Imaging the serotonin transporter with positron emission tomography: Initial human studies with [11C]DAPP and [11C]DASB

European Journal of Nuclear Medicine

Volumn 27, Issue 11, 2000, Pages 1719-1722

  Houle, S ^a   Ginovart, N ^a   Hussey, D ^a   Meyer, J H ^a   Wilson, A A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

DAPP; DASB; Positron emission tomography; Serotonin transporter; Substituted phenylthiobenzylamines

Indexed keywords

CARBON 11; CITALOPRAM; N,N DIMETHYL 2 (2 AMINO 4 CYANOPHENYLTHIO)BENZYLAMINE CARBON 11; N,N DIMETHYL 2 (2 AMINO 4 METHOXYPHENYLTHIO)BENZYLAMINE CARBON 11; RADIOLIGAND; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING AFFINITY; DRUG INHIBITION; DRUG METABOLISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; HUMAN EXPERIMENT; KINETICS; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEROTONIN UPTAKE;

ADULT; BENZYLAMINES; CARBON RADIOISOTOPES; CARRIER PROTEINS; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033765742     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590000365     Document Type: Article

References (8)

1. Neuroimaging of serotonin uptake sites and antidepressant binding sites in the thalamus of humans and 'higher' animals
2. 11C](+)McN5652
3. 123I]IDAM
4. Radiosynthesis of carbon-11 labelled N-methyl-2- (arylthio)benzylamines: Potential radiotracers for the serotonin reuptake receptor
5. 11C]-labelled 2-(phenylthio)araalkylamines
6. Radiotracer synthesis from [11C]-iodomethane: A remarkably simple captive solvent method
7. 3H]paroxetine binding, a marker of serotonin uptake sites
8. 3H]paroxetine binding to serotonin uptake sites in human brain tissue