Fluorine in pharmaceuticals: Looking beyond intuition

Science

Volumn 317, Issue 5846, 2007, Pages 1881-1886

  Müller, Klaus ^a   Faeh, Christoph ^b   Diederich, François ^b  

^a Pharma Research   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CIPROFLOXACIN; FLUORINE; FLUOXETINE;

BIOAVAILABILITY; DATABASE; DRUG; FLUORINE; LEAD; ORGANOFLUORINE;

CHEMICAL BOND; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG CONFORMATION; FLUORINATION; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR INTERACTION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DATA BANK; REACTION ANALYSIS; REFERENCE DATABASE; REVIEW; STRUCTURE ANALYSIS;

BIOLOGICAL AVAILABILITY; CARBON; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DATABASES, PROTEIN; FLUORINE; HYDROGEN-ION CONCENTRATION; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHARMACOLOGY; PROTEIN BINDING; PROTEINS;

EID: 34848848499     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1131943     Document Type: Review

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