A new positron emission tomography imaging agent for the serotonin transporter: Synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5- fluoromethylphenylamine ([11C]AFM)

Nuclear Medicine and Biology

Volumn 31, Issue 5, 2004, Pages 543-556

  Huang, Yiyun ^a   Hwang, Dah Ren ^a   Bae, Sung A ^a   Sudo, Yasuhiko ^a   Guo, Ningning ^a   Zhu, Zhihong ^a   Narendran, Raj ^a   Laruelle, Marc ^a  

^a Box 31 ^*  (United States)

Author keywords

PET; Radioligand; Serotonin transporter; Synthesis

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; 2 [2 (DIMETHYLAMINOMETHYL)PHENYLTHIO] 5 FLUOROMETHYLPHENYLAMINE C 11; 4 CHLORO 3 NITROBENZYLACETATE; ACETIC ACID DERIVATIVE; CARBON 11; CITALOPRAM; METHYL IODIDE; METHYLAMINE; NISOXETINE; NORADRENALIN UPTAKE INHIBITOR; RADIOLIGAND; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; THIOSALICYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD ANALYSIS; BLOOD SAMPLING; BRAIN CORTEX; BRAIN FUNCTION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BINDING; DRUG DISTRIBUTION; DRUG SELECTIVITY; DRUG SYNTHESIS; HIPPOCAMPUS; ISOTOPE LABELING; LIGAND BINDING; MALE; MESENCEPHALON; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RAT; THALAMUS;

ANILINE COMPOUNDS; ANIMALS; BRAIN; IMAGE INTERPRETATION, COMPUTER-ASSISTED; ISOTOPE LABELING; KINETICS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; PAPIO; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE DISTRIBUTION;

EID: 3042669425     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2003.11.008     Document Type: Article

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