Binding of S-citalopram and paroxetine discriminates between species

Synapse

Volumn 55, Issue 4, 2005, Pages 280-282

  Elfving, Betina ^a   Wiborg, Ove ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; CITALOPRAM; PAROXETINE; SEROTONIN; SEROTONIN TRANSPORTER; SERTRALINE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BRAIN HOMOGENATE; CEREBELLUM; CHICKEN; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONIN UPTAKE; SEROTONINERGIC TRANSMISSION; SPECIES DIFFERENCE;

ANIMALS; BENZYLAMINES; BINDING, COMPETITIVE; BRAIN; CELLS, CULTURED; CHICKENS; CITALOPRAM; EVOLUTION, MOLECULAR; HUMANS; ISOQUINOLINES; LIGANDS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PAROXETINE; RADIOLIGAND ASSAY; RATS; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; SPECIES SPECIFICITY; TRITIUM;

EID: 13844289397     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.20116     Document Type: Article

References (12)

1. Chalon S, Tarkiainen J, Garreau L, Hall H, Emond P, Vercouillie J, Farde L, Dasse P, Varnas K, Besnard JC, Halldin C, Guilloteau D. 2003. Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity. J Pharmacol Exp Ther 304:81-87.
2. Elfving B, Bjørnholm B, Ebert B, Knudsen GM. 2001. Binding characteristics of selective serotonin reuptake inhibitors with relation to emission tomography studies. Synapse 41:203-211.
3. Erreboe I, Plenge P, Mellerup ET. 1995. Differences in brain 5-HT transporter dissociation rates among animal species. Pharmacol Toxicol 76:376-379.
4. Fuller RW, Wong DT. 1990. Serotonin uptake and serotonin uptake inhibition. Ann N Y Acad Sci 600:68-78.
5. 3H]Sertraline binding to rat brain membranes. Psychopharmacology 100:470-476.
6. Larsen MB, Elfving B, Wiborg O. 2004. The chicken serotonin transporter discriminates between selective serotonin reuptake inhibitors: a species-scanning mutagenesis study. J Biol Chem 279:42147-42156.
7. 3H]paroxetine binding, a marker of serotonin uptake sites. Biol Psychiatry 24:299-309.
8. Maryanoff BE, Vaught JL, Shank RP, McComsey DF, Costanzo MJ, Nortey SO. 1990. Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem 33:2793-2797.
9. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. 1997. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
10. Owens MJ, Knight DL, Nemeroff CB. 2001. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50:345-350.
11. Tatsumi M, Groshan K, Blakely RD, Richelson E. 1997. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-258.
12. White FJ. 1998. Cocaine and the serotonin saga. Nature 393:118-119.