Synthesis of S-([18F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter

Nuclear Medicine and Biology

Volumn 28, Issue 7, 2001, Pages 857-863

  Zessin, Jörg ^a   Eskola, Olli ^b   Brust, Peter ^a   Bergman, Jörgen ^b   Steinbach, Jörg ^a   Lehikoinen, Pertti ^b   Solin, Olof ^b   Johannsen, Bernd ^a  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b TURKU PET CENTRE   (Finland)

Author keywords

(+) McN5652; 18F bromofluoromethane; 18F fluoromethyl analogue; Positron emission tomography; Serotonin transporter

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 1,2,3,5,6,10B HEXAHYDRO 6 [4 (FLUOROMETHYLTHIO)PHENYL]PYRROLO[2,1 A]ISOQUINOLINE F 18; BROMOFLUOROMETHANE F 18; FLUORINE 18; RADIOLIGAND; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG; CARRIER PROTEIN; DIAGNOSTIC AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLUORINE; ISOQUINOLINE DERIVATIVE; MEMBRANE PROTEIN; NERVE PROTEIN; PAROXETINE; RADIOPHARMACEUTICAL AGENT; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SOLVENT;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; ANIMAL; CAUDATE NUCLEUS; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG STABILITY; ISOTOPE LABELING; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RADIOASSAY; SWINE; SYNTHESIS;

ANIMALS; CARRIER PROTEINS; CAUDATE NUCLEUS; DRUG STABILITY; FLUORINE RADIOISOTOPES; INDICATORS AND REAGENTS; ISOQUINOLINES; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PAROXETINE; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SOLVENTS; SWINE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034741137     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00248-7     Document Type: Article

References (24)

1. 18F]bromofluoromethane at high specific radioactivity
2. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide
3. Radioligands for the study of the 5-HT transporter in vivo
4. 2BrF via aminopolyether supported nucleophilic substitution
5. Radiosynthesis of [F-18]Fluoxetine as a potential radiotracer for serotonin reuptake sites
6. PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter
7. 11C]DASB
8. Citalopram: Labelling with carbon-11 and evaluation in rat as a potential radioligand for in vivo studies of 5-HT re-uptake sites
9. Synthesis of radiolabelled inhibitors of presynaptic monamine uptake systems: Fluorine-18 GBR-13119 DA, carbon-11 nisoxetine NE and carbon-11 fluoxetine 5-HT
10. 11C]-sertraline
11. Decreased serotonin transporter binding in unaffected relatives of manic depressive patients
12. 18F]fluoro-McN5652, a novel PET-radiotracer for serotonin uptake site
13. Depression and anxiety in Parkinson's disease: Possible effect of genetic variation in the serotonin transporter
14. 18F]fluoromethylphenyl)tropane-2β-carboxylic acid methyl esters: New ligands for mapping brain dopamine transporter with positron emission tomography
15. Counting of positron-emitting radionuclides on thin layer chromatograms
16. 18F]fluoroethyl analog of McN5652
17. An improved method for the synthesis of radiolabeled McN5652 via thioester precursors
18. A PET radiotracer for studying serotonin uptake sites: Carbon-11-McN-5652Z
19. 18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET
20. 11C](+)-McN5652
21. 1H NMR of α-methoxy-α-(trifluoromethyl)phenylacetic acid complexes
22. PET imaging of central serotonin uptake sites in the baboon brain with [C-11]-N-Me-Paroxetine
23. 123I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder
24. 11C]McN-5652 from racemic McN-5652