Fluorinated diaryl sulfides as serotonin transporter ligands: Synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2559-2570

  Huang, Yiyun ^a   Bae, Sung A ^a   Zhu, Zhihong ^a   Guo, Ningning ^a   Roth, Bryan L ^b   Laruelle, Marc ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(2 AMINO 4 FLUOROMETHYLPHENYL)THIO] N,N DIMETHYLBENZENEMETHANAMINE; 2 [(2 AMINO 4 FLUOROPHENYL)THIO] N,N DIMETHYLBENZENEMETHANAMINE; 2 [[2 AMINO 4 (2 FLUOROETHYL)PHENYL]THIO] N,N DIMETHYLBENZENEMETHANAMINE; 2 [[2 AMINO 4 (3 FLUOROPROPYL)PHENYL]THIO] N,N DIEMTHYLBENZENEMETHANAMINE; DOPAMINE TRANSPORTER; FLUORINE DERIVATIVE; FLUORODEOXYGLUCOSE F 18; NORADRENALIN TRANSPORTER; RADIOLIGAND; SEROTONIN TRANSPORTER; SULFIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZENE DERIVATIVES; BINDING, COMPETITIVE; BRAIN; CELL LINE; FLUORINE RADIOISOTOPES; HUMANS; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; TISSUE DISTRIBUTION;

EID: 17144418906     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0400808     Document Type: Article

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