immunolocalization of the cocaine- and antidepressant-sensitive 1-norepinephrine transporter
    • Schroeter S., Apparsundaram S., Wiley R.G., et al. Immunolocalization of the cocaine- and antidepressant-sensitive 1-norepinephrine transporter. J Comp Neurol 420 (2000) 211-232
    • (2000) J Comp Neurol , vol.420 , pp. 211-232
    • Schroeter, S.1    Apparsundaram, S.2    Wiley, R.G.3
  • 260
    • 60549092240 scopus 로고    scopus 로고
    • The locus coeruleus and noradrenergic modulation of cognition
    • Sara S.J. The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci 10 (2009) 211-223
    • (2009) Nat Rev Neurosci , vol.10 , pp. 211-223
    • Sara, S.J.1
  • 261
    • 34250025128 scopus 로고    scopus 로고
    • Norepinephrine: the redheaded stepchild of Parkinson's disease
    • Rommelfanger K.S., and Weinshenker D. Norepinephrine: the redheaded stepchild of Parkinson's disease. Biochem Pharmacol 74 (2007) 177-190
    • (2007) Biochem Pharmacol , vol.74 , pp. 177-190
    • Rommelfanger, K.S.1    Weinshenker, D.2
  • 262
    • 0033232482 scopus 로고    scopus 로고
    • Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder
    • Biederman J., and Spencer T. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry 46 (1999) 1234-1242
    • (1999) Biol Psychiatry , vol.46 , pp. 1234-1242
    • Biederman, J.1    Spencer, T.2
  • 263
    • 0036848458 scopus 로고    scopus 로고
    • Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder
    • Bymaster F.P., Katner J.S., Nelson D.L., et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27 (2002) 699-711
    • (2002) Neuropsychopharmacology , vol.27 , pp. 699-711
    • Bymaster, F.P.1    Katner, J.S.2    Nelson, D.L.3
  • 264
    • 0033232481 scopus 로고    scopus 로고
    • Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder
    • Southwick S.M., Bremner D.J., Rasmusson A., et al. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry 46 (1999) 1192-1204
    • (1999) Biol Psychiatry , vol.46 , pp. 1192-1204
    • Southwick, S.M.1    Bremner, D.J.2    Rasmusson, A.3
  • 265
    • 0033232510 scopus 로고    scopus 로고
    • Role of norepinephrine in the pathophysiology and treatment of mood disorders
    • Ressler K.J., and Nemeroff C.B. Role of norepinephrine in the pathophysiology and treatment of mood disorders. Biol Psychiatry 46 (1999) 1219-1233
    • (1999) Biol Psychiatry , vol.46 , pp. 1219-1233
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 266
    • 0032719985 scopus 로고    scopus 로고
    • Noradrenaline (norepinephrine) and depression: role in aetiology and therapeutic implications
    • Van Moffaert M., and Dierick M. Noradrenaline (norepinephrine) and depression: role in aetiology and therapeutic implications. CNS Drugs 12 (1999) 293-305
    • (1999) CNS Drugs , vol.12 , pp. 293-305
    • Van Moffaert, M.1    Dierick, M.2
  • 267
    • 0033232508 scopus 로고    scopus 로고
    • Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression
    • Zhu M.Y., Klimek V., Dilley G.E., et al. Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46 (1999) 1275-1286
    • (1999) Biol Psychiatry , vol.46 , pp. 1275-1286
    • Zhu, M.Y.1    Klimek, V.2    Dilley, G.E.3
  • 268
    • 33645017331 scopus 로고    scopus 로고
    • The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice
    • Ahern T.H., Javors M.A., Eagles D.A., et al. The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice. Neuropsychopharmacology 31 (2006) 730-738
    • (2006) Neuropsychopharmacology , vol.31 , pp. 730-738
    • Ahern, T.H.1    Javors, M.A.2    Eagles, D.A.3
  • 269
    • 16944362115 scopus 로고    scopus 로고
    • Reduced levels of norepinephrine transporters in the locus coeruleus in major depression
    • Klimek V., Stockmeier C., Overholser J., et al. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci 17 (1997) 8451-8458
    • (1997) J Neurosci , vol.17 , pp. 8451-8458
    • Klimek, V.1    Stockmeier, C.2    Overholser, J.3
  • 270
    • 20744446933 scopus 로고    scopus 로고
    • Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
    • Logan J., Ding Y.S., Lin K.S., et al. Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region. Nucl Med Biol 32 (2005) 531-542
    • (2005) Nucl Med Biol , vol.32 , pp. 531-542
    • Logan, J.1    Ding, Y.S.2    Lin, K.S.3
  • 271
    • 33749824386 scopus 로고    scopus 로고
    • PET imaging of norepinephrine transporters
    • Ding Y.S., Lin K.S., and Logan J. PET imaging of norepinephrine transporters. Curr Pharm Des 12 (2006) 3831-3845
    • (2006) Curr Pharm Des , vol.12 , pp. 3831-3845
    • Ding, Y.S.1    Lin, K.S.2    Logan, J.3
  • 272
    • 36349008186 scopus 로고    scopus 로고
    • Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography
    • Schou M., Pike V.W., and Halldin C. Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography. Curr Top Med Chem 7 (2007) 1806-1816
    • (2007) Curr Top Med Chem , vol.7 , pp. 1806-1816
    • Schou, M.1    Pike, V.W.2    Halldin, C.3
  • 273
    • 68449100414 scopus 로고    scopus 로고
    • Patient selection and antidepressant therapy with reboxetine, a new selective norepinephrine reuptake inhibitor
    • Patient selection and antidepressant therapy with reboxetine, a new selective norepinephrine reuptake inhibitor. J Clin Psychiatry 59 Suppl 14 (1998)
    • (1998) J Clin Psychiatry , vol.59 , Issue.SUPPL. 14
  • 274
    • 15044347050 scopus 로고    scopus 로고
    • Asymmetric synthesis of (+)-(S, S)-reboxetine via a new (S)-2-(hydroxymethyl)morpholine preparation
    • Brenner E., Baldwin R.M., and Tamagnan G. Asymmetric synthesis of (+)-(S, S)-reboxetine via a new (S)-2-(hydroxymethyl)morpholine preparation. Org Lett 7 (2005) 937-939
    • (2005) Org Lett , vol.7 , pp. 937-939
    • Brenner, E.1    Baldwin, R.M.2    Tamagnan, G.3
  • 275
    • 0242653791 scopus 로고    scopus 로고
    • Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs
    • Ding Y.S., Lin K.S., Garza V., et al. Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs. Synapse 50 (2003) 345-352
    • (2003) Synapse , vol.50 , pp. 345-352
    • Ding, Y.S.1    Lin, K.S.2    Garza, V.3
  • 276
    • 0242340372 scopus 로고    scopus 로고
    • Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter
    • Wilson A.A., Johnson D.P., Mozley D., et al. Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter. Nucl Med Biol 30 (2003) 85-92
    • (2003) Nucl Med Biol , vol.30 , pp. 85-92
    • Wilson, A.A.1    Johnson, D.P.2    Mozley, D.3
  • 277
    • 10744228667 scopus 로고    scopus 로고
    • Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S, S)- [11C]MeNER
    • Schou M., Halldin C., Sóvágó J., et al. Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S, S)- [11C]MeNER. Nucl Med Biol 30 (2003) 707-714
    • (2003) Nucl Med Biol , vol.30 , pp. 707-714
    • Schou, M.1    Halldin, C.2    Sóvágó, J.3
  • 278
    • 19244366615 scopus 로고    scopus 로고
    • PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain
    • Schou M., Halldin C., Sóvágó J., et al. PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain. Synapse 53 (2004) 57-67
    • (2004) Synapse , vol.53 , pp. 57-67
    • Schou, M.1    Halldin, C.2    Sóvágó, J.3
  • 282
    • 33747616636 scopus 로고    scopus 로고
    • Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S, S)- [18F]FMeNER-D2
    • Seneca N., Gulyás B., Varrone A., et al. Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S, S)- [18F]FMeNER-D2. Psychopharmacology 188 (2006) 119-127
    • (2006) Psychopharmacology , vol.188 , pp. 119-127
    • Seneca, N.1    Gulyás, B.2    Varrone, A.3
  • 284
    • 18844363250 scopus 로고    scopus 로고
    • Synthesis, enantiomeric resolution, F-18 labeling and biodistribution of reboxetine analogs: promising radioligands for imaging the norepinephrine transporter with positron emission tomography
    • Lin K.S., Ding Y.S., Kim S.W., et al. Synthesis, enantiomeric resolution, F-18 labeling and biodistribution of reboxetine analogs: promising radioligands for imaging the norepinephrine transporter with positron emission tomography. Nucl Med Biol 32 (2005) 415-422
    • (2005) Nucl Med Biol , vol.32 , pp. 415-422
    • Lin, K.S.1    Ding, Y.S.2    Kim, S.W.3
  • 285
    • 22244464188 scopus 로고    scopus 로고
    • Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S, S) and (R, R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl- [11C]methylreboxetine and [18F]fluororeboxetine), (R)- [11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine
    • Ding Y.S., Lin K.S., Logan J., et al. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S, S) and (R, R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl- [11C]methylreboxetine and [18F]fluororeboxetine), (R)- [11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. J Neurochem 94 (2005) 337-351
    • (2005) J Neurochem , vol.94 , pp. 337-351
    • Ding, Y.S.1    Lin, K.S.2    Logan, J.3
  • 286
    • 38549120307 scopus 로고    scopus 로고
    • Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter
    • Zeng F., Jarkas N., Stehouwer J.S., et al. Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorg Med Chem 16 (2008) 783-793
    • (2008) Bioorg Med Chem , vol.16 , pp. 783-793
    • Zeng, F.1    Jarkas, N.2    Stehouwer, J.S.3
  • 287
    • 59449083651 scopus 로고    scopus 로고
    • Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter
    • Zeng F., Mun J., Jarkas N., et al. Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter. J Med Chem 52 (2009) 62-73
    • (2009) J Med Chem , vol.52 , pp. 62-73
    • Zeng, F.1    Mun, J.2    Jarkas, N.3
  • 288
    • 15144359144 scopus 로고    scopus 로고
    • Ketamine interacts with the noradrenaline transporter at a site partly overlapping the desipramine binding site
    • Hara K., Yanagihara N., Minami K., et al. Ketamine interacts with the noradrenaline transporter at a site partly overlapping the desipramine binding site. Naunyn Schmiedebergs Arch Pharmacol 358 (1998) 328-333
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.358 , pp. 328-333
    • Hara, K.1    Yanagihara, N.2    Minami, K.3
  • 289
    • 0034613462 scopus 로고    scopus 로고
    • 3α-(4-Substituted phenyl)nortropane-2β-carboxylic acid methyl esters show selective binding at the norepinephrine transporter
    • Blough B.E., Holmquist C.R., Abraham P., et al. 3α-(4-Substituted phenyl)nortropane-2β-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett 10 (2000) 2445-2447
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 2445-2447
    • Blough, B.E.1    Holmquist, C.R.2    Abraham, P.3
  • 290
    • 0034087204 scopus 로고    scopus 로고
    • Novel conformationally constrained tropane analogues by 6- endo-trig radical cyclization and stille coupling: switch of activity toward the serotonin and/or norepinephrine transporter
    • Hoepping A., Johnson K.M., George C., et al. Novel conformationally constrained tropane analogues by 6- endo-trig radical cyclization and stille coupling: switch of activity toward the serotonin and/or norepinephrine transporter. J Med Chem 43 (2000) 2064-2071
    • (2000) J Med Chem , vol.43 , pp. 2064-2071
    • Hoepping, A.1    Johnson, K.M.2    George, C.3
  • 291
    • 0034615075 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine
    • Tamiz A.P., Smith M.P., and Kozikowski A.P. Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine. Bioorg Med Chem Lett 10 (2000) 297-300
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 297-300
    • Tamiz, A.P.1    Smith, M.P.2    Kozikowski, A.P.3
  • 292
    • 0038077563 scopus 로고    scopus 로고
    • Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites
    • Zhou J., Zhang A., Kläss T., et al. Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. J Med Chem 46 (2003) 1997-2007
    • (2003) J Med Chem , vol.46 , pp. 1997-2007
    • Zhou, J.1    Zhang, A.2    Kläss, T.3
  • 293
    • 20144368899 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter binding properties of 3α-(substituted phenyl)nortropane-2β-carboxylic acid methyl esters: norepinephrine transporter selective compounds
    • Carroll F.I., Tyagi S., Blough B.E., et al. Synthesis and monoamine transporter binding properties of 3α-(substituted phenyl)nortropane-2β-carboxylic acid methyl esters: norepinephrine transporter selective compounds. J Med Chem 48 (2005) 3852-3857
    • (2005) J Med Chem , vol.48 , pp. 3852-3857
    • Carroll, F.I.1    Tyagi, S.2    Blough, B.E.3
  • 294
    • 18144365841 scopus 로고    scopus 로고
    • Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants
    • Zhou J., Kläß T., Johnson K.M., et al. Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorg Med Chem Lett 15 (2005) 2461-2465
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 2461-2465
    • Zhou, J.1    Kläß, T.2    Johnson, K.M.3
  • 295
    • 33746233399 scopus 로고    scopus 로고
    • Synthesis and monoamine transporter affinity of front bridged tricyclic 3β-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2β-position
    • Zeng F., Jarkas N., Owens M.J., et al. Synthesis and monoamine transporter affinity of front bridged tricyclic 3β-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2β-position. Bioorg Med Chem Lett 16 (2006) 4661-4663
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 4661-4663
    • Zeng, F.1    Jarkas, N.2    Owens, M.J.3
  • 296
    • 43949130429 scopus 로고    scopus 로고
    • From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies
    • Eildal J.N.N., Andersen J., Kristensen A.S., et al. From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J Med Chem 51 (2008) 3045-3048
    • (2008) J Med Chem , vol.51 , pp. 3045-3048
    • Eildal, J.N.N.1    Andersen, J.2    Kristensen, A.S.3
  • 297
    • 3042789525 scopus 로고    scopus 로고
    • 11C]talsupram: candidate PET ligands for the norepinephrine transporter
    • 11C]talsupram: candidate PET ligands for the norepinephrine transporter. Nucl Med Biol 31 (2004) 705-718
    • (2004) Nucl Med Biol , vol.31 , pp. 705-718
    • McConathy, J.1    Owens, M.J.2    Kilts, C.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.