Carboxylesterases - Detoxifying enzymes and targets for drug therapy

Current Medicinal Chemistry

Volumn 13, Issue 9, 2006, Pages 1045-1054

  Potter, Philip M ^a   Wadkins, Randy M ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Carboxylesterase; Drug metabolism; Enzyme structure; Inhibitor

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; BENZENESULFONAMIDE DERIVATIVE; BENZIL; CAPECITABINE; CARBOXYLESTERASE; CARBOXYLESTERASE INHIBITOR; CEFPODOXIME PROXETIL; CEFUROXIME AXETIL; COCAINE; DIAMORPHINE; ENZYME INHIBITOR; ESMOLOL; FLESTOLOL; IRINOTECAN; LIDOCAINE; PETHIDINE; RECOMBINANT ENZYME; SARIN; TABUN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANTINEOPLASTIC ACTIVITY; COCAINE DEPENDENCE; COLON CANCER; DIARRHEA; DRUG CONJUGATION; DRUG DETOXIFICATION; DRUG DISPOSITION; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG INACTIVATION; DRUG INHIBITION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TARGETING; DRUG TRANSFORMATION; ENZYME ACTIVE SITE; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESTERIFICATION; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; TOXICITY TESTING;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; CARCINOGENS; ENZYME INHIBITORS; HUMANS; PRODRUGS;

EID: 33645958909     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706776360969     Document Type: Review

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