Novel radiotracers for imaging the serotonin transporter by positron emission tomography: Synthesis, radiosynthesis, and in vitro and ex vivo evaluation of 11C-labeled 2-(phenylthio)araalkylamines

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 3103-3110

  Wilson, A A ^a   Ginovart, N ^a   Schmidt, M ^b   Meyer, J H ^a   Threlkeld, P G ^b   Houle, S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 DIMETHYLAMINOMETHYLPHENYLSULFANYL) 5 METHOXYPHENYLAMINE; 3 AMINO 4 (2 DIMETHYLAMINOMETHYLPHENYLSULFANYL)BENZONITRILE; ARALKYLAMINE; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYPOTHALAMUS; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; THALAMUS;

ANILINE COMPOUNDS; ANIMALS; BRAIN; CARBON RADIOISOTOPES; CARRIER PROTEINS; HUMANS; ISOTOPE LABELING; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MEMBRANES; NERVE TISSUE PROTEINS; P-CHLOROAMPHETAMINE; PROTEIN BINDING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGENTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034632763     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000079i     Document Type: Article

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