-
2
-
-
0141642224
-
Medicine: The NIH roadmap
-
Zerhouni E. Medicine: the NIH roadmap. Science. 2003;302:63-72.
-
(2003)
Science
, vol.302
, pp. 63-72
-
-
Zerhouni, E.1
-
3
-
-
0035819471
-
Advances in biomedical imaging
-
Tempany CM, McNeil BJ. Advances in biomedical imaging. JAMA. 2001;285:562-567.
-
(2001)
JAMA
, vol.285
, pp. 562-567
-
-
Tempany, C.M.1
McNeil, B.J.2
-
4
-
-
1542283700
-
Seeing within: Molecular imaging of the cardiovascular system
-
Jaffer FA, Weissleder R. Seeing within: molecular imaging of the cardiovascular system. Circ Res. 2004;94:433-445.
-
(2004)
Circ Res
, vol.94
, pp. 433-445
-
-
Jaffer, F.A.1
Weissleder, R.2
-
5
-
-
0036507615
-
Would near-infrared fluorescence signals propagate through large human organs for clinical studies?
-
Ntziachristos V, Ripoll J, Weissleder R. Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Opt Lett. 2002;27:333-335.
-
(2002)
Opt Lett
, vol.27
, pp. 333-335
-
-
Ntziachristos, V.1
Ripoll, J.2
Weissleder, R.3
-
6
-
-
2442652873
-
Catheter-based in vivo imaging of enzyme activity and gene expression: Feasibility study in mice
-
Funovics MA, Weissleder R, Mahmood U. Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice. Radiology. 2004;231:659-666.
-
(2004)
Radiology
, vol.231
, pp. 659-666
-
-
Funovics, M.A.1
Weissleder, R.2
Mahmood, U.3
-
7
-
-
0037236238
-
Shedding light onto live molecular targets
-
Weissleder R, Ntziachristos V. Shedding light onto live molecular targets. Nat Med 2003;9:123-128.
-
(2003)
Nat Med
, vol.9
, pp. 123-128
-
-
Weissleder, R.1
Ntziachristos, V.2
-
8
-
-
13844299671
-
-
InfraRedx technology development. Available at: http://www.infraredx.com/ technology.index.htm. Accessed January 20, 2005.
-
InfraRedx Technology Development
-
-
-
9
-
-
0036066218
-
Fluorescence molecular tomography resolves protease activity in vivo
-
Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med 2002;8:757-760.
-
(2002)
Nat Med
, vol.8
, pp. 757-760
-
-
Ntziachristos, V.1
Tung, C.H.2
Bremer, C.3
Weissleder, R.4
-
10
-
-
2342513540
-
Targeted ultrasonic contrast agents for molecular imaging and therapy
-
Lanza GM, Wickline SA. Targeted ultrasonic contrast agents for molecular imaging and therapy. Curr Probl Cardiol. 2003;28:625-653.
-
(2003)
Curr Probl Cardiol
, vol.28
, pp. 625-653
-
-
Lanza, G.M.1
Wickline, S.A.2
-
11
-
-
3042544619
-
Microbubbles in medical imaging: Current applications and future directions
-
Lindner JR, Microbubbles in medical imaging: current applications and future directions. Nat Rev Drug Discov. 2004;3:527-532.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 527-532
-
-
Lindner, J.R.1
-
12
-
-
13844280663
-
-
National Library of Medicine. PubChem. Available at: http://pubchem.ncbi. nlm.nih.gov/. Accessed December 29, 2004.
-
PubChem
-
-
-
13
-
-
0036359767
-
Scaling down imaging: Molecular mapping of cancer in mice
-
Weissleder R. Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer. 2002;2:11-18.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 11-18
-
-
Weissleder, R.1
-
14
-
-
0038469746
-
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
-
Harisinghani MG, Barentsz J, Hahn PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003;348:2491-2499.
-
(2003)
N Engl J Med
, vol.348
, pp. 2491-2499
-
-
Harisinghani, M.G.1
Barentsz, J.2
Hahn, P.F.3
-
15
-
-
0037313516
-
Molecular imaging in drug discovery and development
-
Rudin M, Weissleder R. Molecular imaging in drug discovery and development. Nat Rev Drug Discov. 2003;2:123-131.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 123-131
-
-
Rudin, M.1
Weissleder, R.2
-
16
-
-
85047695615
-
Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for pre-phase I positron emission tomography studies in cancer patients
-
Aboagye EO, Luthra SK, Brady F, et al. Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for pre-phase I positron emission tomography studies in cancer patients. Br J Cancer. 2002;86:1052-1056.
-
(2002)
Br J Cancer
, vol.86
, pp. 1052-1056
-
-
Aboagye, E.O.1
Luthra, S.K.2
Brady, F.3
-
17
-
-
0037338436
-
Molecular imaging in living subjects: Seeing fundamental biological processes in a new light
-
Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003;17:545-580.
-
(2003)
Genes Dev
, vol.17
, pp. 545-580
-
-
Massoud, T.F.1
Gambhir, S.S.2
-
18
-
-
0038142321
-
Molecular-genetic imaging: Current and future perspectives
-
Blasberg RG, Tjuvajev JG. Molecular-genetic imaging: current and future perspectives. J Clin Invest. 2003;111:1620-1629.
-
(2003)
J Clin Invest
, vol.111
, pp. 1620-1629
-
-
Blasberg, R.G.1
Tjuvajev, J.G.2
-
19
-
-
8844232710
-
Molecular, cellular and functional imaging of atherothrombosis
-
Choudhury RP, Fuster V, Fayad ZA. Molecular, cellular and functional imaging of atherothrombosis. Nat Rev Drug Discov. 2004;3:913-925.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 913-925
-
-
Choudhury, R.P.1
Fuster, V.2
Fayad, Z.A.3
-
20
-
-
2342565832
-
Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: An update for the US Preventive Services Task Force
-
Humphrey LL, Teutsch S, Johnson M. Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the US Preventive Services Task Force. Ann Intern Med. 2004;140:740-753.
-
(2004)
Ann Intern Med
, vol.140
, pp. 740-753
-
-
Humphrey, L.L.1
Teutsch, S.2
Johnson, M.3
-
21
-
-
0037433450
-
Colorectal cancer screening: Scientific review
-
Walsh JM, Terdiman JP. Colorectal cancer screening: scientific review. JAMA. 2003;289:1288-1296.
-
(2003)
JAMA
, vol.289
, pp. 1288-1296
-
-
Walsh, J.M.1
Terdiman, J.P.2
-
22
-
-
0037464536
-
Mammographic screening for breast cancer
-
Fletcher SW, Elmore JG. Mammographic screening for breast cancer. N Engl J Med. 2003;348:1672-1680.
-
(2003)
N Engl J Med
, vol.348
, pp. 1672-1680
-
-
Fletcher, S.W.1
Elmore, J.G.2
-
23
-
-
0037016030
-
Screening for prostate cancer: An update of the evidence for the US Preventive Services Task Force
-
Harris R, Lohr KN. Screening for prostate cancer: an update of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2002;137:917-929.
-
(2002)
Ann Intern Med
, vol.137
, pp. 917-929
-
-
Harris, R.1
Lohr, K.N.2
-
24
-
-
0032951071
-
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
-
Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol. 1999;17:375-378.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 375-378
-
-
Weissleder, R.1
Tung, C.H.2
Mahmood, U.3
Bogdanov Jr., A.4
-
25
-
-
0034283034
-
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
-
Tung CH, Mahmood U, Bredow S, Weissleder R. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res. 2000;60:4953-4958.
-
(2000)
Cancer Res
, vol.60
, pp. 4953-4958
-
-
Tung, C.H.1
Mahmood, U.2
Bredow, S.3
Weissleder, R.4
-
26
-
-
0034954524
-
In vivo molecular target assessment of matrix metalloproteinase inhibition
-
Bremer C, Tung CH, Weissleder R. In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat Med. 2001;7:743-748.
-
(2001)
Nat Med
, vol.7
, pp. 743-748
-
-
Bremer, C.1
Tung, C.H.2
Weissleder, R.3
-
27
-
-
0036161155
-
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
-
Marten K, Bremer C, Khazale K, et al. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology. 2002;122:406-414.
-
(2002)
Gastroenterology
, vol.122
, pp. 406-414
-
-
Marten, K.1
Bremer, C.2
Khazale, K.3
-
28
-
-
4344679634
-
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide
-
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R. Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide. Cancer Res. 2004;64:6247-6251.
-
(2004)
Cancer Res
, vol.64
, pp. 6247-6251
-
-
Kelly, K.1
Alencar, H.2
Funovics, M.3
Mahmood, U.4
Weissleder, R.5
-
29
-
-
2342603891
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
-
Joyce JA, Baruch A, Chehade K, et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell. 2004;5:443-453.
-
(2004)
Cancer Cell
, vol.5
, pp. 443-453
-
-
Joyce, J.A.1
Baruch, A.2
Chehade, K.3
-
30
-
-
0034646351
-
Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
-
Ntziachristos V, Yodh AG, Schnall M, Chance B. Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. Proc Natl Acad Sci U S A. 2000;97:2767-2772.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 2767-2772
-
-
Ntziachristos, V.1
Yodh, A.G.2
Schnall, M.3
Chance, B.4
-
31
-
-
0142030499
-
In vivo absorption and scattering spectroscopy of biological tissues
-
Taroni P, Pifferi A, Torricelli A, Comelli D, Cubeddu R. In vivo absorption and scattering spectroscopy of biological tissues. Photochem Photobiol Sci. 2003;2:124-129.
-
(2003)
Photochem Photobiol Sci
, vol.2
, pp. 124-129
-
-
Taroni, P.1
Pifferi, A.2
Torricelli, A.3
Comelli, D.4
Cubeddu, R.5
-
32
-
-
7044260963
-
Diffuse optical imaging of brain activation: Approaches to optimizing image sensitivity, resolution, and accuracy
-
Boas DA, Dale AM, Franceschini MA. Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy. Neuroimage. 2004;23(suppl 1):S275-S288.
-
(2004)
Neuroimage
, vol.23
, Issue.1 SUPPL.
-
-
Boas, D.A.1
Dale, A.M.2
Franceschini, M.A.3
-
33
-
-
0037792992
-
Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography
-
Lardinois D, Weder W, Hany TF, et al. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med. 2003;348:2500-2507.
-
(2003)
N Engl J Med
, vol.348
, pp. 2500-2507
-
-
Lardinois, D.1
Weder, W.2
Hany, T.F.3
-
34
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer. 2002;2:683-693.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 683-693
-
-
Gambhir, S.S.1
-
35
-
-
2942622376
-
The potential of positron-emission tomography to study anticancer-drug resistance
-
West CM, Jones T, Price P. The potential of positron-emission tomography to study anticancer-drug resistance. Nat Rev Cancer. 2004;4:457-469.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 457-469
-
-
West, C.M.1
Jones, T.2
Price, P.3
-
36
-
-
0041765752
-
Is positron emission tomography an accurate noninvasive alternative to sentinel lymph node biopsy in breast cancer patients?
-
Guller U, Nitzsche E, Moch H, Zuber M. Is positron emission tomography an accurate noninvasive alternative to sentinel lymph node biopsy in breast cancer patients? J Natl Cancer Inst. 2003;95:1040-1043.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1040-1043
-
-
Guller, U.1
Nitzsche, E.2
Moch, H.3
Zuber, M.4
-
37
-
-
13844255912
-
Sensitive, noninvasive detection of lymph node metastases
-
Harisinghani MG, Weissleder R. Sensitive, noninvasive detection of lymph node metastases. PLoS Med. 2004;1:e66.
-
(2004)
PLoS Med
, vol.1
-
-
Harisinghani, M.G.1
Weissleder, R.2
-
38
-
-
0036769690
-
Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs)
-
Van den Abbeele AD, Badawi RD. Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs). Eur J Cancer. 2002;38(suppl 5):S60-S65.
-
(2002)
Eur J Cancer
, vol.38
, Issue.5 SUPPL.
-
-
Van Den Abbeele, A.D.1
Badawi, R.D.2
-
39
-
-
12244310130
-
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes
-
Koehne G, Doubrovin M, Doubrovina E, et al. Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nat Biotechnol. 2003;21:405-413,
-
(2003)
Nat Biotechnol
, vol.21
, pp. 405-413
-
-
Koehne, G.1
Doubrovin, M.2
Doubrovina, E.3
-
40
-
-
0026426157
-
Phase I and imaging trial of indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma
-
Divgi CR, Welt S, Kris M, et al. Phase I and imaging trial of indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma. J Natl Cancer Inst. 1991;83:97-104.
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 97-104
-
-
Divgi, C.R.1
Welt, S.2
Kris, M.3
-
41
-
-
0033179332
-
Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development
-
Burns HD, Hamill TG, Eng WS, Francis B, Fioravanti C, Gibson RE. Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development. Curr Opin Chem Biol. 1999;3:388-394.
-
(1999)
Curr Opin Chem Biol
, vol.3
, pp. 388-394
-
-
Burns, H.D.1
Hamill, T.G.2
Eng, W.S.3
Francis, B.4
Fioravanti, C.5
Gibson, R.E.6
-
42
-
-
2542643923
-
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
-
Smith-Jones PM, Solit DB, Akhurst T, Afroze F, Rosen N, Larson SM. Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors. Nat Biotechnol. 2004;22:701-706.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 701-706
-
-
Smith-Jones, P.M.1
Solit, D.B.2
Akhurst, T.3
Afroze, F.4
Rosen, N.5
Larson, S.M.6
-
43
-
-
0141885294
-
From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I
-
Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108:1664-1672.
-
(2003)
Circulation
, vol.108
, pp. 1664-1672
-
-
Naghavi, M.1
Libby, P.2
Falk, E.3
-
44
-
-
0037062686
-
In vivo imaging of proteolytic activity in atherosclerosis
-
Chen J, Tung CH, Mahmood U, et al. In vivo imaging of proteolytic activity in atherosclerosis. Circulation. 2002;105:2766-2771.
-
(2002)
Circulation
, vol.105
, pp. 2766-2771
-
-
Chen, J.1
Tung, C.H.2
Mahmood, U.3
-
45
-
-
0038179627
-
Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging
-
Kooi ME, Cappendijk VC, Cleutjens KB, et al. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation. 2003;107:2453-2458.
-
(2003)
Circulation
, vol.107
, pp. 2453-2458
-
-
Kooi, M.E.1
Cappendijk, V.C.2
Cleutjens, K.B.3
-
46
-
-
3042637502
-
In vivo detection of macrophages in human carotid atheroma: Temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI
-
Trivedi RA, U-King-Im JM, Graves MJ, et al. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke. 2004;35:1631-1635.
-
(2004)
Stroke
, vol.35
, pp. 1631-1635
-
-
Trivedi, R.A.1
U-King-Im, J.M.2
Graves, M.J.3
-
47
-
-
0842265841
-
Intravascular ultrasound molecular imaging of atheroma components in vivo
-
Hamilton AJ, Huang SL, Warnick D, et al. Intravascular ultrasound molecular imaging of atheroma components in vivo. J Am Coll Cardiol. 2004;43:453-460.
-
(2004)
J Am Coll Cardiol
, vol.43
, pp. 453-460
-
-
Hamilton, A.J.1
Huang, S.L.2
Warnick, D.3
-
48
-
-
13844281929
-
-
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. Detection of vascular adhesion molecule 1 expression using a novel multimodal nanoparticle. Available at: http://circres.ahajournals.org. Accessed January 25, 2005.
-
Detection of Vascular Adhesion Molecule 1 Expression Using a Novel Multimodal Nanoparticle
-
-
Kelly, K.A.1
Allport, J.R.2
Tsourkas, A.3
Shinde-Patil, V.R.4
Josephson, L.5
Weissleder, R.6
-
49
-
-
1842483342
-
Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis
-
Kietselaer BL, Reutelingsperger CP, Heidendal GA, et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis. N Engl J Med. 2004;350:1472-1473.
-
(2004)
N Engl J Med
, vol.350
, pp. 1472-1473
-
-
Kietselaer, B.L.1
Reutelingsperger, C.P.2
Heidendal, G.A.3
-
51
-
-
10644257909
-
Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin
-
Matter CM, Schuler PK, Alessi P, et al. Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin. Circ Res. 2004;95:1225-1233.
-
(2004)
Circ Res
, vol.95
, pp. 1225-1233
-
-
Matter, C.M.1
Schuler, P.K.2
Alessi, P.3
-
52
-
-
0037180771
-
Inflammation in atherosclerosis
-
Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-874.
-
(2002)
Nature
, vol.420
, pp. 868-874
-
-
Libby, P.1
-
53
-
-
0034661803
-
Visualisation of cell death in vivo in patients with acute myocardial infarction
-
Hofstra L, Liem IH, Dumont EA, et al. Visualisation of cell death in vivo in patients with acute myocardial infarction. Lancet 2000;356:209-212.
-
(2000)
Lancet
, vol.356
, pp. 209-212
-
-
Hofstra, L.1
Liem, I.H.2
Dumont, E.A.3
-
54
-
-
18244408264
-
Annexin-V imaging for noninvasive detection of cardiac allograft rejection
-
Narula J, Acio ER, Narula N, et al. Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med. 2001;7:1347-1352.
-
(2001)
Nat Med
, vol.7
, pp. 1347-1352
-
-
Narula, J.1
Acio, E.R.2
Narula, N.3
-
55
-
-
0036846990
-
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
-
Jaffer FA, Tung CH, Gerszten RE, Weissleder R. In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol. 2002;22:1929-1935.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 1929-1935
-
-
Jaffer, F.A.1
Tung, C.H.2
Gerszten, R.E.3
Weissleder, R.4
|