Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization anti stille coupling - Switch of activity toward the serotonin anti/or norepinephrine transporter

Journal of Medicinal Chemistry

Volumn 43, Issue 10, 2000, Pages 2064-2071

  Hoepping, Alexander ^a   Johnson, Kenneth M ^b   George, Clifford ^c   Flippen Anderson, Judith ^c   Kozikowski, Alan P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ACETOXYMETHYL) 9 (3,4 DICHLOROPHENYLMETHYLENE) 7 AZATRICYCLO[4.3.1.0]DECANE; COCAINE; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CYCLIZATION; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARRIER PROTEINS; CORPUS STRIATUM; CYCLIZATION; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HETEROCYCLIC COMPOUNDS, 3-RING; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MESENCEPHALON; MOLECULAR CONFORMATION; NERVE TISSUE PROTEINS; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; OCCIPITAL LOBE; PARIETAL LOBE; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS; SYNAPTOSOMES; TRITIUM; TROPANES;

EID: 0034087204     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0001121     Document Type: Article

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