A PET imaging agent with fast kinetics: Synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2- dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA)

Nuclear Medicine and Biology

Volumn 31, Issue 6, 2004, Pages 727-738

  Huang, Yiyun ^a,b   Narendran, Raj ^a   Bae, Sung A ^b   Erritzoe, David ^a   Guo, Ningning ^a   Zhu, Zhihong ^b   Hwang, Dah Ren ^a,b   Laruelle, Marc ^a,b  

^a Box 31 ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

In vivo evaluation; PET; Radioligand; Serotonin transporter; Synthesis

Indexed keywords

2 [2 (DIMETHYLAMINOMETHYLPHENYLTHIO)] 5 FLUOROPHENYLAMINE; 2 [2 (DIMETHYLAMINOMETHYLPHENYLTHIO)] 5 FLUOROPHENYLAMINE C 11; ANILINE DERIVATIVE; CITALOPRAM; FLUORINE DERIVATIVE; NISOXETINE; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BABOON; BINDING AFFINITY; BRAIN CORTEX; BRAIN TISSUE; CONTROLLED STUDY; CORPUS STRIATUM; DIAGNOSTIC IMAGING; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG SELECTIVITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MESENCEPHALON; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; REACTION TIME; SENSITIVITY AND SPECIFICITY; THALAMUS;

ANILINE COMPOUNDS; ANIMALS; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INDICATORS AND REAGENTS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; TISSUE DISTRIBUTION;

EID: 3042719513     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2004.03.010     Document Type: Article

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