Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2β-carbo-1'-fluoro-2-propoxy-3β-(4-chlorophenyl)tropanes. Ligands for the imaging of dopamine transporters by positron emission tomography

Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2000, Pages 639-648

  Xing, Dongxia ^a,b   Chen, Ping ^a,b   Keil, Robert ^a,b   Kilts, Clinton D ^a,b   Shi, Bing ^a,b   Camp, Vernon M ^a,b   Malveaux, Gene ^a,b   Ely, Timothy ^b   Owens, Michael J ^b   Votaw, John ^a,b   Davis, Margaret ^a,b   Hoffman, John M ^a,b   BaKay, Roy A E ^b   Subramanian, Thygarajan ^b   Watts, Ray L ^b   Goodman, Mark M ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ACETONITRILE; CITALOPRAM; DOPAMINE TRANSPORTER; FLUORINE 18; N METHYL 2BETA CARBO 1 FLUORO 2 ISOPROPANOXY 3BETA (4 CHLOROPHENYL)TROPANE; POTASSIUM FLUORIDE; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN; DRUG DISTRIBUTION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGING; ISOTOPE LABELING; MALE; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL LINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PUTAMEN; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; TRANSFECTION; TROPANES; URODELA;

EID: 17744415283     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9902234     Document Type: Article

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